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Background: Landslides, among the most catastrophic natural hazards, result from natural and anthropogenic factors, causing substantial financial losses, infrastructural damage, fatalities, and environmental degradation. Uttarakhand, with its unique topographical and hydrological conditions, unplanned human settlements, and changing precipitation patterns, is highly susceptible to landslides. Methods: This study evaluates landslide susceptibility for Uttarakhand, a Himalayan state in India, by employing bivariate analysis, multi-criteria decision-making, and advanced machine learning models, such as Random Forest and Extreme Gradient Boosting (XGBoost). A total of sixteen landslide influencing factors were used for performing landslide hazard susceptibility zonation, including the innovative use of geomorphons for detailed terrain analysis. Results: Approximately 18.47% of the study area was classified as high to very high landslide susceptibility zones, and 21% was classified into the moderate susceptibility category. High to very high susceptibility zones were concentrated in the Uttarkashi, Chamoli, and Pithoragarh districts of the Lesser and Higher Himalayas, areas characterized by rangelands and high annual rainfall. Conversely, very low to low susceptibility zones were predominantly located in the Tarai-Bhabar and Sub-Himalayan districts, including Haridwar and Udham Singh Nagar. The Random Forest and XGBoost models demonstrated superior predictive performance. Conclusions: The spatially explicit landslide susceptibility maps provide critical insights for urban planners, disaster management agencies, and environmentalists, aiding in developing effective strategies for landslide risk reduction and promoting sustainable development in Uttarakhand. This study exemplifies applying advanced analytical techniques to address landslide susceptibility and related soil erosion and water resource management challenges in Uttarakhand. [ABSTRACT FROM AUTHOR]

Amongst the academic community there has been an increasing acceptance that knowledge and learning is no longer situated solely within academic settings and that workplace settings are also legitimate spaces for reflecting on practice in order to enhance professional capabilities. Learners are uniquely placed to draw on their workplace experiences as they explore the relationship between this experience and the academic curriculum. Moreover, biography, prior experience and lived experiences are being recognised as legitimate knowledge arenas in tackling challenging issues of inequality and promoting diversity. Within this context, which teaching and learning methodologies enable facilitators and learners to negotiate the boundaries between workplace and academic environments? This article discusses a multi-disciplinary research project in which youth and community practitioners engaged in participatory theatre as a site for critical action learning. We argue this approach furthers our understanding of the process of in-depth learning concerning issues of equality across disciplinary and cross service dialogues.

Focuses on the initiative to develop a pedagogy for Black perspectives in Global Youth Work which calls for a reassesment of past and present relationships between the minority and the majority worlds. Challenge for youth work and community work; Perspectives on the challenges for global youth work; Objective to place Black people at the forefront of global and local decision-making; Core elements of Black perspectives in Global Youth Work; Practice of Black perspectives in Global Youth Work.

Background & objectives: in drug resistant, especially multi-drug resistant (MDR) tuberculosis, fluoroquinolones (FQs) are used as second line drugs. However, the incidence of FQ-resistant Mycobacterium tuberculosis is rapidly increasing which may be due to extensive use of FQs in the treatment of various other diseases. The most important known mechanism i.e., gyrA mutation in FQ resistance is not observed in a significant proportion of FQ resistant M. tuberculosis isolates suggesting that the resistance may be because of other mechanisms such as an active drug efflux pump. In this study we evaluated the role of the efflux pumps in quinolone resistance by using various inhibitors such as carbonyl cyanide m-chlorophenyl hydrazone (CCCP), 2,4-dinitrophenol (DNP) and verapamil, in clinical isolates of M. tuberculosis. Methods: A total of 55 M. tuberculosis clinical isolates [45 ofloxacin (OFL) resistant and 10 ofloxacin sensitive] were tested by Resazurin microtitre assay (REMA) to observe the changes in ofloxacin minimum inhibitory concentration (MIC) levels in presence of efflux inhibitors as compared to control (without efflux inhibitor). Results: The MIC levels of OFL showed 2-8 folds reduction in presence of CCCP (16/45; 35.5%), verapamil (24/45; 53.3%) and DNP (21/45; 46.6%) while in case of isolates identified as OFL sensitive these did not show any effect on ofloxacin MICs. In 11 of 45 (24.5%) isolates change in MIC levels was observed with all the three inhibitors. Overall 30 (66.6%) isolates had reduction in OFL MIC after treatment with these inhibitors. A total of eight isolates were sequenced for gyrA gene, of which, seven (87.5%) showed known mutations. Of the eight sequenced isolates, seven (87.5%) showed 2 to 8 fold change in MIC in presence of efflux inhibitors. Interpretation & conclusions: Our findings suggest the involvement of active efflux pumps of both Major Facilitator Super Family (MFS) family (inhibited by CCCP and DNP) and ATP Binding Cassette (ABC) transporters (inhibited by verapamil) in the development of OFL resistance in M. tuberculosis isolates. Epidemiological significance of these findings needs to be determined in prospective studies with appropriate number of samples / isolates. [ABSTRACT FROM AUTHOR]