158 results on '"Charpiot, P."'
Search Results
2. Distinct global DNA methylation and NF-κB expression profile of preimplantation biopsies from ideal and non-ideal kidneys
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do Nascimento Gonçalves, Naiane, Caldas, Heloisa Cristina, da Silva Florim, Greiciane Maria, Sormani, Giovanna Mattiello, Arantes, Lidia Maria Rebolho Batista, Sorroche, Bruna Pereira, Baptista, Maria Alice Sperto Ferreira, Fernandes-Charpiot, Ida Maria Maximina, Nascimento-Filho, Carlos Henrique Viese, de Castilho, Rogério Moraes, and Abbud-Filho, Mario
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- 2022
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3. Attitudes of Children with Autism towards Robots: An Exploratory Study
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Costa, Andreia, Schweich, Tonie, Charpiot, Louise, and Steffgen, Georges
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Computer Science - Human-Computer Interaction ,Computer Science - Robotics - Abstract
In this exploratory study we assessed how attitudes of children with autism spectrum disorder (ASD) towards robots together with children's autism-related social impairments are linked to indicators of children's preference of an interaction with a robot over an interaction with a person. We found that children with ASD have overall positive attitudes towards robots and that they often prefer interacting with a robot than with a person. Several of children's attitudes were linked to children's longer gazes towards a robot compared to a person. Autism-related social impairments were linked to more repetitive and stereotyped behaviors and to a shorter gaze duration in the interaction with the robot compared to the person. These preliminary results contribute to better understand factors that might help determine sub-groups of children with ASD for whom robots could be particularly useful., Comment: Presented at Interaction Design and Children (IDC-CRI2018) Workshop (arXiv:submit/2277826)
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- 2018
4. Vestibular schwannomas with spontaneous shrinkage: about 35 cases
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Trau, Guillaume, Venkatasamy, Aïna, and Charpiot, Anne
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- 2021
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5. Skull Vibration-Induced Nystagmus Test in a Human Model of Horizontal Canal Plugging
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Georges Dumas, Christol Fabre, Anne Charpiot, Lea Fath, Hella Chaney-Vuong, Philippe Perrin, and Sébastien Schmerber
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skull vibration-induced nystagmus ,horizontal canal plugging ,disabling Menière’s disease ,caloric test ,video head impulse test ,Otorhinolaryngology ,RF1-547 - Abstract
Background/Aim: the aim of this study was to assess the skull vibration-induced nystagmus test (SVINT) results and vestibular residual function after horizontal semicircular canal (HSCC) plugging. Methods: In this retrospective chart review performed in a tertiary referral center, 11 patients who underwent unilateral horizontal semicircular canal plugging (uHSCCP) for disabling Menière’s disease (MD) were included. The skull vibration-induced nystagmus (SVIN) slow-phase velocity (SPV) was compared with the results of the caloric test (CaT), video head impulse test (VHIT), and cervical vestibular-evoked myogenic potentials (cVEMP) performed on the same day. Results: Overall, 10 patients had a strong SVIN beating toward the intact side (Horizontal SVIN-SPV: 8.8°/s ± 5.6°/s), 10 had a significant or severe ipsilateral CaT hypofunction, 10 had an ipsilateral horizontal VHIT gain impairment, and 3 had altered cVEMP on the operated side. Five had sensorineural hearing worsening. SVIN-positive results were correlated with CaT and horizontal VHIT (HVHIT) results (p < 0.05) but not with cVEMP. SVIN-SPV was correlated with CaT hypofunction in % (p < 0.05). Comparison of pre- and postoperative CaT % hypofunction showed a significant worsening (p = 0.028). Conclusion: SVINT results in a human model of horizontal canal plugging are well correlated with vestibular tests exploring horizontal canal function, but not with cVEMP. SVINT always showed a strong lesional nystagmus beating away from the lesion side. SVIN acts as a good marker of HSCC function. This surgical technique showed invasiveness regarding horizontal canal vestibular function.
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- 2021
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6. Imaging of facial neuritis using T2-weighted gradient-echo fast imaging employing steady-state acquisition after gadolinium injection
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Hector, Magali, Alnadji, Ahmad, Veillon, Francis, Abu Eid, Maher, Charpiot, Anne, Debry, Christian, and Venkatasamy, Aïna
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- 2021
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7. MRI of endolymphatic hydrops in patients with intralabyrinthine schwannomas: a case-controlled study using non-enhanced T2–weighted images at 3 T
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Venkatasamy, Aïna, Bretz, Pauline, Karol, Anne, Karch-Georges, Aurélie, Charpiot, Anne, and Veillon, Francis
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- 2021
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8. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease
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Patrícia de Carvalho Ribeiro, Fernando Henrique Lojudice, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Stanley de Almeida Araújo, Gloria Elisa Florido Mendes, Mari Cleide Sogayar, Mario Abbud-Filho, and Heloisa Cristina Caldas
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Cell- and tissue-based therapy ,Chronic kidney disease ,Pluripotent stem cells ,Stem cells ,Medicine (General) ,R5-920 ,Biochemistry ,QD415-436 - Abstract
Abstract Background Chronic kidney disease (CKD) is a global public health problem. Cell therapy using pluripotent stem cells represents an attractive therapeutic approach for the treatment of CKD. Methods We transplanted mitomycin C (MMC)-treated human induced pluripotent stem cells (hiPSCs) and renal progenitor cells (RPCs) into a CKD rat model system. The RPC and hiPSC cells were characterized by immunofluorescence and qRT-PCR. Untreated 5/6 nephrectomized rats were compared to CKD animals receiving the same amount of MMC-treated hiPSCs or RPCs. Renal function, histology, and immunohistochemistry were evaluated 45 days post-surgery. Results We successfully generated hiPSCs from peripheral blood and differentiated them into RPCs expressing renal progenitor genes (PAX2, WT1, SIX2, and SALL1) and podocyte-related genes (SYNPO, NPHS1). RPCs also exhibited reduced OCT4 expression, confirming the loss of pluripotency. After cell transplantation into CKD rats, the body weight change was significantly increased in both hiPSC and RPC groups, in comparison with the control group. Creatinine clearance (CCr) was preserved only in the hiPSC group. Similarly, the number of macrophages in the kidneys of the hiPSC group reached a statistically significant reduction, when compared to control rats. Both treatments reduced positive staining for the marker α-smooth muscle actin. Histological features showed decreased tubulointerstitial damage (interstitial fibrosis and tubular atrophy) as well as a reduction in glomerulosclerosis in both iPSC and RPC groups. Conclusions In conclusion, we describe that both MMC-treated hiPSCs and RPCs exert beneficial effects in attenuating CKD progression. Both cell types were equally efficient to reduce histological damage and weight loss caused by CKD. hiPSCs seem to be more efficient than RPCs, possibly due to a paracrine effect triggered by hiPSCs. These results demonstrate that the use of MMC-treated hiPSCs and RPCs improves clinical and histological CKD parameters, avoided tumor formation, and therefore may be a promising cell therapy strategy for CKD. Graphical abstract
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- 2020
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9. Validation of the Perform-FES: a new fear of falling scale for hospitalized geriatric patients
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Ferrer Soler, Cecilia, Cuvelier, Clémence, Hars, Mélany, Herrmann, François R., Charpiot, Adrienne, Ducharne Wieczorkiewicz, Catherine, Bruyère, Olivier, Beaudart, Charlotte, Zekry, Dina, Gold, Gabriel, and Trombetti, Andrea
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- 2021
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10. Do farming conditions influence brominated flame retardant levels in pig and poultry products?
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A. Huneau-Salaün, R. Cariou, E. Royer, C. Jondreville, L. Balaine, C. Souchet, J. Coton, A. Vénisseau, R. Thomas, Y. Rousselière, A. Charpiot, P. Marchand, G. Dervilly-Pinel, M. Marcon, B. Le Bizec, A. Travel, and S. Le Bouquin
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egg ,chicken ,pork ,persistent organic pollutant ,farm ,Animal culture ,SF1-1100 - Abstract
Brominated flame retardants (BFR) are primarily used as flame retardant additives in insulating materials. These lipophilic compounds can bioaccumulate in animal tissues, leading to human exposure via food ingestion. Although their concentration in food is not yet regulated, several of these products are recognised as persistent organic pollutants; they are thought to act as endocrine disruptors. The present study aimed to characterise the occurrence of two families of BFRs (hexabromocyclododecane (HBCDD) and polybrominated diphenyl ethers (PBDE)) in hen eggs and broiler or pig meat in relation to their rearing environments. Epidemiological studies were carried out on 60 hen egg farms (34 without an open-air range, 26 free-range), 57 broiler farms (27 without an open-air range, 30 free-range) and 42 pig farms without an open-air range in France from 2013 to 2015. For each farm, composite samples from either 12 eggs, five broiler pectoral muscles or three pig tenderloins were obtained. Eight PBDE congeners and three HBCDD stereoisomers were quantified in product fat using gas chromatography–high-resolution mass spectrometry, or high-performance liquid chromatography–tandem mass spectrometry, respectively. The frequencies of PBDE detection were 28% for eggs (median concentration 0.278 ng/g fat), 72% for broiler muscle (0.392 ng/g fat) and 49% for pig muscle (0.403 ng/g fat). At least one HBCDD stereoisomer was detected in 17% of eggs (0.526 ng/g fat), 46% of broiler muscle (0.799 ng/g fat) and 36% of pig muscle (0.616 ng/g fat). Results were similar in concentration to those obtained in French surveillance surveys from 2012 to 2016. Nevertheless, the contamination of free-range eggs and broilers was found to be more frequent than that of conventional ones, suggesting that access to an open-air range could be an additional source of exposure to BFRs for animals. However, the concentration of BFRs in all products remained generally very low. No direct relationship could be established between the occurrence of BFRs in eggs and meat and the characteristics of farm buildings (age, building materials). The potential presence of BFRs in insulating materials is not likely to constitute a significant source of animal exposure as long as the animals do not have direct access to these materials.
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- 2020
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11. Importance of signal intensity on T1-weighted spin-echo sequence for the diagnosis of chronic cholesteatomatous otitis
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Moustin, Deborah, Veillon, Francis, Karch-Georges, Aurelie, Riehm, Sophie, Djennaoui, Idir, Charpiot, Anne, and Venkatasamy, Aina
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- 2020
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12. CT and MRI for the diagnosis of perilymphatic fistula: a study of 17 surgically confirmed patients
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Venkatasamy, Aïna, Al Ohraini, Ziad, Karol, Anne, Karch-Georges, Aurélie, Riehm, Sophie, Rohmer, Dominique, Charpiot, Anne, and Veillon, Francis
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- 2020
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13. Superior vestibular neuritis: improved detection using FLAIR sequence with delayed enhancement (1 h)
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Venkatasamy, Aina, Huynh, Tri Thai, Wohlhuter, Nathan, Vuong, Hella, Rohmer, Dominique, Charpiot, Anne, Meyer, Nicolas, and Veillon, Francis
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- 2019
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14. Magnetic resonance imaging after cochlear implants
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Naif Bawazeer, Hella Vuong, Sophie Riehm, Francis Veillon, and Anne Charpiot
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Otorhinolaryngology ,RF1-547 - Abstract
Introduction: Most cochlear implants are currently compatible with magnetic resonance imaging (MRI) up to 3 T. Nevertheless, this does not completely eliminate the risk of serious accidents. Implant displacements and other adverse events with compatible implants have been reported in the literature. Case reports: Among the six patients who had MRI after receiving implants at our center, we report three cases with adverse events related to the examination. The first case was complicated by magnet displacement with partial demagnetization. The second case showed total demagnetization, which necessitated removal and reimplantation of the implant. The third case involved severe pain sensation which disrupted the MRI scan. The smallest artifact was found with 3D MRI angiography, and largest artifact was found with diffusion and T2 FLASH. Discussion: Moving the patient into the MRI apparatus must be supervised by an otorhinolaryngology specialist or an experienced radiologist. It is important to consider the magnetic field directions, so that angle between the implant magnetic fields and the MRI B0 always remains less than or equal to 90°. In addition, we recommend the use of an “arrow drawing” to facilitate the orientation of the magnetic field directions. Furthermore, to prevent magnet displacement, we recommend systematic use of a protective splint in addition to bandaging. Keywords: MRI, Cochlear implant, Risk
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- 2019
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15. Influence of diet and manure management on ammonia and greenhouse gas emissions from dairy barns
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N. Edouard, A. Charpiot, P. Robin, E. Lorinquer, J.-B. Dollé, and P. Faverdin
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dairy cow ,nitrogen excretion ,liquid manure ,deep litter ,gas emission ,Animal culture ,SF1-1100 - Abstract
Dairy systems are a source of pollutant emissions, such as greenhouse gases (GHG) and NH3 that are associated with impacts on the environment. Gas emissions in barns are related mainly to diet intake and chemical composition, N excretion and manure management. A reduction in dietary N is known to be an effective way to reduce N excretion and the resulting NH3 emissions. However, most studies consider manure in liquid form with frequent removal from the barn. In deep litter systems, several processes can occur during the accumulation of solid manure that result in variable gas emissions. The objective of this experiment was to investigate the influence of the interaction between dietary CP (low or high) and manure management (liquid or solid) on gas emissions (NH3, N2O, CH4) at the barn level. Dietary treatments provided either low (LowN; 12% CP) or high (HighN; 18% CP) degradable protein to modify the amount of total ammonia nitrogen (TAN) excreted. The cows were housed for two 8-week periods in two mechanically ventilated rooms equipped to manage manure either in liquid (LM; slurry) or solid form (SM; deep litter). In the LM treatment, N balance was measured for 4 days. As expected, animals fed the LowN diet ingested 35% less N and excreted 65% less N in their urine, with no reduction in faecal N excretion and N secretion in milk. On the LowN diet, excretion of urea-N and NH3-N emissions were reduced regardless of the manure management. On the HighN diet, urinary urea-N excretion was three times as high, while NH3-N emissions were 3.0 and 4.5 times as high in LM and SM, respectively. Manure management strongly influenced CH4-C emissions, which were 30% higher in SM than in LM, due to the accumulation of litter. Moreover, gas emissions from solid manure increased over the accumulation period, except for NH3 on the LowN diet. Finally, our results suggest that methods used for national inventories would become more accurate by considering the variability in TAN excretion, which is the primary factor that influences NH3 emissions.
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- 2019
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16. Thrombotic microangiopathy after kidney transplantation: Analysis of the Brazilian Atypical Hemolytic Uremic Syndrome cohort
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Hong Si Nga, Lilian Monteiro Pereira Palma, Miguel Ernandes Neto, Ida Maria Maximina Fernandes-Charpiot, Valter Duro Garcia, Roger Kist, Silvana Maria Carvalho Miranda, Pedro Augusto Macedo de Souza, Gerson Marques Pereira, and Luis Gustavo Modelli de Andrade
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Medicine ,Science - Abstract
Background Atypical Hemolytic Uremic Syndrome (aHUS) is an ultra-rare disease that potentially leads to kidney graft failure due to ongoing Thrombotic Microangiopathy (TMA). The aim was evaluating the frequency of TMA after kidney transplantation in patients with aHUS in a Brazilian cohort stratified by the use of the specific complement-inhibitor eculizumab. Methods This was a multicenter retrospective cohort study including kidney transplant patients diagnosed with aHUS. We collected data from 118 transplant centers in Brazil concerning aHUS transplanted patients between 01/01/2007 and 12/31/2019. Patients were stratified into three groups: no use of eculizumab (No Eculizumab Group), use of eculizumab for treatment of after transplantation TMA (Therapeutic Group), and use of eculizumab for prophylaxis of aHUS recurrence (Prophylactic Group). Results Thirty-eight patients with aHUS who received kidney transplantation were enrolled in the study. Patients’ mean age was 30 years (24–40), and the majority of participants was women (63% of cases). In the No Eculizumab Group (n = 11), there was a 91% graft loss due to the TMA. The hazard ratio of TMA graft loss was 0.07 [0.01–0.55], p = 0.012 in the eculizumab Prophylactic Group and 0.04 [0.00–0.28], p = 0.002 in the eculizumab Therapeutic Group. Conclusion The TMA graft loss in the absence of a specific complement-inhibitor was higher among the Brazilian cohort of kidney transplant patients. This finding reinforces the need of eculizumab use for treatment of aHUS kidney transplant patients. Cost optimization analysis and the early access to C5 inhibitors are suggested, especially in low-medium income countries.
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- 2021
17. MRI of endolymphatic hydrops in patients with vestibular schwannomas: a case-controlled study using non-enhanced T2-weighted images at 3 Teslas
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Karch-Georges, Aurélie, Veillon, Francis, Vuong, Hella, Rohmer, Dominique, Karol, Anne, Charpiot, Anne, Meyer, Nicolas, and Venkatasamy, Aina
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- 2019
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18. Extension patterns of vestibular schwannomas towards the middle ear: three new cases and review of the literature
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Venkatasamy, Aina, Nicolas-Ong, Caroline, Vuong, Hella, Charpiot, Anne, and Veillon, Francis
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- 2019
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19. Malformations of the lateral semicircular canal correlated with data from the audiogram
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Venkatasamy, Aina, Foll, Daphné Le, Eyermann, Carine, Vuong, Hella, Rohmer, Dominique, Charpiot, Anne, and Veillon, Francis
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- 2019
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20. Therapeutic potential of human induced pluripotent stem cells and renal progenitor cells in experimental chronic kidney disease
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Ribeiro, Patrícia de Carvalho, Lojudice, Fernando Henrique, Fernandes-Charpiot, Ida Maria Maximina, Baptista, Maria Alice Sperto Ferreira, de Almeida Araújo, Stanley, Mendes, Gloria Elisa Florido, Sogayar, Mari Cleide, Abbud-Filho, Mario, and Caldas, Heloisa Cristina
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- 2020
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21. Differentiation of vestibular schwannomas from meningiomas of the internal auditory canal using perilymphatic signal evaluation on T2-weighted gradient-echo fast imaging employing steady state acquisition at 3T
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Venkatasamy, A., Le Foll, D., Karol, A., Lhermitte, B., Charpiot, A., Debry, C., Proust, F., Meyer, N., and Veillon, F.
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- 2017
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22. Clinical and laboratorial profiles of dengue virus infection in kidney transplant recipients: Report of a single center.
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Ida Maria Maximina Fernandes-Charpiot, Cassia Fernanda Estofolete, Heloisa Cristina Caldas, Gabriela Rodrigues de Souza, Rita de Cássia Martins Alves da Silva, Maria Alice Sperto Ferreira Baptista, Mauricio Lacerda Nogueira, and Mario Abbud-Filho
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Medicine ,Science - Abstract
Dengue infection (DI) is the most important arboviral infection in the world. The majority of immunocompetent patients will have asymptomatic or mild infections, but the degree of dengue severity in kidney transplant recipients (KTx) is unknown. In this study, we report the clinical profile and outcomes of 39 dengue cases in KTx. From a total of 1,186 KTx outpatients in follow-up we reviewed clinical and laboratory records of 60 (5%) patients admitted with suspected DI initially screened by NS-1, IgM, and when possible, multiplex nested PCR. The prevalence of DI in KTx was 3% (39/1,118), with symptoms leading to hospital admission being fever, myalgia, malaise, and headache. Laboratory tests showed leucopenia, thrombocytopenia, and liver enzyme elevation. DI was confirmed by positivity of NS-1 (33%), IgM (69%), and/or RT-PCR (59%). Twenty-three patients (59%) had dengue with warning signs, and 15% had severe dengue, 2 of them with a fatal course. Acute graft dysfunction occurred in 59% (mean nadir serum creatinine: 2.9 ± 2.6mg/dL), 4 of them requiring dialysis. CMV coinfection diagnosed in 19% of the cases and patients was associated with worse clinical presentation. Our results suggest that KTx with DI presented initial physical and laboratorial profile similar to the general population. However, DI in KTx seems to have a higher risk for graft dysfunction, severe dengue, and death. Because CMV coinfection aggravates the DI clinical presentation and recovery, it must be evaluated in all cases.
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- 2019
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23. Cross-species identification of genomic drivers of squamous cell carcinoma development across preneoplastic intermediates
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Vida Chitsazzadeh, Cristian Coarfa, Jennifer A. Drummond, Tri Nguyen, Aaron Joseph, Suneel Chilukuri, Elizabeth Charpiot, Charles H. Adelmann, Grace Ching, Tran N. Nguyen, Courtney Nicholas, Valencia D. Thomas, Michael Migden, Deborah MacFarlane, Erika Thompson, Jianjun Shen, Yoko Takata, Kayla McNiece, Maxim A. Polansky, Hussein A. Abbas, Kimal Rajapakshe, Adam Gower, Avrum Spira, Kyle R. Covington, Weimin Xiao, Preethi Gunaratne, Curtis Pickering, Mitchell Frederick, Jeffrey N. Myers, Li Shen, Hui Yao, Xiaoping Su, Ronald P. Rapini, David A. Wheeler, Ernest T. Hawk, Elsa R. Flores, and Kenneth Y. Tsai
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Science - Abstract
Cutaneous squamous cell of the skin is a common neoplasm that frequently arises from precancerous actinic keratoses. Here, the authors carry out genomic analysis on matched sets of human lesions and compare with those in ultraviolet treated mice and identify conserved drivers of tumour development.
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- 2016
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24. Head-to-head comparison between 18F-FDOPA PET/CT and MR/CT angiography in clinically recurrent head and neck paragangliomas
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Heimburger, Céline, Veillon, Francis, Taïeb, David, Goichot, Bernard, Riehm, Sophie, Petit-Thomas, Julie, Averous, Gerlinde, Cavalcanti, Marcela, Hubelé, Fabrice, Chabrier, Gerard, Namer, Izzie Jacques, Charpiot, Anne, and Imperiale, Alessio
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- 2017
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25. Preimplantation Kidney Biopsies of Extended Criteria Donors Have a Heavier Inflammatory Burden Than Kidneys From Standard Criteria Donors
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Camila M. Mazeti-Felicio, PhD, Heloisa C. Caldas, PhD, Ida M.M. Fernandes-Charpiot, MD, PhD, Camila Z. Dezotti, Maria A.S.F. Baptista, MD, PhD, and Mario Abbud-Filho, MD, PhD
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Surgery ,RD1-811 - Abstract
Background. Donors after brain death develop a systemic proinflammatory state that may predispose the kidneys to injury after transplantation. Because it is not known whether this inflammatory environment similarly affects the kidneys from expanded criteria donor (ECD) and standard criteria donors (SCD), we sought to evaluate differences in the gene expression of inflammatory cytokines in preimplantation biopsies (PIBx) from ECD and SCD kidneys. Methods. Cytokines gene expression was measured in 80 PIBx (SCD, 52; ECD, 28) and associated with donor variables. Results. Normal histology and chronic histological lesions were not different between both types of kidneys. ECD kidneys showed significant increase in the transcripts of MCP-1, RANTES, TGF-β1, and IL-10 when compared with SCD. Kidneys presenting normal histology had similar inflammatory profile except by a higher expression of RANTES observed in ECD (P = 0.04). Interstitial fibrosis and tubular atrophy (interstitial fibrosis and tubular atrophy ≥ 1) were associated with higher expression of TGF-β1, RANTES, and IL-10 in ECD compared with SCD kidneys. Cold ischemia time of 24 hours or longer was significantly associated with upregulation of FOXP3, MCP-1, RANTES, and IL10, whereas longer duration of donor hospitalization significantly increased gene expression of all markers. High FOXP3 expression was also associated with lower level of serum creatinine at 1 year. Donor age was not associated with any of the transcripts studied. Conclusions. PIBx of ECD exhibit a higher gene expression of inflammatory cytokines when compared with SCD kidneys. This molecular profile may be a specific ECD kidney response to brain death and may help to predict the posttransplant outcomes of ECD recipients.
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- 2017
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26. Induced Pluripotent Stem Cells Reduce Progression of Experimental Chronic Kidney Disease but Develop Wilms’ Tumors
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Heloisa Cristina Caldas, Fernando Henrique Lojudice, Cinthia Dias, Ida Maria Maximina Fernandes-Charpiot, Maria Alice Sperto Ferreira Baptista, Rosa Sayoko Kawasaki-Oyama, Mari Cleide Sogayar, Christina Maeda Takiya, and Mario Abbud-Filho
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Internal medicine ,RC31-1245 - Abstract
The therapeutic effect of induced pluripotent stem cells (iPSs) on the progression of chronic kidney disease (CKD) has not yet been demonstrated. In this study, we sought to assess whether treatment with iPSs retards progression of CKD when compared with bone marrow mesenchymal stem cells (BMSCs). Untreated 5/6 nephrectomized rats were compared with CKD animals receiving BMSCs or iPSs. Renal function, histology, immunohistochemistry, and gene expression were studied. Implanted iPSs were tracked by the SRY gene expression analysis. Both treatments minimized elevation in serum creatinine, significantly improved clearance, and slowed down progression of disease. The proteinuria was reduced only in the iPS group. Both treatments reduced glomerulosclerosis, iPSs decreased macrophage infiltration, and TGF-β was reduced in kidneys from the BMSC group. Both types of treatments increased VEGF gene expression, TGF-β was upregulated only in the iPS group, and IL-10 had low expression in both groups. The SRY gene was found in 5/8 rats treated with iPSs. These 5 animals presented tumors with histology and cells highly staining positive for PCNA and Wilms’ tumor protein antibody characteristics of Wilms’ tumor. These results suggest that iPSs may be efficient to retard progression of CKD but carry the risk of Wilms’ tumor development.
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- 2017
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27. Les collectivités : une source de déchets organiques et une voie de valorisation de la chaleur pour la méthanisation agricole ?
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LEVASSEUR, Pascal ; CHARPIOT, Alicia ; LE GUEN, Gaëlle
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METHANISATION ,AGRICULTURE ,BIOGAZ ,CO-DIGESTION ,DECHETS ORGANIQUES ,COLLECTIVITES ,VALORISATION ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
Un des intérêts de la méthanisation est qu'elle peut participer à un recyclage extrêmement rentable des déchets. De fait, les collectivités ont un rôle à jouer dans ce processus car elles génèrent de nombreux types de déchets. Mais dans quelles mesures leur participation est-elle actuellement intéressante ? La volonté d'aboutir à une plus grande efficacité induit des changements de comportement de la part des foyers et des institutions. Quels sont-ils?
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- 2013
28. Premature birth is associated with not fully differentiated contractile smooth muscle cells in human umbilical artery
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Roffino, S., Lamy, E., Foucault-Bertaud, A., Risso, F., Reboul, R., Tellier, E., Chareyre, C., Dignat-George, F., Simeoni, U., and Charpiot, P.
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- 2012
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29. Levels of circulating endothelial progenitor cells are related to uremic toxins and vascular injury in hemodialysis patients
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JOURDE‐CHICHE, N, DOU, L, SABATIER, F, CALAF, R, CERINI, C., ROBERT, S, CAMOIN‐JAU, L, CHARPIOT, P, ARGILES, A, DIGNAT‐GEORGE, F, and BRUNET, P
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- 2009
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30. Prevalence of cardiovascular risk factors in superior vestibular neuritis: A cross-sectional study following STROBE guidelines.
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Pâris, P., Charpiot, A., Veillon, F., Severac, F., and Djennaoui, I.
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CARDIOVASCULAR diseases risk factors ,VESTIBULAR nerve ,NEURITIS ,FRENCH people ,HEARING disorders ,SEMICIRCULAR canals - Abstract
To compare the prevalence of cardiovascular risk factors (CVRF) in patients with superior vestibular neuritis (SVN) versus the general French population, and to examine the possibility of vascular etiology in acute superior vestibular deficit. A single-center retrospective study compared the prevalence of hypercholesterolemia, hypertension, diabetes, smoking, cardiovascular disease and atrial fibrillation between patients with SVN and the French general population. Inclusion criteria comprised: rotatory vertigo lasting several days, without hearing impairment or neurological signs, with anterior and lateral semicircular canal involvement on video-Head-Impulse-Test (vHIT). A senior radiologist analyzed superior vestibular nerve and inner ear structure enhancement on cerebellopontine MRI. One hundred and eighteen cases of SVN were included from May 2016 to February 2020. Statistical analyses concerned 106 cases. The SVN population had significantly less hypercholesterolemia (RR = 0.40) than the general French population. There was no significant difference concerning other CVRFs. Superior vestibular nerve enhancement was observed on 84% of MRIs. Prevalence of CVRF was not higher in patients with SVN than in the general population. The present study highlighted involvement of the superior vestibular nerve more than of the anterior vestibular artery in SVN. [ABSTRACT FROM AUTHOR]
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- 2022
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31. Homocysteine modulates the proteolytic potential of human arterial smooth muscle cells through a reactive oxygen species dependant mechanism
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Ke, Xue Dan, Foucault-Bertaud, Alexandrine, Genovesio, Cecile, Dignat-George, Francoise, Lamy, Edouard, and Charpiot, Philippe
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- 2010
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32. Les collectivités : une source de déchets organiques et une voie de valorisation de la chaleur pour la méthanisation agricole ?
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P. LEVASSEUR, A. CHARPIOT, and G. LE GUEN
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méthanisation ,déchet organique ,valorisation énergétique du déchet ,analyse de flière ,collectivité territoriale ,Environmental technology. Sanitary engineering ,TD1-1066 ,Environmental sciences ,GE1-350 - Abstract
Tout projet de méthanisation agricole a besoin de déchets très fermentescibles et doit pouvoir valoriser au mieux la chaleur issue de la cogénération pour améliorer sa rentabilité. Cet article montre que les collectivités produisent de nombreux déchets organiques : déchets verts, déchets de la restauration collective, fraction organique des ordures ménagères, boues de station d'épuration urbaines, algues vertes... Malgré cette diversité, assez peu de déchets peuvent être utilisés pour la méthanisation agricole car ils doivent à la fois cumuler les avantages d'un potentiel méthanogène élevé, être triés, si possible source de redevance et les gisements ne doivent pas être trop atomisés, ni trop loin, autant de facteurs difficiles à réunir. Cependant des exemples, témoignages d'opportunités, et des marges de progrès existent. Parallèlement au traitement d'une partie de leurs déchets, les collectivités disposent d'un large parc de bâtiments avec des besoins thermiques parfois très élevés pour leur chauffage et eau chaude sanitaire. La valorisation de l'énergie thermique produite par la méthanisation agricole peut toutefois se heurter à des contraintes de distance et à la densification de l'habitat engendrant un coût élevé du réseau de chaleur. Les liens pouvant unir collectivités et agriculture au travers de la méthanisation peuvent cependant constituer des opportunités. Ces dernières doivent s'envisager au cas par cas selon le territoire concerné.
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- 2013
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33. Impact environnemental des systèmes bovins laitiers français
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J.B. DOLLÉ, L. DELABY, S. PLANTUREUX, S. MOREAU, B. AMIAUD, A. CHARPIOT, V. MANNEVILLE, A. CHANSEAUME, H. CHAMBAUT, and A. LE GALL
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Animal culture ,SF1-1100 ,Aquaculture. Fisheries. Angling ,SH1-691 - Abstract
La préservation de l’environnement est actuellement au coeur des débats dans l’évolution des systèmes de production laitière. Le défi des années futures réside dans la fourniture de produits laitiers tout en assurant les performances sociales, économiques et environnementales, c'est-à-dire la durabilité des systèmes de production. En matière d’environnement, une attention toute particulière doit être portée à la limitation des risques de pollution vers l'eau, vers l'air et à la préservation de la biodiversité. Les systèmes d'élevage herbivore français, largement basés sur la prairie, présentent pour cela un réel atout du fait du lien au sol et de la part importante de fourrages dans l’alimentation du troupeau. Peu liée aux caractéristiques structurelles, l’efficience environnementale passe notamment par l’optimisation du recyclage du carbone et de l’azote au sein des systèmes de production. Alors que la variabilité des impacts environnementaux entre exploitations de systèmes différents (plaine vs montagne) est faible, une forte variabilité est observée entre exploitations d’un même système. Ceci démontre que les pratiques efficientes sur le plan technique, relatives à la gestion optimale des effectifs animaux, à une sobriété énergétique, etc. ont des incidences environnementales et économiques favorables. C’est pourquoi, une partie significative des exploitations d'élevage d'herbivores françaises devrait pouvoir être considérée à hautes performances environnementales et économiques sans remise en cause lourde du système de production. Par ailleurs l’élevage laitier, qui intervient pour réduire les pertes vers l’air et vers l’eau, est garant du stockage de carbone et de la biodiversité. Au-delà de la production de lait et de viande, l’élevage laitier joue dès lors un rôle majeur dans la préservation de l’environnement.
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- 2013
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34. Rehabilitación vestibular
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Charpiot, A., Fath, L., Perruisseau-Carrier, J., Griess, S., and Schaffner, G.
- Abstract
La rehabilitación vestibular se utiliza mucho en el tratamiento del vértigo crónico. Consta de dos aspectos específicos muy distintos: por una parte, las maniobras posicionales en el vértigo posicional paroxístico benigno, que se describirán como tratamiento físico, aunque no se trata en sentido estricto de una rehabilitación: se ha demostrado la eficacia del procedimiento terapéutico en estas situaciones, aunque precisan una gran vigilancia durante la exploración clínica debido a los diagnósticos diferenciales, sobre todo centrales; por otra parte, las técnicas de rehabilitación vestibular dirigidas a favorecer nuevas estrategias de equilibración tras un déficit vestibular. Los datos fisiológicos respecto a la plasticidad cerebral, las estrategias de equilibración, el sistema vestibular, la compensación y sus factores desfavorables, así como la evaluación de los resultados de la rehabilitación vestibular han permitido su desarrollo en unas indicaciones más amplias (cinetosis, presbivestibulia, intolerancia al movimiento, dependencia visual, etc.). El acceso a nuevas herramientas lúdicas, como la realidad virtual, facilita la adhesión del paciente a los ejercicios dirigidos a favorecer una información sensorial (al suprimir o falsear las otras) o a mantener una habituación (disminución de la reactividad a un estímulo preciso). Su utilización requiere dominar las consecuencias fisiológicas de las situaciones creadas: el establecimiento de un programa de rehabilitación vestibular debe seguir a un diagnóstico médico tan preciso como sea posible, que determina los objetivos deseados, adaptados a cada paciente (refuerzo propioceptivo, vestibular, sustitución, habituación, etc.). Por tanto, la rehabilitación vestibular implica una buena colaboración entre el otorrinolaringólogo (ORL) y el kinesiterapeuta, con una situación de partida y de los objetivos precisados por el ORL, y un programa de rehabilitación establecido por el kinesiterapeuta que indica a su vez las modificaciones obtenidas, lo que lleva a sopesar una posible indicación de renovación de la rehabilitación (después del programa inicial de 2-3 meses) si aún es posible lograr progresos.
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- 2022
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35. Royal academy of medicine in Ireland international conference on homocysteine metabolism from basic science to clinical medicine: Proceedings of meeting held at Dromoland Castle, Co. Clare on July 2nd–6th, 1995
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Björkegren, K., Bergmark, C., de Faire, U., Mansoor, M. Azam, Svardal, A., Bostom, A. G., Roubenoff, R., Dellaripa, P., Nadeau, M. R., Sutherland, P., Wilson, P. W. F., Jacques, P. F., Selhub, J., Rosenberg, I. H., Bostom, A. G., Brosnan, J. T., Hall, B., Nadeau, M. R., Selhub, J., Bostom, A. G., Shemin, D., Lapane, K. L., Sutherland, P., Nadeau, M. R., Wilson, P. W. F., Selhub, J., Bostom, A. G., Shemin, D., Nadeau, M. R., Selhub, J., Bostom, A. G., Selhub, J., Jacques, P. F., Nadeau, M. R., Williams, R. R., Ellison, R. C., Cuskelly, G. J., McNulty, H., Strain, J. J., McPartlin, J. M., Scott, J. M., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Coudé, M., Aral, B., Zabot, M. T., Aupetit, J., Kamoun, P., Chadefaux-Vekemans, B., Calaf, R., Ghiringelli, O., Barlatier, A., Charpiot, P., Rolland, P. H., Garçon, D., Charpiot, P., Augier, T., Chareyre, C., Rolland, P. H., Garçon, D., Chango, A., Hodez, F., Tronel, H., Nuel, G., Michel, F., Frémont, S., Méjean, L., Nicolas, J. P., Candito, M., Chambon, P., Gibelin, P., Amsellem, J., Baudouy, M., Morand, P., Candito, M., Chambon, P., Pringuey, D., Aubin-Brunet, V., Beaulieu, F., Darcourt, G., Bedoucha, P., Alchaar, H., Chatel, M., Candito, M., de Valk, H. W., van der Griend, R., Eeden, M. K. G. van, de Groot, E., Duran, M., Smeitink, J. A. M., de Klerk, J. B. C., Wittebol-Post, D., Rolland, M. -O., Haas, F. J. L. M., Meuwissen, O. J. A. Th., Banga, J. D., Poll-The, B. T., de Vries, J. I. P., Dekker, G. A., van Geijn, H. P., Huigens, P. C., Jakobs, C., von Blomberg, B. M. E., Deulofeu, R., Giralt, M., Aibar, C., Bauchet, C., Ballesta, A. M., Varela, G., Vila, N., Chamorro, A., Casals, F. J., Cremades, J. Diaz, Daly, L., Meleady, R., Graham, I., den Heijer, M., Brouwer, I. A., Gerrits, W. B. J., Bos, G. M. J., Blom, H. J., den Heijer, M., Bos, G. M. J., Koster, T., Vandenbroucke, J. P., Blom, H. J., Briët, E., Rosendaal, F. R., Fischer, G., Behrend, C., Bartholmes, P., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Fermo, I., Paroni, R., Vigano, S., D’Angelo, A., Franken, D. G., Boers, G. H. J., Blom, H. J., Hamel, B. C. J., Franken, D. G., Boers, G. H. J., Blom, H. J., Ruijs, J. H. J., Franken, D. G., Blom, H. J., Boers, G. H. J., Tangerman, A., Guttormsen, A. B., Ueland, P. M., Refsum, H., Svarstad, E., Gao, W., Goldman, E., Jakubowski, H., Sebastio, G., Sperandeo, M. P., de Franchis, R., Andria, G., Garrow, T. A., Hladovec, J., Sommerova, Z., Písariková, A., Halsted, C. H., Villanueva, J., Chandler, C. J., Stabler, S. P., Allen, R. H., Muskhelishvili, L., James, S. J., Poirer, L., Jacobsen, D. W., Savon, S. R., DiCorleto, P. E., Jourdheuil-Rahmani, D., Rolland, P. H., Garçon, D., Joosten, E., Riezler, R., Allen, R., Joosten, E., Riezler, R., Allen, R., Marquardt, T., Ullrich, K., Harms, E., Koch, H. G., Koch, H. G., Evers, S., Grotemeyer, K. H., Vogelpohl, L., von Eckardstein, A., Ullrich, K., Deufel, T., Kraus, J., Harms, E., Kozich, V., Janosik, M., Sokolová, J., Bukovská, G., Kraus, J. P., Kluitmans, L. A. J., van den Heuvel, L. P., Stevens, E., Trubels, J. M. F., Blom, H. J., Boers, G. H. J., van Oost, B. A., Kraus, J. P., Kittner, S., Macko, R., Hebel, J. R., Rohr, J., Malinow, M. R., Upson, B., Buchholz, D., Earley, C., Johnson, C., Price, T. R., Rosario, J., Sloan, M., Stern, B., Wityk, R., Wozniak, M., Sherwin, R., Stolley, P., Kluijtmans, L., Heuvel, L. van den, Stevens, E., Trijbels, F., Blom, H., Boers, G., van Oost, B., den Heijer, M., Rozen, R., Löhrer, F., Angst, C., Fowler, B., Zaugg, M., Brunner, F., Haefeli, W. E., Nedrebø, B., Ericsson, U. -B., Ueland, P. M., Refsum, H., Lien, E. A., London, J., Paly, E., Paul, V., Paris, D., Kamoun, P., Chassé, J. F., Møller, J., Rasmussen, K., Meleady, R., Graham, I., Daly, L., Verhoef, P., Meleady, R., Graham, I., Daly, L., McMartin, K. E., Phifer, T. J., Alexander, J. S., Middlebrooks, M., Childress, L. E., Nicolas, J. P., Tronel, H., Chango, A., Fremont, S., Felden, F., Guerci, B., Creton, C., Drouin, P., Oakley, G. P., Elias, P. R. P., Hann, A. C., Curtis, C. G., Rose, F. A., Tudball, N., Parrot-Roulaud, F., Cochet, C., Catargi, B., Leprat, F., Latapie, J. -L., Perna, A. F., De Santo, N. G., Ingrosso, D., Galletti, P., Zappia, V., Parrot-Roulaud, F., Sassoust, G., Boissieras, P., Blom, H. J., Majors, A. K., Ehrhart, L. A., Pezacka, E. H., Perry, I. J., Morris, R. W., Ebrahim, S. B., Shaper, A. G., Refsum, H., Ueland, P. M., Pietrzik, K., Dierkes, J., Kroesen, M., Bung, P., Rasmussen, K., Moller, J., Rasmussen, K., Remacha, A., Garcia-Die, F., Cadafalch, J., Barceló, H. J., Parellada, H., Regland, B., Gottfries, C. -G., Andersson, M., Bagby, J., Dyrehag, L. -E., Abrahamsson, L., Ronge, E., Kjellman, B., Frosst, P., Christensen, B., Goyette, P., Rosenblatt, D. S., Genest, J., Rozen, R., Riedel, B., Ueland, P. M., Svardal, A. M., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X. W., Xie, L., Dudman, N., Silberberg, J., Crooks, R., Fryer, J., Ray, C., Guo, X., Xie, L., Dudman, N., Smith, B., Kohlman-Trigoboff, D., Simsir, S., Stabler, S. P., Allen, R. H., Strydom, A. J. C., Schlüssel, E., Preibisch, G., Elstner, E. F. E., Pütter, S., Spuijbroek, M. D. E. H., Goddijn-Wessel, T. A. W., Wouters, M. G. A. J., Molen, E. F. v. d., Blom, H. J., Boers, G. H. J., Steegers-Theunissen, R. P. M., Trijbels, J. M. F., Thomas, C. M. G., Eskes, T. K. A. B., Tsai, M. Y., Hanson, N., Key, N., Schwichtenberg, K., Garg, U., Todesco, L., Fowler, B., Pollaert, N., Haefeli, W. E., Thorand, B., Hages, M., Pietrzik, K., Bung, P., Holzgreve, W., Vila, N., Chamorro, A., Deulofeu, R., Aibar, C., Giralt, M., Ballesta, A. M., van der Mooren, M. J., Wouters, M. G. A. J., Schellekens, L. A., Eskes, T. K. A. B., Rolland, R., Blom, H. J., Put, N. v. d., Trijbels, F., Heuvel, L. v. d., Blom, H., Eskes, T., Steegers-Theunissen, R., Mariman, E., Heyer, M. d., Rozen, R., Daher, R., Van Lente, F., Vilkovsky, A. B., Maev, I. V., Richter, E. L., Kirnus, M. D., Varela-Moreiras, G., Alonso-Aperte, E., Rubio, M., Gassó, M., Deulofeu, R., Alvarez, L., Caballeria, J., Rodés, J., Mato, J. M., van Aerts, L. A. G. J. M., Peereboom-Stegeman, J. H. J. Copius, Noordhoek, J., Eskes, T. K. A. B., Molen, E. F. v. d., Spuijbroek, M. D. E. H., Eskes, T. K. A. B., Heuvel, L. P. v. d., Monnens, L. A. H., Blom, H. J., van Guidener, C., Janssen, M. J. F. M., Surachno, J., Stehouwer, C. D. A., van den Berg, M., Bierdrager, E., Rauwerda, J. A., Wilcken, B., Hammond, J., Wouters, M. G. A. J., Hamilton, C. J. C. M., Blom, H. J., Boers, G. H. J., Thomas, C. M. G., Borm, G. F., Eskes, T. K. A. B., Wang, H., Tsai, J. -C., Perrella, M. A., Yoshizumi, M., Sibinga, N. E. S., Haber, E., Chang, T. H. -T., Schlegel, R., Lee, M. -E., Woodside, J., McMaster, D., Yarnell, J., Young, I., Mercer, C., Byrne, K., Evans, A., Gey, F., Gao, X. M., Dougan, G., Wordsworth, P., McMichael, A., Young, P. B., Kennedy, D. G., Molloy, A. M., Scott, J. M., Ward, P., Naughten, E., Cahalane, S., Murphy, D., Mayne, P., Chauveau, P., Chadefaux-Vekemans, B., Coudé, M., Aupetit, J., Kamoun, P., Jungers, P., van Asselt, D. Z. B., Blom, H. J., de Wild, G. M., van Staveren, W. A., Hoefnagels, W. H. L., Naruszewicz, M., Staniewicz, A., Dziewanowski, K., Evrovski, J., Cole, D. E. C., Callaghan, Michael, Lindgren, A., Brattström, L., Hultberg, B., Verhoef, P., Hennekens, C. H., Allen, R. H., Stabler, S. P., Willett, W. C., Stampfer, M. J., Frantzen, F., Sundrehagen, E., Verhoef, P., Kok, F. J., Stampfer, M. J., Willett, W. C., Gaziano, J. M., Hennekens, C. H., Allen, R. H., Stabler, S. P., Reynolds, R. D., Hsu, R. -J., Shane, B., Robinson, K., Kottke-Marchant, K., Green, R., Gupta, A., Jacobsen, D., Robinson, K., Mayer, E., Gupta, A., Miller, D., Marchant, K., Green, R., Jacobsen, D., Greene, R., Chong, Y. -Y., Jacobsen, D., Robinson, K., Gupta, M., Sheppard, C. A., Matthews, R. G., Goyette, P., Frosst, P., Rozen, R., Verhoef, P., Kok, F. J., Kruyssen, H. A. C. M., Witteman, J. C. M., Ueland, P. M., Boushey, C., Beresford, S., Omenn, G., Motulsky, A. G., Nygard, O., Vollset, S. E., Kvale, G., Stensvold, I., Ueland, P. M., Refsum, H., Fiskerstrand, T., Ueland, P. M., Refsum, H., Bugge, K. H., Oshaug, A., Bjønnes, C. H., Refsum, H., Wu, J. T., Wu, L. L., and Wilson, L. W.
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- 1995
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36. Development of tracheal prostheses made of porous titanium: a study on sheep
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Schultz, P., Vautier, D., Charpiot, A., Lavalle, P., and Debry, C.
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- 2007
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37. The Mycophenolate-based Immunosuppressive Regimen Is Associated With Increased Mortality in Kidney Transplant Patients With COVID-19
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Requião-Moura, Lúcio R., Modelli de Andrade, Luís Gustavo, de Sandes-Freitas, Tainá Veras, Cristelli, Marina Pontello, Viana, Laila Almeida, Nakamura, Mônica Rika, Garcia, Valter Duro, Manfro, Roberto Ceratti, Simão, Denise Rodrigues, Almeida, Ricardo Augusto Monteiro de Barros, Ferreira, Gustavo Fernandes, Costa, Kellen Micheline Alves Henrique, de Lima, Paula Roberta, Pacheco-Silva, Alvaro, Charpiot, Ida Maria Maximina Fernandes, Deboni, Luciane Mônica, Ferreira, Teresa Cristina Alves, Mazzali, Marilda, Calazans, Carlos Alberto Chalabi, Oriá, Reinaldo Barreto, Tedesco-Silva, Hélio, Medina-Pestana, José, de Oliveira, Claudia Maria Costa, Esmeraldo, Ronaldo de Matos, Baptista, Maria Alice Sperto Ferreira, de Sousa, Marcos Vinícius, de Mello Santana, Viviane Brandão Bandeira, Romão, Elen Almeida, Zanocco, Juliana Aparecida, Bignelli, Alexandre Tortoza, de Carvalho, Deise De Boni Monteiro, Noronha, Irene de Lourdes, Saldanha, Anita Leme da Rocha, Romao, Joao Egídio, Arimatea, Gustavo Guilherme Queiroz, Lasmar, Marcus Faria, Rioja, Suzimar da Silveira, Kroth, Leonardo Viliano, Madeira, Rafael Lage, Miorin, Luiz Antônio, Malafronte, Patrícia, Pozzi, Carolina Maria, Pinheiro, Helady Sanders, Maciel, Rafael Fabio, Andrade, Larissa Guedes da Fonte, Filho, Lauro Monteiro Vasconcellos, Contieri, Fabiana Loss de Carvalho, Neves, Carolina Lara, Pereira, André Barreto, Silva, Amanda Maíra Damasceno, Palma, Lilian Monteiro Pereira, de Souza, Pedro Augusto Macedo, Machado, David José Barros, and Saber, Luciana Tanajura Santamaria
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- 2022
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38. The defensive role of lysozyme in human gingiva in inflammatory periodontal disease
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Younes, R., Yousfi, M., Ghorra, C., Khalife, S., Igondjo-Tchen-Changotade, S., Willig, C., Senni, K., Charpiot, P., Naaman, N., and Godeau, G.
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- 2009
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39. Rapid determination of desmosine and isodesmosine in tissue hydrolysates by isocratic high performance liquid chromatography and precolumn derivatization
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Charpiot, P., Calaf, R., Chareyre, C., Rolland, P. H., and Garçon, D.
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- 1994
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40. Vascular Wall Remodeling in Patients with Supravalvular Aortic Stenosis and Williams Beuren Syndrome
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Dridi, S. M., Foucault Bertaud, A., Igondjo Tchen, S., Senni, K., Ejeil, A. L., Pellat, B., Lyonnet, S., Bonnet, D., Charpiot, P., and Godeau, G.
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- 2005
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41. The Medi-RIVAGE study (Mediterranean Diet, Cardiovascular Risks and Gene Polymorphisms): rationale, recruitment, design, dietary intervention and baseline characteristics of participants
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Vincent, S, Gerber, M, Bernard, M C, Defoort, C, Loundou, A, Portugal, H, Planells, R, Juhan-Vague, I, Charpiot, P, Grolier, P, Amiot-Carlin, M J, Vague, P, and Lairon, D
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- 2004
42. Development and validation of a simple web‐based tool for early prediction of COVID‐19‐associated death in kidney transplant recipients
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Modelli de Andrade, Luis Gustavo, Sandes‐Freitas, Tainá Veras, Requião‐Moura, Lúcio R., Viana, Laila Almeida, Cristelli, Marina Pontello, Garcia, Valter Duro, Alcântara, Aline Lima Cunha, Esmeraldo, Ronaldo de Matos, Abbud Filho, Mario, Pacheco‐Silva, Alvaro, Lima Carneiro, Erika Cristina Ribeiro, Manfro, Roberto Ceratti, Costa, Kellen Micheline Alves Henrique, Simão, Denise Rodrigues, Sousa, Marcos Vinicius, Santana, Viviane Brandão Bandeira de Mello, Noronha, Irene L., Romão, Elen Almeida, Zanocco, Juliana Aparecida, Arimatea, Gustavo Guilherme Queiroz, De Boni Monteiro de Carvalho, Deise, Tedesco‐Silva, Helio, Medina‐Pestana, José, Keitel, Elizete, Costa de Oliveira, Claudia Maria, Neri, Beatriz de Oliveira, Fernandes Charpiot, Ida Maria Maximina, Ferreira, Teresa Cristina Alves, Vicari, Alessandra Rosa, Pereira, Tomás, Coelho, Maria Eduarda Heinzen de Almeida, Mazzali, Marilda, Ferreira, Gustavo Fernandes, Campos, Juliana Bastos, Rocha, Nicole Gomes Campos, Saldanha, Anita Leme da Rocha, Martinez, Tania Leme da Rocha, Romão, João Egídio, Teixeira Araújo, Maria Regina, Braga, Sibele Lessa, Deboni, Luciane Mônica, Krüger, Franco Silveira da Mota, Neto, Miguel Moysés, Claudino, Auro Buffani, Cláudio de Oliveira, Lívia, Matuck, Tereza Azevedo, Bignelli, Alexandre Tortoza, Hokazono, Silvia Regina, Suassuna, José Hermógenes Rocco, Rioja, Suzimar da Silveira, Madeira, Rafael Lage, Vilaça, Sandra Simone, Calazans, Carlos Alberto Chalabi, Calazans, Daniel Costa Chalabi, Malafronte, Patrícia, Miorin, Antonio, Aguiar, Filipe Carrilho, Andrade, Larissa Guedes da Fonte, Carvalho, Fabiana Loss, Martins, Karoline Sesiuk, Pinheiro, Hélady Sanders, Sertório, Emiliana Spadarotto, Pereira, André Barreto, Machado, David José Barros, Pozzi, Carolina Maria, Kroth, Leonardo Viliano, Filho, Lauro Monteiro Vasconcellos, Maciel, Rafael Fabio, Silva, Amanda Maíra Damasceno, Baptista, Ana Paula Maia, de Souza, Pedro Augusto Macedo, Lasmar, Marcus Faria, Saber, Luciana Tanajura Santamaria, Palma, Lilian Monteiro Pereira, and de Barros Almeida, Ricardo Augusto Monteiro
- Abstract
This analysis, using data from the Brazilian kidney transplant (KT) COVID‐19 study, seeks to develop a prediction score to assist in COVID‐19 risk stratification in KT recipients. In this study, 1379 patients (35 sites) were enrolled, and a machine learning approach was used to fit models in a derivation cohort. A reduced Elastic Net model was selected, and the accuracy to predict the 28‐day fatality after the COVID‐19 diagnosis, assessed by the area under the ROC curve (AUC‐ROC), was confirmed in a validation cohort. The better calibration values were used to build the applicable ImAgeS score. The 28‐day fatality rate was 17% (n= 235), which was associated with increasing age, hypertension and cardiovascular disease, higher body mass index, dyspnea, and use of mycophenolate acid or azathioprine. Higher kidney graft function, longer time of symptoms until COVID‐19 diagnosis, presence of anosmia or coryza, and use of mTOR inhibitor were associated with reduced risk of death. The coefficients of the best model were used to build the predictive score, which achieved an AUC‐ROC of 0.767 (95% CI 0.698–0.834) in the validation cohort. In conclusion, the easily applicable predictive model could assist health care practitioners in identifying non‐hospitalized kidney transplant patients that may require more intensive monitoring. Trial registration:ClinicalTrials.gov NCT04494776. Machine learning applied to national registry data leads to the development and validatation of a web‐based model to predict COVID‐19‐associated death among kidney transplant recipients, identifying those who may may benefit from intensive monitoring.
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- 2022
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43. Study of the Comorbidity Between Cases of Acute Peripheral Vestibulopathies and COVID-19
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Charpiot, Anne, Hautefort, Charlotte, Jourdaine, Clément, Lavieille, Jean-Pierre, Levy, Daniel, Poillon, Guillaume, Tighilet, Brahim, Weckel, Alexandra, and Chabbert, Christian
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- 2021
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44. French Society of ENT (SFORL) guidelines. Management of acute Bell's palsy.
- Author
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Fieux, M., Franco-Vidal, V., Devic, P., Bricaire, F., Charpiot, A., Darrouzet, V., Denoix, L., Gatignol, P., Guevara, N., Montava, M., Roch, J.A., Tankéré, F., Tronche, S., Veillon, F., Vergez, S., Vincent, C., Lamas, G., and Tringali, S.
- Subjects
FACIAL nerve ,MAGNETIC resonance imaging ,GUIDELINES - Abstract
AQFThe authors present the guidelines of the French Society of ENT and Head and Neck Surgery (SFORL) regarding the management of Bell's palsy in adults. After a literature review by a multidisciplinary workgroup, guidelines were drawn up based on retrieved articles and group-members' experience, then read over by an independent group to edit the final version. Guidelines were graded A, B, C or "expert opinion" according to decreasing level of evidence. Thorough ENT and neurological clinical examination is recommended in all patients presenting with peripheral facial palsy to confirm diagnosis of Bell's palsy. MRI with gadolinium enhancement should explore the entire course of the facial nerve, if possible within the first month. ENMG should be performed to assess prognosis for recovery. In confirmed Bell's palsy, corticosteroid therapy should be implemented as early as possible (ideally within 72 h) at a dose of 1 mg/kg/day for 7–10 days. Antiviral therapy should be associated to steroids in patients with severe and early-onset disease and in Ramsay-Hunt syndrome. Isolated antiviral therapy is not recommended. To date, there is no evidence that surgical facial nerve decompression provides benefit. [ABSTRACT FROM AUTHOR]
- Published
- 2020
- Full Text
- View/download PDF
45. Mindfulness Improves Otolaryngology Residents’ Performance in a Simulated Bad-News Consultation: A Pilot Study
- Author
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Mengin, Amaury C., Kayser, Claire, Tuzin, Nicolas, Perruisseau-Carrier, Joffrey, Charpiot, Anne, Berna, Fabrice, Lilot, Marc, and Vidailhet, Pierre
- Abstract
Delivering bad news is a stressful moment for both patient and clinician. As poor bad-news consultation quality may lead to misunderstandings, lack of treatment adherence, acute or even post-traumatic stress in patients, training interventions to improve communication skills and stress-management are necessary. Mindfulness is a recognised stress-management strategy that has shown its efficacy in reducing stress in both health professionals and students. We then supposed that a short mindfulness meditation session performed just before a simulated breaking bad-news consultation to patients with laryngeal cancer may help ear, nose and throat (ENT) residents to master their stress and improve their management of this consultation. This study aims at showing how a short mindfulness meditation performed before a simulated bad-news consultation may improve performance in its realisation by ENT residents.
- Published
- 2021
- Full Text
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46. Recommandations de la SFORL. Prise en charge de la paralysie faciale idiopathique à la phase aiguë chez l’adulte
- Author
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Fieux, M., Franco-Vidal, V., Devic, P., Bricaire, F., Charpiot, A., Darrouzet, V., Denoix, L., Gatignol, P., Guevara, N., Montava, M., Roch, J.A., Tankéré, F., Tronche, S., Veillon, F., Vergez, S., Vincent, C., Lamas, G., and Tringali, S.
- Abstract
Les auteurs exposent les recommandations de la Société française d’oto-rhino-laryngologie et de chirurgie de la face et du cou (SFORL) concernant la prise en charge de la paralysie faciale périphérique à la phase aiguë. Un groupe de travail multidisciplinaire a été chargé d’effectuer une revue de la littérature scientifique sur cette thématique. À partir de ces textes et de l’expérience de chacun, des recommandations ont été rédigées, puis relues par un groupe de lecture indépendant. Les recommandations proposées ont été classées en grade A, B, C ou accord professionnel selon un niveau de preuve scientifique décroissant. Un examen clinique ORL et neurologique complet est recommandé devant tout patient se présentant pour une paralysie faciale périphérique pour confirmer le diagnostic de paralysie faciale idiopathique. Il est recommandé de réaliser une IRM avec injection étudiant tout le trajet du nerf facial si possible dans le premier mois. Il est recommandé de réaliser un ENMG pour évaluer le pronostic de récupération. Il est recommandé devant toute paralysie faciale idiopathique de débuter un traitement corticoïde le plus précocement possible (idéalement dans les 72 heures) à la dose de 1mg/kg/J pendant 7 à 10 jours. Les thérapies antivirales sont à associer avec un traitement corticoïde en cas de paralysie sévère ou précoce et en cas de PFP zostérienne. Il n’est pas recommandé d’utiliser un antiviral seul. À ce jour, le bénéfice d’une décompression chirurgicale du nerf facial n’est pas démontré.
- Published
- 2020
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- View/download PDF
47. Activation of HMGB1–TLR4 Pathway and Inflammasome Contribute to Enhanced Inflammatory Response in Extended Criteria and Kidneys With KDPI ≥85%
- Author
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Florim, Greiciane M.S., Caldas, Heloisa C., Gonçalves, Naiane N., Bueno, Giovanna O.B.E., Baptista, Maria A.S.F., Fernandes-Charpiot, Ida M.M., and Abbud-Filho, Mario
- Published
- 2020
- Full Text
- View/download PDF
48. Guidelines (short version) of the French Society of Otorhinolaryngology (SFORL) on pediatric cochlear implant indications.
- Author
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Simon, F., Roman, S., Truy, E., Barone, P., Belmin, J., Blanchet, C., Borel, S., Charpiot, A., Coez, A., Deguine, O., Farinetti, A., Godey, B., Lazard, D., Marx, M., Mosnier, I., Nguyen, Y., Teissier, N., Virole, B., Lescanne, E., and Loundon, N.
- Subjects
SCIENTIFIC literature ,COCHLEAR implants ,OTOLARYNGOLOGY ,HEARING aids ,PERCEPTION testing ,INNER ear ,AUDITORY neuropathy - Abstract
The authors present the guidelines of the French Society of Otorhinolaryngology – Head and Neck Surgery (Société française d'oto-rhino-laryngologie et de chirurgie de la face et du cou – SFORL) on the indications for cochlear implantation in children. A multidisciplinary work group was entrusted with a review of the scientific literature on the above topic. Guidelines were drawn up, based on the articles retrieved and the group members' individual experience. They were then read over by an editorial group independent of the work group. The guidelines were graded as A, B, C or expert opinion, by decreasing level of evidence. The SFORL recommends that children with bilateral severe/profound hearing loss be offered bilateral cochlear implantation, with surgery before 12 months of age. In sequential bilateral cochlear implantation in children with severe/profound hearing loss, it is recommended to reduce the interval between the two implants, preferably to less than 18 months. The SFORL recommends encouraging children with unilateral cochlear implants to wear contralateral hearing aids when residual hearing is present, and recommends assessing perception with hearing-in-noise tests. It is recommended that the surgical technique should try to preserve the residual functional structures of the inner ear as much as possible. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
49. Cochleovestibular manifestations in Fabry disease: Importance of screening and systematic ENT evaluation.
- Author
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Eyermann, C., Raguin, T., Rohmer, D., Noel, E., and Charpiot, A.
- Subjects
ANGIOKERATOMA corporis diffusum ,LYSOSOMAL storage diseases ,HEARING disorders ,CEREBROVASCULAR disease ,SEMICIRCULAR canals ,AUDIOMETRY ,VESTIBULAR function tests - Abstract
Fabry disease (FD) is an X-linked inherited lysosomal storage disease. It is a multisystem pathology that can include ENT disorders. The aim of the present study was to investigate the cochleovestibular manifestations of FD, in order to show the importance of screening and systematic ENT evaluation. A single-center retrospective study included 14 male and 23 female FD patients. Hearing impairment was defined as hearing loss greater than the 90
th percentile for at least one frequency. Vestibular impairment was defined by lateral semicircular canal dysfunction. Age, ongoing enzyme replacement therapy (ERT) and organic (renal, cardiac and cerebrovascular) complications were used as severity markers. Hearing impairment was found in 62.6% of cases, mostly at high frequencies, and was associated with age, ERT, and cardiac and cerebrovascular disorder. It affected 46.7% of asymptomatic adult patients. Vestibular impairment was found in 56% of cases, associated with age; it affected two-thirds of ERT patients, more than 60% of patients with organic complications, and 50% of asymptomatic adult patients. More than half of patients had ENT involvement. All FD patients should undergo early ENT screening for diagnostic, prognostic and therapeutic purposes. Systematic complete ENT follow-up with auditory and vestibular evaluation should be performed regularly, even for heterozygous women. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
50. French Society of ENT (SFORL) guidelines. Indications for cochlear implantation in adults.
- Author
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Hermann, R., Lescanne, E., Loundon, N., Barone, P., Belmin, J., Blanchet, C., Borel, S., Charpiot, A., Coez, A., Deguine, O., Farinetti, A., Godey, B., Lazard, D., Marx, M., Mosnier, I., Nguyen, Y., Teissier, N., Virole, M.B., Roman, S., and Truy, E.
- Subjects
COCHLEAR implants ,HEAD & neck cancer ,LITERATURE reviews ,FOUR-course radio range (Aeronautics) ,OTOLOGY ,HEARING disorders - Abstract
The authors present the guidelines of the French Society of ENT and Head and Neck Surgery (SFORL) regarding indications for cochlear implantation in adults. After a literature review by a multidisciplinary workgroup, guidelines were drawn up based on retrieved articles and group-members' experience, then read over by an independent reading group to edit the final version. Guidelines were graded A, B, C or "expert opinion" according to decreasing level of evidence. There is no upper age limit to cochlear implantation in the absence of proven dementia and if autonomy is at least partial. Bilateral implantation may be proposed if unilateral implantation fails to provide sufficiently good spatial localization, speech perception in noise and quality of life, and should be preceded by binaural hearing assessment. Rehabilitation by acoustic and electrical stimulation may be proposed when low-frequency hearing persists. Quality of life should be assessed before and after implantation. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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