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The uptake of 48V in developing rat molar enamel was studied in vivo and in vitro using autoradiographic and quantitative methods. It was shown that the uptake of 48V in enamel is less than in bone and dentin, and that plasma protein binding of 48V is primarily responsible for the limited uptake in enamel. [ABSTRACT FROM AUTHOR]

Objectives: To inform the development of targeted sexually transmitted infection (STI) control programmes for persons who inject drugs (PWID)., Methods: We recruited 116 PWID (aged ≥ 18 years) from a community-based syringe exchange programme (SEP) and assessed their STI knowledge and screening preferences via technology assisted self-interview. We estimated prevalence of STI transmission knowledge, attitudes and screening preferences as well as the association between reported sexual behaviours (past 6 months) and willingness to self-collect specimens., Results: Participants were white (77%), female (51%) and heterosexual (77%). STI knowledge regarding transmission and testing was high among the sample. More than 70% of participants were aware extragenital infections were possible and were least likely to know urine tests do not detect rectal infections (40.9%). Site-specific specimen collection was highly reflective of reported sexual behaviour. PWID who reported receptive sex (36% vs 5%, p<0.01) and insertive anal sex (31% vs 6%, p=0.01) were more likely to collect rectal specimens than those who did not. A similar trend was seen for oral sex performance on men and self-collection of oropharyngeal swabs (15% vs 3%, p=0.04). In addition, participants preferred collecting their own sample to having a clinician collect it for them (69% vs 31%, p<0.01) and testing at the SEP compared with a STI clinic (86% vs 14%, p<0.01)., Conclusion: Our findings suggest site-specific specimen collection may be a proxy for risk behaviour engagement in this fairly knowledgeable high-risk population. To increase case finding, STI control programmes should educate patients about site-specific screening and pair outreach with the infrastructure provided by SEPs, in settings where these programmes exist., Competing Interests: Competing interests: None declared., (© Article author(s) (or their employer(s) unless otherwise stated in the text of the article) 2018. All rights reserved. No commercial use is permitted unless otherwise expressly granted.)

About 17.5% of sexually active injection drug users recruited from a syringe exchange in Camden, NJ (n = 120) screened positive for chlamydia/gonorrhea. Among these cases, 40% were detected via extragenital screening. This pilot demonstrates that colocating sexually transmitted infection control with syringe exchange leads to sexually transmitted infection case finding.

Background and Aims: The five-times-sit-to-stand test (FTSST) is a physical performance test commonly-used in clinical geriatric studies. The relationship between FTSST times and dynamic balance has not been widely investigated in older adults. The main objective of this study was to evaluate the validity of the FTSST as a measure of dynamic balance in older adults. A second objective was to quantify relative and absolute reliability, as well as minimum detectable change (MDC) of the FTSST in older adults., Methods: Twenty-nine females (mean age, 73.6 years) performed two trials of the FTSST, timed up and go (TUG), and functional reach (FR) tests. Validity of the FTSST as a measure of dynamic balance was evaluated by quantifying strength of relationships between the FTSST and two measures of dynamic balance, TUG and FR, using Pearson's correlation coefficient. Measures of relative [intraclass correlation coefficient (ICC)] and absolute [standard error of measurement (SEM)] reliability, as well as the MDC at the 95% confidence level (MDC 95 ) were computed for the FTSST., Results: The Pearson's correlation coefficient between FTSST and TUG (r=0.64, p<0.001) indicates that FTSST is a valid measure of dynamic balance and functional mobility in older adults. The ICC 2,1 of 0.95 is indicative of excellent relative reliability of the FTSST. SEM was 0.9 seconds and MDC 95 was 2.5 seconds for the FTSST. SEM (6.3% of mean FTSST) and MDC (17.5% of mean FTSST) percent values were low., Conclusions: The FTSST is a valid measure of dynamic balance and functional mobility in older adults. The high ICC and low SEM and SEM% suggest excellent relative and absolute reliability and reproducibility of the FTSST in older adults. Change in FTSST performance should exceed 2.5 seconds to be considered real change beyond measurement error.

The authors intend to present a more detailed look at the basal cell carcinoma, both clinically and histologically. An in-depth treatment approach, case presentation, and literature review is provided in order to aid the practicing physician to better understand and treat this cutaneous malignancy. Through describing the variety of appearances of the basal cell carcinoma, the practitioner, hopefully, will be made more aware of the very real possibility of carcinoma in the differential diagnosis of dermatologic lesions.

The uptake of 48V in developing rat molar enamel was studied in vivo and in vitro using autoradiographic and quantitative methods. It was shown that the uptake of 48V in enamel is less than in bone and dentin, and that plasma protein binding of 48V is primarily responsible for the limited uptake in enamel.