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1. Prompt gamma energy integration: a new method for online-range verification in proton therapy with pulsed-beams

Author

Pierre Everaere, Denis Dauvergne, Marie-Laure Gallin-Martel, Joël Hérault, Ayoub Koudia, Charbel Koumeir, Jean Michel Létang, and Étienne Testa

Subjects
prompt-gamma, particle therapy, range verification, Monte Carlo simulations, integral method, Physics, QC1-999
Abstract

Introduction: We propose a method for prompt-gamma verification of proton range during particle therapy, called Prompt-Gamma Energy Integration (PGEI).Method: This method is based on the measurement of the total energy deposited in a set of detectors located around a patient. It is particularly suited in the case of high-instantaneous beam intensities, like for pulsed beams extracted from a synchro-cyclotron. GATE simuations were used to evaluate the sensitivity, and dedicated scintillators were tested as a function of beam intensity.Results and discussion: Simulations show that millimetric range shifts can be measured at a beam-spot scale. The sensitivity is slightly degraded as compared to the Prompt-Gamma Peak Integration Method, for which Time-of-Flight can be employed to reduce the background in single-photon detection conditions at cyclotron accelerators. Experimentally, lead tungstate scintillators have shown to cope with the high instantaneous gamma count rates for PGEI at synchro-cyclotrons.

Published
2024
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2. Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos

Author

Gaëlle Saade, Eva Bogaerts, Sophie Chiavassa, PhD, Guillaume Blain, Grégory Delpon, PhD, Manon Evin, Youssef Ghannam, Ferid Haddad, PhD, Karin Haustermans, MD, PhD, Charbel Koumeir, PhD, Ellina Macaeva, PhD, Lydia Maigne, PhD, Quentin Mouchard, PhD, Noël Servagent, PhD, Edmond Sterpin, PhD, Stéphane Supiot, MD, PhD, and Vincent Potiron, PhD

Subjects
Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Purpose: Recently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. Extensive work is on the way to characterize the physical and biological parameters that control the so-called “Flash” effect. However, this healthy/tumor differential effect is observable in in vivo models, which thereby drastically limits the amount of work that is achievable in a timely manner. Methods and Materials: In this study, zebrafish embryos were used to compare the effect of UHDR irradiation (8-9 kGy/s) to conventional RT dose rate (0.2 Gy/s) with a 68 MeV proton beam. Viability, body length, spine curvature, and pericardial edema were measured 4 days postirradiation. Results: We show that body length is significantly greater after UHDR-RT compared with conventional RT by 180 µm at 30 Gy and 90 µm at 40 Gy, while pericardial edema is only reduced at 30 Gy. No differences were obtained in terms of survival or spine curvature. Conclusions: Zebrafish embryo length appears as a robust endpoint, and we anticipate that this model will substantially fasten the study of UHDR proton-beam parameters necessary for “Flash.”

Published
2023
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3. Microdosimetry and radiolytic species production in UHDR proton beam using GATE and Geant4-DNA

Author

Giovanna Rosa Fois, Guillaume Blain, Sophie Chiavassa, Grégory Delpon, Manon Evin, Vincent Fiegel, Mohammad Ghalei, Ferid Haddad, Incerti, S., Charbel Koumeir, Vincent Métivier, Quentin Mouchard, Freddy Poirier, Vincent Potiron, Noël Servagent, Stéphane Supiot, Hoang Ngoc Tran, Johan Vandenborre, Lydia Maigne, Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de Physique des Deux Infinis Bordeaux (LP2I - Bordeaux), Université de Bordeaux (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1 (UB)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Financial support from Inserm Cancer (PCSI FLASHMOD), Giovanni Mettivier, Sébastien Incerti, Jeremy Brown, Susanna Guatelli, Paolo Russo, Antonio Sarno, Daniele Esposito, Gianfranco Paternò, Silvio Pardi, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
UHDR proton beam, Geant4-DNA, GATE, Microdosimetry, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], radiolytic species, [INFO.INFO-MO]Computer Science [cs]/Modeling and Simulation, [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2022

4. Ultrahigh-Dose-Rate Proton Irradiation Elicits Reduced Toxicity in Zebrafish Embryos

Author

Gaëlle Saade, Eva Bogaerts, Sophie Chiavassa, Guillaume Blain, Grégory Delpon, Manon Evin, Youssef Ghannam, Ferid Haddad, Karin Haustermans, Charbel Koumeir, Ellina Macaeva, Lydia Maigne, Quentin Mouchard, Noël Servagent, Edmond Sterpin, Stéphane Supiot, Vincent Potiron, Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Department of Oncology [Leuven, Belgium], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, GIP ARRONAX [Nantes], Université de Nantes (UN), University Hospitals Leuven [Leuven], Institut de Recherche Expérimentale et Clinique (IREC), Université Catholique de Louvain = Catholic University of Louvain (UCL), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), This work was supported by Inserm Cancer, the Ligue Contre le Cancer, IRC Transformed, Institut de Cancérologie de l’Ouest, the Stichting Tegen Kanker (STK) grant ZKD6219, and the Walloon region EPT grant D7.21214.014-P., FLASHMOD, and UCL - SSS/IREC/MIRO - Pôle d'imagerie moléculaire, radiothérapie et oncologie

Subjects
Oncology, [SDV]Life Sciences [q-bio], [SDV.CAN]Life Sciences [q-bio]/Cancer, Radiology, Nuclear Medicine and imaging, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience; PurposeRecently, ultrahigh-dose-rate radiation therapy (UHDR-RT) has emerged as a promising strategy to increase the benefit/risk ratio of external RT. Extensive work is on the way to characterize the physical and biological parameters that control the so-called “Flash” effect. However, this healthy/tumor differential effect is observable in in vivo models, which thereby drastically limits the amount of work that is achievable in a timely manner.Methods and MaterialsIn this study, zebrafish embryos were used to compare the effect of UHDR irradiation (8-9 kGy/s) to conventional RT dose rate (0.2 Gy/s) with a 68 MeV proton beam. Viability, body length, spine curvature, and pericardial edema were measured 4 days postirradiation.ResultsWe show that body length is significantly greater after UHDR-RT compared with conventional RT by 180 µm at 30 Gy and 90 µm at 40 Gy, while pericardial edema is only reduced at 30 Gy. No differences were obtained in terms of survival or spine curvature.ConclusionsZebrafish embryo length appears as a robust endpoint, and we anticipate that this model will substantially fasten the study of UHDR proton-beam parameters necessary for “Flash.”

Published
2022
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5. Hydrogen peroxide formation to investigate the radiolytic ROS production mechanism under proton FLASH conditions

Author

Vincent Fiegel, Guillaume Blain, Manon Evin, Quentin Mouchard, Charbel Koumeir, Noël Servagent, Mohammad Ghalei, Giovanna Rosa Fois, Vincent Métivier, Freddy Poirier, Vincent Potiron, Stéphane Supiot, Ferid Haddad, Grégory Delpon, Sophie Chiavassa, Johan Vandenborre, Lydia Maigne, Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, GIP ARRONAX [Nantes], Université de Nantes (UN), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Unité en Sciences Biologiques et Biotechnologies de Nantes (US2B), Centre National de la Recherche Scientifique (CNRS)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Financial support from Inserm Cancer (PCSI FLASHMOD), GdR MI2B, FLASHMOD, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
FLASHMOD project, Ultra-High Dose Rate, FLASH conditions, [SDV.CAN]Life Sciences [q-bio]/Cancer, ARRONAX cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience

Published
2022

6. Proton Irradiations at Ultra-High Dose Rate vs. Conventional Dose Rate: Strong Impact on Hydrogen Peroxide Yield

Author

Guillaume Blain, Johan Vandenborre, Daphnée Villoing, Vincent Fiegel, Giovanna Rosa Fois, Ferid Haddad, Charbel Koumeir, Lydia Maigne, Vincent Métivier, Freddy Poirier, Vincent Potiron, Stéphane Supiot, Noël Servagent, Grégory Delpon, Sophie Chiavassa, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Laboratoire de Physique de Clermont (LPC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), and ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016)

Subjects
Radiation, Radiochemistry, Hydroxyl Radical, Biophysics, Water, Radiology, Nuclear Medicine and imaging, Hydrogen Peroxide, Protons, [CHIM.RADIO]Chemical Sciences/Radiochemistry
Abstract

International audience; During ultra-high dose rate (UHDR) external radiation therapy, healthy tissues appear to be spared while tumor control remains the same compared to conventional dose rate. However, the understanding of radiochemical and biological mechanisms involved are still to be discussed. This study shows how the hydrogen peroxide (H2O2) production, one of the reactive oxygen species (ROS), could be controlled by early heterogenous radiolysis processes in water during UHDR proton-beam irradiations. Pure water was irradiated in the plateau region (track-segment) with 68 MeV protons under conventional (0.2 Gy/s) and several UHDR conditions (40 Gy/s to 60 kGy/s) at the ARRONAX cyclotron. Production of H2O2 was then monitored using the Ghormley triiodide method. New values of GTS(H2O2) were added in conventional dose rate. A substantial decrease in H2O2 production was observed from 0.2 to 1.5 kGy/s with a more dramatic decrease below 100 Gy/s. At higher dose rate, up to 60 kGy/s, the H2O2 production stayed stable with a mean decrease of 38% ± 4%. This finding, associated to the decrease in the production of hydroxyl radical (•OH) already observed in other studies in similar conditions can be explained by the well-known spur theory in radiation chemistry. Thus, a two-step FLASH-RT mechanism can be envisioned: an early step at the microsecond scale mainly controlled by heterogenous radiolysis, and a second, slower, dominated by O2 depletion and biochemical processes. To validate this hypothesis, more measurements of radiolytic species will soon be performed, including radicals and associated lifetimes.

Published
2022
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9. Technical note: Proton beam dosimetry at ultra-high dose rates (FLASH): Evaluation of GAFchromic™ (EBT3, EBT-XD) and OrthoChromic (OC-1) film performances

Author

Daphnée Villoing, Charbel Koumeir, Arthur Bongrand, Arnaud Guertin, Ferid Haddad, Vincent Métivier, Freddy Poirier, Vincent Potiron, Noël Servagent, Stéphane Supiot, Grégory Delpon, and Sophie Chiavassa

Subjects
Film Dosimetry, Calibration, Proton Therapy, General Medicine, Protons, Radiometry
Abstract

The ARRONAX cyclotron facility offers the possibility to deliver proton beams from low to ultra-high dose rates (UHDR). As a good control of the dosimetry is a prerequisite of UHDR experimentations, we evaluated in different conditions the usability and the dose rate dependency of several radiochromic films commonly used for dosimetry in radiotherapy.We compared the dose rate dependency of three types of radiochromic films: GAFchromic™ EBT3 and GAFchromic™ EBT-XD (Ashland Inc., Wayne, NJ, USA), and OrthoChromic OC-1 (OrthoChrome Inc., Hillsborough, NJ, USA), after proton irradiations at various mean dose rates (0.25, 40, 1500, and 7500 Gy/s) and for 10 doses (2-130 Gy). We also evaluated the dose rate dependency of each film considering beam structures, from single pulse to multiple pulses with various frequencies.EBT3 and EBT-XD films showed differences of response between conventional (0.25 Gy/s) and UHDR (7500 Gy/s) conditions, above 10 Gy. On the contrary, OC-1 films did not present overall difference of response for doses except below 3 Gy. We observed an increase of the netOD with the mean dose rate for EBT3 and EBT-XD films. OC-1 films did not show any impact of the mean dose rate up to 7500 Gy/s, above 3 Gy. No difference was found based on the beam structure, for all three types of films.EBT3 and EBT-XD radiochromic films should be used with caution for the dosimetry of UHDR proton beams over 10 Gy. Their overresponse, which increases with mean dose rate and dose, could lead to non-negligible overestimations of the absolute dose. OC-1 films are dose rate independent up to 7500 Gy/s in proton beams. Films response is not impacted by the beam structure. A broader investigation of the usability of OC-1 films in UHDR conditions should be conducted at intermediate and higher mean dose rates and other beam energies.

Published
2021

10. A Monte Carlo Determination of Dose and Range Uncertainties for Preclinical Studies with a Proton Beam

Author

Daphnée Villoing, Sophie Chiavassa, Arthur Bongrand, Arnaud Guertin, Gregory Delpon, Vincent Potiron, Stéphane Supiot, Ferid Haddad, Noël Servagent, Charbel Koumeir, Freddy Poirier, Vincent Métivier, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), and Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)

Subjects
[PHYS]Physics [physics], Cancer Research, Range (particle radiation), Materials science, Proton, Nuclear engineering, Monte Carlo method, Context (language use), dose calculation, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Tumor response, lcsh:RC254-282, Article, 030218 nuclear medicine & medical imaging, radiation dosimetry, 03 medical and health sciences, 0302 clinical medicine, Oncology, 030220 oncology & carcinogenesis, Absorbed dose, proton therapy, preclinical studies, Proton therapy, Beam (structure), Monte Carlo simulation
Abstract

Simple Summary If reference studies can be found on the uncertainties linked to the clinical context of proton therapy, they, although equally critical, are very patchy in a preclinical context, and are specific to each beam line. This work provides the community with a complete assessment of the sources of uncertainties for a preclinical proton beam line. This aims to ensure that, in this line, the biological results observed and the dose–response relationships are obtained without any bias. Despite being specific to a preclinical line, the results presented here can be transposed to other types of proton preclinical facilities, and thus allow us to effectively compare them to one another. Abstract Proton therapy (PRT) is an irradiation technique that aims at limiting normal tissue damage while maintaining the tumor response. To study its specificities, the ARRONAX cyclotron is currently developing a preclinical structure compatible with biological experiments. A prerequisite is to identify and control uncertainties on the ARRONAX beamline, which can lead to significant biases in the observed biological results and dose–response relationships, as for any facility. This paper summarizes and quantifies the impact of uncertainty on proton range, absorbed dose, and dose homogeneity in a preclinical context of cell or small animal irradiation on the Bragg curve, using Monte Carlo simulations. All possible sources of uncertainty were investigated and discussed independently. Those with a significant impact were identified, and protocols were established to reduce their consequences. Overall, the uncertainties evaluated were similar to those from clinical practice and are considered compatible with the performance of radiobiological experiments, as well as the study of dose–response relationships on this proton beam. Another conclusion of this study is that Monte Carlo simulations can be used to help build preclinical lines in other setups.

Published
2021
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11. Bremsstrahlung X-rays as a non-invasive tool for ion beam monitoring

Author

Quentin Mouchard, Noël Servagent, Ferid Haddad, Arnaud Guertin, Vincent Métivier, F. Ralite, Charbel Koumeir, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Cyclotron ARRONAX, and GIP

Subjects
Nuclear and High Energy Physics, Materials science, Ion beam, Astrophysics::High Energy Astrophysical Phenomena, Physics::Medical Physics, Ion beam monitoring, Signal, 030218 nuclear medicine & medical imaging, Ion, 03 medical and health sciences, 0302 clinical medicine, Optics, Dosimetry, X-rays, Irradiation, Nuclear Experiment, Instrumentation, [PHYS]Physics [physics], business.industry, Non invasive, Bremsstrahlung, Radiobiology, Bremssstrahlung, 030220 oncology & carcinogenesis, Physics::Accelerator Physics, business, Sensitivity (electronics), Beam (structure)
Abstract

International audience; Non-invasive beam monitoring tools are required to guarantee the delivered dose during ion irradiation. Measuring bremsstrahlung X-rays emitted directly from the irradiated medium is a promising approach. This work presents the feasibility of the method for different incident particles with different energies. A PMMA target was bombarded with helium ions of 68 MeV and protons beams of 30, 40, and 50 MeV. The bremsstrahlung signal, measured with a SDD, was in the magnitude of 10 4 X-rays/nC, indicating the significant sensitivity of the method. A good agreement was found (

Published
2021
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12. Experimental study of the influence of the CdZnTe substrate thickness on the response of infrared HgCdTe photodetectors under proton irradiation

Author

Olivier Gravrand, Salima Mouzali, G. Badano, Patrick Mulet, Olivier Limousin, Simone De Camillis, Charbel Koumeir, Thibault Pichon, Olivier Boulade, and Jean-Louis Santailler

Subjects
Materials science, Proton, business.industry, Infrared, Detector, Optoelectronics, Photodetector, Substrate (electronics), Irradiation, Radiation, business, Layer (electronics)
Abstract

Experimental study of the influence of the CdZnTe substrate thickness on the response of IR detectors under irradiation has been performed. Two detectors, with different substrate thickness 800 μm and 50 μm, were submitted to low flux 62 MeV proton irradiation.Images acquired under irradiation were analyzed. Whereas the detector with 800 μm substrate thickness has shown background signal increase under irradiation, the detector with the substrate partially removed has not shown any background signal elevation. The elevation of the background signal under irradiation in the detector with intact substrate is attributed to the large extension of one transient event as reveal by the derivation of one transient event. The results of the irradiation campaign are further compared to simulations. This comparison shows very good agreement and highlights the role of emission of low energy photons inside the substrate which are in turn detected by the light sensitive layer.

Published
2020
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13. Exploring radiation hardness of PEPITES, a new transparent charged particle beam profiler

Author

Eric Delagnes, Y. Geerebaert, Nathalie Michel, F. Gebreyohannes, S. Elidrissi-Moubtassim, O. Thiam, F. Haddad, N. Audouin, Noël Servagent, Thomas Sounalet, B. Boyer, Charbel Koumeir, F. Poirier, O. Gevin, P. Manigot, M. Verderi, C. Thiebaux, Frédéric Magniette, G. Blain, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), ANR-16-IDEX-0007,NExT (I-SITE),NExT (I-SITE)(2016), and ANR-17-CE31-0015,PEPITES,Développement d'un moniteur ultra-mince pour faisceau de particules chargées(2017)

Subjects
[PHYS]Physics [physics], Nuclear and High Energy Physics, Materials science, Protontherapy, 010308 nuclear & particles physics, business.industry, Scanning electron microscope, Beam profiler, 01 natural sciences, Fluence, 030218 nuclear medicine & medical imaging, Kapton, 03 medical and health sciences, 0302 clinical medicine, Damage, 0103 physical sciences, Optoelectronics, Irradiation, Charged particle beam, business, Instrumentation, Radiation hardening, Polyimide, Beam (structure)
Abstract

International audience; PEPITES is a new type of transparent beam profiler (

Published
2020
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14. Ultra-fast prompt gamma detection in single proton counting regime for range monitoring in particle therapy

Author

Jayde Livingstone, Vincent Métivier, Denis Dauvergne, Jean Michel Létang, Etienne Testa, Charbel Koumeir, M. Yamouni, J-Y. Hostachy, Sara Marcatili, Jean-François Muraz, M.L. Gallin-Martel, L. Gallin-Martel, S. Curtoni, J. Collot, Noël Servagent, Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Cyclotron ARRONAX, GIP, Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), HEP, INSPIRE, Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Université de Nantes - Faculté des Sciences et des Techniques, and Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics - Instrumentation and Detectors, Proton, Physics::Instrumentation and Detectors, medicine.medical_treatment, FOS: Physical sciences, Particle detector, 030218 nuclear medicine & medical imaging, [PHYS] Physics [physics], 03 medical and health sciences, 0302 clinical medicine, Optics, Hodoscope, medicine, Proton Therapy, Humans, Radiology, Nuclear Medicine and imaging, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics, [PHYS]Physics [physics], Range (particle radiation), Particle therapy, Radiological and Ultrasound Technology, business.industry, Phantoms, Imaging, Detector, Gamma ray, Instrumentation and Detectors (physics.ins-det), Physics - Medical Physics, 3. Good health, Time of flight, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Gamma Rays, 030220 oncology & carcinogenesis, Medical Physics (physics.med-ph), business, Monte Carlo Method
Abstract

In order to fully exploit the ballistic potential of particle therapy, we propose an online range monitoring concept based on high-resolution Time-Of-Flight (TOF)-resolved Prompt Gamma (PG) detection in a single proton counting regime. In a proof of principle experiment, different types of monolithic scintillating gamma detectors are read in time coincidence with a diamond-based beam hodoscope, in order to build TOF spectra of PG generated in a heterogeneous target presenting an air cavity of variable thickness. Since the measurement was carried out at low beam currents ($, Comment: 17 pages, 18 figures

Published
2020
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15. Thick multi-layers analysis using high energy PIXE

Author

Alexandre Subercaze, Noël Servagent, Ferid Haddad, Arnaud Guertin, Charbel Koumeir, Vincent Métivier, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
010302 applied physics, Nuclear and High Energy Physics, High energy, Ion beam analysis, Materials science, Cyclotron, Analytical chemistry, Multi-layers, 010403 inorganic & nuclear chemistry, 01 natural sciences, 0104 chemical sciences, law.invention, High energy PIXE, law, 0103 physical sciences, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Instrumentation
Abstract

A method for multi-layer analysis using high energy PIXE is described. It is based on the variation of the K α K β ratio as a function of the detection angle. Experiments have been carried out at the ARRONAX cyclotron using 70 MeV protons in order to validate this method. The thicknesses and the sequences of simple multi-layers targets and more complex targets with hidden layers have been determined using this method.

Published
2017
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16. 68 A new transparent beam profiler based on secondary electrons emission for hadrontherapy charged particles beams

Author

B. Boyer, Fayrouz. Haddad, M. Verderi, E. Delagnes, O. Gevin, Y. Geerebaert, T. Sounalet, C. Thiebaux, Frédéric Magniette, G. Blain, Noël Servagent, Charbel Koumeir, F. Poirier, P. Manigot, Nathalie Michel, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Cyclotron ARRONAX, GIP, Commission des Thons de l'Océan Indien (CTOI), FAO, Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique)

Subjects
[PHYS]Physics [physics], Materials science, business.industry, Biophysics, General Physics and Astronomy, General Medicine, Charged particle, Secondary electrons, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, Optics, 030220 oncology & carcinogenesis, Radiology, Nuclear Medicine and imaging, business, Beam (structure), ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2019
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17. Medical applications of diamond detectors: online control of Hadrontherapy with fast timing and Microbeam Radiation Therapy monitoring

Author

Denis Dauvergne, Abbassi, L., Jean-François Adam, Bes, A., Bosson, G., Collot, J., Crozes, T., Curtoni, S., Gallin-Martel, L., L Gallin-Martel, M., Ghimouz, A., Ferid Haddad, Charbel Koumeir, Lacoste, A., Jean Michel Létang, Jayde Livingstone, Marcatili, S., Vincent Métivier, F Motte, J., F Muraz, J., Rarbi, F. E., Rossetto, O., Rosuel, N., Noël Servagent, É, Testa, Tribouilloy, L., Yamouni, M., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Nanofab (Nanofab ), Institut Néel (NEEL), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019])-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Synchrotron Radiation for Biomedicine Laboratory (STROBE), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Université Jean Monnet [Saint-Étienne] (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), and Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)

Subjects
Physics::Instrumentation and Detectors, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det]
Abstract

International audience; This presentation will focus on two applications of diamond detectors in the field of innovative radiotherapies.The first one consists of a beam hodoscope for hadrontherapy (proton or carbon ion beams). This detector will be used for position and time stamp of the incident particle beam, in order to detect secondary particles (mainly prompt-gammas). Time of Flight is used to reduce background from massive particles, and select photons issued from the patient only. This detector will be made of a mosaic assembly of several diamond plates with double-side strip metallization. The electronic readout design will enable high count rate and high time resolution of the detector.Preliminary measurements were performed at ARRONAX with 68 MeV protons. Detection efficiency was measured with mono- and polycrystalline diamond detectors. For the latter, up to 95% efficiency (corrected from noise triggering) was obtained for single-proton detection. The time resolution was close to 100ps rms for prompt gamma detection using diamond and fast scintillators for incoming particles and secondary photon detection, respectively. The potential for ultra-fast timing in prompt gamma imaging leads to spatial discrimination and real time reconstruction capabilities for range verification during treatment.The second application consists in the in vivo monitoring of Microbeam Radiation Therapy. The beam is spatially fractionated with local doses above 1000 Gy/s delivered in narrow peaks of a few tens of μm, separated by 300-500μm. A large area diamond detector with 1D position readout by fast- and high-dynamics charge integration will be used to monitor the transmitted photon beam, and thus evaluate the energy deposited in the patient.

Published
2019

18. Investigation of energy dependance for EBT3 response to irradiation with alpha beams

Author

C. Le Deroff, Gregory Delpon, Charbel Koumeir, F. Haddad, Arnaud Guertin, A. M. Frelin, F. Poirier, Noël Servagent, A. Basset, Sophie Chiavassa, Nathalie Michel, Vincent Métivier, Nicolas Varmenot, Cyclotron ARRONAX, GIP, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - Faculté des Sciences et des Techniques, Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Grand Accélérateur National d'Ions Lourds (GANIL), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)

Subjects
[PHYS]Physics [physics], Nuclear and High Energy Physics, Range (particle radiation), Materials science, Cyclotron, Bragg peak, 030218 nuclear medicine & medical imaging, law.invention, Ionizing radiation, 03 medical and health sciences, 0302 clinical medicine, Stack (abstract data type), law, 030220 oncology & carcinogenesis, Dosimetry, Physics::Accelerator Physics, Irradiation, Atomic physics, Instrumentation, Beam (structure)
Abstract

International audience; The response of EBT3 radiochromic film to ionizing radiation has been investigated for alpha beams. An experiment has been performed at the ARRONAX cyclotron to measure the net optical density (net OD) of EBT3 films as a function of the deposited doses of an alpha beam at different energies. A stack of 4 films was irradiated, therefore the beam energy is changed as a function of the film position between 45 MeV and 22 MeV. No differences in the film responses were observed in function of the alpha beam energy. The same calibration (Dose vs net OD) can be used for EBT3 film in this range of alpha beam energy. It is necessary to extend this study at lower energy down to the Bragg peak region.

Published
2019
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19. THE RADIOBIOLOGICAL PLATFORM AT ARRONAX

Author

Sébastien Gouard, Nathalie Michel, Nicolas Varmenot, Arnaud Guertin, Noël Servagent, Michel Chérel, Eric Garrido, Vincent Métivier, Viviana De Nadal, Roberto Cherubini, Thomas Sounalet, Freddy Poirier, Ferid Haddad, Charbel Koumeir, GIPARRONAX [Saint-Herblain, France], Laboratori Nazionali di Legnaro (LNL), Istituto Nazionale di Fisica Nucleare (INFN), Nuclear Oncology (CRCINA-ÉQUIPE 13), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Laboratoire de physique corpusculaire de Caen (LPCC), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, This project is partially supported by the ‘Agence National de la Recherche’, called ‘Investissements d’Avenir’, Equipex ArronaxPlus n° ANR-11-EQPX-0004., ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), Bernardo, Elizabeth, Nucléaire pour la Santé - - ARRONAXPLUS2011 - ANR-11-EQPX-0004 - EQPX - VALID, Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Université d'Angers (UA)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre hospitalier universitaire de Nantes (CHU Nantes), Normandie Université (NU)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), and Université de Nantes (UN)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique)

Subjects
[PHYS.NEXP] Physics [physics]/Nuclear Experiment [nucl-ex], Cyclotron, [SDV.CAN]Life Sciences [q-bio]/Cancer, Radiation, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 030218 nuclear medicine & medical imaging, law.invention, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, [SDV.CAN] Life Sciences [q-bio]/Cancer, law, Humans, Radiology, Nuclear Medicine and imaging, Irradiation, Physics, Range (particle radiation), [PHYS.PHYS.PHYS-MED-PH] Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Radiological and Ultrasound Technology, Public Health, Environmental and Occupational Health, Radiobiology, General Medicine, Alpha particle, Equipment Design, V79 cells, Cyclotrons, Charged particle, Beamline, 030220 oncology & carcinogenesis, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], France
Abstract

International audience; The cyclotron ARRONAX can deliver different types of particles (protons, deuterons, alpha-particles) in an energy range up to 68 MeV. One of its six experimental halls is dedicated to studying the interactions of radiation with matter including living matter. A horizontal beamline for cell irradiation has been setup and characterized. The radiobiological characterization was done in terms of V79 cells survival after irradiation with 68 MeV protons. The results demonstrate that radiobiological studies can be successfully performed confirming the high potential of the facility.

Published
2018
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20. High energy PIXE: A tool to characterize multi-layer thick samples

Author

Charbel Koumeir, Arnaud Guertin, Ferid Haddad, Alexandre Subercaze, Vincent Métivier, Noël Servagent, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public)

Subjects
Nuclear and High Energy Physics, High energy, Materials science, Sample (material), 010401 analytical chemistry, Cyclotron, Mineralogy, 010403 inorganic & nuclear chemistry, 01 natural sciences, 0104 chemical sciences, Computational physics, law.invention, law, 11. Sustainability, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Instrumentation, Multi layer
Abstract

International audience; High energy PIXE is a useful and non-destructive tool to characterize multi-layer thick samples such as cultural heritage objects. In a previous work, we demonstrated the possibility to perform quantitative analysis of simple multi-layer samples using high energy PIXE, without any assumption on their composition. In this work an in-depth study of the parameters involved in the method previously published is proposed. Its extension to more complex samples with a repeated layer is also presented. Experiments have been performed at the ARRONAX cyclotron using 68 MeV protons. The thicknesses and sequences of a multi-layer sample including two different layers of the same element have been determined. Performances and limits of this method are presented and discussed.

Published
2018
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21. New beam monitoring tool for radiobiology experiments at the cyclotron ARRONAX

Author

L. Schwob, Noël Servagent, Michel Chérel, Ferid Haddad, A. Rahmani, Nicolas Varmenot, Freddy Poirier, Arnaud Guertin, Charbel Koumeir, Vincent Métivier, Nathalie Michel, Centre de Recherche en Cancérologie / Nantes - Angers (CRCNA), Centre hospitalier universitaire de Nantes (CHU Nantes)-Faculté de Médecine d'Angers-Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Centre National de la Recherche Scientifique (CNRS)-Hôpital Laennec-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôtel-Dieu de Nantes, ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Centre de Recherche en Cancérologie et Immunologie Nantes-Angers (CRCINA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Centre hospitalier universitaire de Nantes (CHU Nantes)-Centre National de la Recherche Scientifique (CNRS)-Université d'Angers (UA), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), and UNICANCER

Subjects
Radiobiology, Cyclotron, [SDV.CAN]Life Sciences [q-bio]/Cancer, Electromagnetic radiation, Spectral line, law.invention, Nuclear magnetic resonance, law, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Polymethyl Methacrylate, Computer Simulation, Radiology, Nuclear Medicine and imaging, Saturation (magnetic), ComputingMilieux_MISCELLANEOUS, Photons, Radiation, Radiological and Ultrasound Technology, Radiotherapy Planning, Computer-Assisted, X-Rays, Public Health, Environmental and Occupational Health, Bremsstrahlung, General Medicine, Alpha particle, Cyclotrons, Models, Theoretical, Alpha Particles, Charged particle, Computational physics, Monte Carlo Method
Abstract

International audience; The ARRONAX cyclotron is able to deliver alpha particles at 68 MeV. In the frame of radiological research, a new method is studied to infer in situ the deposited dose: it is based on the online measurement of the bremsstrahlung (>1 keV) produced by the interaction of the incident particle with the medium. Experiments are made using bombarded poly(methyl methacrylate) (PMMA)-equivalent water targets in order to characterise this continuous X-ray spectrum. The intensity of the bremsstrahlung spectrum allows for the beam monitoring. A simulation code of the bremsstrahlung has been built, and a good agreement is found with the experimental spectra. With this simulation, it is possible to predict the sensibility of this method: it varies with the target thickness, showing a good sensibility for thin target (

Published
2015
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22. Absorbed Energy Monitoring during Hadrontherapy via Prompt Gamma Detection

Author

J. Krimmer, L. Balleyguier, Nicolas Freud, Denis Dauvergne, M. Fontana, Jean Michel Létang, Marco Pinto, Joel Herault, Etienne Testa, H. Mathez, Y. Zoccarato, Charbel Koumeir, Institut de Physique Nucléaire de Lyon (IPNL), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA), Imagerie Tomographique et Radiothérapie, Centre de Recherche en Acquisition et Traitement de l'Image pour la Santé (CREATIS), Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université de Lyon-Institut National des Sciences Appliquées (INSA)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Jean Monnet [Saint-Étienne] (UJM)-Hospices Civils de Lyon (HCL)-Institut National des Sciences Appliquées de Lyon (INSA Lyon), Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM), Unité de Radiothérapie, Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA)-Centre Antoine Lacassagne de Nice-Centre de Lutte contre le Cancer, Laboratoire SUBATECH Nantes (SUBATECH), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre Léon Bérard [Lyon], Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), Université Côte d'Azur (UCA)-UNICANCER-Université Côte d'Azur (UCA)-UNICANCER-Centre de Lutte contre le Cancer, and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes)

Subjects
Physics, Scintillation, medicine.medical_specialty, business.industry, Physics::Instrumentation and Detectors, Detector, Gamma ray, Monitoring system, [SDV.CAN]Life Sciences [q-bio]/Cancer, equipment and supplies, 030218 nuclear medicine & medical imaging, 3. Good health, 03 medical and health sciences, 0302 clinical medicine, Data acquisition, Optics, Energy absorbing, 030220 oncology & carcinogenesis, medicine, [PHYS.PHYS.PHYS-MED-PH]Physics [physics]/Physics [physics]/Medical Physics [physics.med-ph], Medical physics, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Gamma detection, business, Beam (structure)
Abstract

International audience; An independent monitoring system aiming for the detection of deviations from the prescribed treatment in hadrontherapy is presented. The system is based on prompt gammaray detection via scintillation detectors and the use of time-offlight information. Test measurements at cyclotrons show the influence of degraders used in passive beam delivery systems. A dedicated data acquisition card has been developed which is suitable to provide timing and energy information from scintillation detectors at counting rates compatible with clinical beam intensities.

Published
2016
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23. 42 Deposited dose measurement using bremsstrahlung X-rays

Author

Nicolas Varmenot, Noël Servagent, Vincent Métivier, F. Haddad, F. Ralite, Charbel Koumeir, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), and UNICANCER

Subjects
0301 basic medicine, Physics, Particle therapy, Proton, medicine.medical_treatment, Cyclotron, Biophysics, Bremsstrahlung, General Physics and Astronomy, General Medicine, Alpha particle, 030218 nuclear medicine & medical imaging, Computational physics, law.invention, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, law, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], medicine, Radiology, Nuclear Medicine and imaging, Particle beam, Charged particle beam, ComputingMilieux_MISCELLANEOUS, Beam (structure)
Abstract

Introduction With the development of particle therapy, patient dose verification tools are needed to ensure the accuracy of treatment. Non-invasive methods to measure the deposited energy exist. These are based on the PET-imaging technique, taking advantage of the radionuclides created during the interaction of hadrons with the medium [1] . An alternative method is studied and presented in this work. The detection of bremsstrahlung X-rays (XR) emitted directly by medium [2] is a promising way to obtain all or part of the deposited energy in the medium. This study describes a method to determine the deposited dose by a charged particle beam, for different incident energies. The results obtained for protons and alpha particles of 70 MeV will be presented. Methods The experimental set-up allows the irradiations of a PMMA target by alpha particles or protons delivered by the cyclotron ARRONAX (energy [3] has been developed to model the emitted XR spectrum. Results The first experiment, with alpha particles of 68 MeV, shows a good agreement between theoretical and simulated XR spectrums. The number of bremsstrahlung XR detected for one gray received by the medium is 1060+/−140. Uncertainty includes detection efficiency, the beam charge and the statistical counting fluctuations, and uncertainties about measurement of the number of the incident particles. The simulated spectrum indicates a number of 970 XR/Gy. Thus the number of XR per gray demonstrates a good sensibility. These encouraging results led us to perform experiments using proton beams with different energies. The analyses are in progress and the results will also be presented. Conclusions This work presents an alternative, on-line, non-invasive method based on the measurement of bremsstrahlung XR emitted during the interaction of a particle beam with matter. Proof of concept was obtained for 68 MeV alpha particles. Proton beams with energies from 17 to 70 MeV are under study. The objective is to evaluate the sensitivity of the method, in order to use the bremsstrahlung to monitor the beam and/or the deposited dose at energies close to those used in protontherapy and hadrontherapy.

Published
2018
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24. Development of a PIXE method at high energy with the ARRONAX cyclotron

Author

J. Gaudillot, Ferid Haddad, Arnaud Guertin, D. Ragheb, Nathalie Michel, Charbel Koumeir, Noël Servagent, Vincent Métivier, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Cyclotron ARRONAX, GIP, and Equipex Arronax Plus no ANR-11-EQPX-0004, CPER 2007-2013, including funding from the Regional Council of Pays de la Loire, the ‘‘Conseil general de Loire-Atlantique’’, the French government and the FEDER (European Union)

Subjects
High energy, High energy particle, Materials science, Proton, Health, Toxicology and Mutagenesis, Ion beam analysis, Cyclotron, Analytical chemistry, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 010403 inorganic & nuclear chemistry, 01 natural sciences, Spectral line, Analytical Chemistry, law.invention, law, 0103 physical sciences, Multilayer, Radiology, Nuclear Medicine and imaging, Spectroscopy, Range (particle radiation), 010308 nuclear & particles physics, Public Health, Environmental and Occupational Health, Pollution, 0104 chemical sciences, Nuclear Energy and Engineering, ARRONAX, High energy PIXE, Nondestructive analysis, Physics::Accelerator Physics, Beam (structure)
Abstract

International audience; The high energy PIXE (HEPIXE) method is a multi-elemental non-destructive ion beam analysis technique. It is based on the detection of the X-ray emitted due to the interaction of high energy particle beam with a sample. This technique is fast and allows the analysis of heavy and medium elements in thin (lm), thick (mm) and multilayer samples. At the ARRONAX facility (Nantes, France), the HEPIXE method has been used to determine the composition of natural and synthetic sodalites. Photochromic properties of these samples are supposed to come from the trace elements (concentration in the ppm range) present in the samples. Taking advantage of the 70 MeV proton beam available at our facility, the HEPIXE methodhas been also used to study multilayer samples. It has been shown that it is possible to determine the composition of each layer, their thicknesses and their depth position by analyzing the recorded X-ray spectra.

Published
2014
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25. EBT2 FILMS RESPONSE TO ALPHA RADIATION AT 48.3 MEV

Author

L. Schwob, C. Le Deroff, Arnaud Guertin, Charbel Koumeir, Nathalie Michel, Ferid Haddad, Freddy Poirier, Noël Servagent, Michel Chérel, Nicolas Varmenot, Vincent Métivier, Cyclotron ARRONAX, GIP, Centre de Recherche en Cancérologie Nantes-Angers (CRCNA), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM)-PRES Université Nantes Angers Le Mans (UNAM)-Hôtel-Dieu de Nantes-Institut National de la Santé et de la Recherche Médicale (INSERM)-Hôpital Laennec-Centre National de la Recherche Scientifique (CNRS)-Faculté de Médecine d'Angers-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), ARRONAX - (GIP) Groupement d'Intérêt Public [Saint-Herblain] (Institut de Recherche Public), Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER, and Equipex Arronax Plus no ANR-11-EQPX-0004, CPER 2007-2013, including funding from the Regional Council of Pays de la Loire, the 'Conseil general de Loire-Atlantique', the French government and the FEDER (European Union)

Subjects
Photon, Materials science, Film Dosimetry, Cyclotron, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], Radiation Dosage, Electromagnetic radiation, Spectral line, law.invention, law, Radiation, Ionizing, Radiology, Nuclear Medicine and imaging, Irradiation, Ions, Photons, Radiation, Radiological and Ultrasound Technology, Spectrometer, X-Rays, Public Health, Environmental and Occupational Health, Dose-Response Relationship, Radiation, General Medicine, Alpha particle, Equipment Design, Cyclotrons, Alpha Particles, Charged particle, Spectrophotometry, Facility Design and Construction, Calibration, Atomic physics, Algorithms
Abstract

International audience; To advance the development of a radiobiological experimental set-up for alpha particle irradiations at the Arronax cyclotron, experiments were performed to get the dose response of Gafchomic EBT2 films for alpha particles at 48.3 MeV. A system has been developed using a thin monitor copper foil and an X-ray spectrometer to measure the beam intensity and to calculate the delivered dose. On the other hand, the authors have irradiated EBT2 films, with 6-MV X rays, to get the dose response of EBT2 films for photons. The dose response curve for alpha particles shows an effect of polymerisation saturation compared with the dose response curve for photons.

Published
2014
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26. Dark matter directional detection with MIMAC

Author

Grignon, C., Billard, J., Bosson, G., Bourrion, O., Guillaudin, O., charbel koumeir, Mayet, F., Santos, D., Colas, P., Ferrer, E., Giomataris, I., Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, E. Augé et al, MIMAC, and Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Institut Polytechnique de Grenoble - Grenoble Institute of Technology-Centre National de la Recherche Scientifique (CNRS)

Subjects
[PHYS.ASTR.CO]Physics [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Cosmology and Nongalactic Astrophysics (astro-ph.CO), [PHYS.ASTR.IM]Physics [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM], Physics::Instrumentation and Detectors, [SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Astrophysics - Cosmology and Nongalactic Astrophysics, [SDU.ASTR.IM]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Instrumentation and Methods for Astrophysic [astro-ph.IM]
Abstract

MiMac is a project of micro-TPC matrix of gaseous (He3, CF4) chambers for direct detection of non-baryonic dark matter. Measurement of both track and ionization energy will allow the electron-recoil discrimination, while access to the directionnality of the tracks will open a unique way to distinguish a geniune WIMP signal from any background. First reconstructed tracks of 5.9 keV electrons are presented as a proof of concept., Comment: 4 pages, proc. of the 44th Rencontres De Moriond: Electroweak Interactions And Unified Theories, 7-14 Mar 2009, La Thuile, Italy

Published
2009

27. Study of ion emission from a germanium crystal surface under impact of fast Pb ions in channeling conditions

Author

D. Jacquet, C. Cohen, Denis Dauvergne, Bruno Manil, Marius Chevallier, Cédric Ray, J.-C. Poizat, D. Schmaus, Ph. Boduch, A. L’hoir, Charbel Koumeir, Amine Cassimi, P. Roussel-Chomaz, S. Della Negra, Hermann Rothard, Marcel Toulemonde, M. Fallavier, Laboratoire SUBATECH Nantes (SUBATECH), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université de Nantes (UN)-Mines Nantes (Mines Nantes), Institut de Physique Nucléaire d'Orsay (IPNO), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Centre de recherche sur les Ions, les MAtériaux et la Photonique (CIMAP - UMR 6252), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Laboratoire de Géographie Physique et Environnementale (GEOLAB), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Université Clermont Auvergne (UCA)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Centre National de la Recherche Scientifique (CNRS), Institut des Nanosciences de Paris (INSP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Institut de Physique Nucléaire de Lyon (IPNL), Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Représentations musicales (Repmus), Sciences et Technologies de la Musique et du Son (STMS), Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche et Coordination Acoustique/Musique (IRCAM)-Université Pierre et Marie Curie - Paris 6 (UPMC)-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Lasers (LPL), Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS), Mines Nantes (Mines Nantes)-Université de Nantes (UN)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche sur les Matériaux Avancés (IRMA), Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Rouen Normandie (UNIROUEN), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Centre National de la Recherche Scientifique (CNRS), Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École Nationale Supérieure d'Ingénieurs de Caen (ENSICAEN), Normandie Université (NU)-Normandie Université (NU)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Centre National de la Recherche Scientifique (CNRS)-Institut Sciences de l'Homme et de la Société (IR SHS UNILIM), Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-Université Blaise Pascal - Clermont-Ferrand 2 (UBP)-Université Clermont Auvergne (UCA), Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS)-Université Pierre et Marie Curie - Paris 6 (UPMC)-IRCAM-Centre National de la Recherche Scientifique (CNRS), and Université Sorbonne Paris Cité (USPC)-Institut Galilée-Université Paris 13 (UP13)-Centre National de la Recherche Scientifique (CNRS)

Subjects
Nuclear and High Energy Physics, ion emission, Spectrometer, [PHYS.PHYS.PHYS-ATOM-PH]Physics [physics]/Physics [physics]/Atomic Physics [physics.atom-ph], Chemistry, Analytical chemistry, 02 engineering and technology, 021001 nanoscience & nanotechnology, 01 natural sciences, Ion, Time of flight, Fragmentation (mass spectrometry), 13. Climate action, Sputtering, Ionization, material modification in semiconductors, 0103 physical sciences, ion sputtering, Irradiation, Atomic physics, Multiplicity (chemistry), 010306 general physics, 0210 nano-technology, Instrumentation, Channeling
Abstract

International audience; A thin germanium crystal has been irradiated at GANIL by Pb beams of 29 MeV/A (charge state Qin = 56 and 72) and of 5.6 MeV/A (Qin = 28). The induced ion emission from the sample entrance surface was studied, impact per impact, as a function of Qin, velocity vin and energy loss DE in the crystal. The Pb ions transmitted through the crystal were analyzed in charge (Qout) and energy using the SPEG spectrometer. The emitted ionized species were detected and analyzed in mass by a Time of Flight multianode detector (LAG). Channeling was used to select peculiar DE in Ge and hence peculiar Pb ion trajectories close to the emitting surface. The experiment was performed in standard vacuum. No Ge emission was found. The dominating emitted species are H+ and hydrocarbon ions originating from the contamination layer on top of the crystal. The mean value of the number of detected species per incoming Pb ion (multiplicity) varies as (Qin/vin)^p, with p values in agreement with previous results. We have clearly observed an influence of the energy deposition DE in Ge on the emission from the top contamination layer. When selecting increasing values of DE, we observed a rather slow increase of . On the contrary, the probabilities of high multiplicity values, that are essentially connected to fragmentation after emission, strongly increase with DE.

Published
2009
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28. High energy PIXE: measurements for Cu, Ag and Ti K-shell ionization cross sections and comparisons with theoretical model

Author

Quentin Mouchard, Charbel Koumeir, Noël Servagent, Arnaud Guertin, Ferid Haddad, Vincent Métivier, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], This work has been in part supported by a grant from the French National Agency for Research called 'Investissements d'Avenir', Equipex ArronaxPlus no ANR-11-EQPX-0004 and by the CPER 2007-2013, including European Union funding (FEDER), and ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

29. Analyses à l'aide de PIXE à haute énergie, de pièces d'argent et de matrices de sceaux en cuivre, provenant des collections du musée Dobrée (France, XIIIe -XIXe siècle)

Author

Quentin Mouchard, Guillaume Pipelier, Jane Echinard, Ferid Haddad, Charbel Koumeir, Stéphane Lemoine, Guy Louarn, Vincent Métivier, Charlène Pelé-Meziani, Gildas Salaün, Noël Servagent, Ambre Vilain, Laboratoire de physique subatomique et des technologies associées (SUBATECH), IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Arc'Antique, Grand Patrimoine de Loire-Atlantique, Département de Loire-Atlantique, Institut des Matériaux Jean Rouxel (IMN), Ecole Polytechnique de l'Université de Nantes (EPUN), Université de Nantes (UN)-Université de Nantes (UN)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN), This work has been in part supported by a grant from the French National Agency for Research called 'Investissements d'Avenir', Equipex ArronaxPlus no ANR-11-EQPX-0004 and by the CPER 2007-2013, including European Union funding (FEDER), Société Française du Vide, ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), and Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC)-Ecole Polytechnique de l'Université de Nantes (EPUN)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], [SHS.ART]Humanities and Social Sciences/Art and art history, ComputingMilieux_MISCELLANEOUS
Abstract

International audience

30. High energy PIXE: measurements for Cu, Ag and Ti K-shell ionization cross sections and comparisons with theoretical model

Author

Quentin Mouchard, Charbel Koumeir, Arnaud Guertin, Hazim, M., Ferid Haddad, Noël Servagent, Naja, A., Vincent Métivier, Laboratoire de physique subatomique et des technologies associées (SUBATECH), Université de Nantes - UFR des Sciences et des Techniques (UN UFR ST), Université de Nantes (UN)-Université de Nantes (UN)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-IMT Atlantique Bretagne-Pays de la Loire (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Accélérateur pour la Recherche en Radiochimie et Oncologie [Nantes Atlantique] (GIP ARRONAX), Université de Nantes (UN)-Institut de Cancérologie de l'Ouest [Angers/Nantes] (UNICANCER/ICO), UNICANCER-UNICANCER-Hôpital Guillaume-et-René-Laennec [Saint-Herblain], Laboratoire des collisions atomiques et moléculaires (LCAM), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), This work has been in part supported by a grant from the French National Agency for Research called 'Investissements d'Avenir', Equipex ArronaxPlus no ANR-11-EQPX-0004 and by the CPER 2007-2013, including European Union funding (FEDER), and ANR-11-EQPX-0004,ARRONAXPLUS,Nucléaire pour la Santé(2011)

Subjects
[PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], ComputingMilieux_MISCELLANEOUS
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