Search

Your search keyword '"Chedhomme, François-Xavier"' showing total 8 results
Start Over Author "Chedhomme, François-Xavier"
8 results on '"Chedhomme, François-Xavier"'

2. A Decision Support Tool Facilitating Medicine Design for Optimal Acceptability in The Older Population

Author

Vallet, Thibault, Belissa, Emilie, Laribe-Caget, Sandra, Chevallier, Alain, Chedhomme, François-Xavier, Leglise, Patrick, Piccoli, Matthieu, Michelon, Hugues, Bloch, Vanessa, Meaume, Sylvie, Grancher, Anne-Sophie, Bachalat, Nathalie, Boulaich, Imad, Abdallah, Fattima, Rabus, Maite, Rwabihama, Jean-Paul, Ribemont, Annie-Claude, Lachuer, Celia, Perquy, Ines, Lechowski, Laurent, Delahaye, Anne, Depoisson, Mathieu, Orven, Yann, Guinot, Caroline, Gibaud, Stephane, Michel, Corinne, Mahiou, Abdel, Belbachir, Sid-Ahmed, Trouvin, Jean-Hugues, Dufaÿ-Wojcicki, Amelie, Boudy, Vincent, and Ruiz, Fabrice

Published
2018
Full Text
View/download PDF

3. Acceptability of oral liquid pharmaceutical products in older adults: palatability and swallowability issues

Author

Belissa, Emilie, primary, Vallet, Thibault, additional, Laribe-Caget, Sandra, additional, Chevallier, Alain, additional, Chedhomme, François-Xavier, additional, Abdallah, Fattima, additional, Bachalat, Nathalie, additional, Belbachir, Sid-Ahmed, additional, Boulaich, Imad, additional, Bloch, Vanessa, additional, Delahaye, Anne, additional, Depoisson, Mathieu, additional, Wojcicki, Amélie Dufaÿ, additional, Gibaud, Stéphane, additional, Grancher, Anne-Sophie, additional, Guinot, Caroline, additional, Lachuer, Celia, additional, Lechowski, Laurent, additional, Leglise, Patrick, additional, Mahiou, Abdel, additional, Meaume, Sylvie, additional, Michel, Corinne, additional, Michelon, Hugues, additional, Orven, Yann, additional, Perquy, Ines, additional, Piccoli, Matthieu, additional, Rabus, Maïté, additional, Ribemont, Annie-Claude, additional, Rwabihama, Jean-Paul, additional, Trouvin, Jean-Hugues, additional, Ruiz, Fabrice, additional, and Boudy, Vincent, additional

Published
2019
Full Text
View/download PDF

4. Brain natriuretic peptide usefulness in very elderly dyspnoeic patients: the BED study

Author

Plichart, Matthieu, Orvoën, Galdric, Jourdain, Patrick, Quinquis, Laurent, Coste, Joël, Escande, Michele, Friocourt, Patrick, Paillaud, Elena, Chedhomme, François-Xavier, Labourée, Florian, Boully, Clémence, Benetos, Athanase, Domerego, Jean-Jacques, Komajda, Michel, Hanon, Olivier, AP-HP - Hôpital Cochin Broca Hôtel Dieu [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), Université Paris Descartes - Paris 5 (UPD5), Centre Hospitalier René Dubos [Pontoise], Unité d’Epidémiologie et de Biostatistiques [APHP Cochin-Broca-Hôtel Dieu], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Clinique Vert Coteau, Centre Hospitalier de Blois (CHB), Hôpital Henri Mondor, Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Gériatrie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Hôpital Privé Gériatrique les Sources, Nice, France, Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Institute of cardiometabolism and nutrition (ICAN), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Institut de cardiologie [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Université Pierre et Marie Curie - Paris 6 (UPMC), Assistance Publique – Hôpitaux de Paris, 2006, Appel d’offre médecine aiguë– Call Acute Medicine, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases (ICAN), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)

Subjects
Elderly, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, [SDV]Life Sciences [q-bio], [SDV.MHEP.GEG]Life Sciences [q-bio]/Human health and pathology/Geriatry and gerontology, Diagnosis, Discrimination, Dyspnoea, cardiovascular system, Heart failure, Brain natriuretic peptide, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; AIMS:To evaluate the interest of brain natriuretic peptide (BNP) for heart failure (HF) diagnosis in very old patients.METHODS AND RESULTS:A total of 383 patients aged 80 years or older, hospitalized in geriatrics care for dyspnoea, had a BNP measurement at the acute phase. Independent cardiologists blinded to BNP values classified the patients into cardiac vs. respiratory aetiology according to the European Society of Cardiology guidelines. Mean (SD) age was 88.5 (5.4) years, 66% (n = 254) of patients were women, 62% (n = 238) had cardiac dyspnoea and 38% (n = 145) had respiratory dyspnoea. The BNP levels were significantly higher in the cardiac group (median = 385.5 ng/L, interquartile range = 174.0-842.0) than in the respiratory group (median = 172.0 ng/L, interquartile range = 70.8-428.0; P < 0.001). On its own, BNP showed poor discriminative ability [area under the curve (AUC) = 0.68; 95% confidence interval (CI) 0.62-0.73] for the diagnostic. In multivariate analysis, BNP remained independently associated with the cardiac aetiology after full-adjustment (odds ratio 1 log increase = 1.87; 95% CI 1.28-2.74), but did not improve the discrimination between the cardiac and the respiratory aetiologies (ΔAUC = 0.013, P = 0.16). In addition, although adding BNP to the other predictive covariates yielded a significant continuous NRI of 57.8% (95% CI 31.2-83.5%), the mean changes in individual predicted probabilities were too low (

Published
2017

5. Brain natriuretic peptide usefulness in very elderly dyspnoeic patients: the BED study

Author

Plichart, Matthieu, primary, Orvoën, Galdric, additional, Jourdain, Patrick, additional, Quinquis, Laurent, additional, Coste, Joël, additional, Escande, Michele, additional, Friocourt, Patrick, additional, Paillaud, Elena, additional, Chedhomme, François-Xavier, additional, Labourée, Florian, additional, Boully, Clémence, additional, Benetos, Athanase, additional, Domerego, Jean-Jacques, additional, Komajda, Michel, additional, and Hanon, Olivier, additional

Published
2016
Full Text
View/download PDF

8. Brain natriuretic peptide usefulness in very elderly dyspnoeic patients: the BED study.

Author

Plichart M, Orvoën G, Jourdain P, Quinquis L, Coste J, Escande M, Friocourt P, Paillaud E, Chedhomme FX, Labourée F, Boully C, Benetos A, Domerego JJ, Komajda M, and Hanon O

Subjects
Aged, 80 and over, Diagnosis, Differential, Dyspnea diagnosis, Dyspnea etiology, Female, Heart Failure complications, Heart Failure diagnosis, Humans, Male, Multivariate Analysis, Odds Ratio, Respiratory Tract Diseases complications, Respiratory Tract Diseases diagnosis, Dyspnea blood, Heart Failure blood, Natriuretic Peptide, Brain blood, Respiratory Tract Diseases blood
Abstract

Aims: To evaluate the interest of brain natriuretic peptide (BNP) for heart failure (HF) diagnosis in very old patients., Methods and Results: A total of 383 patients aged 80 years or older, hospitalized in geriatrics care for dyspnoea, had a BNP measurement at the acute phase. Independent cardiologists blinded to BNP values classified the patients into cardiac vs. respiratory aetiology according to the European Society of Cardiology guidelines. Mean (SD) age was 88.5 (5.4) years, 66% (n = 254) of patients were women, 62% (n = 238) had cardiac dyspnoea and 38% (n = 145) had respiratory dyspnoea. The BNP levels were significantly higher in the cardiac group (median = 385.5 ng/L, interquartile range = 174.0-842.0) than in the respiratory group (median = 172.0 ng/L, interquartile range = 70.8-428.0; P < 0.001). On its own, BNP showed poor discriminative ability [area under the curve (AUC) = 0.68; 95% confidence interval (CI) 0.62-0.73] for the diagnostic. In multivariate analysis, BNP remained independently associated with the cardiac aetiology after full-adjustment (odds ratio 1 log increase = 1.87; 95% CI 1.28-2.74), but did not improve the discrimination between the cardiac and the respiratory aetiologies (ΔAUC = 0.013, P = 0.16). In addition, although adding BNP to the other predictive covariates yielded a significant continuous NRI of 57.8% (95% CI 31.2-83.5%), the mean changes in individual predicted probabilities were too low (<3%) to be clinically relevant., Conclusion: In this population of very old patients with acute dyspnoea, despite being independently associated with the cardiac aetiology, BNP was not useful for better discriminating cardiac vs. respiratory origin., (© 2016 The Authors. European Journal of Heart Failure © 2016 European Society of Cardiology.)

Published
2017
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results