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3. A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Published
2023
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4. Unusual clinical spectra of childhood severe malaria during malaria epidemic in eastern Uganda: a prospective study

Author

Cate Namayanja, Egiru Emma Isaiah Eregu, Paul Ongodia, Charles Benard Okalebo, William Okiror, Francis Okello, Ambrose Okibure, George Paasi, Hellen Kakungulu, Abongo Grace, Rita Muhindo, Duncan Banks, Chebet Martin, Simon Taylor-Robinson, and Peter Olupot-Olupot

Subjects
Clinical spectrum, Severe malaria, Child, Prolonged hospitalization and mortality, Arctic medicine. Tropical medicine, RC955-962, Infectious and parasitic diseases, RC109-216
Abstract

Abstract Background In sub-Saharan Africa (SSA), malaria remains a public health problem despite recent reports of declining incidence. Severe malaria is a multiorgan disease with wide-ranging clinical spectra and outcomes that have been reported to vary by age, geographical location, transmission intensity over time. There are reports of recent malaria epidemics or resurgences, but few data, if any, focus on the clinical spectrum of severe malaria during epidemics. This describes the clinical spectrum and outcomes of childhood severe malaria during the disease epidemic in Eastern Uganda. Methods This prospective cohort study from October 1, 2021, to September 7, 2022, was nested within the ‘Malaria Epidemiological, Pathophysiological and Intervention studies in Highly Endemic Eastern Uganda’ (TMA2016SF-1514-MEPIE Study) at Mbale Regional Referral Hospital, Uganda. Children aged 60 days to 12 years who at admission tested positive for malaria and fulfilled the clinical WHO criteria for surveillance of severe malaria were enrolled on the study. Follow-up was performed until day 28. Data were collected using a customized proforma on social demographic characteristics, clinical presentation, treatment, and outcomes. Laboratory analyses included complete blood counts, malaria RDT (SD BIOLINE Malaria Ag P.f/Pan, Ref. 05FK60-40-1) and blood slide, lactate, glucose, blood gases and electrolytes. In addition, urinalysis using dipsticks (Multistix® 10 SG, SIEMENS, Ref.2300) at the bedside was done. Data were analysed using STATA V15.0. The study had prior ethical approval. Results A total of 300 participants were recruited. The median age was 4.6 years, mean of 57.2 months and IQR of 44.5 months. Many children, 164/300 (54.7%) were under 5 years, and 171/300 (57.0%) were males. The common clinical features were prostration 236/300 (78.7%), jaundice in 205/300 (68.3%), severe malarial anaemia in 158/300 (52.7%), black water fever 158/300 (52.7%) and multiple convulsions 51/300 (17.0%), impaired consciousness 50/300(16.0%), acidosis 41/300(13.7%), respiratory distress 26/300(6.7%) and coma in 18/300(6.0%). Prolonged hospitalization was found in 56/251 (22.3%) and was associated with acidosis, P = 0.041. The overall mortality was 19/300 (6.3%). Day 28 follow-up was achieved in 247/300 (82.3%). Conclusion During the malaria epidemic in Eastern Uganda, severe malaria affected much older children and the spectrum had more of prostration, jaundice severe malarial anaemia, black water fever and multiple convulsions with less of earlier reported respiratory distress and cerebral malaria.

Published
2023
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5. Low Malaria Parasite Density is Associated with Severe Malaria in Children in Eastern Uganda: a cross sectional study

Author

Egiru, Emma Isaiah Eregu, primary, NAMAYANJA, CATE, additional, Tegu, Crispus, additional, Chebet, Martin, additional, Okiror, William, additional, Ongodia, Paul, additional, Okalebo, Charles Bernard, additional, Muhindo, Rita, additional, Abongo, Grace, additional, Paasi, George, additional, Francis, Okello, additional, Okibure, Ambrose, additional, Mukunya, David, additional, and Olupot-Olupot, Peter, additional

Published
2023
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9. High Burden of Neurodevelopmental Delay among Children Born to Women with Obstructed Labour in Eastern Uganda: A Cohort Study

Author

Chebet, Martin, primary, Musaba, Milton W., additional, Mukunya, David, additional, Makoko, Brian, additional, Napyo, Agnes, additional, Nantale, Ritah, additional, Auma, Proscovia, additional, Atim, Ketty, additional, Nahurira, Doreck, additional, Lee, Seungwon, additional, Okello, Dedan, additional, Ssegawa, Lawrence, additional, Bromley, Kieran, additional, Burgoine, Kathy, additional, Ndeezi, Grace, additional, Tumwine, James K., additional, Wandabwa, Julius, additional, and Kiguli, Sarah, additional

Published
2023
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11. Additional file 1 of A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Abstract

Additional file 1: Appendix 1. Poster shown and given in the antenatal period to supplement alcohol based hand rub training in the BabyGel trial.

Published
2023
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12. Additional file 2 of A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Abstract

Additional file 2: Appendix 2. Poster shown and given in the postnatal period to supplement alcohol based hand rub training in the BabyGel trial.

Published
2023
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13. Additional file 6 of A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Abstract

Additional file 6: Picture 1. Components of a Maama birth kit given to pregnant women in the BabyGel Trial. Picture 2. Alcohol Based Handrub Package given to pregnant women in the intervention arm of the BabyGel Trial.

Published
2023
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14. Additional file 4 of A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Abstract

Additional file 4.

Published
2023
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15. Additional file 3 of A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Abstract

Additional file 3: Appendix 3. Alcohol based hand rub training guide used in the BabyGel trial.

Published
2023
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16. Additional file 5 of A cluster randomised trial to evaluate the effectiveness of household alcohol-based hand rub for the prevention of sepsis, diarrhoea, and pneumonia in Ugandan infants (the BabyGel trial): a study protocol

Author

Chebet, Martin, Mukunya, David, Burgoine, Kathy, Kühl, Melf-Jakob, Wang, Duolao, Medina-Lara, Antonieta, Faragher, Eric Brian, Odiit, Amos, Olupot-Olupot, Peter, Stadskleiv Engebretsen, Ingunn Marie, Waniaye, John Baptist, Wandabwa, Julius, Tylleskär, Thorkild, and Weeks, Andrew

Abstract

Additional file 5.

Published
2023
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17. A Clinical and Physiological Prospective Observational Study on the Management of Pediatric Shock in the Post-Fluid Expansion as Supportive Therapy Trial Era*

Author

Obonyo, Nchafatso G., primary, Olupot-Olupot, Peter, additional, Mpoya, Ayub, additional, Nteziyaremye, Julius, additional, Chebet, Martin, additional, Uyoga, Sophie, additional, Muhindo, Rita, additional, Fanning, Jonathon P., additional, Shiino, Kenji, additional, Chan, Jonathan, additional, Fraser, John F., additional, and Maitland, Kathryn, additional

Published
2022
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19. Additional file 3 of Maternal and newborn health priority setting partnership in rural Uganda in association with the James Lind Alliance: a study protocol

Author

Ditai, James, Monicah Nakyazze, Namutebi, Deborah Andrinar, Proscovia Auma, Chebet, Martin, Nalumansi, Cynthia, Nabulo, Grace Martha, Mugabe, Kenneth, Toto Anne Gronlund, Mbonye, Anthony, and Weeks, Andrew D.

Subjects
GeneralLiterature_INTRODUCTORYANDSURVEY, Data_FILES
Abstract

Additional file 3. Initial survey data tool.

Published
2020
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20. Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda

Author

Olupot-Olupot, Peter, primary, Prevatt, Natalie, additional, Engoru, Charles, additional, Nteziyaremye, Julius, additional, Amorut, Denis, additional, Chebet, Martin, additional, Senyondo, Tonny, additional, Ongodia, Paul, additional, Ndila, Carolyne M., additional, Williams, Thomas N., additional, and Maitland, Kathryn, additional

Published
2019
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21. Evaluation of the diagnostic accuracy and cost of different methods for the assessment of severe anaemia in hospitalised children in Eastern Uganda

Author

Olupot-Olupot, Peter, primary, Prevatt, Natalie, additional, Engoru, Charles, additional, Nteziyaremye, Julius, additional, Amorut, Denis, additional, Chebet, Martin, additional, Senyondo, Tonny, additional, Ongodia, Paul, additional, Ndila, Carolyne M., additional, Williams, Thomas N., additional, and Maitland, Kathryn, additional

Published
2018
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22. Phase II trial of standard versus increased transfusion volume in Ugandan children with acute severe anemia

Author

Olupot-Olupot, Peter, primary, Engoru, Charles, additional, Thompson, Jennifer, additional, Nteziyaremye, Julius, additional, Chebet, Martin, additional, Ssenyondo, Tonny, additional, Dambisya, Cornelius M, additional, Okuuny, Vicent, additional, Wokulira, Ronald, additional, Amorut, Denis, additional, Ongodia, Paul, additional, Mpoya, Ayub, additional, Williams, Thomas N, additional, Uyoga, Sophie, additional, Macharia, Alex, additional, Gibb, Diana M, additional, Walker, A Sarah, additional, and Maitland, Kathryn, additional

Published
2014
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23. Decreased renal function among children born to women with obstructed labour in Eastern Uganda: a cohort study.

Author

Mukunya D, Oguttu F, Nambozo B, Nantale R, Makoko TB, Napyo A, Tumuhamye J, Wani S, Auma P, Atim K, Okello D, Wamulugwa J, Ssegawa L, Wandabwa J, Kiguli S, Chebet M, Musaba MW, and Nahurira D

Abstract

Background: Over two million children and adolescents suffer from chronic kidney disease globally. Early childhood insults such as birth asphyxia could be risk factors for development of chronic kidney disease in infancy. Our study aimed to assess renal function among children aged two to four years, born to women with obstructed labour., Methods: We followed up 144 children aged two to four years, born to women with obstructed labor at Mbale regional referral hospital in Eastern Uganda. We used estimated glomerular filtration rate (eGFR) by the Schwartz formula to calculate eGFR (0.413*height)/ serum creatinine as a measure of renal function. eGFR less than 90 ml/min/1.73m 2 was classified as decreased renal function., Results: The mean age of the children was 2.8 years, standard deviation (SD) of 0.4 years. Majority of the children were male (96/144: 66.7%). The mean umbilical lactate level at birth among the study participants was 8.9 mmol/L with a standard deviation (SD) of 5.0. eGFR values ranged from 55 to 163ml/min/1.72m 2 , mean 85.8 ± SD 15.9. One third (31.3%) 45/144 had normal eGFR (> 90 ml/Min/1.72m 2 ), two thirds (67.4%) 97/144 had a mild decrease of eGFR (60-89 ml/Min/1.72m 2 ), and only 2/144 (1.4%) had a moderate decrease of eGFR. Overall incidence of reduced eGFR was 68.8% (99/144)., Conclusion: We observed a high incidence of impaired renal function among children born to women with obstructed labour. We recommend routine follow up of children born to women with obstructed labour and add our voices to those calling for improved intra-partum and peripartum care., Competing Interests: Conflicts of interest The authors declare no conflict of interest.

Published
2023
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