282 results on '"Chène, Patrick"'
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2. Author Correction: Direct and selective pharmacological disruption of the YAP–TEAD interface by IAG933 inhibits Hippo-dependent and RAS–MAPK-altered cancers
3. Study of the TEAD-binding domain of the VGLL1, VGLL2 and VGLL3 proteins from vertebrates
4. The role of lysine palmitoylation/myristoylation in the function of the TEAD transcription factors
5. Direct Inhibition of the YAP : TEAD Interaction: An Unprecedented Drug Discovery Challenge.
6. mRNA Display Identifies Potent, Paralog-Selective Peptidic Ligands for ARID1B
7. A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors
8. 1H, 13C, 15N resonance assignment of human YAP 50–171 fragment
9. Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP‐TEAD Protein‐Protein Interaction Inhibitors
10. Supplementary Figure 7 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
11. Supplementary Figure 3 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
12. Supplementary Figure 6 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
13. Supplementary Materials, Tables 1-2, Figure Legends 1-8 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
14. Supplementary Figure 5 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
15. Supplementary Figure 8 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
16. Supplementary Figure 2 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
17. Supplementary Figure 1 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
18. Supplementary Figure 4 from Identification and Characterization of NVP-BKM120, an Orally Available Pan-Class I PI3-Kinase Inhibitor
19. Supplementary Data from Potent and Selective Inhibition of Polycythemia by the Quinoxaline JAK2 Inhibitor NVP-BSK805
20. Supplementary Material from Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
21. Supplementary Fig from Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity
22. Supplementary Tables from Preclinical Antitumor Activity of the Orally Available Heat Shock Protein 90 Inhibitor NVP-BEP800
23. Design and Biochemical Characterization of Peptidic Inhibitors of the Myb/p300 Interaction
24. Biochemical and Structural Characterization of a Peptidic Inhibitor of the YAP:TEAD Interaction That Binds to the α-Helix Pocket on TEAD
25. N‐terminal β‐strand in YAP is critical for stronger binding to scalloped relative to TEAD transcription factor
26. Front Cover: The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition (ChemMedChem 19/2022)
27. The First Class of Small Molecules Potently Disrupting the YAP‐TEAD Interaction by Direct Competition
28. Effect of the acylation of TEAD4 on its interaction with co‐activators YAP and TAZ
29. M2 isoform of pyruvate kinase is dispensable for tumor maintenance and growth
30. Can biochemistry drive drug discovery beyond simple potency measurements?
31. Long-range structural preformation in yes-associated protein precedes encounter complex formation with TEAD
32. Leveraging the Contribution of Thermodynamics in Drug Discovery with the Help of Fluorescence-Based Thermal Shift Assays
33. Cover Feature: Direct Inhibition of the YAP : TEAD Interaction: An Unprecedented Drug Discovery Challenge (ChemMedChem 19/2024).
34. Biochemical properties of VGLL4 fromHomo sapiensand Tgi fromDrosophila melanogasterand possible biological implications
35. PcrA/UvrD/Rep DNA helicases in bacterial genomes
36. Challenges in design of biochemical assays for the identification of small molecules to target multiple conformations of protein kinases
37. The role of tetramerization in p53 function
38. Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence
39. Study of the TEAD ‐binding domain of the YAP protein from animal species
40. A new perspective on the evolution of the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors
41. An Early Association between the α-Helix of the TEAD Binding Domain of YAP and TEAD Drives the Formation of the YAP:TEAD Complex
42. Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson’s chorioretinal atrophy
43. Development and Implementation of a Highly Miniaturized Confocal 2D-FIDA–Based High-Throughput Screening Assay to Search for Active Site Modulators of the Human Heat Shock Protein 90β
44. Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications.
45. Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors
46. Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy
47. Discovery and Structural Characterization of ATP-Site Ligands for the Wild-Type and V617F Mutant JAK2 Pseudokinase Domain
48. Study of the TEAD‐binding domain of the YAP protein from animal species.
49. Discovery of a novel class of highly potent inhibitors of the p53–MDM2 interaction by structure-based design starting from a conformational argument
50. Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.
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