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ObjectivesThe aim of this study was to evaluate the hypothesis that the adrenergic response of the intraventricular pressure difference (IVPD) is reduced in patients with preserved ejection fraction (EF) and diastolic dysfunction (DD).BackgroundIn early diastole, there is a progressive IVPD extending from the left atrium (LA) to the left ventricular (LV) apex. In response to adrenergic stimulation, as occurs during exercise, the IVPD increases allowing rapid filling without an abnormal increase in LA pressure. Patients with heart failure with a reduced EF have impaired adrenergic augmentation of the IVPD.MethodsWe studied 166 consecutive patients undergoing dobutamine stress echocardiography who had no inducible ischemia and an EF ≥50%, of which 21 had normal diastolic function, 14 had impaired relaxation (grade 1), 80 had pseudonormal filling (grade 2), and 51 had restrictive filling (grade 3). Color M-mode Doppler (CMMD) images of mitral inflow were obtained at rest and during low (10 μg/kg/min) and peak (20 to 40 μg/kg/min) doses of dobutamine. The total IVPD from the LA to LV apex, LA to mid-LV, and mid-LV to the LV apex were calculated using the CMMD data to integrate the Euler equation.ResultsTotal IVPD was not different between groups at rest. With dobutamine, the total IVPD increased by 2.20 ± 1.95 mm Hg in normal subjects and by only 0.73 ± 1.33 mm Hg, 1.84 ± 1.63 mm Hg, and 1.08 ± 1.57 mm Hg in patients with grades 1, 2, and 3 DD, respectively. This difference was due to a failure in augmentation of IVPD from the mid-LV to the LV apex, indicating reduced apical ventricular suction with DD, whereas the IVPD from the LA to the mid-LV responded similarly to dobutamine in normal subjects and those with DD.ConclusionsIn patients with preserved EF, DD is associated with a reduced adrenergic augmentation of the IVPD from the mid-LV to the LV apex, reflecting less apical suction.

The entrainment process in two-phase buoyant jets differs significantly from their singlephase counterparts, and is not well understood. Entrainment models developed for singlephase flow are often used in two-phase jetting simulations, albeit with limited success. In this work, Particle Image Velocimetry (PIV) and shadowgraph flow visualization experiments have been conducted on submerged round gas jets of varying speeds and nozzle diameters with the goal of improving our understanding of the entrainment process in a two-phase (gas-liquid) jet. The total entrainment estimated using the PIV measurements is higher than the respective values suggested by a common empirical model developed for singlephase buoyant jets. A two-phase theoretical entrainment model used for comparison shows an overestimation of entrainment, but predicts the increase in the rate of entrainment with axial distance from the jet nozzle seen in the PIV results. This thesis also presents advances in PIV processing methodology that were developed concurrently with the entrainment research. The novel Spectral Phase Correlation (SPC) allows for particle displacement to be determined directly from phase information in the Fourier domain. Some of the potential benefits of the SPC explored here include (1) avoidance of errors introduced by spatial peak-finding routines; (2) use of a modal analysis that can be used to provide information such as correlation quality; and (3) introduction of a means of incorporating information from multiple image windows. At low image noise levels, the method performs as well as an advanced CC-based method. However, difficulties unwrapping the aliased phase information cause the SPC's performance to degrade at high noise levels. Master of Science

Presented in this paper are experiments to test the hypothesis that drag reduction is possible over hydrophobic surfaces in the Wenzel state during laminar and turbulent flows. Quantification of surface drag reduction in rectangular channel flow over walls with specific hydrophobic or hydrophilic properties was obtained with pressure drop measurements along the channel for a range of Reynolds numbers between 350 and 5900. Several commercially available materials and coatings were chosen in order to span a range of contact angles between 30° and 135°. The results are within the bounds of the theoretical values calculated with the Colebrook equation, and do not show any reduction in wall shear stress as a function of material properties or surface chemistry. The differences between this experiment and others measuring pressure drop over hydrophobic surfaces is the macro-scale conditions and the hydrophobic surfaces being fully wetted. These experiments are further proof of the importance of a liquid-vapor interface for increasing the shear free area to produce drag reduction. Master of Science