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5 results on '"Che-Hsiung Yang"'

1. A 70-Mb/s 100.5-dBm Sensitivity 65-nm LP MIMO Chipset for WiMAX Portable Router.

Author

Shyuan Liao, Yen-Shuo Chang, Chia-Hsin Wu, Hung-Chieh Tsai, Hsin-Hua Chen, Min Chen, Ching-Wen Hsueh, Jian-Bang Lin, Den-Kai Juang, Shun-An Yang, Chin-Tai Liu, Tsai-Pao Lee, Jin-Ru Chen, Chih-Heng Shih, Barry Hong, Heng-Ruey Hsu, Chih-Yuan Wang, Meng-Shiang Lin, Wei-Hsiang Tseng, Che-Hsiung Yang, Lawrence Chen Lee, Ting-Jyun Jheng, Wen-Wei Yang, Ming-Yang Chao, and Jyh-Shin Pan

Published
2012
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2. Low-Cytotoxic Synthetic Bromorutaecarpine Exhibits Anti-Inflammation and Activation of Transient Receptor Potential Vanilloid Type 1 Activities

Author

Sheng-Tung Huang, Feng Yen Lin, Chun Mao Lin, Jiun An Gu, Chi-Ming Lee, Che Hsiung Yang, Wei Chi Yang, Shih Hao Huang, and Tin Gan Rau

Subjects
Lipopolysaccharide, Article Subject, Anti-Inflammatory Agents, Nitric Oxide Synthase Type II, TRPV Cation Channels, lcsh:Medicine, Inflammation, Pharmacology, Endothelial NOS, General Biochemistry, Genetics and Molecular Biology, Nitric oxide, Evodia, Indole Alkaloids, chemistry.chemical_compound, medicine, Cytotoxic T cell, Humans, Cytotoxicity, General Immunology and Microbiology, Macrophages, lcsh:R, General Medicine, Rutaecarpine, chemistry, Gene Expression Regulation, Cardiovascular Diseases, Quinazolines, Tumor necrosis factor alpha, medicine.symptom, Drugs, Chinese Herbal, Research Article
Abstract

Rutaecarpine (RUT), the major bioactive ingredient isolated from the Chinese herbEvodia rutaecarpa, possesses a wide spectrum of biological activities, including anti-inflammation and preventing cardiovascular diseases. However, its high cytotoxicity hampers pharmaceutical development. We designed and synthesized a derivative of RUT, bromo-dimethoxyrutaecarpine (Br-RUT), which showed no cytotoxicity at 20 μM. Br-RUT suppressed nitric oxide (NO) production and tumor necrosis factor-αrelease in concentration-dependent (0~20 μM) manners in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages; protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 induced by LPS were downregulated. Br-RUT inhibited cell migration and invasion of ovarian carcinoma A2780 cells with 0~48 h of treatment. Furthermore, Br-RUT enhanced the expression of transient receptor potential vanilloid type 1 and activated endothelial NOS in human aortic endothelial cells. These results suggest that the synthetic Br-RUT possesses very low cytotoxicity but retains its activities against inflammation and vasodilation that could be beneficial for cardiovascular disease therapeutics.

Published
2013

3. Topoisomerase I inhibitor evodiamine acts as an antibacterial agent against drug-resistant Klebsiella pneumoniae

Author

Hsiang Ping Tsai, Jui Yu Wu, Chun Mao Lin, Che Hsiung Yang, Chien Chun Yang, Chien Shu Chen, Ming Chih Chang, and Hsiu Chen Lin

Subjects
medicine.drug_class, Klebsiella pneumoniae, Antibiotics, Pharmaceutical Science, Microbial Sensitivity Tests, Topoisomerase-I Inhibitor, Analytical Chemistry, Microbiology, Evodia, Minimum inhibitory concentration, chemistry.chemical_compound, Evodiamine, Drug Discovery, Drug Resistance, Bacterial, medicine, Escherichia coli, Antibacterial agent, Pharmacology, biology, Plant Extracts, Topoisomerase, Organic Chemistry, biology.organism_classification, Anti-Bacterial Agents, Complementary and alternative medicine, chemistry, biology.protein, Quinazolines, Molecular Medicine, Topoisomerase I Inhibitors, Topoisomerase inhibitor
Abstract

Topoisomerase inhibitors have been developed in a variety of clinical applications. We investigated the inhibitory effect of evodiamine on E. coli topoisomerase I, which may lead to an anti-bacterial effect. Evodiamine inhibits the supercoiled plasmid DNA relaxation that is catalyzed by E. coli topoisomerase I, and computer-aided docking has shown that the Arg161 and Asp551 residues of topoisomerase I interact with evodiamine. We investigated the bactericidal effect of evodiamine against multidrug-resistant Klebsiella pneumoniae. Evodiamine showed a significantly lower minimal inhibitory concentration value (MIC 128 µg/mL) compared with antibiotics (> 512 µg/mL) against the clinical isolate of K. pneumoniae. The results suggested that evodiamine is a potential agent against drug-resistant bacteria.

Published
2012

4. Low-Cytotoxic Synthetic Bromorutaecarpine Exhibits Anti-Inflammation and Activation of Transient Receptor Potential Vanilloid Type 1 Activities.

Author

Chi-Ming Lee, Jiun-An Gu, Tin-GanRau, Che-Hsiung Yang, Wei-Chi Yang, Shih-Hao Huang, Feng-Yen Lin, Chun-Mao Lin, and Sheng-Tung Huang

Abstract

Rutaecarpine (RUT), the major bioactive ingredient isolated from the Chinese herb Evodia rutaecarpa, possesses a wide spectrum of biological activities, including anti-inflammation and preventing cardiovascular diseases. However, its high cytotoxicity hampers pharmaceutical development. We designed and synthesized a derivative of RUT, bromo-dimethoxyrutaecarpine (Br-RUT), which showed no cytotoxicity at 20 μM. Br-RUT suppressed nitric oxide (NO) production and tumor necrosis factor-a release in concentration-dependent (0~20 μM) manners in lipopolysaccharide (LPS)-treated RAW 264.7 macrophages; protein levels of inducible NO synthase (iNOS) and cyclooxygenase-2 induced by LPS were downregulated. Br-RUT inhibited cell migration and invasion of ovarian carcinoma A2780 cells with 0~48h of treatment. Furthermore, Br-RUT enhanced the expression of transient receptor potential vanilloid type 1 and activated endothelial NOS in human aortic endothelial cells. These results suggest that the synthetic Br-RUT possesses very low cytotoxicity but retains its activities against inflammation and vasodilation that could be beneficial for cardiovascular disease therapeutics. [ABSTRACT FROM AUTHOR]

Published
2013
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