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1. How many skin barriers haveth we: Percutaneous egression of ions?

Author

Chiang, Chavy and Maibach, Howard I

Subjects
Medical Biotechnology, Biomedical and Clinical Sciences, Skin, Epidermis, Humans, Skin Absorption, Water, Water Loss, Insensible, electrolyte efflux, percutaneous egression, skin electrolytes, transepidermal ion flux, Clinical Sciences, Clinical sciences
Abstract

IntroductionSkin provides critical barrier properties that enable terrestrial life. Myriad research has focused on the "water barrier" to transepidermal water loss (TEWL) despite there being a multitude of skin barrier properties. We asked what other barrier properties may have been overlooked and compiled data demonstrating the "electrolyte barrier" to be of potential clinical relevance.MethodsA literature search was conducted through PubMed, Embase, Google Scholar, and Web of Science databases for the following keywords: "transepidermal" or "epidermal" or "cutaneous" or "skin" or "percutaneous" and "ion" or "sodium" or "chloride" or "potassium" or "electrolyte" and "flux" or "egression." Textbooks at the University of California, San Francisco were also hand reviewed. Experimental studies quantifying in vivo or ex vivo percutaneous egression of ions in response to human skin barrier perturbation were included.ResultsExperimental damage to skin, mostly by tape-stripping, frequently induced increased ion flux rates through the epidermis, in addition to increases in TEWL values. Interestingly, barrier perturbation did not always result in a concomitant rise in TEWL and transepidermal ion flux rates, such as in delipidization, indicating a distinction between the two barriers.ConclusionQuantifying the percutaneous egression of ions in response to physical or chemical alterations may offer additional data that are not to be captured with TEWL studies exclusively. Continued efforts should be made to: (1) advance this technique as a method of assessing skin status and (2) enhance our understanding of other barriers and mechanisms.

Published
2022

2. Oxytocin-enhanced group therapy for methamphetamine use disorder: Randomized controlled trial.

Author

Stauffer, Christopher S, Moschetto, Jenna M, McKernan, Scott, Meinzer, Nathan, Chiang, Chavy, Rapier, Rachel, Hsiang, Elaine, Norona, Jerika, Borsari, Brian, and Woolley, Joshua D

Subjects
Humans, Methamphetamine, Oxytocin, Central Nervous System Stimulants, Self Administration, Homosexuality, Male, Psychotherapy, Group, Male, Drug-Seeking Behavior, Sexual and Gender Minorities, Motivational interviewing, Psychotherapy, group, Retention in care, Sexual and gender minorities, Behavioral and Social Science, Mind and Body, Mental Health, Cardiovascular, Clinical Trials and Supportive Activities, Drug Abuse (NIDA only), Substance Misuse, Prevention, Brain Disorders, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Public Health and Health Services, Psychology, Substance Abuse
Abstract

BackgroundMethamphetamine (METH) use is a public health crisis that disproportionately affects men who have sex with men (MSM). There are currently no FDA-approved pharmacological interventions to treat methamphetamine use disorder (MUD). MUD is associated with social impairments and extremely high treatment attrition rates. Administration of oxytocin, a neuropeptide involved in social attachment, may be a novel approach to addressing these issues. Moreover, oxytocin administration has shown promise for reducing METH-related addictive behavior in animal models, but has not yet been investigated in clinical trials for MUD. Last, oxytocin is known to modulate stress responsivity via regulation of the autonomic nervous system, which is dysregulated in METH users. We hypothesize that oxytocin, in combination with group psychotherapy, will increase treatment engagement, reduce addiction behavior, and mitigate stress hyperreactivity.MethodsThis is a randomized, double blind trial of oxytocin 40-IU (n = 24) or placebo (n = 24) administered intranasally prior to each of six weekly motivational interviewing group therapy (MIGT) sessions for MUD in MSM.Primary outcome(a) session attendance.Secondary outcomes(b) group cohesion, (c) anxiety, (d) METH craving, (e) METH use, and (f) in-session cardiac physiology.ResultsParticipants receiving oxytocin had significantly higher group therapy attendance than those receiving placebo, OR 3.26, 95% CI [1.27-8.41], p = .014. There was a small effect of oxytocin on group cohension, but not anxiety or craving. METH use did not change over the six-week MIGT course in either treatment arm. Participants receiving oxytocin had lower average heart rates during MIGT sessions and higher heart rate variability. There were positive main effects of MIGT over Time regardless of study drug.ConclusionsThis evidence, and the lack of any serious adverse events, suggests that oxytocin may safely increase treatment attendance. One possible mechanism by which it may do so is its modulation of the autonomic nervous system. Further investigation is warranted.

Published
2020

6. Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study

Author

Donzeau, Aurelie, El Aridi, Layal, Lety, Sophie, Leboucher, Bertrand, Baur, Agnes, Jeusset, Lucas, Selegny, Maelle, Fedorczuk, Cristian, Lajus, Marion, Bensaid, Philippe, Laoudi, Yacine, Pons, Charlotte, Robert, Anne-Cécile, Beaucourt, Camille, De Pontual, Loïc, Richard, Muriel, Goisque, Etienne, Iriart, Xavier, Brissaud, Olivier, Segretin, Pierre, Molimard, Julie, Orecel, Marie-Clothilde, Benoit, Gregoire, Bongiovanni, Lucille, Guerder, Margaux, Pouyau, Robin, De Guillebon De Resnes, Jean-Marie, Mezgueldi, Ellia, Cour-Andlauer, Fleur, Horvat, Come, Poinsot, Pierre, Frachette, Cecile, Ouziel, Antoine, Gillet, Yves, Barrey, Catherine, Brouard, Jacques, Villedieu, Florence, Ro, Vathanaksambath, Elanga, Narcisse, Gajdos, Vincent, Basmaci, Romain, Mutar, Hadile, Rouget, Sébastien, Nattes, Elodie, Hau, Isabelle, Biscardi, Sandra, El Jurdi, Houmam, Jung, Camille, Semama, Denis, Huet, Frederic, Zoccarato, Anne-Marie, Sarakbi, Mayssa, Mortamet, Guillaume, Bost-Bru, Cécile, Bassil, Joachim, Vinit, Caroline, Hentgen, Véronique, Leroux, Pascal, Bertrand, Valérie, Parrod, Caroline, Craiu, Irina, Kone-Paut, Isabelle, Durand, Philippe, Tissiere, Pierre, Claude, Caroline, Morelle, Guillaume, Guiddir, Tamazoust, Borocco, Charlotte, Delion, Frédérique, Guillot, Camille, Leteurtre, Stéphane, Dubos, François, Jouancastay, Mylene, Martinot, Alain, Voeusler, Valentine, Languepin, Jeanne, Garrec, Nathalie, Demersay, Arnaud Chalvon, Morand, Aurélie, Bosdure, Emmanuelle, Vanel, Noémie, Ughetto, Fabrice, Michel, Fabrice, Caujolle, Marie, Blonde, Renaud, Nguyen, Jacqueline, Vignaud, Olivier, Masserot-Lureau, Caroline, Gouraud, François, Araujo, Carine, Ingrao, Tara, Naji, Sanaa, Sehaba, Mohammed, Roche, Christine, Carbasse, Aurelia, Milesi, Christophe, Mazeghrane, Mustapha, Haupt, Sandrine, Schweitzer, Cyril, Romefort, Benedicte, Launay, Elise, Guen, Christèle Gras-Le, Ali, Ahmed, Blot, Nathalie, Tran, Antoine, Rancurel, Anne, Afanetti, Mickael, Odorico, Sophie, Talmud, Deborah, Chosidow, Anais, Romain, Anne-Sophie, Grimprel, Emmanuel, Pouletty, Marie, Gaschignard, Jean, Corseri, Olivier, Faye, Albert, Melki, Isabelle, Ducrocq, Camille, Benzoïd, Cherine, Lokmer, Johanna, Dauger, Stéphane, Chomton, Maryline, Deho, Anna, Lebourgeois, Fleur, Renolleau, Sylvain, Lesage, Fabrice, Moulin, Florence, Dupic, Laurent, Pinhas, Yael, Debray, Agathe, Chalumeau, Martin, Abadie, Véronique, Frange, Pierre, Cohen, Jeremie F, Allali, Slimane, Curtis, William, Belhadjer, Zahra, Auriau, Johanne, Méot, Mathilde, Houyel, Lucile, Bonnet, Damien, Delacourt, Christophe, Bader Meunier, Brigitte, Quartier, Pierre, Shaim, Youssef, Baril, Laurence, Crommelynck, Samuel, Jacquot, Baptiste, Blanc, Philippe, Maledon, Natacha, Robert, Blandine, Loeile, Camille, Cazau, Clémence, Loron, Gauthier, Gaga, Simona, Vittot, Cécile, El Nabhani, Loubna, Buisson, François, Prudent, Muriel, Flodrops, Hugues, Mokraoui, Fadhila, Escoda, Simon, Deschamps, Nina, Bonnemains, Laurent, Mahi, Sarah-Louisa, Mertes, Clara, Terzic, Joelle, Helms, Julie, Idier, Charlotte, Chenichene, Soraya, Magdolena Ursulescu, Nicoleta, Beaujour, Gladys, Hakim, Abdelhak, Miquel, Alice, Rey, Agnès, Wiedermann, Arnaud, Charbonneau, Anne, Veauvy-Juven, Agnès, Ferry, Alexandrine, Mandelcwajg, Alexis, Rousseau, Alix, Prenant, Amandine, Bourneuf, Anne-Laure, Filleron, Anne, Robine, Audrey, Félix, Arthur, Parizel, Aude, Labarre, Aurélie, Cantais, Aymeric, Ros, Barbara, Coulon, Basile, Biot, Blandine, Dalichoux, Bérengère, Fournier, Benjamin, Cagnard, Benoit, Vanel, Blandine, Brossier, David, Ménager, Bruno, Ozanne, Bruno, Marie-Jeanne, Carole, Bergerot, Camille, Chavy, Camille, Guidon, Camille, Fabre, Candice, Galeotti, Caroline, Baker, Catherine, Ballot-Schmit, Claire, Belleau, Céline, Charasse, Céline, Favel, Caroline, Toumi, Chadia, Ferrandiz, Charlène, Couturier, Charlotte, Pouchoux, Charlotte, Chomton-Cailliez, Maryline, Kevorkian-Verguet, Charlotte, Brunet, Clément, Manteau, Céline, Mougey, Clémence, Santy, Coline, Fitament, Coralie, Petriat, Charlotte, Rebelle, Charlotte, Charron, Cyril, Dartus, Maxime, Toulorge, David, Guillou-Debuisson, Cécile, Bartebin, Dorann, Klein, Valérie, Broustal, E, Desselas, E, Marteau, Elodie, Bouvrot, Emmanuelle, Delacroix, Elise, Coinde, Edeline, Elnabhani, Loubna, Amouyal, Elsa, Chaillou, Emilie, Gabilly-Bernard, Emeline, Ruiz, Emilie, Thibault, Emilie, Robin, Emilie, Darrieux, Etienne, Blondel, Eva, Socchi, Floriane, Cazassus, François, Bajolle, Fanny, Lacin, Fatma, Madhi, Fouad, Zekre, Franck, Guerin, François, Boussicault, Gerald, Ginies, Henri, Magloire, Gnansounou, Arnold, Guilhem, Coulognon, Ines, Sicard-Cras, Iona, Kahn, Jean-Emmanuel, Bordet, Jeanne, Fausser, Jeanne-Lise, Baleine, Jean-François, Brice, Josephine, Gendras, Julie, Pekin, Kaan, Norbert, Karine, Karsenty, Clément, Savary, Léa, Martinat, Laurence, Lesniewski, Léa, Charbonnier, Lorelei, Alexandre, Louise, Percheron, Lucas, Vincenti, Marie, Lanzini, Manon, Grisval, Margot, Mercy, Marianne, Lampin, Marie-Emilie, Desgranges, Marie, Duperril, Marie, Orcel, Marie-Clothilde, Audier, Marion, Favier, Marion, Carpentier, Mathieu, Balcean, Mathilde, Bonnet, Mathilde, Jouret, Maurine, Delattre, Marie, Levy, Michael, Valensi, Michael, Shum, Mickael, Dumortier, Morgane, Gelin, Morgane, Nemmouchi, Morgane, Williaume, Morgane, Sebaha, M, Genetay-Stanescu, Nicoleta, Giroux, Nathan, Crassard, Nicolas, Derridj, Neil, Lachaume, Noemie, Werner, Oscar, Guilluy, Olivier, Richer, Olivier, Tirel, Olivier, Pauvert, Aurianne, Casha, Paul, Perez, Noémie, Gras, Pauline, Leger, Pierre-Louis, Pinchou, Marion, Mornand, Pierre, Largo, Prisca, Ibanez, Ramona-Christina, Roulland, Charlotte, Hadah Albarazi, Salam, Bichali, Said, Faton, Sarah, Schott, Amandine, Walser, Sébastien, Guillaume, Severine, Vincent, Solene, Galene-Gromez, Sophie, Kozisek, Stanislas, Maugard, Thierry, Blanc, Thierry, Navarro, Thierry, Lauvray, Thomas, Kovacs, Tamas, Launay, Valérie, Despert, Véronique, Lhostis, Victoria, Gall, Virginie, Micaelli, Xavier, Benadjaoud, Yasmine, Matoussi, Zied, Géniaux, Hélène, Facile, Anthony, Pietri, Tessa, Palassin, Pascale, Pinel, Sylvine, Chouchana, Laurent, Callot, Delphine, Boulay, Charlène, Ouldali, Naïm, Bagheri, Haleh, Salvo, Francesco, Antona, Denise, Pariente, Antoine, Leblanc, Claire, Tebacher, Martine, Micallef, Joëlle, Levy, Corinne, Cohen, Robert, Javouhey, Etienne, Bader-Meunier, Brigitte, Ovaert, Caroline, Hentgen, Veronique, Guen, Christelle Gras-Le, Angoulvant, François, and Belot, Alexandre

Published
2022
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7. Cartan Invariants and Event Horizon Detection, Extended Version

Author

McNutt, D. D., MacCallum, M. A. H., Gregoris, D., Forget, A., Coley, A. A., Chavy-Waddy, P. C., and Brooks, D.

Subjects
General Relativity and Quantum Cosmology
Abstract

We show that it is possible to locate the event horizons of a black hole (in arbitrary dimensions) as the zeros of certain Cartan invariants. This approach accounts for the recent results on the detection of stationary horizons using scalar polynomial curvature invariants, and improves upon them since the proposed method is computationally less expensive. As an application, we produce Cartan invariants that locate the event horizons for various exact four-dimensional and five-dimensional stationary, asymptotically flat (or (anti) de Sitter) black hole solutions and compare the Cartan invariants with the corresponding scalar curvature invariants that detect the event horizon. In particular, for each of the four-dimensional examples we express the scalar polynomial curvature invariants introduced by Abdelqader and Lake in terms of the Cartan invariants and show a direct relationship between the scalar polynomial curvature invariants and the Cartan invariants that detect the horizon., Comment: 17 pages. This is an extended version of the article published in General Relativity and gravitation, it includes additional examples. Equations in sections 4 and 6 have been corrected

Published
2017

9. Ecology, evolution, and epidemiology of zoonotic and vector-borne infectious diseases in French Guiana: Transdisciplinarity does matter to tackle new emerging threats

Author

de Thoisy, Benoît, Duron, Olivier, Epelboin, Loïc, Musset, Lise, Quénel, Philippe, Roche, Benjamin, Binetruy, Florian, Briolant, Sébastien, Carvalho, Luisiane, Chavy, Agathe, Couppié, Pierre, Demar, Magalie, Douine, Maylis, Dusfour, Isabelle, Epelboin, Yanouk, Flamand, Claude, Franc, Alain, Ginouvès, Marine, Gourbière, Sébastien, Houël, Emeline, Kocher, Arthur, Lavergne, Anne, Le Turnier, Paul, Mathieu, Luana, Murienne, Jérôme, Nacher, Mathieu, Pelleau, Stéphane, Prévot, Ghislaine, Rousset, Dominique, Roux, Emmanuel, Schaub, Roxane, Talaga, Stanislas, Thill, Pauline, Tirera, Sourakhata, and Guégan, Jean-François

Published
2021
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10. A novel pattern language method for tradespace exploration: application to space mission architecting.

Author

Rüede, Anne-Marlene, Chavy-Macdonald, Marc-André, Rinalducci, Antonio, de la Osa, Nils Pachler, de Weck, Olivier, Huang, Jeffrey, and Kneib, Jean-Paul

Subjects
*TECHNOLOGICAL innovations, *LUNAR orbit, *CONCEPTUAL design, *GOAL (Psychology), *SPACE exploration
Abstract

With the growing complexity of systems across diverse domains, key challenges emerge in simultaneously designing networks and their underlying infrastructure, requiring resolution at concept stage. In space mission design, technological advancements and ambitious goals enable numerous mission architecture concepts due to diverse material flow options. Current design support tools function either after the initial concept design, or tend to rapidly converge toward point solutions, limiting the solution space. We introduce a digital tool for early-stage concept design, capable of generating, evaluating, and visualising a wide range of user-defined architectural options. It utilises a pattern language for space missions, incorporating building blocks like ‘launch’ or ‘electrolysis’. Validation with historic missions showcase the tool automatically identifies all four main mission architectures considered during the Apollo design and more, and accurately recommending the Lunar Orbit Rendezvous architecture which was actually selected. Predicted masses, informing costs, vary by 15% and duration by 30% from actual values, which is within expectations. Identifying missions and leveraging expert knowledge is also demonstrated in the Mars Sample Return case. This approach can help minimise the risk of overlooking effective mission concepts early on. Furthermore, the method is applicable in other domains facing concurrent infrastructure and logistics design challenges. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Poppers Dermatitis: A Systematic Review on a Unique Form of Contact Dermatitis in the MSM Community.

Author

Chiang, Chavy, Gessner, Nicholas, Burli, Anuk, Liszewski, Walter, Mansh, Matthew, Cuong V. Nguyen, Howa Yeung, and Trinidad, John C.

Abstract

There are certain demographic characteristics that may serve as risk factors for exposure to a contact allergen. Volatile alkyl nitrites, colloquially known as "poppers," are commonly inhaled by men who have sex with men (MSM) for their psychoactive and muscle-relaxing effects. They have been reported to cause either allergic contact dermatitis (ACD) or irritant contact dermatitis (ICD), termed "poppers dermatitis." We searched PubMed, Embase, and Web of Science to understand the patient population, clinical presentation, diagnosis, and clinical course of poppers dermatitis. Our search returned 13 articles detailing 18 patients total. Most patient cases were male (n = 13/15; 87%), of whom 5 were MSM. The reports on the remaining 8 men did not disclose their sexual behaviors. The chemicals deemed responsible for adverse cutaneous side effects included amyl nitrite (6/18; 33%), butyl nitrite (3/18; 167%), isobutyl nitrite (2/18; 11%), and an unspecified alkyl nitrite (7/18, 39%). The most common diagnosis was ICD (10/18; 56%). Only 3 patients underwent alkyl nitrite patch testing, with 2 testing positive for ACD. The most commonly involved anatomic sites were perinasal (13/18; 72%) and perioral regions (10/18; 56%). Rash morphology has been described as yellow crusting, impetigo-like, eczematous, vesicular, edematous, and erythematous. Ulceration can occur with direct skin contact to concentrated nitrite solution. Poppers dermatitis was often self-limited with complete resolution. Dermatologists should consider poppers dermatitis in those presenting with a characteristic midfacial rash, especially in MSM. [ABSTRACT FROM AUTHOR]

Published
2024
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21. Ecological niche modelling for predicting the risk of cutaneous leishmaniasis in the Neotropical moist forest biome.

Author

Agathe Chavy, Alessandra Ferreira Dales Nava, Sergio Luiz Bessa Luz, Juan David Ramírez, Giovanny Herrera, Thiago Vasconcelos Dos Santos, Marine Ginouves, Magalie Demar, Ghislaine Prévot, Jean-François Guégan, and Benoît de Thoisy

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

A major challenge of eco-epidemiology is to determine which factors promote the transmission of infectious diseases and to establish risk maps that can be used by public health authorities. The geographic predictions resulting from ecological niche modelling have been widely used for modelling the future dispersion of vectors based on the occurrence records and the potential prevalence of the disease. The establishment of risk maps for disease systems with complex cycles such as cutaneous leishmaniasis (CL) can be very challenging due to the many inference networks between large sets of host and vector species, with considerable heterogeneity in disease patterns in space and time. One novelty in the present study is the use of human CL cases to predict the risk of leishmaniasis occurrence in response to anthropogenic, climatic and environmental factors at two different scales, in the Neotropical moist forest biome (Amazonian basin and surrounding forest ecosystems) and in the surrounding region of French Guiana. With a consistent data set never used before and a conceptual and methodological framework for interpreting data cases, we obtained risk maps with high statistical support. The predominantly identified human CL risk areas are those where the human impact on the environment is significant, associated with less contributory climatic and ecological factors. For both models this study highlights the importance of considering the anthropogenic drivers for disease risk assessment in human, although CL is mainly linked to the sylvatic and peri-urban cycle in Meso and South America.

Published
2019
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26. Biodiversity and vector-borne diseases: Host dilution and vector amplification occur simultaneously for Amazonian leishmaniases

Author

Koche,Arthur, Cornuault, Josselin, Gantier, Jean-Charles, Manzi, Sophie, Chavy, Agathe, Girod, Romain, Koche,Arthur, Cornuault, Josselin, Gantier, Jean-Charles, Manzi, Sophie, Chavy, Agathe, and Girod, Romain

Abstract

Changes in biodiversity may impact infectious disease transmission through multiple mechanisms. We explored the impact of biodiversity changes on the transmission of Amazonian leishmaniases, a group of wild zoonoses transmitted by phlebotomine sand flies (Psychodidae), which represent an important health burden in a region where biodiversity is both rich and threatened. Using molecular analyses of sand fly pools and blood-fed dipterans, we characterized the disease system in forest sites in French Guiana undergoing different levels of human-induced disturbance. We show that the prevalence of Leishmania parasites in sand flies correlates positively with the relative abundance of mammal species known as Leishmania reservoirs. In addition, Leishmania reservoirs tend to dominate in less diverse mammal communities, in accordance with the dilution effect hypothesis. This results in a negative relationship between Leishmania prevalence and mammal diversity. On the other hand, higher mammal diversity is associated with higher sand fly density, possibly because more diverse mammal communities harbor higher biomass and more abundant feeding resources for sand flies, although more research is needed to identify the factors that shape sand fly communities. As a consequence of these antagonistic effects, decreased mammal diversity comes with an increase of parasite prevalence in sand flies, but has no detectable impact on the density of infected sand flies. These results represent additional evidence that biodiversity changes may simultaneously dilute and amplify vector-borne disease transmission through different mechanisms that need to be better understood before drawing generalities on the biodiversity-disease relationship.

Published
2023

27. Identification of French Guiana sand flies using MALDI-TOF mass spectrometry with a new mass spectra library.

Author

Agathe Chavy, Cécile Nabet, Anne Cécile Normand, Arthur Kocher, Marine Ginouves, Ghislaine Prévot, Thiago Vasconcelos Dos Santos, Magalie Demar, Renaud Piarroux, and Benoît de Thoisy

Subjects
Arctic medicine. Tropical medicine, RC955-962, Public aspects of medicine, RA1-1270
Abstract

Phlebotomine sand flies are insects that are highly relevant in medicine, particularly as the sole proven vectors of leishmaniasis. Accurate identification of sand fly species is an essential prerequisite for eco-epidemiological studies aiming to better understand the disease. Traditional morphological identification is painstaking and time-consuming, and molecular methods for extensive screening remain expensive. Recent studies have shown that matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TOF MS) is a promising tool for rapid and cost-effective identification of arthropod vectors, including sand flies. The aim of this study was to validate the use of MALDI-TOF MS for the identification of Northern Amazonian sand flies. We constituted a MALDI-TOF MS reference database comprising 29 species of sand flies that were field-collected in French Guiana, which are expected to cover many of the more common species of the Northern Amazonian region, including known vectors of leishmaniasis. Carrying out a blind test, all the sand flies tested (n = 157) with a log (score) threshold greater than 1.7 were correctly identified at the species level. We confirmed that MALDI-TOF MS protein profiling is a useful tool for the study of sand flies, including neotropical species, known for their great diversity. An application that includes the spectra generated here will be available to the scientific community in the near future via an online platform.

Published
2019
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29. Biodiversity and vector‐borne diseases: Host dilution and vector amplification occur simultaneously for Amazonian leishmaniases

Author

Arthur Kocher, Josselin Cornuault, Jean‐Charles Gantier, Sophie Manzi, Agathe Chavy, Romain Girod, Isabelle Dusfour, Pierre‐Michel Forget, Marine Ginouves, Ghislaine Prévot, Jean‐François Guégan, Anne‐Laure Bañuls, Benoît de Thoisy, Jérôme Murienne, Evolution et Diversité Biologique (EDB), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Max Planck Institute for the Science of Human History (MPI-SHH), Max-Planck-Gesellschaft, Maladies infectieuses et vecteurs : écologie, génétique, évolution et contrôle (MIVEGEC), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Université de Montpellier (UM), Real Jardín Botánico de Madrid (RJB), Spanish National Research Council (CSIC), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Laboratoire Identifications Fongiques et Entomo-Parasitologique (L.I.F.E.), Université de Guyane (UG), Mécanismes Adaptatifs et Evolution (MECADEV), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherche pour le Développement (IRD [France-Sud]), Animal, Santé, Territoires, Risques et Ecosystèmes (UMR ASTRE), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Association Kwata - Etude et protection de la nature [Guyane], Fondation de France, European Regional Development Fund, H2020 Marie Sklodowska-Curie Actions, Grant/Award Number: MSCAIF-EF-ST-708207, Agence Nationale de la Recherche, Grant/Award Number: ANR-10-LABX-25-01, ANR-10-LABX-41, ANR-11-INBS-0001 and ANR-11-LABX--0010-DRIIHM, NSF-NIH Ecology of infectious diseases award, Grant/Award Number: 191145, ANR-10-LABX-0041,TULIP,Towards a Unified theory of biotic Interactions: the roLe of environmental(2010), ANR-11-INBS-0001,ANAEE-FR,ANAEE-Services(2011), ANR-11-LABX-0010,DRIIHM / IRDHEI,Dispositif de recherche interdisciplinaire sur les Interactions Hommes-Milieux(2011), and ANR-10-LABX-0025,CEBA,CEnter of the study of Biodiversity in Amazonia(2010)

Subjects
amplification effect, Culicidae, iDNA, [SDV]Life Sciences [q-bio], dilution effect, metabarcoding, fungi, parasitic diseases, Genetics, phlebotomine sand fly, Ecology, Evolution, Behavior and Systematics, zoonotic disease
Abstract

Changes in biodiversity may impact infectious disease transmission through multiple mechanisms. We explored the impact of biodiversity changes on the transmission of Amazonian leishmaniases, a group of wild zoonoses transmitted by phlebotomine sand flies (Psychodidae), which represent an important health burden in a region where biodiversity is both rich and threatened. Using molecular analyses of sand fly pools and blood-fed dipterans, we characterized the disease system in forest sites in French Guiana undergoing different levels of human-induced disturbance. We show that the prevalence of Leishmania parasites in sand flies correlates positively with the relative abundance of mammal species known as Leishmania reservoirs. In addition, Leishmania reservoirs tend to dominate in less diverse mammal communities, in accordance with the dilution effect hypothesis. This results in a negative relationship between Leishmania prevalence and mammal diversity. On the other hand, higher mammal diversity is associated with higher sand fly density, possibly because more diverse mammal communities harbor higher biomass and more abundant feeding resources for sand flies, although more research is needed to identify the factors that shape sand fly communities. As a consequence of these antagonistic effects, decreased mammal diversity comes with an increase of parasite prevalence in sand flies, but has no detectable impact on the density of infected sand flies. These results represent additional evidence that biodiversity changes may simultaneously dilute and amplify vector-borne disease transmission through different mechanisms that need to be better understood before drawing generalities on the biodiversity-disease relationship. 1 Introduction 2 Material and methods 2.1 Sampling 2.2 Laboratory 2.3 Bioinformatic analyses 2.4 Estimating mammal diversity from individual dipteran blood meals 2.5 Effect of mammal diversity on Leishmania transmission 3 Results 3.1 Sampling and molecular analyses 3.2 Sand fly, vertebrate and Leishmania identifications 3.3 Statistical analyses 4 Discussion

Published
2022
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36. When is the use of suboptimal treatment in functionally untreatable multi-drug resistant tuberculosis morally permissible?

Author

Chavy Arora

Subjects
Public Health, Environmental and Occupational Health
Abstract

Multidrug-resistant tuberculosis (MDR-TB) is well recognised as a serious threat to controlling and ending the TB epidemic. Treatment is time-intensive and costly. Current treatment guidelines recommend the use of at least four effective drugs plus pyrazinamide for a period of 18-24 months. There are, however, situations in which this is not feasible. This may be due to severe patterns of drug-resistance, poor tolerance to the medications, or supply chain issues. In this paper, I use the term functionally untreatable MDR-TB to refer to such situations. Patients may be assigned to waiting lists until appropriate medications are available, and many die while awaiting treatment. Clinicians face a serious ethical dilemma in these cases, and some may choose to treat their patients with suboptimal regimens in the interim. While this practice may alleviate symptoms and even cure some patients, it is known to extend drug-resistance, limiting further the availability of efficacious anti-TB medicines. This paper explores the relevant ethical considerations faced by clinicians providing MDR-TB treatment, and how this differs from formal ethical principles and guidance. It outlines extreme situations in which suboptimal regimens may be considered, and requisite conditions to be fulfilled by stakeholders for this to be morally permissible.

Published
2022

37. Im Zeichen des Surrealismus (1924–1938)

Author

Breton, André, Goll, Yvan, Voronca, Ilarie, Picabia, Francis, Gordesiani, Bruno, Aragon, Louis, Artaud, Antonin, Baron, Jacques, Bousquet, Joë, Boiffard, J. -A., Carrive, Jean, Crevel, René, Desnos, Robert, Eluard, Paul, Ernst, Max, Fraenkel, T., Gérard, Francis, Leiris, Michel, Limbour, Georges, Lübeck, Mathias, Malkine, Georges, Masson, André, Morise, Max, Naville, Pierre, Noll, Marcel, Péret, Benjamin, Queneau, Raymond, Soupault, Philippe, Sunbeam, Dédé, Tual, Roland, Seuphor, Michel, Lecomte, Marcel, Nougé, Paul, Altmann, Georges, Aucouturier, Georges, Bernier, Jean, Crastre, Victor, Fégy, Camille, Fourrier, Marcel, Guitard, Paul, Montrevel, G., Goemans, Camille, Barsalou, André, Beauroy, Gabriel, Benvéniste, Emile, Gutermann, Norbert, Jourdan, Henri, Lefebvre, Henri, Morhange, Pierre, Muller, Maurice, Politzer, Georges, Zimmermann, Paul, Alexandre, Maxime, Bessière, Georges, de Boully, Monny, Brasseur, Pierre, Éluard, Paul, Fraenkel, Theodore, Matitch, Douchan, Neveux, Georges, Viot, Jacques, Closson, Hermann, Jeanson, Henri, de Massot, Pierre, Ribemont-Dessaignes, Georges, Huidobro, Vincent, Micić, Ljubomir, Léger, Fernand, Vallejo, César, Mariategui, José Carlos, Gasch, Sebastià, Arp, Boiffard, Jacques-André, Duhamel, Marcel, Genbach, Jean, Hooreman, Paul, Jolas, Eugène, Malkine, George, Paul, Elliot, Prévert, Jaques, Ray, Man, Sadoul, Georges, Tanguy, Yves, Unik, Pierre, Štyrský, Jindřich, Toyen, Nezval, Vitëzslav, Dali, Salvador, Montanyá, Lluis, Panä, Saşa, de Andrade, Oswald, Teige, Karel, Eisenstein, S. M., Pudowkin, W. I., Alexandrow, G. W., Feuerträger, Alexandre, Aragon, Buñuel, Char, Crevel, Dalí, Eluard, Ernst, Malkine, Péret, Sadoul, Tanguy, Thirion, Unik, Valentin, Vučo, Aleksandar, Jovanović, Dorde, Matić, Dušan, Ristić, Marko, Carlsund, Doesburg, Hélion, Tutundjian, Wantz, Cuadro, Pablo Antonio, Arp, Hans, Beckett, Samuel, Einstein, Carl, Jolas, Eugene, McGreevy, Thomas, Pelorson, Georges, Rutra, Theo, Sweeney, James J., Symond, Ronald, Werkman, Hendrik, Galdikas, Gudaitis, Jonynas, Kulakauskas, Mikènas, Samulevičius, Vizgirda, Magritte, René, Mesens, E.-L.-T., Scutenaire, Jean, Singer, Maurice, Souris, André, Chavee, Achille, Dieu, Jean, Dumont, Fernand, Havrenne, Marcel, Lorant, André, Lude, Albert, Servais, Max, Dominguez, Oscar, Heine, Maurice, Henry, Maurice, Hugnet, Georges, Itkine, Sylvain, Jean, Marcel, Maar, Dora, Malet, Léo, Mayoux, Marie-Louise, Mayoux, Jehan, Mésens, E.-L.-T., Oppenheim, Meret, Parisot, Henri, Valançay, Robert, Acker, Adolphe, Aimery, Pierre, Ambrosino, Georges, Bataille, Georges, Bernard, Blin, Roger, Brunius, Jacques, Cahun, Claude, Chavance, Louis, Chavy, Jacques, Chenon, René, Dautry, Jean, Delmas, Jean, Dubief, Henri, Duval, Jean, Fischbein, Jacques, Foulon, Lucien, Garbag, Reya, Harfaux, Arthur, Henri, Maurice, Jane, Janine, Klossowski, Pierre, Loris, Malherbe, Suzanne, Mouton, Georges, Pastoureau, Henry, Pontabrie, Germaine, Nezval, Vítezlav, Agar, Eileen, Burra, Edward, Davies, Hugh Sykes, Evans, Mervyn, Gascoyne, David, Howard, Charles, Jennings, Humphrey, Lee, Rupert, Legge, Sheila, Lye, Len, Mesens, E. L. T., Moore, Henry, Nash, Paul, Penrose, Roland, Read, Herbert, Reavey, Georges, Roughton, Roger, Todd, Ruthven, Trevelyan, Julian, Paz, Magdeleine Maurice, Rivet, Paul, Alain, Desjardins, Paul, Martinet, Marcel, Dumoulin, Georges, Jean-Galtier-Boisière, Challaye, Félicien, Alexandre, Jeanne Michel, Michon, Georges, Werth, Léon, Emery, Pioch, Georges, Poulaille, Henry, Cancouet, L., Margueritte, Victor, Philip, André, Giono, Jean, Jacques, Lucien, Decaris, Germain, Vildrac, Charles, Largentier, Goudchaux-Brunschwig, Brunschwig, Betty, Loewel, Pierre, Lévy, Suzanne, Massé, Ludovic, Alba, André, Lalou, René, Prévert, Jacques, Hagnauer, Charbit, Wullens, Monatte, Pierre, Bouet, Louis Gabrielle, Reynier, Elie, Colliard, Lucie, Guigui, Drevet, Camille, de Toury, Gouttenoire, Louzon, R., Guérin, Daniel, Mabille, Dr., Weber, Maurice, Crommelynk, Fernand, Bovet, Chambelland, Zoretti, Jospin, Limbour, A., Rosenthal, Gérard, Van Heyenoort, Jean, Dommaget, Boris, Georges, Caillaud, Barrué, Pichorel, Marthe, Ogouz, Pierre, Depreux, Weil-Curiel, Romains, Jules, Pound, Ezra, Rivera, Diego, Gruppe, Die Surrealistische, Asholt, Wolfgang, editor, and Fähnders, Walter, editor

Published
2005
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38. Correction to “Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study”

Author

Ouldali, Naïm, primary, Bagheri, Haleh, additional, Salvo, Francesco, additional, Antona, Denise, additional, Pariente, Antoine, additional, Leblanc, Claire, additional, Tebacher, Martine, additional, Micallef, Joëlle, additional, Levy, Corinne, additional, Cohen, Robert, additional, Javouhey, Etienne, additional, Bader-Meunier, Brigitte, additional, Ovaert, Caroline, additional, Renolleau, Sylvain, additional, Hentgen, Veronique, additional, Kone-Paut, Isabelle, additional, Deschamps, Nina, additional, De Pontual, Loïc, additional, Iriart, Xavier, additional, Guen, Christelle Gras-Le, additional, Angoulvant, Francois, additional, Belot, Alexandre, additional, Donzeau, Aurelie, additional, Aridi, Layal El, additional, Lety, Sophie, additional, Leboucher, Bertrand, additional, Baur, Agnes, additional, Jeusset, Lucas, additional, Selegny, Maelle, additional, Fedorczuk, Cristian, additional, Lajus, Marion, additional, Bensaid, Philippe, additional, Laoudi, Yacine, additional, Pons, Charlotte, additional, Robert, Anne-Cécile, additional, Beaucourt, Camille, additional, Richard, Muriel, additional, Goisque, Etienne, additional, Brissaud, Olivier, additional, Segretin, Pierre, additional, Molimard, Julie, additional, Orecel, Marie-Clothilde, additional, Benoit, Gregoire, additional, Bongiovanni, Lucille, additional, Guerder, Margaux, additional, Pouyau, Robin, additional, De Guillebon De Resnes, Jean-Marie, additional, Mezgueldi, Ellia, additional, Cour-Andlauer, Fleur, additional, Horvat, Come, additional, Poinsot, Pierre, additional, Frachette, Cecile, additional, Ouziel, Antoine, additional, Gillet, Yves, additional, Barrey, Catherine, additional, Brouard, Jacques, additional, Villedieu, Florence, additional, Ro, Vathanaksambath, additional, Elanga, Narcisse, additional, Gajdos, Vincent, additional, Basmaci, Romain, additional, Mutar, Hadile, additional, Rouget, Sébastien, additional, Nattes, Elodie, additional, Hau, Isabelle, additional, Biscardi, Sandra, additional, Jurdi, Houmam El, additional, Jung, Camille, additional, Semama, Denis, additional, Huet, Frederic, additional, Zoccarato, Anne-Marie, additional, Sarakbi, Mayssa, additional, Mortamet, Guillaume, additional, Bost-Bru, Cécile, additional, Bassil, Joachim, additional, Vinit, Caroline, additional, Hentgen, Véronique, additional, Leroux, Pascal, additional, Bertrand, Valérie, additional, Parrod, Caroline, additional, Craiu, Irina, additional, Durand, Philippe, additional, Tissiere, Pierre, additional, Claude, Caroline, additional, Morelle, Guillaume, additional, Guiddir, Tamazoust, additional, Borocco, Charlotte, additional, Delion, Frédérique, additional, Guillot, Camille, additional, Leteurtre, Stéphane, additional, Dubos, François, additional, Jouancastay, Mylene, additional, Martinot, Alain, additional, Voeusler, Valentine, additional, Languepin, Jeanne, additional, Garrec, Nathalie, additional, Demersay, Arnaud Chalvon, additional, Morand, Aurélie, additional, Bosdure, Emmanuelle, additional, Vanel, Noémie, additional, Ughetto, Fabrice, additional, Michel, Fabrice, additional, Caujolle, Marie, additional, Blonde, Renaud, additional, Nguyen, Jacqueline, additional, Vignaud, Olivier, additional, Masserot-Lureau, Caroline, additional, Gouraud, François, additional, Araujo, Carine, additional, Ingrao, Tara, additional, Naji, Sanaa, additional, Sehaba, Mohammed, additional, Roche, Christine, additional, Carbasse, Aurelia, additional, Milesi, Christophe, additional, Mazeghrane, Mustapha, additional, Haupt, Sandrine, additional, Schweitzer, Cyril, additional, Romefort, Benedicte, additional, Launay, Elise, additional, Guen, Christèle Gras-Le, additional, Ali, Ahmed, additional, Blot, Nathalie, additional, Tran, Antoine, additional, Rancurel, Anne, additional, Afanetti, Mickael, additional, Odorico, Sophie, additional, Talmud, Deborah, additional, Chosidow, Anais, additional, Romain, Anne-Sophie, additional, Grimprel, Emmanuel, additional, Pouletty, Marie, additional, Gaschignard, Jean, additional, Corseri, Olivier, additional, Faye, Albert, additional, Melki, Isabelle, additional, Ducrocq, Camille, additional, Benzoïd, Cherine, additional, Lokmer, Johanna, additional, Dauger, Stéphane, additional, Chomton, Maryline, additional, Deho, Anna, additional, Lebourgeois, Fleur, additional, Lesage, Fabrice, additional, Moulin, Florence, additional, Dupic, Laurent, additional, Pinhas, Yael, additional, Debray, Agathe, additional, Chalumeau, Martin, additional, Abadie, Véronique, additional, Frange, Pierre, additional, Cohen, Jeremie F, additional, Allali, Slimane, additional, Curtis, William, additional, Belhadjer, Zahra, additional, Auriau, Johanne, additional, Méot, Mathilde, additional, Houyel, Lucile, additional, Bonnet, Damien, additional, Delacourt, Christophe, additional, Meunier, Brigitte Bader, additional, Quartier, Pierre, additional, Shaim, Youssef, additional, Baril, Laurence, additional, Crommelynck, Samuel, additional, Jacquot, Baptiste, additional, Blanc, Philippe, additional, Maledon, Natacha, additional, Robert, Blandine, additional, Loeile, Camille, additional, Cazau, Clémence, additional, Loron, Gauthier, additional, Gaga, Simona, additional, Vittot, Cécile, additional, Nabhani, Loubna El, additional, Buisson, François, additional, Prudent, Muriel, additional, Flodrops, Hugues, additional, Mokraoui, Fadhila, additional, Escoda, Simon, additional, Bonnemains, Laurent, additional, Mahi, Sarah-Louisa, additional, Mertes, Clara, additional, Terzic, Joelle, additional, Helms, Julie, additional, Idier, Charlotte, additional, Chenichene, Soraya, additional, Ursulescu, Nicoleta Magdolena, additional, Beaujour, Gladys, additional, Hakim, Abdelhak, additional, Miquel, Alice, additional, Rey, Agnès, additional, Wiedermann, Arnaud, additional, Charbonneau, Anne, additional, Veauvy-Juven, Agnès, additional, Ferry, Alexandrine, additional, Mandelcwajg, Alexis, additional, Rousseau, Alix, additional, Prenant, Amandine, additional, Bourneuf, Anne-Laure, additional, Filleron, Anne, additional, Robine, Audrey, additional, Félix, Arthur, additional, Parizel, Aude, additional, Labarre, Aurélie, additional, Cantais, Aymeric, additional, Ros, Barbara, additional, Coulon, Basile, additional, Biot, Blandine, additional, Dalichoux, Bérengère, additional, Fournier, Benjamin, additional, Cagnard, Benoit, additional, Vanel, Blandine, additional, Brossier, David, additional, Ménager, Bruno, additional, Ozanne, Bruno, additional, Marie-Jeanne, Carole, additional, Bergerot, Camille, additional, Chavy, Camille, additional, Guidon, Camille, additional, Fabre, Candice, additional, Galeotti, Caroline, additional, Baker, Catherine, additional, Ballot-Schmit, Claire, additional, Belleau, Céline, additional, Charasse, Céline, additional, Favel, Caroline, additional, Toumi, Chadia, additional, Ferrandiz, Charlène, additional, Couturier, Charlotte, additional, Pouchoux, Charlotte, additional, Chomton-Cailliez, Maryline, additional, Kevorkian-Verguet, Charlotte, additional, Brunet, Clément, additional, Manteau, Céline, additional, Mougey, Clémence, additional, Santy, Coline, additional, Fitament, Coralie, additional, Petriat, Charlotte, additional, Rebelle, Charlotte, additional, Charron, Cyril, additional, Dartus, Maxime, additional, Toulorge, David, additional, Guillou-Debuisson, Cécile, additional, Bartebin, Dorann, additional, Klein, Valérie, additional, Broustal, E, additional, Desselas, E., additional, Marteau, Elodie, additional, Bouvrot, Emmanuelle, additional, Delacroix, Elise, additional, Coinde, Edeline, additional, Elnabhani, Loubna, additional, Amouyal, Elsa, additional, Chaillou, Emilie, additional, Gabilly-Bernard, Emeline, additional, Ruiz, Emilie, additional, Thibault, Emilie, additional, Robin, Emilie, additional, Darrieux, Etienne, additional, Blondel, Eva, additional, Socchi, Floriane, additional, Cazassus, François, additional, Bajolle, Fanny, additional, Lacin, Fatma, additional, Madhi, Fouad, additional, Zekre, Franck, additional, Guerin, François, additional, Boussicault, Gerald, additional, Ginies, Henri, additional, Magloire, Gnansounou, additional, Arnold, Guilhem, additional, Coulognon, Ines, additional, Sicard-Cras, Iona, additional, Kahn, Jean-Emmanuel, additional, Bordet, Jeanne, additional, Fausser, Jeanne-Lise, additional, Baleine, Jean-François, additional, Brice, Josephine, additional, Gendras, Julie, additional, Pekin, Kaan, additional, Norbert, Karine, additional, Karsenty, Clément, additional, Savary, Léa, additional, Martinat, Laurence, additional, Lesniewski, Léa, additional, Charbonnier, Lorelei, additional, Alexandre, Louise, additional, Percheron, Lucas, additional, Vincenti, Marie, additional, Lanzini, Manon, additional, Grisval, Margot, additional, Mercy, Marianne, additional, Lampin, Marie-Emilie, additional, Desgranges, Marie, additional, Duperril, Marie, additional, Orcel, Marie-Clothilde, additional, Audier, Marion, additional, Favier, Marion, additional, Carpentier, Mathieu, additional, Balcean, Mathilde, additional, Bonnet, Mathilde, additional, Jouret, Maurine, additional, Delattre, Marie, additional, Levy, Michael, additional, Valensi, Michael, additional, Shum, Mickael, additional, Dumortier, Morgane, additional, Gelin, Morgane, additional, Nemmouchi, Morgane, additional, Williaume, Morgane, additional, Sebaha, M., additional, Genetay-Stanescu, Nicoleta, additional, Giroux, Nathan, additional, Crassard, Nicolas, additional, Derridj, Neil, additional, Lachaume, Noemie, additional, Werner, Oscar, additional, Guilluy, Olivier, additional, Richer, Olivier, additional, Tirel, Olivier, additional, Pauvert, Aurianne, additional, Casha, Paul, additional, Perez, Noémie, additional, Gras, Pauline, additional, Leger, Pierre-Louis, additional, Pinchou, Marion, additional, Mornand, Pierre, additional, Largo, Prisca, additional, Ibanez, Ramona-Christina, additional, Roulland, Charlotte, additional, Albarazi, Salam Hadah, additional, Bichali, Said, additional, Faton, Sarah, additional, Schott, Amandine, additional, Walser, Sébastien, additional, Guillaume, Severine, additional, Vincent, Solene, additional, Galene-Gromez, Sophie, additional, Kozisek, Stanislas, additional, Maugard, Thierry, additional, Blanc, Thierry, additional, Navarro, Thierry, additional, Lauvray, Thomas, additional, Kovacs, Tamas, additional, Launay, Valérie, additional, Despert, Véronique, additional, Lhostis, Victoria, additional, Gall, Virginie, additional, Micaelli, Xavier, additional, Benadjaoud, Yasmine, additional, Matoussi, Zied, additional, Géniaux, Hélène, additional, Facile, Anthony, additional, Pietri, Tessa, additional, Palassin, Pascale, additional, Pinel, Sylvine, additional, Chouchana, Laurent, additional, Callot, Delphine, additional, and Boulay, Charlène, additional

Published
2022
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43. Theory of Orbital Optimisation in SCF and MCSCF Calculations

Author

Chavy, C., Ridard, J., Levy, B., Lipscomb, W. N., editor, Maruani, Jean, editor, Atlan, Henri, editor, Barton, Derek, editor, Bonnelle, Christiane, editor, Caro, Paul, editor, Christov, Stefan, editor, Csizmadia, I. G., editor, de Gennes, P-G., editor, Dubois, J-E., editor, Eigen, Manfred, editor, Fukui, Kenishi, editor, Herzberg, Gerhard, editor, Laforgue, Alexandre, editor, Lehn, J-M., editor, Löwdin, P-O., editor, MacLeod, Patrick, editor, McConnell, H. M., editor, McDowell, C. A., editor, McWeeny, Roy, editor, Prigogine, Ilya, editor, Rigny, Paul, editor, Woolley, R. G., editor, Ellinger, Y., editor, and Defranceschi, M., editor

Published
2002
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45. Correction to “Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study”

Author

Donzeau, Aurelie, Aridi, Layal El, Lety, Sophie, Leboucher, Bertrand, Baur, Agnes, Jeusset, Lucas, Selegny, Maelle, Fedorczuk, Cristian, Lajus, Marion, Bensaid, Philippe, Laoudi, Yacine, Pons, Charlotte, Robert, Anne-Cécile, Beaucourt, Camille, De Pontual, Loïc, Richard, Muriel, Goisque, Etienne, Iriart, Xavier, Brissaud, Olivier, Segretin, Pierre, Molimard, Julie, Orecel, Marie-Clothilde, Benoit, Gregoire, Bongiovanni, Lucille, Guerder, Margaux, Pouyau, Robin, De Guillebon De Resnes, Jean-Marie, Mezgueldi, Ellia, Cour-Andlauer, Fleur, Horvat, Come, Poinsot, Pierre, Frachette, Cecile, Ouziel, Antoine, Gillet, Yves, Barrey, Catherine, Brouard, Jacques, Villedieu, Florence, Ro, Vathanaksambath, Elanga, Narcisse, Gajdos, Vincent, Basmaci, Romain, Mutar, Hadile, Rouget, Sébastien, Nattes, Elodie, Hau, Isabelle, Biscardi, Sandra, Jurdi, Houmam El, Jung, Camille, Semama, Denis, Huet, Frederic, Zoccarato, Anne-Marie, Sarakbi, Mayssa, Mortamet, Guillaume, Bost-Bru, Cécile, Bassil, Joachim, Vinit, Caroline, Hentgen, Véronique, Leroux, Pascal, Bertrand, Valérie, Parrod, Caroline, Craiu, Irina, Kone-Paut, Isabelle, Durand, Philippe, Tissiere, Pierre, Claude, Caroline, Morelle, Guillaume, Guiddir, Tamazoust, Borocco, Charlotte, Delion, Frédérique, Guillot, Camille, Leteurtre, Stéphane, Dubos, François, Jouancastay, Mylene, Martinot, Alain, Voeusler, Valentine, Languepin, Jeanne, Garrec, Nathalie, Demersay, Arnaud Chalvon, Morand, Aurélie, Bosdure, Emmanuelle, Vanel, Noémie, Ughetto, Fabrice, Michel, Fabrice, Caujolle, Marie, Blonde, Renaud, Nguyen, Jacqueline, Vignaud, Olivier, Masserot-Lureau, Caroline, Gouraud, François, Araujo, Carine, Ingrao, Tara, Naji, Sanaa, Sehaba, Mohammed, Roche, Christine, Carbasse, Aurelia, Milesi, Christophe, Mazeghrane, Mustapha, Haupt, Sandrine, Schweitzer, Cyril, Romefort, Benedicte, Launay, Elise, Guen, Christèle Gras-Le, Ali, Ahmed, Blot, Nathalie, Tran, Antoine, Rancurel, Anne, Afanetti, Mickael, Odorico, Sophie, Talmud, Deborah, Chosidow, Anais, Romain, Anne-Sophie, Grimprel, Emmanuel, Pouletty, Marie, Gaschignard, Jean, Corseri, Olivier, Faye, Albert, Melki, Isabelle, Ducrocq, Camille, Benzoïd, Cherine, Lokmer, Johanna, Dauger, Stéphane, Chomton, Maryline, Deho, Anna, Lebourgeois, Fleur, Renolleau, Sylvain, Lesage, Fabrice, Moulin, Florence, Dupic, Laurent, Pinhas, Yael, Debray, Agathe, Chalumeau, Martin, Abadie, Véronique, Frange, Pierre, Cohen, Jeremie F, Allali, Slimane, Curtis, William, Belhadjer, Zahra, Auriau, Johanne, Méot, Mathilde, Houyel, Lucile, Bonnet, Damien, Delacourt, Christophe, Meunier, Brigitte Bader, Quartier, Pierre, Shaim, Youssef, Baril, Laurence, Crommelynck, Samuel, Jacquot, Baptiste, Blanc, Philippe, Maledon, Natacha, Robert, Blandine, Loeile, Camille, Cazau, Clémence, Loron, Gauthier, Gaga, Simona, Vittot, Cécile, Nabhani, Loubna El, Buisson, François, Prudent, Muriel, Flodrops, Hugues, Mokraoui, Fadhila, Escoda, Simon, Deschamps, Nina, Bonnemains, Laurent, Mahi, Sarah-Louisa, Mertes, Clara, Terzic, Joelle, Helms, Julie, Idier, Charlotte, Chenichene, Soraya, Ursulescu, Nicoleta Magdolena, Beaujour, Gladys, Hakim, Abdelhak, Miquel, Alice, Rey, Agnès, Wiedermann, Arnaud, Charbonneau, Anne, Veauvy-Juven, Agnès, Ferry, Alexandrine, Mandelcwajg, Alexis, Rousseau, Alix, Prenant, Amandine, Bourneuf, Anne-Laure, Filleron, Anne, Robine, Audrey, Félix, Arthur, Parizel, Aude, Labarre, Aurélie, Cantais, Aymeric, Ros, Barbara, Coulon, Basile, Biot, Blandine, Dalichoux, Bérengère, Fournier, Benjamin, Cagnard, Benoit, Vanel, Blandine, Brossier, David, Ménager, Bruno, Ozanne, Bruno, Marie-Jeanne, Carole, Bergerot, Camille, Chavy, Camille, Guidon, Camille, Fabre, Candice, Galeotti, Caroline, Baker, Catherine, Ballot-Schmit, Claire, Belleau, Céline, Charasse, Céline, Favel, Caroline, Toumi, Chadia, Ferrandiz, Charlène, Couturier, Charlotte, Pouchoux, Charlotte, Chomton-Cailliez, Maryline, Kevorkian-Verguet, Charlotte, Brunet, Clément, Manteau, Céline, Mougey, Clémence, Santy, Coline, Fitament, Coralie, Petriat, Charlotte, Rebelle, Charlotte, Charron, Cyril, Dartus, Maxime, Toulorge, David, Guillou-Debuisson, Cécile, Bartebin, Dorann, Klein, Valérie, Broustal, E, Desselas, E., Marteau, Elodie, Bouvrot, Emmanuelle, Delacroix, Elise, Coinde, Edeline, Elnabhani, Loubna, Amouyal, Elsa, Chaillou, Emilie, Gabilly-Bernard, Emeline, Ruiz, Emilie, Thibault, Emilie, Robin, Emilie, Darrieux, Etienne, Blondel, Eva, Socchi, Floriane, Cazassus, François, Bajolle, Fanny, Lacin, Fatma, Madhi, Fouad, Zekre, Franck, Guerin, François, Boussicault, Gerald, Ginies, Henri, Magloire, Gnansounou, Arnold, Guilhem, Coulognon, Ines, Sicard-Cras, Iona, Kahn, Jean-Emmanuel, Bordet, Jeanne, Fausser, Jeanne-Lise, Baleine, Jean-François, Brice, Josephine, Gendras, Julie, Pekin, Kaan, Norbert, Karine, Karsenty, Clément, Savary, Léa, Martinat, Laurence, Lesniewski, Léa, Charbonnier, Lorelei, Alexandre, Louise, Percheron, Lucas, Vincenti, Marie, Lanzini, Manon, Grisval, Margot, Mercy, Marianne, Lampin, Marie-Emilie, Desgranges, Marie, Duperril, Marie, Orcel, Marie-Clothilde, Audier, Marion, Favier, Marion, Carpentier, Mathieu, Balcean, Mathilde, Bonnet, Mathilde, Jouret, Maurine, Delattre, Marie, Levy, Michael, Valensi, Michael, Shum, Mickael, Dumortier, Morgane, Gelin, Morgane, Nemmouchi, Morgane, Williaume, Morgane, Sebaha, M., Genetay-Stanescu, Nicoleta, Giroux, Nathan, Crassard, Nicolas, Derridj, Neil, Lachaume, Noemie, Werner, Oscar, Guilluy, Olivier, Richer, Olivier, Tirel, Olivier, Pauvert, Aurianne, Casha, Paul, Perez, Noémie, Gras, Pauline, Leger, Pierre-Louis, Pinchou, Marion, Mornand, Pierre, Largo, Prisca, Ibanez, Ramona-Christina, Roulland, Charlotte, Albarazi, Salam Hadah, Bichali, Said, Faton, Sarah, Schott, Amandine, Walser, Sébastien, Guillaume, Severine, Vincent, Solene, Galene-Gromez, Sophie, Kozisek, Stanislas, Maugard, Thierry, Blanc, Thierry, Navarro, Thierry, Lauvray, Thomas, Kovacs, Tamas, Launay, Valérie, Despert, Véronique, Lhostis, Victoria, Gall, Virginie, Micaelli, Xavier, Benadjaoud, Yasmine, Matoussi, Zied, Géniaux, Hélène, Facile, Anthony, Pietri, Tessa, Palassin, Pascale, Pinel, Sylvine, Chouchana, Laurent, Callot, Delphine, Boulay, Charlène, Ouldali, Naïm, Bagheri, Haleh, Salvo, Francesco, Antona, Denise, Pariente, Antoine, Leblanc, Claire, Tebacher, Martine, Micallef, Joëlle, Levy, Corinne, Cohen, Robert, Javouhey, Etienne, Bader-Meunier, Brigitte, Ovaert, Caroline, Hentgen, Veronique, Guen, Christelle Gras-Le, Angoulvant, Francois, and Belot, Alexandre

Published
2022
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46. Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study

Author

Naïm Ouldali, Haleh Bagheri, Francesco Salvo, Denise Antona, Antoine Pariente, Claire Leblanc, Martine Tebacher, Joëlle Micallef, Corinne Levy, Robert Cohen, Etienne Javouhey, Brigitte Bader-Meunier, Caroline Ovaert, Sylvain Renolleau, Veronique Hentgen, Isabelle Kone-Paut, Nina Deschamps, Loïc De Pontual, Xavier Iriart, Christelle Gras-Le Guen, François Angoulvant, Alexandre Belot, Aurelie Donzeau, Layal El Aridi, Sophie Lety, Bertrand Leboucher, Agnes Baur, Lucas Jeusset, Maelle Selegny, Cristian Fedorczuk, Marion Lajus, Philippe Bensaid, Yacine Laoudi, Charlotte Pons, Anne-Cécile Robert, Camille Beaucourt, Muriel Richard, Etienne Goisque, Olivier Brissaud, Pierre Segretin, Julie Molimard, Marie-Clothilde Orecel, Gregoire Benoit, Lucille Bongiovanni, Margaux Guerder, Robin Pouyau, Jean-Marie De Guillebon De Resnes, Ellia Mezgueldi, Fleur Cour-Andlauer, Come Horvat, Pierre Poinsot, Cecile Frachette, Antoine Ouziel, Yves Gillet, Catherine Barrey, Jacques Brouard, Florence Villedieu, Vathanaksambath Ro, Narcisse Elanga, Vincent Gajdos, Romain Basmaci, Hadile Mutar, Sébastien Rouget, Elodie Nattes, Isabelle Hau, Sandra Biscardi, Houmam El Jurdi, Camille Jung, Denis Semama, Frederic Huet, Anne-Marie Zoccarato, Mayssa Sarakbi, Guillaume Mortamet, Cécile Bost-Bru, Joachim Bassil, Caroline Vinit, Véronique Hentgen, Pascal Leroux, Valérie Bertrand, Caroline Parrod, Irina Craiu, Philippe Durand, Pierre Tissiere, Caroline Claude, Guillaume Morelle, Tamazoust Guiddir, Charlotte Borocco, Frédérique Delion, Camille Guillot, Stéphane Leteurtre, François Dubos, Mylene Jouancastay, Alain Martinot, Valentine Voeusler, Jeanne Languepin, Nathalie Garrec, Arnaud Chalvon Demersay, Aurélie Morand, Emmanuelle Bosdure, Noémie Vanel, Fabrice Ughetto, Fabrice Michel, Marie Caujolle, Renaud Blonde, Jacqueline Nguyen, Olivier Vignaud, Caroline Masserot-Lureau, François Gouraud, Carine Araujo, Tara Ingrao, Sanaa Naji, Mohammed Sehaba, Christine Roche, Aurelia Carbasse, Christophe Milesi, Mustapha Mazeghrane, Sandrine Haupt, Cyril Schweitzer, Benedicte Romefort, Elise Launay, Christèle Gras-Le Guen, Ahmed Ali, Nathalie Blot, Antoine Tran, Anne Rancurel, Mickael Afanetti, Sophie Odorico, Deborah Talmud, Anais Chosidow, Anne-Sophie Romain, Emmanuel Grimprel, Marie Pouletty, Jean Gaschignard, Olivier Corseri, Albert Faye, Isabelle Melki, Camille Ducrocq, Cherine Benzoïd, Johanna Lokmer, Stéphane Dauger, Maryline Chomton, Anna Deho, Fleur Lebourgeois, Fabrice Lesage, Florence Moulin, Laurent Dupic, Yael Pinhas, Agathe Debray, Martin Chalumeau, Véronique Abadie, Pierre Frange, Jeremie F Cohen, Slimane Allali, William Curtis, Zahra Belhadjer, Johanne Auriau, Mathilde Méot, Lucile Houyel, Damien Bonnet, Christophe Delacourt, Brigitte Bader Meunier, Pierre Quartier, Youssef Shaim, Laurence Baril, Samuel Crommelynck, Baptiste Jacquot, Philippe Blanc, Natacha Maledon, Blandine Robert, Camille Loeile, Clémence Cazau, Gauthier Loron, Simona Gaga, Cécile Vittot, Loubna El Nabhani, François Buisson, Muriel Prudent, Hugues Flodrops, Fadhila Mokraoui, Simon Escoda, Laurent Bonnemains, Sarah-Louisa Mahi, Clara Mertes, Joelle Terzic, Julie Helms, Charlotte Idier, Soraya Chenichene, Nicoleta Magdolena Ursulescu, Gladys Beaujour, Abdelhak Hakim, Alice Miquel, Agnès Rey, Arnaud Wiedermann, Anne Charbonneau, Agnès Veauvy-Juven, Alexandrine Ferry, Alexis Mandelcwajg, Alix Rousseau, Amandine Prenant, Anne-Laure Bourneuf, Anne Filleron, Audrey Robine, Arthur Félix, Aude Parizel, Aurélie Labarre, Aymeric Cantais, Barbara Ros, Basile Coulon, Blandine Biot, Bérengère Dalichoux, Benjamin Fournier, Benoit Cagnard, Blandine Vanel, David Brossier, Bruno Ménager, Bruno Ozanne, Carole Marie-Jeanne, Camille Bergerot, Camille Chavy, Camille Guidon, Candice Fabre, Caroline Galeotti, Catherine Baker, Claire Ballot-Schmit, Céline Belleau, Céline Charasse, Caroline Favel, Chadia Toumi, Charlène Ferrandiz, Charlotte Couturier, Charlotte Pouchoux, Maryline Chomton-Cailliez, Charlotte Kevorkian-Verguet, Clément Brunet, Céline Manteau, Clémence Mougey, Coline Santy, Coralie Fitament, Charlotte Petriat, Charlotte Rebelle, Cyril Charron, Maxime Dartus, David Toulorge, Cécile Guillou-Debuisson, Dorann Bartebin, Valérie Klein, E Broustal, E Desselas, Elodie Marteau, Emmanuelle Bouvrot, Elise Delacroix, Edeline Coinde, Loubna Elnabhani, Elsa Amouyal, Emilie Chaillou, Emeline Gabilly-Bernard, Emilie Ruiz, Emilie Thibault, Emilie Robin, Etienne Darrieux, Eva Blondel, Floriane Socchi, François Cazassus, Fanny Bajolle, Fatma Lacin, Fouad Madhi, Franck Zekre, François Guerin, Gerald Boussicault, Henri Ginies, Gnansounou Magloire, Guilhem Arnold, Ines Coulognon, Iona Sicard-Cras, Jean-Emmanuel Kahn, Jeanne Bordet, Jeanne-Lise Fausser, Jean-François Baleine, Josephine Brice, Julie Gendras, Kaan Pekin, Karine Norbert, Clément Karsenty, Léa Savary, Laurence Martinat, Léa Lesniewski, Lorelei Charbonnier, Louise Alexandre, Lucas Percheron, Marie Vincenti, Manon Lanzini, Margot Grisval, Marianne Mercy, Marie-Emilie Lampin, Marie Desgranges, Marie Duperril, Marie-Clothilde Orcel, Marion Audier, Marion Favier, Mathieu Carpentier, Mathilde Balcean, Mathilde Bonnet, Maurine Jouret, Marie Delattre, Michael Levy, Michael Valensi, Mickael Shum, Morgane Dumortier, Morgane Gelin, Morgane Nemmouchi, Morgane Williaume, M Sebaha, Nicoleta Genetay-Stanescu, Nathan Giroux, Nicolas Crassard, Neil Derridj, Noemie Lachaume, Oscar Werner, Olivier Guilluy, Olivier Richer, Olivier Tirel, Aurianne Pauvert, Paul Casha, Noémie Perez, Pauline Gras, Pierre-Louis Leger, Marion Pinchou, Pierre Mornand, Prisca Largo, Ramona-Christina Ibanez, Charlotte Roulland, Salam Hadah Albarazi, Said Bichali, Sarah Faton, Amandine Schott, Sébastien Walser, Severine Guillaume, Solene Vincent, Sophie Galene-Gromez, Stanislas Kozisek, Thierry Maugard, Thierry Blanc, Thierry Navarro, Thomas Lauvray, Tamas Kovacs, Valérie Launay, Véronique Despert, Victoria Lhostis, Virginie Gall, Xavier Micaelli, Yasmine Benadjaoud, Zied Matoussi, Hélène Géniaux, Anthony Facile, Tessa Pietri, Pascale Palassin, Sylvine Pinel, Laurent Chouchana, Delphine Callot, Charlène Boulay, Hôpital Robert Debré, CHU Sainte Justine [Montréal], Association Clinique et Thérapeutique Infantile du Val de Marne (ACTIV), Epidémiologie Clinique et Evaluation Economique Appliquées aux Populations Vulnérables (ECEVE (U1123 / UMR_S_1123)), Institut National de la Santé et de la Recherche Médicale (INSERM)-AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPCité), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Bordeaux population health (BPH), Université de Bordeaux (UB)-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Bordeaux [Bordeaux], Santé publique France - French National Public Health Agency [Saint-Maurice, France], Les Hôptaux universitaires de Strasbourg (HUS), CHU Strasbourg, CHU Marseille, Institut de Neurosciences des Systèmes (INS), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHI Créteil, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Femme Mère Enfant [CHU - HCL] (HFME), Hospices Civils de Lyon (HCL), Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques / Pathophysiology of Injury-induced Immunosuppression (PI3), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre de Référence pour les Maladies Rhumatologiques Auto-Immunes et Systémiques [CHU Necker] (RAISE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital de la Timone [CHU - APHM] (TIMONE), Marseille medical genetics - Centre de génétique médicale de Marseille (MMG), Evaluation thérapeutique et pharmacologie périnatale et pédiatrique (EA_7323), Université Paris Descartes - Paris 5 (UPD5), Centre Hospitalier de Versailles André Mignot (CHV), Centre de Référence des Maladies Auto-Inflammatoires et des Amyloses [CH Versailles] (CeRéMAIA - Hôpital André Mignot), Hôpital Bicêtre, Université Paris-Saclay, CH de Saint-Malo [Broussais], Hôpital Jean Verdier [AP-HP], Institut de rythmologie et modélisation cardiaque [Pessac] (IHU Liryc), Centre de recherche Cardio-Thoracique de Bordeaux [Bordeaux] (CRCTB), Université Bordeaux Segalen - Bordeaux 2-CHU Bordeaux [Bordeaux]-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité (CRESS (U1153 / UMR_A_1125 / UMR_S_1153)), Conservatoire National des Arts et Métiers [CNAM] (CNAM), HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-HESAM Université - Communauté d'universités et d'établissements Hautes écoles Sorbonne Arts et métiers université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Centre d’Investigation Clinique de Nantes (CIC Nantes), Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre hospitalier universitaire de Nantes (CHU Nantes), Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre de référence des rhumatismes inflammatoires et maladies auto-immunes systémiques rares de l’enfant / National Referee Centre for Rheumatic and AutoImmune and Systemic Diseases in Children [Lyon] (RAISE), European Society for Paediatric Infectious Diseases, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Cité (UPC), CHU Toulouse [Toulouse], Physiopathologie de l'immunodépression associée aux réponses inflammatoires systémiques - EA 7426 (PI3), Centre de Référence pour les Maladies Rhumatologiques Auto-Immunes et Systémiques [Paris] (Institut IMAGINE/RAISE), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut Imagine [Paris Necker] (2I), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC), HESAM Université (HESAM)-HESAM Université (HESAM)-Université Sorbonne Paris Cité (USPC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPC)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPC), Centre International de Recherche en Infectiologie - UMR (CIRI), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Health data- and model- driven Knowledge Acquisition (HeKA), Inria de Paris, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre de Recherche des Cordeliers (CRC (UMR_S_1138 / U1138)), and Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Université Paris Cité (UPCité)-École Pratique des Hautes Études (EPHE)

Subjects
Oncology, [SDV]Life Sciences [q-bio], Health Policy, Multisystem inflammatory syndrome in children, Internal Medicine, COVID-19 mRNA vaccine, BNT162b2, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, SARS-COV-2, Hyper-inflammatory syndrome, Child
Abstract

International audience; BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is the most severe clinical entity associated with pediatric SARS-CoV-2 infection with a putative role of the spike protein into the immune system activation. Whether COVID-19 mRNA vaccine can induce this complication in children is unknown. We aimed to assess the risk of hyper-inflammatory syndrome following COVID-19 mRNA vaccine in children. METHODS: We conducted a post-authorization national population-based surveillance using the French enhanced pharmacovigilance surveillance system for COVID-19 vaccines. All cases of suspected hyper-inflammatory syndrome following COVID-19 mRNA vaccine in 12-17-year-old children between June 15(th), 2021 and January 1(st), 2022, were reported. Cases were reviewed according to WHO criteria for MIS-C. The reporting rate of this syndrome was compared to the MIS-C rate per 1,000,000 12-17-year-old children infected by SARS-CoV-2. FINDINGS: Up to January 2022, 8,113,058 COVID-19 mRNA vaccine doses were administered to 4,079,234 12-17-year-old children. Among them, 12 presented a hyper-inflammatory syndrome with multisystemic involvement. Main clinical features included male predominance (10/12, 83%), cardiac involvement (10/12, 83%), digestive symptoms (10/12, 83%), coagulopathy (7/12, 58%), cytolytic hepatitis (6/12, 50%), and shock (5/12, 42%). 4/12 (33%) required intensive care unit transfer, and 3/12 (25%) hemodynamic support. All cases recovered. In eight cases, no evidence of previous SARS-CoV-2 infection was found. The reporting rate was 1.5 (95%CI [0.8; 2.6]) per 1,000,000 doses injected, i.e. 2.9 (95%CI [1.5; 5.1]) per 1,000,000 12-17-year-old vaccinated children. As a comparison, 113 MIS-C (95%CI [95; 135]) occurred per 1,000,000 12-17-year-old children infected by SARS-CoV-2. INTERPRETATION: Very few cases of hyper-inflammatory syndrome with multi-organ involvement occurred following COVID-19 mRNA vaccine in 12-17-year-old children. The low reporting rate of this syndrome, compared to the rate of post-SARS-CoV-2 MIS-C in the same age-group, largely supports the vaccination in a context of an important circulation of SARS-CoV-2. FUNDING: ESPID Fellowship Award; Grandir-Fonds de Solidarité Pour L'enfance.

Published
2022
Full Text
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48. Hyper inflammatory syndrome following COVID-19 mRNA vaccine in children: A national post-authorization pharmacovigilance study

Author

Ouldali, Naïm, primary, Bagheri, Haleh, additional, Salvo, Francesco, additional, Antona, Denise, additional, Pariente, Antoine, additional, Leblanc, Claire, additional, Tebacher, Martine, additional, Micallef, Joëlle, additional, Levy, Corinne, additional, Cohen, Robert, additional, Javouhey, Etienne, additional, Bader-Meunier, Brigitte, additional, Ovaert, Caroline, additional, Renolleau, Sylvain, additional, Hentgen, Veronique, additional, Kone-Paut, Isabelle, additional, Deschamps, Nina, additional, De Pontual, Loïc, additional, Iriart, Xavier, additional, Guen, Christelle Gras-Le, additional, Angoulvant, François, additional, Belot, Alexandre, additional, Donzeau, Aurelie, additional, El Aridi, Layal, additional, Lety, Sophie, additional, Leboucher, Bertrand, additional, Baur, Agnes, additional, Jeusset, Lucas, additional, Selegny, Maelle, additional, Fedorczuk, Cristian, additional, Lajus, Marion, additional, Bensaid, Philippe, additional, Laoudi, Yacine, additional, Pons, Charlotte, additional, Robert, Anne-Cécile, additional, Beaucourt, Camille, additional, Richard, Muriel, additional, Goisque, Etienne, additional, Brissaud, Olivier, additional, Segretin, Pierre, additional, Molimard, Julie, additional, Orecel, Marie-Clothilde, additional, Benoit, Gregoire, additional, Bongiovanni, Lucille, additional, Guerder, Margaux, additional, Pouyau, Robin, additional, De Guillebon De Resnes, Jean-Marie, additional, Mezgueldi, Ellia, additional, Cour-Andlauer, Fleur, additional, Horvat, Come, additional, Poinsot, Pierre, additional, Frachette, Cecile, additional, Ouziel, Antoine, additional, Gillet, Yves, additional, Barrey, Catherine, additional, Brouard, Jacques, additional, Villedieu, Florence, additional, Ro, Vathanaksambath, additional, Elanga, Narcisse, additional, Gajdos, Vincent, additional, Basmaci, Romain, additional, Mutar, Hadile, additional, Rouget, Sébastien, additional, Nattes, Elodie, additional, Hau, Isabelle, additional, Biscardi, Sandra, additional, El Jurdi, Houmam, additional, Jung, Camille, additional, Semama, Denis, additional, Huet, Frederic, additional, Zoccarato, Anne-Marie, additional, Sarakbi, Mayssa, additional, Mortamet, Guillaume, additional, Bost-Bru, Cécile, additional, Bassil, Joachim, additional, Vinit, Caroline, additional, Hentgen, Véronique, additional, Leroux, Pascal, additional, Bertrand, Valérie, additional, Parrod, Caroline, additional, Craiu, Irina, additional, Durand, Philippe, additional, Tissiere, Pierre, additional, Claude, Caroline, additional, Morelle, Guillaume, additional, Guiddir, Tamazoust, additional, Borocco, Charlotte, additional, Delion, Frédérique, additional, Guillot, Camille, additional, Leteurtre, Stéphane, additional, Dubos, François, additional, Jouancastay, Mylene, additional, Martinot, Alain, additional, Voeusler, Valentine, additional, Languepin, Jeanne, additional, Garrec, Nathalie, additional, Demersay, Arnaud Chalvon, additional, Morand, Aurélie, additional, Bosdure, Emmanuelle, additional, Vanel, Noémie, additional, Ughetto, Fabrice, additional, Michel, Fabrice, additional, Caujolle, Marie, additional, Blonde, Renaud, additional, Nguyen, Jacqueline, additional, Vignaud, Olivier, additional, Masserot-Lureau, Caroline, additional, Gouraud, François, additional, Araujo, Carine, additional, Ingrao, Tara, additional, Naji, Sanaa, additional, Sehaba, Mohammed, additional, Roche, Christine, additional, Carbasse, Aurelia, additional, Milesi, Christophe, additional, Mazeghrane, Mustapha, additional, Haupt, Sandrine, additional, Schweitzer, Cyril, additional, Romefort, Benedicte, additional, Launay, Elise, additional, Guen, Christèle Gras-Le, additional, Ali, Ahmed, additional, Blot, Nathalie, additional, Tran, Antoine, additional, Rancurel, Anne, additional, Afanetti, Mickael, additional, Odorico, Sophie, additional, Talmud, Deborah, additional, Chosidow, Anais, additional, Romain, Anne-Sophie, additional, Grimprel, Emmanuel, additional, Pouletty, Marie, additional, Gaschignard, Jean, additional, Corseri, Olivier, additional, Faye, Albert, additional, Melki, Isabelle, additional, Ducrocq, Camille, additional, Benzoïd, Cherine, additional, Lokmer, Johanna, additional, Dauger, Stéphane, additional, Chomton, Maryline, additional, Deho, Anna, additional, Lebourgeois, Fleur, additional, Lesage, Fabrice, additional, Moulin, Florence, additional, Dupic, Laurent, additional, Pinhas, Yael, additional, Debray, Agathe, additional, Chalumeau, Martin, additional, Abadie, Véronique, additional, Frange, Pierre, additional, Cohen, Jeremie F, additional, Allali, Slimane, additional, Curtis, William, additional, Belhadjer, Zahra, additional, Auriau, Johanne, additional, Méot, Mathilde, additional, Houyel, Lucile, additional, Bonnet, Damien, additional, Delacourt, Christophe, additional, Bader Meunier, Brigitte, additional, Quartier, Pierre, additional, Shaim, Youssef, additional, Baril, Laurence, additional, Crommelynck, Samuel, additional, Jacquot, Baptiste, additional, Blanc, Philippe, additional, Maledon, Natacha, additional, Robert, Blandine, additional, Loeile, Camille, additional, Cazau, Clémence, additional, Loron, Gauthier, additional, Gaga, Simona, additional, Vittot, Cécile, additional, El Nabhani, Loubna, additional, Buisson, François, additional, Prudent, Muriel, additional, Flodrops, Hugues, additional, Mokraoui, Fadhila, additional, Escoda, Simon, additional, Bonnemains, Laurent, additional, Mahi, Sarah-Louisa, additional, Mertes, Clara, additional, Terzic, Joelle, additional, Helms, Julie, additional, Idier, Charlotte, additional, Chenichene, Soraya, additional, Magdolena Ursulescu, Nicoleta, additional, Beaujour, Gladys, additional, Hakim, Abdelhak, additional, Miquel, Alice, additional, Rey, Agnès, additional, Wiedermann, Arnaud, additional, Charbonneau, Anne, additional, Veauvy-Juven, Agnès, additional, Ferry, Alexandrine, additional, Mandelcwajg, Alexis, additional, Rousseau, Alix, additional, Prenant, Amandine, additional, Bourneuf, Anne-Laure, additional, Filleron, Anne, additional, Robine, Audrey, additional, Félix, Arthur, additional, Parizel, Aude, additional, Labarre, Aurélie, additional, Cantais, Aymeric, additional, Ros, Barbara, additional, Coulon, Basile, additional, Biot, Blandine, additional, Dalichoux, Bérengère, additional, Fournier, Benjamin, additional, Cagnard, Benoit, additional, Vanel, Blandine, additional, Brossier, David, additional, Ménager, Bruno, additional, Ozanne, Bruno, additional, Marie-Jeanne, Carole, additional, Bergerot, Camille, additional, Chavy, Camille, additional, Guidon, Camille, additional, Fabre, Candice, additional, Galeotti, Caroline, additional, Baker, Catherine, additional, Ballot-Schmit, Claire, additional, Belleau, Céline, additional, Charasse, Céline, additional, Favel, Caroline, additional, Toumi, Chadia, additional, Ferrandiz, Charlène, additional, Couturier, Charlotte, additional, Pouchoux, Charlotte, additional, Chomton-Cailliez, Maryline, additional, Kevorkian-Verguet, Charlotte, additional, Brunet, Clément, additional, Manteau, Céline, additional, Mougey, Clémence, additional, Santy, Coline, additional, Fitament, Coralie, additional, Petriat, Charlotte, additional, Rebelle, Charlotte, additional, Charron, Cyril, additional, Dartus, Maxime, additional, Toulorge, David, additional, Guillou-Debuisson, Cécile, additional, Bartebin, Dorann, additional, Klein, Valérie, additional, Broustal, E, additional, Desselas, E, additional, Marteau, Elodie, additional, Bouvrot, Emmanuelle, additional, Delacroix, Elise, additional, Coinde, Edeline, additional, Elnabhani, Loubna, additional, Amouyal, Elsa, additional, Chaillou, Emilie, additional, Gabilly-Bernard, Emeline, additional, Ruiz, Emilie, additional, Thibault, Emilie, additional, Robin, Emilie, additional, Darrieux, Etienne, additional, Blondel, Eva, additional, Socchi, Floriane, additional, Cazassus, François, additional, Bajolle, Fanny, additional, Lacin, Fatma, additional, Madhi, Fouad, additional, Zekre, Franck, additional, Guerin, François, additional, Boussicault, Gerald, additional, Ginies, Henri, additional, Magloire, Gnansounou, additional, Arnold, Guilhem, additional, Coulognon, Ines, additional, Sicard-Cras, Iona, additional, Kahn, Jean-Emmanuel, additional, Bordet, Jeanne, additional, Fausser, Jeanne-Lise, additional, Baleine, Jean-François, additional, Brice, Josephine, additional, Gendras, Julie, additional, Pekin, Kaan, additional, Norbert, Karine, additional, Karsenty, Clément, additional, Savary, Léa, additional, Martinat, Laurence, additional, Lesniewski, Léa, additional, Charbonnier, Lorelei, additional, Alexandre, Louise, additional, Percheron, Lucas, additional, Vincenti, Marie, additional, Lanzini, Manon, additional, Grisval, Margot, additional, Mercy, Marianne, additional, Lampin, Marie-Emilie, additional, Desgranges, Marie, additional, Duperril, Marie, additional, Orcel, Marie-Clothilde, additional, Audier, Marion, additional, Favier, Marion, additional, Carpentier, Mathieu, additional, Balcean, Mathilde, additional, Bonnet, Mathilde, additional, Jouret, Maurine, additional, Delattre, Marie, additional, Levy, Michael, additional, Valensi, Michael, additional, Shum, Mickael, additional, Dumortier, Morgane, additional, Gelin, Morgane, additional, Nemmouchi, Morgane, additional, Williaume, Morgane, additional, Sebaha, M, additional, Genetay-Stanescu, Nicoleta, additional, Giroux, Nathan, additional, Crassard, Nicolas, additional, Derridj, Neil, additional, Lachaume, Noemie, additional, Werner, Oscar, additional, Guilluy, Olivier, additional, Richer, Olivier, additional, Tirel, Olivier, additional, Pauvert, Aurianne, additional, Casha, Paul, additional, Perez, Noémie, additional, Gras, Pauline, additional, Leger, Pierre-Louis, additional, Pinchou, Marion, additional, Mornand, Pierre, additional, Largo, Prisca, additional, Ibanez, Ramona-Christina, additional, Roulland, Charlotte, additional, Hadah Albarazi, Salam, additional, Bichali, Said, additional, Faton, Sarah, additional, Schott, Amandine, additional, Walser, Sébastien, additional, Guillaume, Severine, additional, Vincent, Solene, additional, Galene-Gromez, Sophie, additional, Kozisek, Stanislas, additional, Maugard, Thierry, additional, Blanc, Thierry, additional, Navarro, Thierry, additional, Lauvray, Thomas, additional, Kovacs, Tamas, additional, Launay, Valérie, additional, Despert, Véronique, additional, Lhostis, Victoria, additional, Gall, Virginie, additional, Micaelli, Xavier, additional, Benadjaoud, Yasmine, additional, Matoussi, Zied, additional, Géniaux, Hélène, additional, Facile, Anthony, additional, Pietri, Tessa, additional, Palassin, Pascale, additional, Pinel, Sylvine, additional, Chouchana, Laurent, additional, Callot, Delphine, additional, and Boulay, Charlène, additional

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2022
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