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2. Optical Actuation Performance of Phase-Change RF Switches

Author

Charlet, I., Guerber, S., Naoui, A., Charbonnier, B., Dupre, C., Lugo-Alvarez, J., Hellion, C., Allain, M., Podevin, F., Perret, E., and Reig, B.

Abstract

Optical actuation of GeTe-based radio frequency switches is studied for the first time at 915-nm optical wavelength. By inducing self-heating of the phase change material through light absorption, this approach removes the need for integrated micro-heaters. First, laser pulse conditions required to set the RF switches in ON-and OFF-states are found with optical pulse peak powers up to few hundred mW. Amorphization is obtained for optical pulses of 100 to 500 ns, and crystallization for pulses of 2 to $6~\mu \text{s}$ . A resistivity ratio of 2E4 is measured between both states. Cycling endurance is performed on a ${4}\times {5}\,\,\mu \text{m}^{{2}}$ switch, overpassing 1500 cycles, which is much higher compared to previously reported optical demonstrations. Small-signal measurements show 10% lower OFF-state capacitances using optical actuation compared to electrical actuation through micro-heaters. 37 dBm power handling capability is reported in the switch OFF-state at 915 MHz. This optical actuation demonstration corresponds to a standard wavelength in integrated photonic circuits and thus, this work constitutes a first step towards a CMOS compatible fully-integrated optical actuation solution for RF switches based on phase-change material.

Published
2024
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4. Multiparametric influence of 3D-printed organo-mineral scaffolds on bone regeneration

Author

Touya Nicolas, Reiss Ségolène, Rouillon Thierry, Dutilleul Maeva, Veziers Joelle, Pare Arnaud, Brasset Ludmila, Weiss Pierre, Corre Pierre, and Charbonnier Baptiste

Subjects
Hyaluronic acid, Cement, Calcium phosphate, Magnesium phosphate, Architecture, 3D printing, Medicine, Science
Abstract

Abstract The development of synthetic bone substitutes that equal or exceed the efficacy of autologous graft remains challenging. In this study, a rat calvarial defect model was used as a reference to investigate the influence of composition and architecture of 3D-printed cement, with or without bioactives, on tissue regeneration. Printable cement pastes were formulated by combining hyaluronic acid and cement precursors. Cementitious scaffolds were printed with 3 different patterns. After 7 weeks of implantation with or without bone marrow, multiparametric qualitative and quantitative assessments were performed using µCT, SEM, and histology. None of the set-up strategies was as efficient as autologous cancellous bone graft to repair calvarial defects. Nonetheless, the presence of scaffold improved the skull vault closure, particularly when the scaffold was soaked in total bone marrow before implantation. No significant effect of scaffold macro-architecture was observed on tissue mineralization. Magnesium phosphate-based scaffolds (MgP) seemed to induce higher bone formation than their calcium-phosphate-based counterparts. They also displayed a quicker biodegradation and sparse remaining material was found after 7 weeks of implantation. Although further improvements are required to reach clinical settings, this study demonstrated the potential of organo-mineral cements for bone regeneration and highlighted the peculiar properties of MgP-based cements.

Published
2024
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7. Millimeter-wave photonic components for broadband wireless systems

Author

Stohr, A., Babiel, S., Cannard, P.J., Charbonnier, B., van Dijk, F., Fedderwitz, S., Moodie, D., Pavlovic, L., Ponnampalam, L., Renaud, C.C., Rogers, D., Rymanov, V., Seeds, A., Steffan, A.G., Umbach, A., and Weiss, M.

Subjects
Broadband transmission -- Analysis, Microwaves -- Analysis, Photonics -- Research, Semiconductor lasers -- Design and construction, Mobile communication systems -- Analysis, Wireless communication systems -- Analysis, Broadband Internet, Wireless technology, Business, Computers, Electronics, Electronics and electrical industries
Published
2010

8. Asset management evaluation: a pilot case study

Author

Bauby, C.E., Charbonnier, B., Haik, P., Lacombe, S., Lonchampt, J., and Remy, E.

Subjects
Decision-making -- Methods, Production management -- Economic aspects, Production management -- Methods, Multimedia asset management software, Engineering and manufacturing industries
Abstract

The long term management of a production asset raises several major issues, among which rank the technical management of the plant, its economics, and the fleet level perspective one has to adopt. Decision makers are therefore faced with the need in define long term policies (up to the end of asset operation) that take into account multiple criteria including safety (which is paramount) and performance. In this paper we first remind the reader of the EDF three-level methodology for asset management. As introduced in PVP 2003 and PVP 2004, this methodology addresses the component/technical level (how to safely operate daily and invest for the future), the plant level (how to translate technical decisions into plant-wide consequences including economic performance), and the fleet level (how to manage a large number of similar assets). We then focus on the software tool that implements this methodology in order to allow decision makers to define, evaluate, and analyze long term plant operation and maintenance policies. Lastly we show how the methodology and the software tool were used on a pilot case study. The technical and economic results obtained at the plant level are described as well as the conclusions one can draw from them in order to help decision makers evaluate and analyze long term asset management strategies. [DOI: 10.1115/1.2389032]

Published
2007

12. Recent results from the EU POF-PLUS project: multi-gigabit transmission over 1 mm core diameter plastic optical fibers

Author

Okonkwo, C.M., Tangdiongga, E., Yang, H., Visani, D., Loquai, S., Kruglov, R., Charbonnier, B., Ouzzif, M., Greiss, I., Ziemann, O., Gaudino, R., and Koonen, A.M.J.

Subjects
Mass communications
Abstract

Recent activity to achieve multi-gigabit transmission over 1 mm core diameter graded-index and step-index plastic optical fibers for distances up to 50 meters is reported in this paper. By employing a simple intensity-modulated direct-detection system with pulse amplitude or digital multi-tone modulation techniques, low-cost transceivers and easy to install large-core POFs, it is demonstrated that multi-gigabit transmission up to 10 Gbit/s over 1-mm core diameter POF infrastructure is feasible. The results presented in this paper were obtained in the EU FP7 POF-PLUS project, which focused on applications in different scenarios, such as in next-generation in-building residential networks and in datacom applications. Index Terms--In-building networks, orthogonal frequency division multiplexing, plastic optical fibers, pulse-amplitude modulation., I. INTRODUCTION THE commercialization of polymethylmetacrylate (PMMA) plastic optical fibers (POFs) with large core diameters of 1 mm for providing in excess of 1 Gbit/s has gathered pace in short [...]

Published
2011
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20. Expert consensus document on the use of antiplatelet agents. The task force on the use of antiplatelet agents in patients with atherosclerotic cardiovascular disease of the European society of cardiology

Author

Patrono, C, Bachmann, F, Baigent, C, Bode, C, De Caterina, R, Charbonnier, B, Fitzgerald, D, Hirsh, J, Husted, S, Kvasnicka, J, Montalescot, G, García Rodríguez, LA, Verheugt, F, Vermylen, J, Wallentin, L, Priori, SG, Alonso Garcia, MA, Blanc, JJ, Budaj, A, Cowie, M, Dean, V, Deckers, J, Fernández Burgos, E, Lekakis, J, Lindahl, B, Mazzotta, G, Morais, J, Oto, A, Smiseth, OA, Ferreira, R, Steg, PG, Teixeira, F, Wilcox, R, and Cardiology

Subjects
Blood Platelets, medicine.medical_specialty, Process (engineering), media_common.quotation_subject, Alternative medicine, Coronary Artery Disease, Risk Assessment, Task (project management), SDG 3 - Good Health and Well-being, Risk Factors, Internal medicine, medicine, Humans, In patient, Quality (business), Heart, lung and circulation [UMCN 2.1], media_common, Clinical Trials as Topic, Atherosclerotic cardiovascular disease, business.industry, Patient Selection, Expert consensus, Clinical trial, Cardiology, Cardiology and Cardiovascular Medicine, business, Platelet Aggregation Inhibitors
Abstract

Guidelines and Expert Consensus Documents aim to present all the relevant evidence on a particular issue in order to help physicians to weigh the benefits and risks of a particular diagnostic or therapeutic procedure. They should be helpful in everyday clinical decision-making. A great number of Guidelines and Expert Consensus Documents have been issued in recent years by different organizations, the European Society of Cardiology (ESC) and by other related societies. By means of links to web sites of National Societies several hundred guidelines are available. This profusion can put at stake the authority and validity of guidelines, which can only be guaranteed if they have been developed by an unquestionable decision-making process. This is one of the reasons why the ESC and others have issued recommendations for formulating and issuing Guidelines and Expert Consensus Documents. In spite of the fact that standards for issuing good quality Guidelines and Expert Consensus Documents are well defined, recent surveys of Guidelines and Expert Consensus Documents published in peer-reviewed journals between 1985 and 1998 have shown that methodological standards were not complied within the vast majority of cases. It is therefore of great importance that guidelines and recommendations are presented in formats that are easily interpreted. Subsequently, their implementation programmes must also be well conducted. Attempts have been made to determine whether guidelines improve the quality of clinical practice and the utilization of health resources. The ESC Committee for Practice Guidelines ( CPG ) supervises and coordinates the preparation of new Guidelines and Expert Consensus Documents produced by Task Forces, expert groups or consensus panels. The Committee is also responsible for the endorsement of these Guidelines and Expert Consensus Documents or statements. The role of aspirin and other platelet-active drugs in the treatment and prevention of atherothrombosis has been reviewed recently by the Sixth American …

Published
2016

21. [Expert consensus document on the use of antiplatelet agents]

Author

Patrono, C, Bachmann, F, Baigent, C, Bode, C, De Caterina, R, Charbonnier, B, Fitzgerald, D, Hirsh, J, Husted, S, Kvasnicka, J, Montalescot, G, García Rodríguez, L, Verheugt, F, Vermylen, J, Wallentin, L, and Cardiología, Grupo de Trabajo sobre el uso de agentes antiplaquetarios en pacientes con enfermedad cardiovascular aterosclerótica de la Sociedad Europea de

Published
2016
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22. Packaging of photonic integrated circuit based high-speed coherent transmitter module

Author

Bernabé, Stéphane, Blampey, Benjamin, Myko, André, Mottet, Alexandre, Charbonnier, B., Hauden, Jérôme, Jillard, S, Frigui, Bouchra, Frigui, Kamel, Ngoho Moungoho, Stéphane Samuel, Bila, Stéphane, Charlet, Gabriel, Duan, G.H., Pommarede, Xavier, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Photline Technologies (Photline Technologies), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Centre d'Ingénierie des Systèmes en Télécommunication, en ÉlectroMagnétisme et en Electronique (CISTEME), Systèmes RF (XLIM-SRF), XLIM (XLIM), Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Alcatel-Lucent Bell Labs France [Nozay], and Alcatel-Lucent Bell Labs France

Subjects
ComputingMilieux_MISCELLANEOUS, [SPI.TRON]Engineering Sciences [physics]/Electronics
Abstract

International audience

Published
2016

23. Efficacy and safety of once weekly subcutaneous idrabiotaparinux in the treatment of patients with symptomatic deep venous thrombosis

Author

Büller, Hr, Destors, Jm, Gallus, A, Prins, Mh, Raskob, G, Charbonnier, B, Decousus, H, Leizorovicz, A, Laporte, S, Brandjes, Dp, Middeldorp, S, Pillion, G, Ceresetto, Jm, Hendler, H, Xavier, Dl, Santini, F, del Carmen Gallo, M, Coughlin, P, Chong, B, Leahy, M, Ward, C, Leyden, M, Prosser, I, Carroll, P, Gan, E, Mcrae, S, Salem, H, Pilger, E, Koppensteiner, R, Jurecka, W, Forstner, K, Hainaut, P, Motte, S, Vermassen, F, Araujo, Gr, Timi, Jr, Costa, Ja, Manenti, F, Yoshida, Wb, Kovacs, M, Delle Siega, A, Rodger, M, Miron, Mj, Anderson, D, Yeo, E, Kassis, J, Spacek, R, Klimsa, Z, Patek, F, Matoska, P, Maly, J, Srnsky, V, Cepelak, C, Nielsen, H, Noelsen, Hk, Avstrom, S, Husted, S, Tuxen, C, Stender, S, Azarian, R, Leftheriotis, G, Jego, P, Achkar, A, Zeltser, D, Keidar, S, Inbal, A, Piovella, F, Barone, M, Prandoni, Paolo, Imberti, D, Palaretti, G, Jerjes, C, Calvo, C, Van Marwijk Kooij, M, Timmerman, R, Mol, J, Ten Cate, H, Kamphuisen, P, Dullemond, A, Kroon, C, Veth, D, Biesma, D, Van Leendert, R, Ockelford, P, Chunilal, S, Szyber, P, Strzelczyk, J, Checinsli, P, Nizankowki, R, Cianciara, J, Kloczko, J, Tomkowski, W, Gutowski, P, Stupin, V, Sokurenko, G, Kirienko, A, Baesukov, A, Sokora, V, Katelnitsky, I, Didenko, Y, Lukianov, Y, Zatevakhin, I, Gavrilenko, A, Van Zyl LJ, Basson, Mm, Becker, Lh, Siebert, S, Engelbrecht, Jm, Otero, Dr, Paloma, Mj, del Toro, H, Kürşat Bozkurt, A, Joseph, S, Nadar, V, Baird, I, Han, D, Jacobson, A, Martin, J, Smith, D, Comerota, A, Guza, E, Wright, P., Epidemiologie, MUMC+: KIO Kemta (9), Interne Geneeskunde, Biochemie, RS: CARIM School for Cardiovascular Diseases, RS: CAPHRI School for Public Health and Primary Care, Amsterdam Cardiovascular Sciences, and Vascular Medicine

Subjects
Adult, Male, medicine.medical_specialty, Time Factors, medicine.drug_mechanism_of_action, Injections, Subcutaneous, Idraparinux, Factor Xa Inhibitor, Biotin, Oligosaccharides, Once weekly, Hemorrhage, Risk Assessment, Gastroenterology, bioequipotency, Drug Administration Schedule, treatment randomized trial, law.invention, auticoagulants, Double-Blind Method, Randomized controlled trial, Recurrence, law, Internal medicine, medicine, Humans, Blood Coagulation, deep venous thrombosis, Aged, Venous Thrombosis, Idrabiotaparinux, business.industry, Incidence (epidemiology), Anticoagulants, Hematology, Middle Aged, medicine.disease, United States, Confidence interval, Europe, Venous thrombosis, Treatment Outcome, Factor Xa, Female, business, Factor Xa Inhibitors
Abstract

Idraparinux, a long acting inhibitor of factor (F) Xa, is as effective as standard anticoagulant therapy for patients with symptomatic deep venous thrombosis. We investigated the potential use of the biotinylated molecule, idrabiotaparinux. Biotinylation enables reversal of the anticoagulant effect.We performed a randomized double-blind trial in 757 patients with symptomatic deep venous thrombosis, comparing equimolar doses of idrabiotaparinux (3 mg) with idraparinux (2.5 mg), both given subcutaneously, once weekly for 6 months. Inhibition of FXa activity was measured at days 15, 36, 57, 92 and 183. The efficacy outcome was recurrent venous thromboembolism. The safety outcomes were clinically relevant bleeding and death.Inhibition of FXa was similar in the two treatment groups at each time point of measurement. Recurrent venous thromboembolism during the 6-month treatment period occurred in nine of 386 patients (2.3%) in the idrabiotaparinux group and in 12 of 371 patients (3.2%) in the idraparinux group, a difference of - 0.9% (95% confidence interval, -3.2-1.4%). The incidence of clinically relevant bleeding was 5.2% in the idrabiotaparinux group and 7.3% in the idraparinux group (P = 0.29), a difference of - 2.1% (95% confidence interval, -5.6-1.4%). Six patients (1.6%) who received idrabiotaparinux died, compared with 12 patients (3.2%) given idraparinux, a difference of - 1.7% (95% confidence interval, -3.9-0.5%).Idrabiotaparinux has a similar time course of FXa inhibition, efficacy and safety to idraparinux for the treatment of deep venous thrombosis.? 2010 International Society on Thrombosis and Haemostasis.

Published
2011
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26. [Expert consensus document on the use of antiplatelet agents]

Author

Patrono, C., Bachmann, F., Baigent, C., Bode, C., Caterina, R. de, Charbonnier, B., Fitzgerald, D., Hirsh, J., Husted, S., Kvasnicka, J., Montalescot, G., Garcia Rodriguez, L.A., Verheugt, F.W.A., Vermylen, J., and Wallentin, L.

Subjects
Cardiovascular diseases [NCEBP 14], Heart, lung and circulation [UMCN 2.1]
Abstract

Item does not contain fulltext 01 oktober 2004

Published
2004
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27. Single-bolus tenecteplase plus heparin compared with heparin alone for normotensive patients with acute pulmonary embolism who have evidence of right ventricular dysfunction and myocardial injury: rationale and design of the Pulmonary Embolism Thrombolysis (PEITHO) trial

Author

Konstantinides SV, Meyer G, Lang I, Verschuren F, Meneveau N, Charbonnier B, Bouvaist H, Geibel A, Beyer Westendorf J, Dellas C, Empen K, Kupatt C, Giancarlo, Becattini C, Salvi A, Pruszczyk P, Torbicki A, Franca A, Lohmann C, Kozak M, Jiménez D, Kucher N, Goldhaber SZ, Danays T, Bluhmki E, Gallula P., GALIE', NAZZARENO, Konstantinides SV, Meyer G, Lang I, Verschuren F, Meneveau N, Charbonnier B, Bouvaist H, Geibel A, Beyer-Westendorf J, Dellas C, Empen K, Kupatt C, Galiè N, Giancarlo, Becattini C, Salvi A, Pruszczyk P, Torbicki A, Franca A, Lohmann C, Kozak M, Jiménez D, Kucher N, Goldhaber SZ, Danays T, Bluhmki E, and Gallula P.

Subjects
Heparin, Patient Selection, Ventricular Dysfunction, Right, Myocardial Infarction, Blood Pressure, Pulmonary Embolism Thrombolysi, Treatment Outcome, Fibrinolytic Agents, Research Design, Tissue Plasminogen Activator, Injections, Intravenous, Tenecteplase, Humans, Cardiology and Cardiovascular Medicine, Pulmonary Embolism, CLINICAL TRIALS
Abstract

Background: In acute pulmonary embolism (PE), overt right ventricular (RV) failure with cardiogenic shock indicates a poor prognosis. However, normotensive patients with acute RV dysfunction on echocardiography or computed tomography and with myocardial troponin elevation may also have an adverse outcome. Thrombolysis rapidly reverses RV pressure overload in PE, but it remains unclear whether it may improve the early and long-term clinical outcome of selected normotensive patients. Design: The Pulmonary EmbolIsm THrOmbolysis (PEITHO) trial is a prospective, multicenter, international, randomized (1:1), double-blind comparison of thrombolysis with tenecteplase vs placebo in normotensive patients with confirmed PE, an abnormal right ventricle on echocardiography or computed tomography, and a positive troponin I or T test result. Both treatment groups receive standard anticoagulation. The primary efficacy outcome is the composite of death from any cause or hemodynamic collapse within 7 days of randomization. Safety outcomes include ischemic/hemorrhagic strokes and other major bleeding episodes. In addition, 180-day clinical and echocardiographic follow-up will be performed. The study is expected to enroll approximately 1,000 patients. Conclusions: By determining the benefits vs risks of thrombolysis in submassive or intermediate-risk PE, this trial is expected to answer a long-standing query on the management of this patient population

Published
2011

31. Reflective silicon Mach Zender modulator with Faraday rotator mirror effect for self-coherent and self-polarization-aligned transmission

Author

Menezo, S., Charbonnier, B., Beninca De Farias, G., Grosse, P., Myko, A., Thomson, D.J., Reed, G.T., Lebreton, A, Fedeli, J.M., and Ben Bakir, B.

Abstract

An all-Silicon Reflective Mach Zehnder Modulator (Si-R-MZM) is proposed, providing the Faraday Rotator Mirror effect for achieving simple coherent demodulation. The Si-R-MZM is analytically described and measurements are made to assess the transmission performances.

Published
2013

32. Enoxaparin followed by once-weekly idrabiotaparinux versus enoxaparin plus warfarin for patients with acute symptomatic pulmonary embolism: a randomised, double-blind, double-dummy, non-inferiority trial

Author

Büller, Hr, Gallus, As, Prins, Mh, Raskob, G, Decousus, H, Charbonnier, B, Leizorovicz, A, Laporte, S, Quenet, S, Brandjes, Dp, Middeldorp, S, Blüguermann, J, Amuchastegui, L, Ahuad Guerrero, R, Oberti, P, Alvarez, C, Cassettari, A, Santos, D, Macin, S, Santini, F, Ward, C, Coughlin, P, Salem, H, Gan, E, Leyden, M, Prosser, I, Crispin, P, Carroll, P, Gallus, A, Mcrae, S, Waites, J, Pilger, E, Koppensteiner, R, Kyrle, P, Schinko, H, Mrochek, A, Mitkovskaya, N, Prystrom, A, Motte, S, Ninane, V, Delcroix, M, Hainaut, P, Schneider, E, Saraiva, J, Maia, L, Barreto, S, Fernandes Manenti, E, Araujo, G, Dutra, O, Fiss, E, Moreira, R, Yankov, K, Nenkova, S, Ivanov, Y, Kostov, V, Bhargava, R, Chan, Y, Miron, Mj, Cusson, J, Ugarte, S, Morales, A, Andresen, M, Lanas, F, Arriagada, G, Mendoza, Jj, Zuñiga, C, Sepulveda, P, Wang, C, Liu, Z, Yuan, Y, Ma, Z, Fang, B, Liu, J, Bai, C, Wu, H, Yang, L, Ying, K, Kang, J, Li, Q, Cheng, Z, Zhang, J, Wang, H, Xie, C, Xia, G, Du, Y, Wu, Q, Zhou, X, Chen, L, Yi, Q, Wu, C, Hao, Q, Liu, S, Xiong, S, Jiang, S, Zhao, L, Xiao, Q, Qin, Z, Zhou, J, Dennis, R, Miserque, N, Igueredo, M, Londoño, D, Hildebrando, J, Granados, M, Buitrago, R, Solano, Mh, Pacheco Alvis PM, Botero, R, Saenz, O, Bergovec, M, Padovan, M, Vucic, N, Samarzija, M, Chlumsky, J, Spacek, R, Klimsa, Z, Gregor, P, Povolny, J, Podpera, I, Holm, F, Lang, P, Matoska, P, Sabl, P, Spinar, J, Spac, J, Husted, S, Avnstrom, S, Rasmussen, S, Christensen, A, Guindy, R, Hassanein, M, Paumets, M, Meriste, S, Ferrari, E, Achkar, A, Azarian, R, Meneveau, N, Lorut, C, Mouallem, J, Crestani, B, Proton, A, Salmeron, S, Lerousseau, L, Mottier, D, Wahl, D, Siafakas, N, Papadimitriou, D, Katis, K, Katsaris, G, Gaga, A, Damianos, A, Tipparaju, S, Kalkunte, S, Vidhut, J, Kalashetti, S, Mehta, P, Talwar, D, Ramanathan, R, Mishra, R, Zeltzer, D, Lahav, M, Brenner, B, Caraco, Y, Elias, M, Piovella, F, Barone, M, Poggio, R, Palla, A, Ghirarduzzi, A, Pini, M, Lodigiani, C, Prandoni, Paolo, Agnelli, G, Imberti, D, Scannapieco, G, Salvi, A, Bautista, E, Diaz, J, Mercado, R, Ranero, A, Rodriguez, D, Jerjes, C, Villeda Espinoza, E, Van Der Meer, J, Ijfering, W, Van Marwijk Kooy, M, Boersma, W, Van Leendert, R, Kroon, C, Dullemond Westland, A, Viergever, P, Kuipers, A, Grootenboers, M, Creemers, J, Pieters, W, De Munck, D, Timmer, H, Jackson, S, Sandset, P, Meyer, P, Kristiansen, T, Portugal, J, Paz, E, Salazar, D, Chavez, W, Castillo, L, De Guia, T, Lenora, F, Tomkowski, W, Kloczko, J, Rybak, Z, Gaciong, Z, Sobkowicz, B, Pruszczyk, P, Nizankowski, R, Mirek Bryniarska, E, Kukla, P, Reis, A, França, A, Cortez, M, Sa, J, Santos, F, Marques, Ma, Gordeev, I, Gendlin, G, Yablonsky, P, Sokurenko, G, Soroka, V, Lusov, V, Markov, V, Shvats, Y, Katerlnitskiy, I, Lapin, O, Lyamina, N, Subbotin, Y, Kim, I, Zilber, E, Kchaisheva, L, Poliacik, P, Macek, V, Pretorius, Jp, Abdullah, I, Basson, M, Bollinger, C, Breedt, J, Gani, M, Jansen, J, Le Roux, G, Nortje, H, Van Der Linder, M, Van Zyl, L, Viljoen, J, Bruning, A, Pujol Farriols, R, Raguer, E, Nuffal, D, Sanchez Rodriguez, A, Eriksson, H, Almgren, T, Carlsson, A, Elf, J, Olsson, Cg, Aagesen, J, Savas, I, Sahin, A, Erdogan, Y, Ozhan, M, Ongen, G, Celikel, T, Turker, H, Arseven, O, Tuncay, E, Ozacar, R, Gudz, I, Nykonenko, O, Skupyy, O, Kovalskyy, I, Prasol, V, Cohen, A, Rodriguez Cintron, W, Gurka, D, Bradley, J, Oliver, G, Spyropoulos, A, Lerner, R, Fulmer, J, Lu, Np, Wright, P, Han, D, Servi, R, Nadar, V, Quaranta, A, Gehring, J, Ginsberg, R, Jacobson, A, Colan, D, Vanway, C, Gurza, E, Braslow, B, Shorr, A, Rehm, J, Martin, J, Sellers, M, Concha, M, Gordon, I, Pullman, J, Moran, J, Welker, J, Panzarella, P, Mullins, M, Willms, D, Mcgrew, F, Turki, M, Menajovsky, L., Epidemiologie, MUMC+: KIO Kemta (9), RS: CAPHRI School for Public Health and Primary Care, Amsterdam Cardiovascular Sciences, Vascular Medicine, Department of Vascular Medicine (DVM - AMC), Academic Medical Center - Academisch Medisch Centrum [Amsterdam] (AMC), University of Amsterdam [Amsterdam] (UvA)-University of Amsterdam [Amsterdam] (UvA), SA Pathology at Flinders Medical Center (ASG), Flinders University, Department of Epidemiology (MHP), Maastricht University [Maastricht], College of Public Health (CPH), University of Oklahoma (OU), Centre d'Investigation Clinique (CIC - Brest), Université de Brest (UBO)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groupe d'Etude de la Thrombose de Bretagne Occidentale (GETBO), Université de Brest (UBO)-Institut Brestois Santé Agro Matière (IBSAM), and Université de Brest (UBO)-Université de Brest (UBO)

Subjects
Male, MESH: Pulmonary Embolism, Oligosaccharides, MESH: Factor X, 030204 cardiovascular system & hematology, MESH: Intention to Treat Analysis, MESH: Aged, 80 and over, 0302 clinical medicine, MESH: Double-Blind Method, 030212 general & internal medicine, MESH: Warfarin, Aged, 80 and over, MESH: Aged, education.field_of_study, Idrabiotaparinux, MESH: Middle Aged, General Medicine, Heparin, Middle Aged, Intention to Treat Analysis, 3. Good health, Pulmonary embolism, Acute Disease, MESH: Acute Disease, Drug Therapy, Combination, Female, medicine.drug, Adult, medicine.medical_specialty, MESH: Enoxaparin, Adolescent, Population, Biotin, MESH: Anticoagulants, Double blind, 03 medical and health sciences, Double-Blind Method, Internal medicine, MESH: Biotin, medicine, Humans, Enoxaparin, education, Aged, MESH: Adolescent, MESH: Humans, Intention-to-treat analysis, business.industry, Warfarin, Anticoagulants, MESH: Adult, Odds ratio, medicine.disease, MESH: Male, Surgery, MESH: Drug Therapy, Combination, Factor X, Pulmonary Embolism, business, MESH: Female, MESH: Oligosaccharides, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; BACKGROUND: Treatment of pulmonary embolism with low-molecular-weight heparin and vitamin K antagonists, such as warfarin, is not ideal. We aimed to assess non-inferiority of idrabiotaparinux, a reversible longlasting indirect inhibitor of activated factor X, to warfarin in patients with acute symptomatic pulmonary embolism. METHODS: In our randomised, double-blind, double-dummy, non-inferiority trial, we enrolled adults with objectively documented acute symptomatic pulmonary embolism attending 291 centres in 37 countries. We excluded patients who were pregnant, had active bleeding, kidney failure, or malignant hypertension, or were at high risk of death, bleeding, or adverse reactions to study drugs. We randomly allocated patients to receive 5-10 days' enoxaparin 1*0 mg/kg twice daily followed by subcutaneous idrabiotaparinux (starting dose 3*0 mg) or adjusted-dose warfarin (target international normalised ratio 2*0-3*0); regimens lasted 3 months or 6 months dependent on clinical presentation. Block randomisation was done with a central interactive computerised system, stratified by study centre and intended treatment duration. The primary efficacy outcome was recurrent venous thromboembolism at 99 days after randomisation. We estimated the odds ratio and 95% CI with a Mantel-Haenzsel χ(2) analysis (non-inferiority margin 2*0) in the intention-to-treat population. The main safety outcome was clinically relevant bleeding (major or non-major) in all patients at day 99. This study is registered with ClinicalTrials.gov, number NCT00345618. FINDINGS: Between Aug 1, 2006, and Jan 31, 2010, we enrolled 3202 patients aged 18-96 years. 34 (2%) of 1599 patients randomly allocated to receive enoxaparin-idrabiotaparinux and 43 (3%) of 1603 patients randomly allocated to receive enoxaparin-warfarin had recurrent venous thromboembolism (odds ratio 0*79, 95% CI 0*50-1*25; p(non-inferiority)=0*0001). 72 (5%) of 1599 patients in the enoxaparin-idrabiotaparinux group and 106 (7%) of 1603 patients in the enoxaparin-warfarin group had clinically relevant bleeding (0*67, 0*49-0*91; p(superiority)=0*0098). We noted similar differences in outcomes in those patients treated to 6 months. INTERPRETATION: Idrabiotaparinux could provide an attractive alternative to warfarin for the long-term treatment of pulmonary embolism, and seems to be associated with reduced bleeding. FUNDING: Sanofi-Aventis (Paris, France).

Published
2012
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33. POF - beyond today home networking concepts and performance. A comparison of technologies for the future optical home network

Author

Faller, J. F., Nakamura, K., Koonen, A. M.J., Charbonnier, B., Larsen, C. P., Ortego, E., Popov, M., and Electro-Optical Communication

Subjects
Infrastructure, Business cases, Integrated network, Home network, All-IP, Technology comparison, System architecture
Abstract

For the future of new digital services the home network infrastructure and its management is one of the big challenges for all players in the values chain. The challenge concerns business cases, system installation and architecture as well as the operation and management of the home network, related services and applications. The optical in-home backbone with POF is offering innovative new possibilities and solutions. It shows significant advantages compared with other existing home network technologies. The optical in-home backbone has the potential to revolutionize the electrical and home network installation of the future. It opens the "One Network for All" concept to make the optical home network a standard infrastructure in the future home. It offers high flexible and reliable service integration, low cost basic installation and significant technical advantages for All-IP traffic and mixed signal architecture between optical and wireless.

Published
2011

34. Interventricular delay measurement using equilibrium radionuclide angiography before resynchronization therapy should be performed outside the area of segmental wall motion abnormalities

Author

Danchin, N., Fauchier, Laurent, Marijon, E., Barnay, C., Furber, A., Mabo, P., Bernard, P., Blanc, J.-J., Jouven, X., Le Heuzey, J.-Y., Charbonnier, B., Ferrieres, J., Simon, T., Courtehoux, Maxime, Zannad, Noura, Babuty, Dominique, Eder, Veronique, Paris-Centre de Recherche Cardiovasculaire (PARCC - UMR-S U970), Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Clinique Pasteur et Groupe Rythmologie Stimulation Cardiaque/SFC, Clinique Pasteur [Toulouse], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), CIC-IT Rennes, Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), EDF (EDF), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Dpt Cardiologie [CHU Georges Pompidou], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Orange Labs [Lannion], France Télécom, Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT), Centre hospitalier régional Metz-Thionville (CHR Metz-Thionville), Laboratoire de physiopathologie de la paroi artérielle, and Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
musculoskeletal diseases, Male, medicine.medical_specialty, medicine.medical_treatment, Heart Ventricles, Movement, Cardiomyopathy, Cardiac resynchronization therapy, [SHS]Humanities and Social Sciences, Cardiac Resynchronization Therapy, QRS complex, Radionuclide angiography, Internal medicine, medicine, Segmental wall motion, Humans, Radiology, Nuclear Medicine and imaging, In patient, cardiovascular diseases, Aged, Heart Failure, Ejection fraction, medicine.diagnostic_test, business.industry, Gated Blood-Pool Imaging, Stroke Volume, General Medicine, musculoskeletal system, medicine.disease, Biomechanical Phenomena, medicine.anatomical_structure, Treatment Outcome, Ventricle, cardiovascular system, Cardiology, Female, Nuclear medicine, business, circulatory and respiratory physiology
Abstract

The aim of this study was to demonstrate that only mechanical dyssynchrony outside the area of segmental wall motion abnormalities (WMA) can be reduced by cardiac resynchronization therapy (CRT). Included in the study were 28 consecutive patients with nonischaemic cardiomyopathy selected for CRT. Equilibrium radionuclide angiography (ERNA) was carried out before and after implantation of a multisite pacemaker. Patients were separated into two groups depending on the presence or absence of segmental WMA. A reduction in QRS duration was observed in all patients after CRT. The interventricular delay (IVD) decreased significantly after CRT only in patients without WMA (homogeneous contraction, HG group; IVD 44 ± 11.4° vs. 17 ± 3.1°, p = 0.04). In contrast, no significant decrease was observed in patients with WMA (WMA group; IVD 51 ± 6° vs. 38 ± 6°, p NS). However, when dyssynchrony was considered outside the WMA area, a significant reduction in IVD was obtained, in the same range as in the HG group (IVD 32 ± 3° vs. 19 ± 3°, p = 0.04). In 9 of 15 patients (60%) with a reduction in IVD after CRT, the left ventricle ejection fraction (LVEF) increased by about +10%. In contrast, in 13 of 13 patients (100%) with no reduction in IVD, no modification of LVEF was obtained. In the presence of segmental WMA without significant delays outside the WMA area, no reduction in IVD was observed and LVEF did not increase (IVD 34 ± 5° before CRT vs. 37 ± 7° after CRT; LVEF 19 ± 4% before CRT vs. 22 ± 3% after CRT, p NS). ERNA can be used to predict good mechanical resychronization (decrease in IVD) in patients after pacing. IVD has to be determined excluding the area of WMA in order to select patients who will show an increase in their left ventricle function after CRT.

Published
2011
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35. Optical home network based on an N×N multimode fiber architecture and CWDM technology

Author

Richard, F., Guignard, P., Pizzinat, A., Guillo, L., Guillory, J., Charbonnier, B., Ton Koonen, Ortego Martinez, E., Tanguy, E., Li, H. W., and Electro-Optical Communication

Abstract

With this optical home network solution associating an N×N multimode architecture and CWDM technology, various applications and network topologies are supported by a unique multiformat infrastructure. Issues related to the use of MMF are discussed.

Published
2011

38. Low Cost Transparent Radio-over-Fiber System for In-Building Distribution of UWB Signals IEEE/OSA

Author

Le Guennec, Yannis, Pizzinat, A., Meyer, S., Charbonnier, B., Lombard, P., Lourdiane, Mounia, Cabon, B., Algani, C., Billabert, A.-L., Terré, M., Rumelhard, C., Polleux, J.-L., Jacquinot, H., Bories, S., Sillans, C., Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2009

42. Low Cost Transparent Radio-over-Fibre System for UWB Based Home Network

Author

Pizzinat, A., Louriki, I., Charbonnier, B., Meyer, S., Sillans, C., Jaquinot, H., Bories, S., Terré, M., Algani, C., Billabert, A.L., Le Guennec, Yannis, Lombard, P., Froc, G., Institut de Microélectronique, Electromagnétisme et Photonique - Laboratoire d'Hyperfréquences et Caractérisation (IMEP-LAHC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National Polytechnique de Grenoble (INPG)-Centre National de la Recherche Scientifique (CNRS), and Domenget, Chahla

Subjects
[SPI.ELEC]Engineering Sciences [physics]/Electromagnetism, [SPI.ELEC] Engineering Sciences [physics]/Electromagnetism, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2008

44. Comparison of Thrombolysis Followed by Broad Use of Percutaneous Coronary Intervention With Primary Percutaneous Coronary Intervention for ST-Segment-Elevation Acute Myocardial Infarction

Author

Danchin, N., Coste, P., Ferrières, J., Steg, P.-G., Cottin, Y., Blanchard, Dominique, Belle, L., Ritz, B., Kirkorian, G., Angioi, M., Sans, P., Charbonnier, B., Eltchaninoff, H., Guéret, P., Khalife, K., Asseman, P., Puel, J., Goldstein, P., Cambou, J.-P., Simon, Tabassome, Evaluation et modélisation des effets thérapeutiques, Département biostatistiques et modélisation pour la santé et l'environnement [LBBE], Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE), and Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
Published
2008

45. [Effects of delay in onset of revascularisation strategies in the acute phase of myocardial infarction]

Author

de Labriolle, A, Pacouret, G, Bertrand, P, Barbey, C, Magdelaine, B, Desveaux, B, Quilliet, L, Fauchier, Laurent, Charbonnier, B, and Dorogoichenko, Aleksandra

Subjects
[SHS] Humanities and Social Sciences
Abstract

thrombolysis (THL) and primary percutaneous coronary intervention (PCI) are therapeutic options in acute myocardial infarction (MI). These strategies have similar efficiency, particularly in the early phase. However, in these randomized studies, different times to treatment (TT) threshold are recognized as discriminant.

Published
2006

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