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4 results on '"Chawdury A"'

1. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection (vol 44, pg 46, 2016)

Author

Heaton, Nicholas S, Moshkina, Natasha, Fenouil, Romain, Gardner, Thomas J, Aguirre, Sebastian, Shah, Priya S, Zhao, Nan, Manganaro, Lara, Hultquist, Judd F, Noel, Justine, Sachs, David, Hamilton, Jennifer, Leon, Paul E, Chawdury, Amit, Tripathi, Shashank, Melegari, Camilla, Campisi, Laura, Hai, Rong, Metreveli, Giorgi, Gamarnik, Andrea V, Garcia-Sastre, Adolfo, Greenbaum, Benjamin, Simon, Viviana, Fernandez-Sesma, Ana, Krogan, Nevan J, Mulder, Lubbertus CF, van Bakel, Harm, Tortorella, Domenico, Taunton, Jack, Palese, Peter, and Marazzi, Ivan

Subjects
Immunology
Published
2016

2. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection.

Author

Heaton, Nicholas S, Heaton, Nicholas S, Moshkina, Natasha, Fenouil, Romain, Gardner, Thomas J, Aguirre, Sebastian, Shah, Priya S, Zhao, Nan, Manganaro, Lara, Hultquist, Judd F, Noel, Justine, Sachs, David, Hamilton, Jennifer, Leon, Paul E, Chawdury, Amit, Tripathi, Shashank, Melegari, Camilla, Campisi, Laura, Hai, Rong, Metreveli, Giorgi, Gamarnik, Andrea V, García-Sastre, Adolfo, Greenbaum, Benjamin, Simon, Viviana, Fernandez-Sesma, Ana, Krogan, Nevan J, Mulder, Lubbertus CF, van Bakel, Harm, Tortorella, Domenico, Taunton, Jack, Palese, Peter, Marazzi, Ivan, Heaton, Nicholas S, Heaton, Nicholas S, Moshkina, Natasha, Fenouil, Romain, Gardner, Thomas J, Aguirre, Sebastian, Shah, Priya S, Zhao, Nan, Manganaro, Lara, Hultquist, Judd F, Noel, Justine, Sachs, David, Hamilton, Jennifer, Leon, Paul E, Chawdury, Amit, Tripathi, Shashank, Melegari, Camilla, Campisi, Laura, Hai, Rong, Metreveli, Giorgi, Gamarnik, Andrea V, García-Sastre, Adolfo, Greenbaum, Benjamin, Simon, Viviana, Fernandez-Sesma, Ana, Krogan, Nevan J, Mulder, Lubbertus CF, van Bakel, Harm, Tortorella, Domenico, Taunton, Jack, Palese, Peter, and Marazzi, Ivan

Abstract

Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress viral replication and a potential pan-antiviral therapy. To define the cellular proteins and processes required for a virus during infection is thus crucial to understanding the mechanisms of virally induced disease. In this report, we generated fully infectious tagged influenza viruses and used infection-based proteomics to identify pivotal arms of cellular signaling required for influenza virus growth and infectivity. Using mathematical modeling and genetic and pharmacologic approaches, we revealed that modulation of Sec61-mediated cotranslational translocation selectively impaired glycoprotein proteostasis of influenza as well as HIV and dengue viruses and led to inhibition of viral growth and infectivity. Thus, by studying virus-human protein-protein interactions in the context of active replication, we have identified targetable host factors for broad-spectrum antiviral therapies.

Published
2016

3. Corrections to Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection. (Immunity 44, 46-58, January 19, 2016).

Author

Heaton, NS, Heaton, NS, Moshkina, N, Fenouil, R, Gardner, TJ, Aguirre, S, Shah, PS, Zhao, N, Manganaro, L, Hultquist, JF, Noel, J, Sachs, D, Hamilton, J, Leon, PE, Chawdury, A, Tripathi, S, Melegari, C, Campisi, L, Hai, R, Metreveli, G, Gamarnik, AV, García-Sastre, A, Greenbaum, B, Simon, V, Fernandez-Sesma, A, Krogan, NJ, Mulder, LCF, van Bakel, H, Tortorella, D, Taunton, J, Palese, P, Marazzi, I, Heaton, NS, Heaton, NS, Moshkina, N, Fenouil, R, Gardner, TJ, Aguirre, S, Shah, PS, Zhao, N, Manganaro, L, Hultquist, JF, Noel, J, Sachs, D, Hamilton, J, Leon, PE, Chawdury, A, Tripathi, S, Melegari, C, Campisi, L, Hai, R, Metreveli, G, Gamarnik, AV, García-Sastre, A, Greenbaum, B, Simon, V, Fernandez-Sesma, A, Krogan, NJ, Mulder, LCF, van Bakel, H, Tortorella, D, Taunton, J, Palese, P, and Marazzi, I

Published
2016

4. Targeting Viral Proteostasis Limits Influenza Virus, HIV, and Dengue Virus Infection

Author

Harm van Bakel, Laura Campisi, Paul E. Leon, Jack Taunton, Peter Palese, Lubbertus C. F. Mulder, Nan Zhao, David H. Sachs, Ana Fernandez-Sesma, Giorgi Metreveli, Nevan J. Krogan, Domenico Tortorella, Justine Noel, Nicholas S. Heaton, Amit Chawdury, Sebastian Aguirre, Camilla Melegari, Priya S. Shah, Judd F. Hultquist, Thomas J. Gardner, Adolfo García-Sastre, Jennifer Hamilton, Rong Hai, Viviana Simon, Lara Manganaro, Shashank Tripathi, Andrea V. Gamarnik, Ivan Marazzi, Romain Fenouil, Benjamin Greenbaum, and Natasha Moshkina

Subjects
Proteomics, 0301 basic medicine, Protein Folding, VIRAL PROTEASTASIS, viruses, Viral pathogenesis, Dengue virus, Virus Replication, medicine.disease_cause, Interactome, Mass Spectrometry, Theoretical, Models, Influenza A virus, 2.2 Factors relating to the physical environment, 2.1 Biological and endogenous factors, Immunology and Allergy, Aetiology, health care economics and organizations, Infectivity, ANTIVIRALS, Infectious Diseases, Pneumonia & Influenza, HIV/AIDS, Infection, CIENCIAS NATURALES Y EXACTAS, Otras Ciencias Biológicas, education, Immunology, Biology, Article, Virus, Host-Parasite Interactions, Microbiology, Vaccine Related, Ciencias Biológicas, 03 medical and health sciences, Rare Diseases, Immunity, Biodefense, medicine, Humans, Immunoprecipitation, Antibody-dependent enhancement, DENGUE VIRUS, Host (biology), Prevention, HIV, Dengue Virus, Models, Theoretical, Virology, Influenza, Obligate parasite, Vector-Borne Diseases, Emerging Infectious Diseases, Good Health and Well Being, 030104 developmental biology, Proteostasis, Viral replication, HOST-VIRUS INTERACTIONS
Abstract

Viruses are obligate parasites and thus require the machinery of the host cell to replicate. Inhibition of host factors co-opted during active infection is a strategy hosts use to suppress viral replication and a potential pan-antiviral therapy. To define the cellular proteins and processes required for a virus during infection is thus crucial to understanding the mechanisms of virally induced disease. In this report, we generated fully infectious tagged influenza viruses and used infection-based proteomics to identify pivotal arms of cellular signaling required for influenza virus growth and infectivity. Using mathematical modeling and genetic and pharmacologic approaches, we revealed that modulation of Sec61-mediated cotranslational translocation selectively impaired glycoprotein proteostasis of influenza as well as HIV and dengue viruses and led to inhibition of viral growth and infectivity. Thus, by studying virus-human protein-protein interactions in the context of active replication, we have identified targetable host factors for broad-spectrum antiviral therapies. Viruses are obligate parasites dependent on the host cell machinery. Using infection-based proteomics, biochemistry, and mathematical modeling, Marazzi and colleagues reveal that targeting host factors controlling essential cellular functions can provide broad-spectrum antiviral effects. Loss-of-function and chemical inhibition of one such factor, Sec61, inhibited influenza, HIV, and dengue virus replication. Fil: Heaton, Nicholas S.. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Moshkina, Natasha. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Fenouil, Romain. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Gardner, Thomas J.. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Aguirre, Sebastian. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Shah, Priya S.. University of California; Estados Unidos Fil: Zhao, Nan. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Manganaro, Lara. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Hultquist, Judd F.. University of California; Estados Unidos Fil: Noel, Justine. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Sachs, David H.. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Hamilton, Jennifer. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Leon, Paul E.. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Chawdury, Amit. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Tripathi, Shashank. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Melegari, Camilla. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Campisi, Laura. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Hai, Rong. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Metreveli, Giorgi. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Gamarnik, Andrea Vanesa. Fundación Instituto Leloir; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina Fil: García Sastre, Adolfo. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Greenbaum, Benjamin. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Simon, Viviana. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Fernandez Sesma, Ana. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Krogan, Nevan J.. University of California; Estados Unidos Fil: Mulder, Lubbertus C.F.. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: van Bakel, Harm. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Tortorella, Domenico. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Taunton, Jack. University of California; Estados Unidos Fil: Palese, Peter. Icahn School Of Medicine At Mount Sinai; Estados Unidos Fil: Marazzi, Ivan. Icahn School Of Medicine At Mount Sinai; Estados Unidos

Published
2016
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