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301 results on '"Chardonnet Y"'

1. Skin Cancers in Organ Transplant Recipients

Author

Euvrard, S., Kanitakis, J., Pouteil-Noble, C., Chardonnet, Y., Dureau, G., Touraine, J. L., Faure, M., Claudy, A., Thivolet, J., Altmeyer, Peter, editor, Hoffmann, Klaus, editor, and Stücker, Markus, editor

Published
1997
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23. Heterogeneous immunoreactivity of frozen human benign and malignant breast lesions to C-MYC and C-Ha-ras cellular oncogenes

Author

pechoux, C., Chardonnet, Y., Chignol, M.C., and Noël, P.

Subjects
5 - Ciencias puras y naturales::57 - Biología::576 - Biología celular y subcelular. Citología [CDU], Breast lesions, Immunohistochemistry
Abstract

C-myc and c-Ha-ras oncoprotein expression was studied by immunohistochemistry and gene detection by in situ hybridization on serial frozen sections of 32 breast lesions (19 benign biopsies and 13 infiltrating carcinomas). C-myc protein was expressed in 15/19 benign and 12/13 malignant lesions; c-myc gene was detected in 17/19 benign and 13/13 malignant lesions. Although a higher proportion of benign biopsies (819) showed more than 50% of protein-positive cells than malignant specimens, this cannot predict the outcome of a lesion. Conversely, p2 1 ras protein was expressed only in 2/19 benign lesions and in most cases of grade 1 to 111 carcinomas. The c-Ha-ras gene was always detected in a small percentage of cells, in both benign and malignant lesions. The results obtained with atypical hyperplasia, a doubtful proliferating lesion, suggests that p21 c-Ha-ras protein expression is not restricted to breast carcinomas. Although Southern blot is commonly considered as a very sensitive technique for oncogene analysis, no amplification of c-myc and c-Ha-ras gene has been demonstrated either in benign or malignant lesions. The detection, on serial frozen sections, of proteins and DNA of c-myc and c-Ha-ras, showed a possible amplification of the c-myc and c-Ha-ras genes in various benign and malignant lesions.

Published
1994

46. Specific immunity in patients suffering from recurring warts before and after repetitive intradermal tests with human papilloma virus.

Author

Viac, J., Thivolet, J., and Chardonnet, Y.

Subjects
WARTS, SKIN infections, PAPILLOMA, PAPILLOMAVIRUSES, ONCOGENIC DNA viruses, IMMUNOGLOBULIN G, CELLULAR immunity, DERMATOLOGY
Abstract

The specific humoral and cellular immunity of 22 patients with multiple or recurring warts was studied. After repeated intradermal tests, using an inactivated, purified viral antigen, the responses obtained could be classed into two groups. The first group (10 patients) was characterized immunologically by the acquisition of a specific cellular immunity and the appearance of circulating IgG antibodies, and clinically by a total regression or resolution of the warts two to three weeks after the final intradermal test. The second group (12 patients) was characterized immunologically by a weak or non-existent specific immune response, and clinically by the unmodified persistence of the warts. [ABSTRACT FROM AUTHOR]

Published
1977
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47. Comparative study of delayed hypersensitivity skin reactions and antibodies to human papilloma virus (HPV).

Author

Viac, J., Thivolet, J., Hegazy, M. R., Chardonnet, Y., and Dambuyant, C.

Subjects
PAPILLOMAVIRUSES, WARTS, SERUM, IMMUNOGLOBULINS, IMMUNOFLUORESCENCE, SKIN tests
Abstract

Purified human papilloma virus (HPV) was prepared from plantar warts, inactivated by formalin, adjusted to 1010 particles per 0.1 ml and used in intradermal tests (IDT) on 120 patients having warts at that time, or having had warts in the past, together with sixty-three controls. Antibodies were evaluated in the sera from most of the patients by the indirect immunofluorescence (IF) test before and after the skin tests. The results showed a specific delayed-hypersensitivity reaction (DHR) to HPV, especially in patients with 'regressing' or 'past' warts (76%). DHR was most frequent in patients with a wart of 6 months-2 years duration (77.0-68.8%) and persisted much longer than antibodies, which disappeared with the passage of time. The incidence of antibodies was much higher after IDT in patients with a positive reaction, thus suggesting a booster effect. [ABSTRACT FROM AUTHOR]

Published
1977

50. Persistence of Adenovirus 5 in Guinea Pigs

Author

Faucon, N., Chardonnet, Y., and Sohier, R.

Abstract

One intracardiac inoculation of adenovirus 5 in guinea pigs leads to virus persistence in different organs, viz., 5 days in lungs and liver, 14 days in blood and lymph nodes, and 56 days or more in the spleen. After cultivation of tissue cells for 1 week, virus was recovered from blood, lymph nodes, or spleen lymphocytes, but virus could be detected directly in cells only when organs were removed within 48 h of inoculation. To determine how the virus persisted in low concentrations and as a latent infection, spleens were primarily selected for study by three techniques: homogenization of spleens, suspended Maitland fragment cultures, and in vitro cultivation of spleen cells. The last procedure showed virus in fibroblast-like cells (probably macrophages or reticuloendothelial cells) for 56 days after infection of guinea pigs. With other methods, the virus was found only within the first 2 days after inoculation.

Published
1974
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