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Yijie Liu,1,2,* Chaoyang Guo,1,* Shuting Liu,1 Shuai Zhang,3 Yun Mao,4 Lei Fang1 1School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 2Institute of Rehabilitation Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, People’s Republic of China; 3Department of Orthopaedics, Shanghai Pudong New District Hospital of Traditional Chinese Medicine, Shanghai, 201200, People’s Republic of China; 4Department of Rehabilitation Medicine, Shanghai General Hospital, Shanghai Jiao Tong University, Shanghai, 201803, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Fang Email fanglei586@126.comBackground: Sarcopenia is a syndrome characterized by the loss of skeletal muscle mass and strength. Most studies have focused on dynamic resistance exercises for preventing muscular decline and maintaining the muscle strength of older individuals. However, this training mode is impractical for older people with osteoarthritis and a limited range of motion. The static strength training mode is more suitable for older people. Therefore, a determination of the effect and mechanism of static strength training on sarcopenia is critical.Methods: In this study, we developed a training device designed to collect training data and evaluate the effects of static training on the upper limbs of rats. The expression of PGC-1α was locally blocked by injecting a siRNA at the midpoint of the biceps to determine whether PGC-1α signal transduction participates in the effects of high-intensity interval static training on muscle strength. Then, the rat’s motor capacity was measured after static strength training. Immunohistochemistry and Western blotting were applied to determine PGC-1α/FNDC5/UCP1 expression levels in the muscle and adipose tissue. The serum irisin level was also detected using an enzyme-linked immunosorbent assay (ELISA).Results: Increased levels of serum irisin and local expression of FNDC5, PGC-1α, and UCP1 were observed in the biceps brachii and surrounding fatty tissue after static strength training. Static strength training showed an advantage in reducing body weight and white fat accumulation while increasing the muscle fiber volume, which resulted in a longer training time and shorter rest time.Conclusion: Overall, these results indicated that high-intensity interval static training prevents skeletal muscle atrophy and improves the motor function of aged rats through the PGC-1α/FNDC5/UCP1 signaling pathway.Keywords: sarcopenia, static strength training, muscle function, PGC-1α, FNDC5

Background : There are several effective complementary and integrative therapies for patients with severe COVID-19. The trial aims to evaluate the efficacy and advantages of the qigong exercise and acupressure rehabilitation program (QARP) for treating patients with severe COVID-19. Methods : A total of 128 patients with COVID-19 aged 20 to 80 years were recruited and randomly allocated in a 1:1 ratio to receive QARP plus standard therapies or standard therapies alone. QARP consisted of acupressure therapy and qigong exercise (Liu Zi Jue). The primary outcome was measured with the modified Medical Research Council (mMRC) dyspnea scale, and the secondary outcomes included the modified Borg dyspnea scale (MBS), fatigue Scale-14 (FS-14), patient health questionnaire-9 scale (PHQ-9), duration of respiratory symptoms, and vital signs. Results : In total, 128 patients completed the treatment. The QARP group and standard therapies group showed significant improvements in vital signs (except blood pressure) and clinical scales compared with baseline (p

The SMC cold temperature asphalt mixture consumed less energy and harmful emission compares with the traditional HMA and WMA, and it can be worked at the subzero temperature or after a long time storage, which makes the construction and maintenance of the asphalt pavement in a special environment (low temperature) and special conditions (without a hot mix station) come true. It has been widely used in Beijing, Xinjiang, Sichuan, Tibet, etc. with a satisfied performance. Highway construction and maintenance technology level of China would be positively promoted by using the SMC asphalt mixtures.

For the semantics of existing product information models is too simple, the lack of adequate semantic description of the product information model during collaborative product design process, and the information sharing and interoperability in the semantic level between the collaborative designers are difficulties and other issues, this paper presents a product information model for collaborative product design based on ontology. To achieve the description of semantic information of products, ontology is introduced in this paper. Then which can enable the collaborative product designers to carry out the semantic level of information sharing and interoperability. Finally, an instance of the presented product information model is proposed.