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1. Acupuncture and moxibustion for endometriosis: A systematic review and analysis

Author

Yongxia Wang, Meaghan E. Coyle, Miaowen Hong, Siya He, Anthony L. Zhang, Xinfeng Guo, Chuanjian Lu, Charlie C.L. Xue, and Xuefang Liang

Subjects
Acupuncture, Endometriosis, Systematic review, Other systems of medicine, RZ201-999
Abstract

Objectives: This study aimed to examine the effect of acupuncture on symptoms and health-related quality of life in patients with endometriosis. Methods: Nine biomedical databases were searched to April 2022 to identify randomized controlled trials of acupuncture and/or moxibustion used alone or as adjunct to guideline-recommended pharmacotherapy for the treatment of endometriosis. One reviewer extracted data and another verified the data. A random effects model was used to calculate mean differences. Results: Fifteen trials involving 1018 patients met the inclusion criteria, but diversity in comparisons and outcome measures prevented meta-analysis. Compared to sham acupuncture, manual acupuncture was more effective at reducing dysmenorrhea VAS pain score (mean difference [MD] − 2.40, 95 % CI [− 2.80, − 2.00]; moderate certainty evidence), pelvic pain VAS score (MD − 2.65, 95 % CI [− 3.40, − 1.90]; high certainty evidence) and dyspareunia VAS scores (MD − 2.88, [− 3.83, − 1.93]), lessened the size of ovarian cyst (MD − 3.88, 95 % CI [− 7.06, − 0.70]), and improved quality of life. Compared to conventional therapy, manual acupuncture plus conventional therapy and warm needle alone resulted in greater improvements in quality of life than conventional therapy. Among the six studies that reported safety, fewer adverse events were reported in participants who received acupuncture or moxibustion. Conclusions: Low to moderate certainty evidence from single studies showed that manual acupuncture may improve pain-related symptoms and quality of life; however, there is insufficient evidence on the overall effectiveness of acupuncture and moxibustion for endometriosis.

Published
2023
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2. Preparation and characterisation of solid dispersions of tanshinone IIA, cryptotanshinone and total tanshinones

Author

Xifeng Zhai, Chunguang Li, George Binh Lenon, Charlie C.L. Xue, and Weize Li

Subjects
Cryptotanshinone, Tanshinone IIA, Total tanshinones, Solid dispersion, Dissolution rate, Therapeutics. Pharmacology, RM1-950
Abstract

Total tanshinones are lipophilic active constituents extracted from Salvia miltiorrhiza Bge. Tanshinone IIA and cryptotanshinone are the major components in total tanshinones. However, the bioavailability of both compounds is low due to poor water solubility. To enhance the solubility and dissolution rate of tanshinone IIA, cryptotanshinone and total tanshinones, three common used hydrophilic carriers including PEG 6000, poloxamer 188 and PVP K30 were used to prepare the solid dispersions at different ratios, respectively. The solid dispersions were characterised by scanning electron microscopy (SEM), differential scanning calorimetry (DSC) and Fourier transform infrared spectroscopy (FTIR). The results of powder X-ray diffraction confirmed the microcrystal state of total tanshinones in solid dispersions and no chemical interaction between total tanshinones and carriers was observed in FTIR spectra. The solubility and dissolution rate of tanshinone IIA and cryptotanshinone were significantly increased in all solid dispersions. Regarding tanshinone IIA, the solubility and dissolution rate of in solid dispersions prepared with poloxamer 188 were significantly higher than that with PEG 6000 and PVP K30. The higher solubility and dissolution rate of cryptotanshinone were obtained in solid dispersion of PVP K30 than that of PEG 6000 solid dispersions but no significant difference from poloxamer 188 solid dispersions. The results indicate that the superior carrier for preparation of tanshinone IIA and total tanshinones solid dispersions is poloxamer 188, and that for cryptotanshinone is PVP K30.

Published
2017
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4. List of Contributors

Author

Angela Marie Abbatecola, Koji Abe, Jose F. Abisambra, Aliya Ahmad, Hojjatollah Alaei, Kannayiram Alagiakrishnan, Gjumrakch Aliev, Ricardo Francisco Allegri, Osvaldo P. Almeida, Fernando J. Álvarez-Cervera, Nor Amalina Ahmad Alwi, David Ames, Amelia Jane Anderson-Mooney, José Paulo Andrade, Neus Anglés, R.A. Armstrong, Marco Assunção, Hebatallah Husseini Atteia, Marco Fidel Avila, Ming-Jong Bair, Mario Barbagallo, Pascale Barberger-Gateau, Michelangela Barbieri, George E. Barreto, José L. Bata-García, Monirun Begum, Francesco Bellia, Mario Belvedere, Louise E. Bennett, Monika Białecka, Michael Bird, Carlo Blundo, Virginia Boccardi, Irene Bolea, Domenico Bosco, Elske M. Brouwer-Brolsma, John C.M. Brust, Roberto Buffa, Kendra D. Bunner, Lena Burri, Ricardo Cabezas, María Alicia Camina, Tessa N. Campbell, Lourdes Rexach Cano, Huan-Lin Chen, Jianmin Chen, David Wing-Shing Cheung, Francis Y.M. Choy, J. Chua, Carmen Colica, Philippe Corcia, Suzanne Craft, Dario Cristiano, Michael D. Cusimano, Kate Dalton, Terry L. Davidson, Matteo De Bartolo, Andreza Fabro de Bem, Isac de Castro, Lisette C.P.G.M. de Groot, Sandra de la Cruz Marcos, Jade de Oliveira, Valeria del Balzo, Kentaro Deguchi, Shoko Deguchi, Richard Deth, Ligia J. Dominguez, Lorenzo M. Donini, Huseyin Doruk, Rainer Dziewas, Rafael Carles Díes, Ramon Santos El-Bachá, Sahar Elsayed El-Swefy, Laura Carreño Enciso, Caterina Ermio, Begoña M. Escribano, Ana María Estrada-Sánchez, Thorleif Etgen, Marcelo Farina, Antonietta Fava, Catherine Feart, Lei Feng, Laura Fernández-Fernández, Danilio Alvear Sampaio Ferreira, Milan Fiala, Renata Caruso Fialdini, Cheryl Fisher, Daniela Galimberti, James E. Galvin, Rebecca P. Gelber, Carmela Gerace, Panteleimon Giannakopoulos, Phillip F. Giannopoulos, Vijayasree V. Giridharan, Anna Maria Giusti, Janneth Gonzalez, José L. Góngora-Alfaro, Paul H. Gordon, Jeffrey S. Greiwe, Natalie A. Grima, Rubem Guedes, Susham Gupta, Erika Gyengesi, Sven Haller, Angela J. Hanson, Jenni Harvey, Ossama Morsi Hassan, Samuel T. Henderson, Karl Herrup, M.A. Hickey, Robert Hoerr, Xiaoli Hou, Chengyu Huang, Helmut M. Hügel, Sam-Long Hwang, Yoshio Ikeda, Kazuhiro Irie, Alexandria Jack, Neale Jackson, Richard L. Jackson, Brittany Jannise, Yugang Jiang, C.Shanthi Johnson, James S. Jolliff, Mariona Jové, Jonathan S. Kam, Scott E. Kanoski, Khurshid Khan, Takemi Kimura, Yasuko Kitagishi, Tetsuya Konishi, Gabor G. Kovacs, Debra Krause, Ee-Heok Kua, Tomoko Kurata, Mini Kurian, Timothy Kwok, Wai Ping Lam, Fabrizia Lattanzio, Catherine B. Lawrence, Tih-Shih Lee, Yuan-Kai Lee, Paula Leslie, Ping Chung Leung, Runping Li, Willmann Liang, Siong-Meng Lim, Fengwu Lin, I-Tsung Lin, Martin Loef, Karl-Olof Lovblad, Evelio Luque, Protásio Lemos da Luz, S.Lance Macaulay, Swati Madan, Walter Maetzler, R. Mahendran, Abu Bakar Abdul Majeed, Alastair G. Mander, Vasudevan Mani, Graham Manley, Danny Manor, Christine Margetts, Elisabetta Marini, J.Javier Martin-Fernandez, José Manuel Martínez-Martos, Irene Villegas Martínez, Beatriz de Mateo Silleras, Satoru Matsuda, Brian H. May, Alexander McGirr, Laurie M. McCormick, Jatin Mehta, Elena Mereu, Antonino Messina, Akari Minami, John Mirowsky, Eileen M. Moore, Eduardo Luiz Gasnhar Moreira, José Ramón Morelló, Takashi Mori, Gerald Münch, Kazuma Murakami, Joachim Mutter, Mehmet Ilkin Naharci, Frank Shigeo Nakao, Tze-Pin Ng, Julie Nigro, Toshiharu Ninomiya, Marcelo Nishiyama, Erum Nomani, Astrid C.J. Nooyens, Adriana Leico Oda, Hitoshi Okamura, Acary Souza Bulle Oliveira, Yuna Ono, Giuseppe Orsitto, Mio Ozawa, Véronique Pallet, Reinald Pamplona, Giuseppe Paolisso, Sergio Paradiso, Matthew P. Pase, Gaurav Patki, Olivier Piguet, Alessandro Pinto, Domenico Pirritano, Massimiliano Plastino, Eleonora Poggiogalle, M.Cristina Polidori, Renato Polimanti, Manuel Portero-Otin, Brian D. Power, Domenico Praticò, Rui Daniel S. Prediger, Victor R. Preedy, Mark A. Prendergast, Daniela Rae, Kalavathy Ramasamy, Muhammad Zaki Ramli, Bartolomé Ramirez, María Jesús Ramírez-Expósito, George V. Rebec, V.Prakash Reddy, María Paz Redondo del Río, Jordi Reguant, Parham Reisi, Ruth Remington, Monica Ricci, Enrico Rizzarelli, Stephen R. Robinson, Eugene Rogers, Francesca Rosini, Peter Roupas, Alessandra Rufa, María Julieta Russo, Ramesh Sahathevan, Samina Salim, Cristina Cleide dos Santos Salvioni, Camille H. Sample, Abel Santamaría, Maher Saqqur, Bruno Saragat, Julie Sauvant, Patrick Sauvant, Elio Scarpini, M.F.Z. Scelza, Richard J. Schwen, Rachel L. Self, José C.E. Serrano, Thomas B. Shea, Ping-Hsiao Shih, Takahiko Shimizu, Shinagawa Shunichiro, Zahra Siahmard, Jarosław Sławek, Christine Smoliner, Montse Solé, Delia Sprini, Rosanna Squitti, Karin Srulijes, Wilhelm Stahl, Patricia Stanich, Brian R. Stephens, Mingxue Sun, Junichi Takamatsu, Hong Chai Tang, Rajarajan A. Thandavarayan, Daniel Torrente, Terrence Town, Isaac Túnez, Lynn Ulatowski, Mercedes Unzeta, Tony Valente, Jolanda van Keizerswaard, Ondine van de Rest, Nikita L. van der Zwaluw, Graziella Vecchio, Judith Jimenez Veiga, Fidel Vila-Rodriguez, Harald Walach, Tobias Warnecke, David A.K. Watters, Wolfgang Weber, Rachel Weitzman, Lon R. White, Rainer Wirth, Chia-Hsien Wu, Kai Xiao, Charlie C.L. Xue, Gow-Chin Yen, David Tai-Wai Yew, Teruo Yokoi, Anthony L. Zhang, Lihong Zhang, and Giancarlo Zito

Published
2015
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5. TREATMENT FOR SEASONAL ALLERGIC RHINITIS BY CHINESE HERBAL MEDICINE: A RANDOMIZED PLACEBO CONTROLLED TRIAL.

Author

Charlie C.L. Xue, Thien, Francis C.K., Jerry J.S. Zhang, da Costa, Cliff, and Chun G. Li

Subjects
*ALLERGIC rhinitis, *CHINESE medicine, *HERBAL medicine
Abstract

Context · Chinese herbal medicine (CHM) is widely used to treat seasonal allergic rhinitis (SAR), however, evidence of efficacy is lacking. Objective · To evaluate the efficacy of a Chinese herbal formulation for the treatment of SAR. Design · Randomized, double blind, placebo controlled trial. Setting · RMIT Chinese Medicine Clinic. Patients · 55 patients with seasonal allergic rhinitis (active 28, placebo 27). Interventions · CHM extract capsule (containing 18 herbs) or placebo, given daily for 8 weeks. Main Outcome Measures · The primary measure of efficacy were changes in severity of nasal and non-nasal symptoms using a Five Point Scale (FPS) measured by both patients and the practitioner. The secondary measure was the change in score for the domains measured in the Rhinoconjunctivitis and Rhinitis Quality of Life Questionnaire (RQLQ) assessed by patients. Results · Forty-nine patients completed the study (active 24; placebo 25). After eight weeks, the severity of nasal symptoms and non-nasal symptoms were significantly less in the active treatment group than in the control group, both for measurements made by patients and those by the practitioner. Comparison of active and placebo treatment groups RQLQ scores also indicated significant beneficial effects of treatment (end point Section 1: P<0.05; Section 2: P<0.01). Intention-to-treat analyses of categorical items showed moderate to marked improvement rates were 60.7% and 29.6% for active and placebo respectively. Eleven patients reported mild adverse events including I withdrawn from the trial. Conclusions · This CHM formulation appears to offer symptomatic relief and improvement of quality of life for some patients with seasonal allergic rhinitis. [ABSTRACT FROM AUTHOR]

Published
2003

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