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Background: Truncating variants in desmoplakin ( DSP tv) are an important cause of arrhythmogenic cardiomyopathy; however the genetic architecture and genotype-specific risk factors are incompletely understood. We evaluated phenotype, risk factors for ventricular arrhythmias, and underlying genetics of DSP tv cardiomyopathy. Methods: Individuals with DSP tv and any cardiac phenotype, and their gene-positive family members were included from multiple international centers. Clinical data and family history information were collected. Event-free survival from ventricular arrhythmia was assessed. Variant location was compared between cases and controls, and literature review of reported DSP tv performed. Results: There were 98 probands and 72 family members (mean age at diagnosis 43±8 years, 59% women) with a DSP tv, of which 146 were considered clinically affected. Ventricular arrhythmia (sudden cardiac arrest, sustained ventricular tachycardia, appropriate implantable cardioverter defibrillator therapy) occurred in 56 (33%) individuals. DSP tv location and proband status were independent risk factors for ventricular arrhythmia. Further, gene region was important with variants in cases (cohort n=98; Clinvar n=167) more likely to occur in the regions resulting in nonsense mediated decay of both major DSP isoforms, compared with n=124 genome aggregation database control variants (148 [83.6%] versus 29 [16.4%]; P Conclusions: In the largest series of individuals with DSP tv, we demonstrate that variant location is a novel risk factor for ventricular arrhythmia, can inform variant interpretation, and provide critical insights to allow for precision-based clinical management.

Truncating variants in desmoplakin (Individuals withThere were 98 probands and 72 family members (mean age at diagnosis 43±8 years, 59% women) with aIn the largest series of individuals with

Preimplantation genetic diagnosis (PGD) ensures a disease-causing variant is not passed to the next generation, including for inherited heart diseases. PGD is known to cause significant emotional burden, but little is known about how parents experience PGD to select against inherited heart disease. We aim to understand how people with inherited heart disease, and their partners, experience and make decisions about PGD. Participants were recruited from a specialised inherited heart disease clinic. Qualitative semi-structured interviews were conducted with adult participants who had considered PGD. A semi-structured interview schedule explored overall experiences and reasons for undergoing PGD. Broad topics included experience of disease, reproductive history, psychosocial and financial considerations. Interviews were recorded, transcribed verbatim and thematically analysed using a framework method. Twenty participants were included (15 with inherited cardiomyopathy, 3 with inherited arrhythmia syndrome and 2 partners). In contemplating PGD, participants considered 3 main issues: past experience of disease e.g. sudden cardiac death, sport restrictions and clinical heterogeneity; intergenerational responsibilities; and practical considerations such as finances and maternal age. Among those who chose to undergo PGD (n = 7/18), past experience of a significant cardiac event, such as family history of sudden cardiac death, was important in the decision process. The decision to undergo PGD for inherited heart disease is complex and influenced by individual values and experience of disease. We highlight key areas where further discussion may assist in PGD decision processes.

IntroductionSudden cardiac death (SCD) is a devastating event for the family and the community, especially when it occurs in a young person (MethodsIn-depth interviews were conducted with eighteen family members of young people (ResultsIn total, 18 interviews were conducted from 17 families. The following themes were identified: (1) Experiences with postmortem genetic testing including managing expectations and psychological impact, (2) appreciation of care such as access to genetic counselling and relief following cardiac evaluation of relatives, and (3) need for support including unmet psychological support needs and better coordination of care immediately after the death.ConclusionAlthough participants appreciated the opportunity for cardiogenetic evaluation, they also experienced a lack of coordination of cardiogenetic and psychological care. Our findings stress the importance of access to expert multidisciplinary teams, including psychological care, to adequately support these families after a SCD in a young family member.

This symposium assesses the trajectory of European Union (EU) environmental policy and integration in light of the rising pressure for policy dismantling and disintegration. This introductory article discusses the literature and the mixed evidence of EU environmental policy dismantling. Building on the three symposium articles, we investigate the role of the European Commission in this process, evaluating its role as a general ‘motor of integration’ and more specifically as an environmental policy entrepreneur. We find that the current political context does push the Commission to reconsider its entrepreneurial role and adopt the role of a ‘normalised bureaucracy’. Nonetheless, organisational features, such as new organisational hierarchies and presidential leadership, and ideas that frame policy initiatives explain continued policy evolution and resistance to outright dismantling. Scholars also should pay close attention to implementing measures and patterns of enforcement to detect the more subtle policy shifts.

Britain's approach to environmental policy fundamentally changed because of its membership in the European Union.

BackgroundTruncating variants in desmoplakin (DSPtv) are an important cause of arrhythmogenic cardiomyopathy (ACM), however the genetic architecture and genotype-specific risk factors are incompletely understood. We evaluated phenotype, risk factors for ventricular arrhythmias, and underlying genetics ofDSPtv cardiomyopathy.MethodsIndividuals withDSPtv and any cardiac phenotype, and their gene-positive family members were included from multiple international centers. Clinical data and family history information were collected. Event-free survival from ventricular arrhythmia was assessed. Variant location was compared between cases and controls, and literature review of reportedDSPtv performed.ResultsThere were 98 probands and 72 family members (mean age at diagnosis 43 ± 18 years, 59% female) with aDSPtv, of which 146 were considered clinically affected. Ventricular arrhythmia (sudden cardiac arrest, sustained ventricular tachycardia, appropriate implantable cardioverter defibrillator therapy) occurred in 56 (33%) individuals.DSPtv location and proband status were independent risk factors for ventricular arrhythmia, while prior risk factors showed no association. Further, gene region was important with variants in cases (cohort n=98, Clinvar n=168) more likely to occur in the regions resulting in nonsense mediated decay of both majorDSPisoforms, compared to n=124 gnomAD control variants (148 [83.6%] versus 29 [16.4%], pConclusionsIn the largest series of individuals withDSPtv, we demonstrate variant location is a novel risk factor for ventricular arrhythmia, can inform variant interpretation, and provide critical insights to allow precision-based clinical management.

The decision of the UK to leave the EU has far‐reaching, and often shared, implications for agriculture and fisheries. To ensure the future sustainability of the UK’s agricultural and fisheries systems, we argue that it is essential to grasp the opportunity that Brexit is providing to develop integrated policies that improve the management and protection of the natural environments, upon which these industries rely. This article advances a stakeholder informed vision of the future design of UK agriculture and fisheries policies. We assess how currently emerging UK policy will need to be adapted in order to implement this vision. Our starting point is that Brexit provides the opportunity to redesign current unsustainable practices and can, in principle, deliver a sustainable future for agriculture and fisheries. Underpinning policies with an ecosystem approach, explicit inclusion of public goods provision and social welfare equity were found to be key provisions for environmental, agricultural and fishery sustainability. Recognition of the needs of, and innovative practices in, the devolved UK nations is also required as the new policy and regulatory landscape is established. Achieving the proposed vision will necessitate drawing on best practice and creating more coherent and integrated food, environment and rural and coastal economic policies. Our findings demonstrate that “bottom‐up” and co‐production approaches will be key to the development of more environmentally sustainable agriculture and fisheries policies to underpin prosperous livelihoods. However, delivering this vision will involve overcoming significant challenges. The current uncertainty over the nature and timing of the UK’s Brexit agreement hinders forward planning and investment while diverting attention away from further in‐depth consideration of environmental sustainability. In the face of this uncertainty, much of the UK’s new policy on the environment, agriculture and fisheries is therefore ambitious in vision but light on detail. Full commitment to co‐production of policy with devolved nations and stakeholders also appears to be lacking, but will be essential for effective policy development and implementation. A free Plain Language Summary can be found within the Supporting Information of this article.

ObjectivesUnlike adults, malignant melanoma in children and adolescents is rare. In adult melanoma, significant progress in understanding tumor biology and new treatments, including targeted therapies and immunotherapy have markedly improved overall survival. In sharp contrast, there is a paucity of data on the biology and clinical behavior of pediatric melanoma. We report a national case series of all pediatric and adolescent malignant melanoma presenting to ANZCHOG Childhood Cancer Centers in Australia and New Zealand.MethodsA retrospective, descriptive, multi-center study was undertaken to identify patients less than 18 years of age treated for cutaneous malignant melanoma over a twenty-year period (1994 to 2014). Data on clinical characteristics, histopathology, and extent of disease, treatment and follow-up are described.ResultsA total of 37 cases of malignant melanoma were identified from all of the Australasian tertiary Childhood Cancer Centers. The median age was 10 years (range 1 month – 17 years). Clinically, the most common type of lesion was pigmented, occurring in sixteen (57%) patients, whilst amelanotic was seen in 7 patients (25%). In 11 (27.9%) the Breslow thickness was greater than 4mm. A total of 11 (29.7%) patients relapsed and 90% of these died of disease. Five-year event free survival (EFS) and overall survival were 63.2 (95% CI: 40.6 – 79.1) and 67.7% (95% CI: 45.1 – 82.6) respectively.ConclusionOur data confirms that melanoma is a rare presentation of cancer to tertiary Australasian Childhood Cancer Centers with only 37 cases identified over two decades. Notably, melanoma managed in Childhood Cancer Centers is frequently at an advanced stage, with a high percentage of patients relapsing and the majority of these patients who relapsed died of disease. This study confirms previous clinical and prognostic information to support the early multidisciplinary management in Childhood Cancer Centers, in conjunction with expert adult melanoma centers, of this rare and challenging patient group.

This chapter examines policies and the patterns of policy making in the European Union (EU). First it surveys the range of EU policy responsibilities, and identifies ways in which policy dynamics differ between them, the most striking difference in policy making relating to the Common Foreign and Security Policy (CFSP) and its defence affiliate, the Common Security and Defence Policy (CSDP). It then explores the different stages in the EU policy cycle: the passage of policy issues from agenda-setting stage through policy formulation and decision making to the implementation stage and feedback loops. In a final section, it identifies some important policy areas that are worth being aware of but where space precludes chapter-length treatment.

This chapter examines two important developments in the history of the European Union (EU): the signing of the Maastricht and Amsterdam Treaties. In June 1989, the European Council agreed to European Commission President Jacques Delors’s three-stage plan for monetary union by 1999, despite British opposition. In 1991, intergovernmental conferences (IGCs) were held on both monetary union and political union. The proposals of these IGCs were incorporated into the Treaty on European Union (TEU), agreed at Maastricht in December 1991. The TEU marked a major step on the road to European integration. It committed most of the member states to adopting a single currency and introduced the concept of European citizenship, among others. This chapter considers the events leading up to the signing of the TEU, from the Maastricht negotiations to the issue of enlargement, the 1996 IGC, and the Treaty of Amsterdam.

This chapter brings together what have usually been presented as separate ‘consequences’ of European integration. First, it examines Europeanization: the process through which domestic politics and polities are changed by their engagement with the EU. Second, it considers three literatures that capture contemporary challenges to integration: a new domestic politicization of the EU; the rise of Euroscepticism; and a questioning of whether the EU is experiencing disintegration. Third, a continuing challenge for the EU has been its democratic legitimacy, and rising Europeanization is linked to questions of legitimacy of the EU amongst the public. This chapter deals with these interrelated phenomena: the EU’s impact on its member states and the issues arising.

Politics in the European Union examines the theory, history, institutions, and policies of the European Union (EU). The EU is a unique, complex, and ever-changing political entity, which continues to shape both international politics and the politics of its individual member states. The text provides a clear analysis of the organization and presents a well-rounded introduction to the subject. Complete and detailed in its coverage, including coverage of the eurozone, refugee crises, and Brexit, along with the latest theoretical developments, the text provides a comprehensive assessment of EU politics and policy at the start of the 2020s. The book is divided into four parts: Part One provides the student with a strong foundation in political theory and analysis; Part Two charts European integration from 1995 through to the 2010s; Part Three addresses the distinctive character of the EU institutions; and in Part Four, key EU policy areas, both internal and external, are covered.

This chapter examines the revival of European integration from the mid-1970s to the late 1980s. It first considers leadership changes in the European Commission before turning to the European Council and the European Monetary System (EMS), the Commission’s southern enlargements, and the British budget rebate. It then discusses leadership changes in the Commission from 1981 to 1982, the Single European Act (SEA), and the European Council meeting at Fontainebleau in June 1984. It also looks at the initiatives of various Commission presidents such as Roy Jenkins, Gaston Thorn, and Jacques Delors. Finally, it describes the implementation of the SEA, widely seen as the big breakthrough in the revival of European integration.

This chapter examines a number of theories of European integration. It first considers the intellectual predecessors of the first attempts to theorize European integration, focusing in particular on the functionalism of David Mitrany, the federalism of Altiero Spinelli, and the ‘federal-functionalism’ of Jean Monnet. It discusses neofunctionalism and intergovernmentalism, along with liberal intergovernmentalism, and the fact that while theorizing European integration has moved on significantly from these early approaches, much of what followed was either framed by this debate or developed as a rejection of it. The chapter then introduces postfunctionalism as a more recent rival theory that helps explain the greater political controversy surrounding integration in the period following the Maastricht period, and particularly during the 2010s.

This chapter examines the European Union’s (EU’s) original decision to create a single market and the moves to complete the internal market—what became known as the single market programme—in the 1980s. The economic ideal of a common or single European market lies at the core of the EU. The decision to institute a drive to achieve a single internal market by the end of 1992 played a key role in the revival of European integration. The chapter first traces the development of internal market policy before discussing the record of implementation beyond 1992. It then considers recent policy developments in relation to the single market in the context of the Barroso (2005–14) and Juncker (2014–19) Commission presidencies. It also reviews the academic literature on the single market, focusing on the main explanations for its development and some key ideological or normative perspectives on its consequences, including political economy critiques.

This chapter examines the European Union’s (EU’s) policy activity in the area of freedom, security, and justice (AFSJ). Introduced mainly by the Maastricht Treaty of 1992, the AFSJ was initially given the name Justice and Home Affairs (JHA). The AFSJ was greatly enhanced by the Treaty of Lisbon and has matured over time, despite the controversy surrounding the way in which it strikes at national sovereignty. A key characteristic of JHA, later AFSJ, has been the use of differentiated integration. The chapter first provides a historical background on the AFSJ, focusing on the policy dynamics and JHA structures under the Treaty on European Union (TEU) as well as the reforms of the Treaty of Amsterdam. It then considers the AFSJ’s institutional character and policy content, before examining the refugee crisis. It concludes with an assessment of key explanations and debates relating to the AFSJ.

This chapter examines the various attempts to create the economic and monetary union (EMU), which first became an official objective of the European Community (EC) in 1969 but was achieved only thirty years later. The chapter first provides a historical background on efforts to create the EMU, including long-standing debates between France and West Germany on its design, before discussing the launch of the single currency, the euro, and its subsequent progress up to and including the eurozone crisis in the late 2000s. On the eurozone crisis, it considers both the short-term efforts at crisis management and the long-term reforms that were implemented in an attempt to prevent further crises. Finally, it considers some of the explanations for and critiques of EMU, including critiques of the responses to the eurozone crisis that have been offered by various academic commentators.

This chapter examines the European Union’s (EU’s) policy on agriculture. The importance that the EU has given to the agricultural sector can be attributed in large part to food shortages at the end of the Second World War. Governments agreed that it was important to ensure adequate supplies of food at reasonable prices. To achieve this, it was necessary to provide an adequate income to farmers, while taking measures to increase their productivity. The Common Agricultural Policy (CAP) was the first redistributive policy of the European Community, and for many years the only one. The chapter reviews the history of the CAP and explains the main drivers for reform, which include costs, EU enlargement, environmental pressures, and the growing powers of the European Parliament. Another key driver for change has stemmed from external pressure from world trade talks. The chapter concludes by reviewing the prospects for the next iteration of the CAP from 2021–27.

This chapter examines the pattern of European Union (EU) institutions and the formal rules that govern them. It first considers the Treaties that form the founding ‘constitutional’ documents of the EU, from the Treaty of Paris to the Treaty on Stability, Co-ordination and Governance in the economic and monetary union (EMU), before turning to the main institutions involved in the processes of decision making, namely: the European Commission, the Council of the European Union, and the European Parliament, plus two consultative committees, the Economic and Social Committee and the Committee of the Regions. The chapter proceeds by analysing the Union method of decision making, focusing on the budgetary and legislative procedures, as well as the process on the Common Foreign and Security Policy. It also discusses the implementation of EU decisions once they have been made, and concludes with some reflections on the post-Lisbon institutional architecture of the EU, including differentiated integration.

This chapter examines the evolution of the European Union’s (EU) environmental policy. The environment is a relatively new policy area of the EU. It was not officially created until 1973 and acquired a sound legal basis in the Treaties only with the passage of the Single European Act (SEA) in 1987. When the EU was established, environmental issues were low on the political agenda. However, they have become increasingly important at both national and European levels, and there is now a comprehensive environmental policy at the EU level and the EU has developed a reputation as an environmental leader in international environmental diplomacy, especially on climate change. The chapter first explains the main drivers for the development of the EU’s environmental policy, before discussing recent developments, and some of the major issues of current concern. It concludes by evaluating the theoretical leverage of the key integration theories for explaining and critiquing this policy sector.

This chapter examines the new strategy adopted in March 2000 by a special European Council in Lisbon to make the European Union (EU) more competitive, culminating in the signing of the Treaty of Lisbon. The Amsterdam Treaty had scarcely entered into force before further Treaty reform emerged on the agenda. Throughout the year 2000, a new intergovernmental conference met to address outstanding institutional issues that had not been settled at Amsterdam. It concluded in December 2000 with the longest European Council in history, which led to the Treaty of Nice. The chapter first considers the Nice Treaty, before discussing the Lisbon Strategy, the European Security and Defence Policy, the Constitutional Treaty, the issue of enlargement, the European Parliament (EP), and the nomination of a new European Commission. It ends with a discussion of the Treaty of Lisbon.

This chapter focuses on the ‘other’ European communities and the origins of the European Economic Community (EEC). Negotiations over a plan for a European Defence Community (EDC) ran parallel to those over the European Coal and Steel Community (ECSC). Connected with the EDC was a proposal to create a European Political Community (EPC) to provide democratic European structures for co-ordinating foreign policies. This chapter first considers the Pleven Plan for an EDC, before discussing the development of the EDC/EPC plan and the ultimate failure to reach agreement in 1954. It also analyses the Messina negotiations and the road to the Treaties of Rome. Finally, it looks at the experience of the other organization that was created at the same time as the EEC, the European Atomic Energy Community (Euratom), which, like the ECSC, was institutionally merged with the EEC in 1967.

This chapter examines the European Commission’s functions and structure, along with its role in policy making. The Commission initiates legislation, may act as a mediator, manages some policy areas, is guardian of the Treaties, is a key actor in international relations, and the ‘conscience of the European Union’. The chapter proceeds by discussing the debate on the extent to which the Commission is an autonomous political actor or simply an agent of the member states. Finally, it analyses the increasing challenges faced by the Commission in securing effective implementation of EU policies and its response to concerns over its financial management of EU programmes.

This chapter focuses on the European Parliament (EP), the one directly elected institution of the European Union. It first provides an overview of the EP’s composition and functions, before discussing the struggle for increased powers within the EP. It then considers debates and research on the EP. The focus of contemporary research on the EP includes political behaviour and EP elections, the internal politics and organization of the EP, and inter-institutional bargaining between the EP, the European Council, and the European Commission. One theme of the academic debate is the extent to which the EP has become an effective independent actor in the affairs of the EU.

This chapter examines theories of European Union governance. As European integration progressed, the academic focus began to shift from explaining the integration process to understanding the EU as a political system. As such, EU scholars increasingly drew on approaches from the study of domestic and comparative politics. This chapter surveys a number of approaches that focus on the EU as a political system. These approaches are quite varied and include new institutionalism, governance, and policy network approaches. At the end of the chapter attention is turned to some of the overall characterizations of EU governance that also offer valuable insights: supranational governance; new intergovernmentalism; and differentiated integration.

This chapter first examines the European Union’s (EU’s) main enlargement rounds. The first enlargement occurred in 1973 when Britain, Denmark, and Ireland were admitted as members. The second (1981) and third (1986) enlargements are often treated as a single ‘southern enlargement’. The fourth enlargement took place in 1995, and admitted Austria, Finland, and Sweden. The fifth and sixth enlargements, in 2004 and 2007, are known as the ‘eastern enlargement’. The seventh enlargement saw the admittance of Croatia in 2013. A number of further states in the western Balkans are at various stages in their accession processes. The chapter describes what happened during each round and the evolution of the procedure for joining. It reviews academic explanations of why the various applications for membership were made, and why they were accepted by the European Community (EC)/EU. Finally, the chapter looks at the controversial case of Turkey and considers the notion of ‘enlargement fatigue’.

This chapter examines the European Union’s (EU’s) external trade relations in the context of the wider framework of global trade agreements, along with its related policies on development aid, particularly with the African, Caribbean, and Pacific (ACP) states. It first looks at the history of the EU’s trade and development aid, before discussing its contemporary external trade and development policies. It explains the workings of the common commercial policy, considers disputes within the World Trade Organization (WTO), especially with the United States, and explores the EU’s trading relationship with developing countries and near neighbours in the context of the European Neighbourhood Policy (ENP). It then considers theoretical explanations of the EU’s external trade and development aid policies, as well as criticisms of such policies. Analysis of the EU’s external economic relations brings to the fore a number of theoretical themes, such as the tension between nationalism and supranationalism, the complexities of bargaining within multiple international forums, and the dominance of particular ideas across different forums.

This chapter examines the range of critical perspectives now applied to the European Union, including social constructivism, critical political economy, critical social theory, critical feminism, and post-structuralism. These critical—often termed ‘post-positivist’—approaches emphasize the constructed and changeable nature of the social and political world. Many such approaches reject the notion that social reality can be objectively observed and argue that various agents, including policy actors and scholars themselves, are involved in its construction. They highlight the less obvious manifestations of power that pervade the interrelated worlds of political action and political theorizing. It is important to consider why these more critical perspectives have been absent for so long within mainstream studies of the EU.

This chapter focuses on two European Union (EU) institutions that are principally composed of government representatives: the European Council and the Council of the EU. By virtue of their composition of government representatives (government heads, ministers, and civil servants), both the European Council and the Council of the EU remain part of a hierarchy of EU institutions. The chapter first provides an overview of definitions and distinctions, before discussing the intergovernmentalism of the European Council and how the Council of the European Union helped increase the supranationalism of the EU. It also considers the role of the Committee of Permanent Representatives (COREPER) and various preparatory committees.

This chapter charts the long history of plans for European unity, from the end of the Second World War to the Hague Congress, the Cold War, the Schuman Plan, and the Treaty of Paris. It also considers European federalism and the practical reasons why some moves to European unity found favour with the new governments of the post-war period: the threat of communism and the emergence of the Cold War; the so-called German Problem; and the need to ensure adequate supplies of coal for the post-war economic reconstruction. As a solution to these intersecting problems, Jean Monnet, came up with a proposal that paved the way for the establishment of the European Coal and Steel Community. The chapter examines Monnet’s proposal, national reactions to it, and the negotiations that led to the creation of the first of the European communities.

This chapter focuses on the Court of Justice of the European Union (CJEU), which comprises two courts: the CJEU and the General Court. It first provides an overview of the CJEU’s structure and functions, and then discusses some of its main rulings and their significance. It further considers rulings on the powers of the institutions, some key legal judgments made in response to questions referred to the CJEU by national courts, the impact of CJEU rulings on EU policy, and post-Maastricht trends in the CJEU and EU law. It also assesses the evolving political reactions towards the judgments of the Court, along with the debate over whether the member states have been able to effectively curb the CJEU’s radical jurisprudence.

This chapter examines the European Union’s (EU’s) Common Foreign and Security Policy (CFSP). It tells the story of increasing co-operation between member states on foreign policy matters, first with European Political Co-operation (EPC) and, since the 1990s, with CFSP and a Common Security and Defence Policy (CSDP). The chapter highlights the internal dynamics and external events that drove the member states towards such co-operation and considers the most recent example of such efforts: the 2017 attempt to create a system of permanent structured co-operation (PESCO). However, it is noted that the EU remains far from having a truly supranational foreign policy and there remains a reluctance from member states to push much further integration, given states’ keen desire to remain sovereign in this area. Finally, the chapter considers the EU’s status as a ‘power’ in international relations, noting that it has diminished in important respects since 2003, but remains an important economic power.

This chapter focuses on the first years of the European Economic Community (EEC). It describes the early 1960s as a period of apparent success for the supranational elements within the EEC, noting the rapid progress made towards the creation of both a common market and a common agricultural policy. The chapter also examines the crisis sparked by France’s decision to boycott meetings of the Council of Ministers in response to proposals for a more supranational method of funding the EEC budget; the impact of this crisis on the process of European integration; the so-called Luxembourg Compromise; and the Hague Summit. It concludes by discussing the EEC’s expansion of its membership at the start of the 1970s, as well as its first moves towards an Economic and Monetary Union and a Common Foreign and Security Policy.

This chapter examines the crises that dominated the period after the Lisbon Treaty was adopted in 2009: first, the eurozone crisis that began in 2009 and threatened the existence of the single currency; second, the refugee crisis that unfolded from 2015 as large numbers of refugees fled an intensifying war in Syria and attempted perilous crossings of the Mediterranean Sea; third, Britain’s decision to leave the EU, which followed a referendum on membership in 2016; and finally, the challenge of populist politics in the EU, with reference to the emergence of governments led by or including populist parties in Hungary, Poland, and Italy. The chapter then considers other developments during this period, including elections to the European Parliament (EP) in 2014 and 2019, a further enlargement to include Croatia in 2013, and the launch of the ‘Europe 2020’ strategy. It also looks at the United Kingdom’s adoption of a series of measures that raised doubts about its future relationship with the EU.