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The mechanisms of coronavirus disease-2019 (COVID-19)-related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity., Competing Interests: Dr Nazarian has received grants from the National Institutes of Health, ImriCor, Biosense Webster, and ADAS; and is a consultant to CardioSolv and ImroCor. All other authors have reported that they have no relationships relevant to the contents of this paper to disclose., (© 2022 The Authors.)