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2. Transitioning from 0.5 to 0.9 mT: Protecting against inadvertent activation of magnet mode in active implants.

Author

Steckner, Michael C., Grainger, David, and Charles‐Edwards, Geoff

Subjects
ELECTRONIC equipment, ARTIFICIAL implants, MEDICAL equipment, CARDIAC pacemakers, IMPLANTABLE cardioverter-defibrillators
Abstract

The "5 gauss line" is a phrase that is likely to be familiar to everyone working with MRI, but what is its significance, how was it defined, and what changes are currently in progress? This review explores the history of 5 gauss (0.5 mT) as a threshold for protecting against inadvertently putting cardiac pacemakers, implantable cardioverter defibrillators, and other active implantable medical devices into a "magnet mode." Additionally, it describes the background to the recent change of this threshold to 9 gauss (0.9 mT) in the International Standard IEC 60601‐2‐33 edition 4.0 that defines basic safety requirements for MRI. Practical implications of this change and some ongoing and emerging issues are also discussed. [ABSTRACT FROM AUTHOR]

Published
2024
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6. Joint British Society consensus recommendations for magnetic resonance imaging for patients with cardiac implantable electronic devices.

Author

Bhuva, Anish, Charles-Edwards, Geoff, Ashmore, Jonathan, Lipton, Alexandra, Benbow, Matthew, Grainger, David, Lobban, Trudie, Gopalan, Deepa, Slade, Alistair, Roditi, Giles, and Manisty, Charlotte

Subjects
CARDIAC magnetic resonance imaging, ELECTRONIC equipment, ARRHYTHMIA, ARTIFICIAL implants, VENTRICULAR arrhythmia, MAGNETIC resonance imaging, MAGNETIC resonance imaging equipment
Abstract

Magnetic Resonance Imaging (MRI) is increasingly a fundamental component of the diagnostic pathway across a range of conditions. Historically, the presence of a cardiac implantable electronic device (CIED) has been a contraindication for MRI, however, development of MR Conditional devices that can be scanned under strict protocols has facilitated the provision of MRI for patients. Additionally, there is growing safety data to support MR scanning in patients with CIEDs that do not have MR safety labelling or with MR Conditional CIEDs where certain conditions are not met, where the clinical justification is robust. This means that almost all patients with cardiac devices should now have the same access to MRI scanning in the National Health Service as the general population. Provision of MRI to patients with CIED, however, remains limited in the UK, with only half of units accepting scan requests even for patients with MR Conditional CIEDs. Service delivery requires specialist equipment and robust protocols to ensure patient safety and facilitate workflows, meanwhile demanding collaboration between healthcare professionals across many disciplines. This document provides consensus recommendations from across the relevant stakeholder professional bodies and patient groups to encourage provision of safe MRI for patients with CIEDs. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Reliability and safety of anaesthetic equipment around an high-field 7-Tesla MRI scanner

Author

Bridgen, Philippa, primary, Malik, Shaihan, additional, Wilkinson, Thomas, additional, Cronin, John N., additional, Bhagat, Tahzeeb, additional, Hart, Nicholas, additional, Corkell, Stuart Mc, additional, Perkins, Joanne, additional, Tibby, Shane, additional, Hanna, Sara, additional, Kirwan, Richard, additional, Pauly, Thomas, additional, Weeks, Arthur, additional, Charles-Edwards, Geoff, additional, Padormo, Francesco, additional, Stell, David, additional, El-Boghdadly, Kariem, additional, Ourselin, Sebastien, additional, Giles, Sharon L., additional, Edwards, Anthony D., additional, Hajnal, Joseph V., additional, and Blaise, Benjamin J., additional

Published
2023
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9. Joint British Society consensus recommendations for magnetic resonance imaging for patients with cardiac implantable electronic devices

Author

Bhuva, Anish, primary, Charles-Edwards, Geoff, additional, Ashmore, Jonathan, additional, Lipton, Alexandra, additional, Benbow, Matthew, additional, Grainger, David, additional, Lobban, Trudie, additional, Gopalan, Deepa, additional, Slade, Alistair, additional, Roditi, Giles, additional, and Manisty, Charlotte, additional

Published
2022
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12. Ethnic differences in beta cell function occur independently of insulin sensitivity and pancreatic fat in black and white men

Author

Ladwa, Meera, primary, Bello, Oluwatoyosi, additional, Hakim, Olah, additional, Shojaee-Moradie, Fariba, additional, Boselli, Maria Linda, additional, Charles-Edwards, Geoff, additional, Peacock, Janet, additional, Umpleby, A Margot, additional, Amiel, Stephanie A, additional, Bonadonna, Riccardo C, additional, and Goff, Louise M, additional

Published
2021
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13. Anticonvulsant effect of xenon on neonatal asphyxial seizures

Author

Azzopardi, Denis, Robertson, Nicola J, Kapetanakis, Andrew, Griffiths, James, Rennie, Janet M, Mathieson, Sean R, Edwards, A David, Deierl, Aniko, Merchant, Nazakat, Srinivasan, Latha, Viac, Isabelle, Kendall, Giles, Dinan, Mary, Uria, Cristina, Nandiran, Ratnaval, Turner, Mark, Wallace, Virginia, Franks, Nicholas, Maze, Mervyn, Fagiolo, Gianlorenzo, Hajnal, Joseph, Charles-Edwards, Geoff, Cady, Ernest, and Abernethy, Lawrence

Published
2013
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15. Insulin clearance as the major player in the hyperinsulinaemia of black African men without diabetes

Author

Ladwa, Meera, primary, Bello, Oluwatoyosi, additional, Hakim, Olah, additional, Shojaee‐Moradie, Fariba, additional, Boselli, Linda, additional, Charles‐Edwards, Geoff, additional, Stadler, Marietta, additional, Peacock, Janet L., additional, Umpleby, Anne Margot, additional, Amiel, Stephanie A., additional, Bonadonna, Riccardo C., additional, and Goff, Louise M., additional

Published
2020
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17. Associations Between Pancreatic Lipids and β-Cell Function in Black African and White European Men With Type 2 Diabetes

Author

Hakim, Olah, primary, Bonadonna, Riccardo C, additional, Mohandas, Cynthia, additional, Billoo, Zoya, additional, Sunderland, Alexander, additional, Boselli, Linda, additional, Alberti, K George M M, additional, Peacock, Janet L, additional, Umpleby, A Margot, additional, Charles-Edwards, Geoff, additional, Amiel, Stephanie A, additional, and Goff, Louise M, additional

Published
2018
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18. UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer

Author

Barnes, Anna, primary, Alonzi, Roberto, additional, Blackledge, Matthew, additional, Charles-Edwards, Geoff, additional, Collins, David J, additional, Cook, Gary, additional, Coutts, Glynn, additional, Goh, Vicky, additional, Graves, Martin, additional, Kelly, Charles, additional, Koh, Dow-mu, additional, McCallum, Hazel, additional, Miquel, Marc E, additional, O’Connor, James, additional, Padhani, Anwar, additional, Pearson, Rachel, additional, Priest, Andrew, additional, Rockall, Andrea, additional, Stirling, James, additional, Taylor, Stuart, additional, Tunariu, Nina, additional, van der Meulen, Jan, additional, Walls, Darren, additional, Winfield, Jessica, additional, and Punwani, Shonit, additional

Published
2018
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20. [IC-P-088]: DEEP AND FREQUENT PHENOTYPING STUDY: PET AND MR IMAGING PROTOCOL

Author

Heise, Verena, primary, Firouzian, Azadeh, additional, Thomas, David L., additional, Newbould, Rexford D., additional, Aigbirhio, Franklin I., additional, Williams, Guy B., additional, Lucatelli, Christophe, additional, Macnaught, Gillian, additional, Waldman, Adam, additional, Hallett, William, additional, Rabiner, Eugenii A., additional, Marsden, Paul, additional, Charles-Edwards, Geoff, additional, Matthews, Julian, additional, Parkes, Laura, additional, Brooks, David J., additional, Firbank, Michael J., additional, Klein, Johannes C., additional, Gunn, Roger N., additional, and Mackay, Clare E., additional

Published
2017
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21. [P4-265]: DEEP AND FREQUENT PHENOTYPING STUDY: PET AND MR IMAGING PROTOCOL

Author

Heise, Verena, primary, Firouzian, Azadeh, additional, Thomas, David L., additional, Newbould, Rexford D., additional, Aigbirhio, Franklin I., additional, Williams, Guy B., additional, Lucatelli, Christophe, additional, Macnaught, Gillian, additional, Waldman, Adam, additional, Hallett, William, additional, Rabiner, Eugenii A., additional, Marsden, Paul, additional, Charles-Edwards, Geoff, additional, Matthews, Julian, additional, Parkes, Laura, additional, Brooks, David J., additional, Firbank, Michael J., additional, Klein, Johannes C., additional, Gunn, Roger N., additional, and Mackay, Clare E., additional

Published
2017
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22. Depiction of lower limb venous anatomy in patients undergoing interventional deep venous reconstruction—the role of balanced steady state free precession MRI.

Author

Helyar, Vincent G, Gupta, Yuri, Blakeway, Lyndall, Charles-Edwards, Geoff, Katsanos, Konstantinos, and Karunanithy, Narayan

Subjects
MAGNETIC resonance imaging, ANGIOGRAPHY, POSTTHROMBOTIC syndrome, VENOUS thrombosis diagnosis, HYPERTENSION, LEG abnormalities
Abstract

This study evaluates the use of balanced steady-state free precession MRI (bSSFP-MRI) in the diagnostic work-up of patients undergoing interventional deep venous reconstruction (I-DVR). Intravenous digital subtraction angiography (IVDSA) was used as the gold-standard for comparison to assess disease extent and severity. A retrospective comparison of bSSFP-MRI to IVDSA was performed in all patients undergoing both examinations for treatment planning prior to I-DVR. The severity of disease in each venous segment was graded by two board-certified radiologists working independently, according to a predetermined classification system. In total, 44 patients (225 venous segments) fulfilled the inclusion criteria. A total of 156 abnormal venous segments were diagnosed using bSSFP-MRI compared with 151 using IVDSA. The prevalence of disease was higher in the iliac and femoral segments (range, 79.6–88.6%). Overall sensitivity, specificity, positive likelihood ratio, negative likelihood ratio and the diagnostic ratio for bSSFP-MRI were 99.3%, 91.9%, 12.3, 0.007 and 1700, respectively. This study supports the use of non-contrast balanced SSFP-MRI in the assessment of the deep veins of the lower limb prior to I-DVR. The technique offers an accurate, fast and non-invasive alternative to IVDSA. Although balanced SSFP-MRI is commonly used in cardiac imaging, its use elsewhere is limited and its use in evaluating the deep veins prior to interventional reconstruction is not described. Our study demonstrates the usefulness of this technique in the work-up of patients awaiting interventional venous reconstruction compared with the current gold standard. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Associations Between Pancreatic Lipids and β-Cell Function in Black African and White European Men With Type 2 Diabetes.

Author

Hakim, Olah, Bonadonna, Riccardo C, Mohandas, Cynthia, Billoo, Zoya, Sunderland, Alexander, Boselli, Linda, Alberti, K George M M, Peacock, Janet L, Umpleby, A Margot, Charles-Edwards, Geoff, Amiel, Stephanie A, and Goff, Louise M

Abstract

Intrapancreatic lipid (IPL) has been linked to β-cell dysfunction. Black populations disproportionately develop type 2 diabetes (T2D) and show distinctions in β-cell function compared with white populations.

Published
2019
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24. PET/MRI in Oncological Imaging: State of the Art

Author

Bashir, Usman, primary, Mallia, Andrew, additional, Stirling, James, additional, Joemon, John, additional, MacKewn, Jane, additional, Charles-Edwards, Geoff, additional, Goh, Vicky, additional, and Cook, Gary, additional

Published
2015
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25. DEEP AND FREQUENT PHENOTYPING STUDY: PET AND MR IMAGING PROTOCOL

Author

Heise, Verena, Firouzian, Azadeh, Thomas, David L., Newbould, Rexford D., Aigbirhio, Franklin I., Williams, Guy B., Lucatelli, Christophe, Macnaught, Gillian, Waldman, Adam, Hallett, William, Rabiner, Eugenii A., Marsden, Paul, Charles-Edwards, Geoff, Matthews, Julian, Parkes, Laura, Brooks, David J., Firbank, Michael J., Klein, Johannes C., Gunn, Roger N., and Mackay, Clare E.

Published
2017
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29. UK quantitative WB-DWI technical workgroup: consensus meeting recommendations on optimisation, quality control, processing and analysis of quantitative whole-body diffusion-weighted imaging for cancer

Author

Barnes, Anna, Alonzi, Roberto, Blackledge, Matthew, Charles-Edwards, Geoff, Collins, David J, Cook, Gary, Coutts, Glynn, Goh, Vicky, Graves, Martin, Kelly, Charles, Koh, Dow-Mu, McCallum, Hazel, Miquel, Marc E, O'Connor, James, Padhani, Anwar, Pearson, Rachel, Priest, Andrew, Rockall, Andrea, Stirling, James, Taylor, Stuart, Tunariu, Nina, Van Der Meulen, Jan, Walls, Darren, Winfield, Jessica, and Punwani, Shonit

Subjects
Quality Control, Diffusion Magnetic Resonance Imaging, Neoplasms, Humans, Whole Body Imaging, Medical Oncology, United Kingdom, 3. Good health
Abstract

OBJECTIVE: Application of whole body diffusion-weighted MRI (WB-DWI) for oncology are rapidly increasing within both research and routine clinical domains. However, WB-DWI as a quantitative imaging biomarker (QIB) has significantly slower adoption. To date, challenges relating to accuracy and reproducibility, essential criteria for a good QIB, have limited widespread clinical translation. In recognition, a UK workgroup was established in 2016 to provide technical consensus guidelines (to maximise accuracy and reproducibility of WB-MRI QIBs) and accelerate the clinical translation of quantitative WB-DWI applications for oncology. METHODS: A panel of experts convened from cancer centres around the UK with subspecialty expertise in quantitative imaging and/or the use of WB-MRI with DWI. A formal consensus method was used to obtain consensus agreement regarding best practice. Questions were asked about the appropriateness or otherwise on scanner hardware and software, sequence optimisation, acquisition protocols, reporting, and ongoing quality control programs to monitor precision and accuracy and agreement on quality control. RESULTS: The consensus panel was able to reach consensus on 73% (255/351) items and based on consensus areas made recommendations to maximise accuracy and reproducibly of quantitative WB-DWI studies performed at 1.5T. The panel were unable to reach consensus on the majority of items related to quantitative WB-DWI performed at 3T. CONCLUSION: This UK Quantitative WB-DWI Technical Workgroup consensus provides guidance on maximising accuracy and reproducibly of quantitative WB-DWI for oncology. The consensus guidance can be used by researchers and clinicians to harmonise WB-DWI protocols which will accelerate clinical translation of WB-DWI-derived QIBs.

30. A framework for developing Generic Implant Safety Procedures (GISPs) for scanning patients with medical implants and devices in MRI.

Author

Ashmore JP, Prescott SJ, McLean J, Wilson DJ, Charles-Edwards G, Wright P, Grainger D, Barker GJ, Lipton AJ, Watt R, Gopalan D, and Radon MR

Abstract

UK guidelines for MR safety recommend that MRI departments refer to the implant manufacturer for advice regarding the MRI safety of scanning patients with an implantable medical device prior to scanning [1]. This process of assuring safety can be time consuming, leading to delays and potential cancellations of a patient's MRI. Furthermore, at times the implant cannot be identified, or the implant manufacturers cannot provide up to date MRI safety information. The purpose of generic implant safety procedures (GISPs) is to define a process for managing patients with certain types of implants where the risk from scanning is low. This process incorporates scope for an evidence-based risk-benefit decision to scan some groups of patients under locally-approved conditions, without seeking to identify the exact make and model of the implant and subsequent assurance of MR safety from the implant manufacturer. This publication provides best practice recommendations from a multi-professional working group for the development of these procedures. It is supported by The Institute of Physics and Engineering in Medicine, The Society of Radiographers, The Royal College of Radiologists, The British institute of Radiology, The British Association of MR Radiographers, The International Society of Magnetic Resonance in Medicine British and Irish Chapter and the NHS Scotland MRI Physics Group., (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology.)

Published
2024
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