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Background and Purpose A ruptured peripheral cerebral aneurysm (PPCA) associated with moyamoya disease (MMD) is a rare but potentially life-threatening condition with controversial management strategies. We aim to summarize the clinical characteristics, treatment strategies, and prognostic factors of PPCAs in MMD. Methods We reviewed studies published in PubMed between 1980 and 2023 and used logistic regression analysis to identify the risk factors for adverse outcomes. Results Of 425 identified studies, 48 eligible studies involving 121 participants were included in the current study. The mean age at diagnosis was 40.8±15.1 years, with a peak age of onset between 41 and 50 years. Among the identified participants, 59.6% were female, and 55.9% presented with impaired consciousness. Aneurysms were present in the posterior (35.5%) or anterior (30.6%) choroidal arteries in 66.1% of the cases, and 71.1% of the patients presented with intraventricular hemorrhage (IVH) with or without intracerebral hematoma (ICH). The treatment strategies were embolization (28.9%), direct surgery (21.5%), revascularization (22.3%), and conservation (27.3%). Favorable outcomes were achieved in 86.8% of all cases, with 97.1% for embolization, 65.4% for direct surgery, 96.3% for revascularization, and 84.8% for conservative treatment. Aneurysm rebleeding occurred in 11 (26.8%) of 41 patients managed conservatively, leading to worse outcomes in 7 patients (63.6%). Impaired consciousness (odds ratio [OR], 8.61; 95% confidence interval [CI], 2.06–36.00) and aneurysm rebleeding (OR, 16.54; 95% CI, 3.08–88.90) independently predicted poor outcomes. Conclusion PPCA should be considered in patients with hemorrhagic MMD, particularly those with IVH with or without ICH. Endovascular and bypass treatments are recommended as first-line options, with direct open surgery as an alternative in urgent hematoma evacuation cases. Detailed preoperative planning and intraoperative technical assistance are necessary to reduce procedure-related complications. Conservative management should be selected with caution because of the high risk of rebleeding and poor outcomes. Impaired consciousness and aneurysm rebleeding appeared to be independent risk factors for adverse prognoses. We emphasize that treatment selection should be personalized, and the potential benefits should be weighed against the associated risks.

Abstract Colorectal cancer (CRC) is a wide-spread gastrointestinal cancer that is associated with augmented morbidity and mortality, and we do not yet have a deep understanding of its epidemiology and carcinogenicity. The transcriptome can reveal the complexity and heterogeneity of tumors and uncover new biomarkers or treatment options. In this study, we identified messenger RNAs (mRNAs), long non-coding RNAs (lncRNAs), round RNAs (circRNAs), and microRNAs (miRNAs) using whole-transcriptome sequencing and generated competing endogenous RNA (ceRNA) modulatory axes. We conducted whole transcriptome sequencing on 10 CRC and para-cancer (CRCP) samples and discovered 2465 differentially expressed (DE) mRNAs (DEmRNAs), 77 DE miRNAs (DEmiRNAs). 2852 DE lncRNAs (DElncRNAs) and 1477 DE circRNAs (DEcircRNAs). In addition, utilizing co-DE analysis, we generated the ceRNA axis. Subsequently, we employed the ceRNA axis to identify essential genes and corresponding associations with lncRNAs, circRNAs, and miRNAs in CRC. ceRNA regulatory network including mRNA-miRNA-lncRNA and mRNA-miRNA-circRNA. These modulatory axes potentially modulate the positive regulation of smooth muscle contraction, melanosome, plasma membrane, integral plasma membrane component and so on. Finally, the results of RNA sequencing (RNA-SEQ) were combined with the TCGA and GEO databases, and the DEGs strongly correlated with the TCGA-COAD overall survival (OS) as estimated by univariate cox and logarithmic rank analyses were cross-analyzed, and the co-upregulated DEGs were screened. Among the many DEs, KPNA2 was chosen for additional analysis. Using invitro experimentations, western blot, CCK8, EdU and other experiments were performed to verify the results. We found siRNA-based KPNA2 depletion reduces bladder cancer cells’ viability, migratory, and proliferative activities, which showed that the DEmRNA profiles were comparable to the sequencing information, confirming that the sequencing data were very reliable. These evidences highlight the ceRNA regulatory mechanisms in CRC and will aid future research into the molecular mechanisms behind colorectal cancer prevention and treatment.

Abstract Objective This study aimed to examine prospective associations of different intensity levels and types of physical activity (PA) in early pregnancy with premature rupture of membranes (PROM) among Chinese pregnant women. Methods A total of 6284 pregnant women were included from the Tongji-Shuangliu Birth Cohort. Household/caregiving, occupational, sports/exercise and transportation activities during early pregnancy were investigated by the pregnancy physical activity questionnaire (PPAQ), and the diagnosis of PROM was ascertained during the whole pregnancy. Multivariate logistic regression models were used to estimate the odds ratios (ORs) and 95% confidence interval (CI) for the associations between PA and PROM. Results Among the 6284 pregnant women, 1246 were identified to have PROM (19.8%). Women undertaking the highest level (3 third tertile) of PA during pregnancy appeared to have a lower risk of PROM [OR = 0.68, 95%CI 0.58–0.80) when compared to those at the lowest tertile of PA. Similarly, women with increased levels of light intensity activity, moderate-vigorous intensive, household/caregiving activity and meeting exercise guidelines during pregnancy were associated with reduced risks of PROM (OR = 0.69, 95% CI 0.59–0.81, OR = 0.70, 95% CI 0.60–0.82, OR = 0.62, 95% CI 0.53–0.73 and OR = 0.82, 95% CI 0.70–0.97, respectively). Conclusions High levels of PA of different intensities and PA of household/caregiving activities and meeting exercise guidelines during the first trimester were associated with a lower incidence of PROM. Trial registration The data of human participants in this study were conducted in accordance with the Helsinki Declaration. This study has been approved by the Ethics Committee of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China ([2017] No. S225). All participants provided written informed consent prior to enrollment. A statement to confirm that all methods were carried out in accordance with relevant guidelines and regulations.

Abstract Electron paramagnetic resonance (EPR) studies were performed on La0.88Sr0.12MnO3 (LSMO) nanocrystalline together with the measurement of its magnetization. Various spectrum parameters including line width, effective g-value and double-integrated intensities have been analyzed in detail. We found nonlinear behavior occurred in the inverse susceptibility far above the Curie temperature T C, indicating short-range ferromagnetic (FM) clusters and Griffiths-like phase behavior in the paramagnetic (PM) phase. Based on the variation of EPR spectra, except for a typical PM resonance peak, an extra resonance signal was observed in the lower field region and developed as temperature decreased from 320 K to 110 K, which gave a direct evidence of the existence of FM cluster in the PM region of LSMO nanocrystalline. We proposed that the appearance of the Griffiths phase was due to the short FM correlation in the PM regime enhanced by surface spin ordering.

Abstract Introduction The attentional boost effect, characterized by better memory for background scenes coinciding with a detection target than a nontarget, is believed to stem from a temporary increase in attentional capacity at the time of an acute behavior‐related event occurring. Sisk and Jiang's study found that the attentional boost effect also occurs when the target's appearance was predictable. Unfortunately, the duration of the predictive interval in Sisk and Jiang's study was fixed. Since different predictive intervals had different weakening degrees to the acuteness of the target, this fixed duration hindered further investigation into the impact of different levels of predictability on the attentional boost effect. Method Using the encoding‐recognition paradigm and the remembering/knowing paradigm, and setting target stimuli with different predictive interval in target detection tasks, the current study aimed to explore the influence of varying the duration of the predictive interval on the attentional boost effect. Results The attentional boost effect was observed only in the short and medium predictive duration conditions, but not in the long predictive duration condition. Moreover, as the duration of the predictive interval increased, participants’ memory performance on target‐paired words gradually declined, while their memory performance on distractor‐paired and baseline‐paired words gradually improved. Conclusions Predictability may alter the task demands, allowing participants to more effectively allocate attentional resources to the two tasks at hand.

Abstract Background As the greenhouse effect intensifies, global temperatures are steadily increasing, posing a challenge to bread wheat (Triticum aestivum L.) production. It is imperative to comprehend the mechanism of high temperature tolerance in wheat and implement breeding programs to identify and develop heat-tolerant wheat germplasm and cultivars. Results To identify quantitative trait loci (QTL) related to heat stress tolerance (HST) at seedling stage in wheat, a panel of 253 wheat accessions which were re-sequenced used to conduct genome-wide association studies (GWAS) using the factored spectrally transformed linear mixed models (FaST-LMM). For most accessions, the growth of seedlings was found to be inhibited under heat stress. Analysis of the phenotypic data revealed that under heat stress conditions, the main root length, total root length, and shoot length of seedlings decreased by 47.46%, 49.29%, and 15.19%, respectively, compared to those in normal conditions. However, 17 varieties were identified as heat stress tolerant germplasm. Through GWAS analysis, a total of 115 QTLs were detected under both heat stress and normal conditions. Furthermore, 15 stable QTL-clusters associated with heat response were identified. By combining gene expression, haplotype analysis, and gene annotation information within the physical intervals of the 15 QTL-clusters, two novel candidate genes, TraesCS4B03G0152700/TaWRKY74-B and TraesCS4B03G0501400/TaSnRK3.15-B, were responsive to temperature and identified as potential regulators of HST in wheat at the seedling stage. Conclusions This study conducted a detailed genetic analysis and successfully identified two genes potentially associated with HST in wheat at the seedling stage, laying a foundation to further dissect the regulatory mechanism underlying HST in wheat under high temperature conditions. Our finding could serve as genomic landmarks for wheat breeding aimed at improving adaptation to heat stress in the face of climate change.

Abstract Background Despite the increasing focus on strengthening One Health capacity building on global level, challenges remain in devising and implementing real-world interventions particularly in the Asia-Pacific region. Recognizing these gaps, the One Health Action Commission (OHAC) was established as an academic community for One Health action with an emphasis on research agenda setting to identify actions for highest impact. Main text This viewpoint describes the agenda of, and motivation for, the recently formed OHAC. Recognizing the urgent need for evidence to support the formulation of necessary action plans, OHAC advocates the adoption of both bottom-up and top-down approaches to identify the current gaps in combating zoonoses, antimicrobial resistance, addressing food safety, and to enhance capacity building for context-sensitive One Health implementation. Conclusions By promoting broader engagement and connection of multidisciplinary stakeholders, OHAC envisions a collaborative global platform for the generation of innovative One Health knowledge, distilled practical experience and actionable policy advice, guided by strong ethical principles of One Health. Graphical Abstract

Abstract Background Physical activity (PA) plays an important role in the process of several chronic diseases. It may be also associated with the incidence of sarcopenia. This study aimed to determine the association of PA from different components including frequency, duration, intensity, and volume with the incidence of sarcopenia in middle-aged and older adults. Methods This study used data from the China Health and Retirement Longitudinal Study in 2011 and 2015. A total of 3,760 individuals aged ≥ 40 years were involved in this study. Sarcopenia was diagnosed using muscle mass, strength and physical performance according to the Asian Working Group for Sarcopenia. PA information including frequency, duration, intensity, and volume was obtained by a self-reported questionnaire. Logistic regression analysis was employed to examine the association between PA and the incidence of sarcopenia at 4-year follow-up. Results The incidence of sarcopenia was 5.9% during the 4-year follow-up. Compared to sedentary individuals, those taking 1–2 days or more per week, or a minimum of 10 min each time on vigorous-intensity PA (VPA) had a lower incidence of sarcopenia. Adults spending 3 days or more each week, a minimum of 30 min each time, or 150 min or more per week on moderate-intensity PA (MPA) had a lower presence of sarcopenia than sedentary adults. Adults taking 3 days or more per week, at least 30 min each time, or 150 min or more each week on light-intensity PA (LPA) tended to have a lower incidence of sarcopenia than sedentary individuals. Sensitivity analyses confirmed the robustness of the findings after removing persons with hypertension, dyslipidemia, or diabetes. Conclusions These findings suggest that the frequency, duration, and volume of VPA or MPA are negatively associated with the presence of sarcopenia. Participation in LPA tends to have a lower incidence of sarcopenia in middle-aged and older adults.

Sub-atmospheric pressure environment and oscillation laser are both excellent ways to improve welded joint quality. However, the differences in their effects and mechanisms are unclear. Therefore, the differences between sub-atmospheric pressure and oscillating laser in weld formation, porosity suppression and grain size refinement were analyzed in this study. The results revealed that penetration depth of welded joint was increased to 6.09 mm under sub-atmospheric pressure environment while it was decreased to 3.3 mm under oscillation laser. Furthermore, reducing fluctuating vapor pressure and suppressing vortex formation were the main means to improve the keyhole stability and promote the escape of bubbles in a sub-atmospheric pressure environment. The improvement of the oscillating laser in these two aspects was attributed to enlarging keyhole area, shortening escape path and oscillation keyhole absorption. Additionally, the average grain size in the upper weld was reduced from 134.6 μm to 118.6 μm and 114.1 μm under the sub-atmospheric pressure environment and laser oscillation, respectively. The reduction of the temperature gradient led to former grain refinement while the increase of heterogeneous nucleation rate was responsible for latter grain refinement. Correspondingly, the mechanical properties of welded joints were improved. The study offered valuable insights for the application of laser welding with oscillation laser and sub-atmospheric pressure in industrial production.

ObjectiveThe objective of this study is to explore the risk factors associated with new-onset postoperative atrial fibrillation (POAF) following Sun's surgery(total arch replacement using a tetrafurcate graft with stented elephant trunk implantation) for acute type A aortic dissection(AAAD) and to develop a predictive model for assessing the likelihood of new-onset POAF in patients undergoing Sun's surgery for AAAD.MethodsWe reviewed the clinical parameters of patients diagnosed with AAAD who underwent Sun's surgery at Qilu Hospital between December 1, 2017 and December 31, 2022. The data was analyzed through univariable and multivariable logistic regression analysis. Variance inflation factor was used to investigate for variable collinearity. A nomogram for predicting new-onset POAF was developed and verified by bootstrap resampling. In addition, the calibration of our model was evaluated by the calibration curve and Hosmer-Lemeshow test. Furthermore, the clinical utility of our model was evaluated using the net benefit curve.ResultsThis study focused on a cohort of 242 patients with AAAD, among whom 42 experienced new-onset POAF, indicating an incidence rate of 17.36%. Age, left atrial diameter (LA), right atrial diameter (RA), preoperative red blood cells (RBC), and previous acute coronary syndrome (preACS) emerged as independent influences on new-onset POAF following Sun's surgery, as identified by univariable and multivariable logistic regression analysis. Collinearity analysis with demonstrated no collinearity among the variables. A user-friendly prediction nomogram for new onset POAF following Sun's surgery was formulated. The model demonstrated commendable diagnostic accuracy with an area under the curve (AUC) of 0.7852. Validation of the model through bootstrapping (1,000 repetitions) yielded an AUC of 0.8080 (95% CI: 0.8056–0.8104). affirming its robustness. Additionally, the model exhibited favorable fit, calibration, and positive net benefits in decision curve analysis.ConclusionsDrawing upon these findings, we have developed a predictive model for the occurrence of new-onset POAF. These results suggest the potential efficacy of this prediction model for identifying patients at risk of developing POAF. The visualization of this model empowers healthcare professionals to conveniently and promptly assess the risk of AF in patients, thereby facilitating the timely intervention implementation.

IntroductionTo assess the performance of the European Thyroid Association Thyroid Imaging and Reporting Data System (EU-TIRADS) and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS), which combine risk stratification systems for thyroid nodules (TN-RSS) and cervical lymph nodes (LN-RSS) in diagnosing malignant and metastatic thyroid cancer in a single referral center.MethodsWe retrospectively analyzed 2,055 consecutive patients who underwent thyroidectomy or fine-needle aspiration (FNA) from January 2021 to December 2022. TNs and LNs were categorized according to the ultrasonography (US) features of EU-TIRADS and K-TIRADS, respectively. The diagnostic performance and postponed malignancy rate (PMR) were compared with those of EU-TIRADS and K-TIRADS. PMR was defined as the number of patients with malignant nodules not recommended for biopsy among patients with cervical LN metastasis.ResultsAccording to the EU-TIRADS and K-TIRADS, for TN-RSS alone, there were no significant differences in sensitivity, specificity, accuracy, unnecessary FNA rate (UFR), missed malignancy rate (MMR), and PMR between the two TIRADSs (29.0% vs. 28.8%, 50.5% vs. 51.1%, 32.3% vs. 32.2%, 23.6% vs. 23.5%, 88.6% vs. 88.5%, and 54.2% vs. 54.5%, P > 0.05 for all). Combining the LN-RSS increased the diagnostic accuracy (42.7% vs. 32.3% in EU-TIRADS; 38.8% vs. 32.2% in K-TIRADS) and decreased the PMR (54.2% vs. 33.9% in EU-TIRADS; 54.5% vs. 39.3% in K-TIRADS). EU-TIRADS had higher sensitivity and accuracy and lower PMR than K-TIRADS (41.3% vs. 36.7%, 42.7% vs. 38.8%,33.9% vs. 39.3%, P < 0.05 for all).ConclusionsA combination of TN-RSS and LN-RSS for the management of thyroid nodules may be associated with a reduction in PMR, with enhanced sensitivity and accuracy for thyroid cancers in EU-TIRADS and K-TIRADS. These results may offer a new direction for the detection of aggressive thyroid cancers.

Proton exchange membrane water electrolysis (PEMWE) with high‐purity H2 and O2 products and swift response to electricity fluctuation is of great interest for renewable energy, chemical and pharmaceutical industries. Ruthenium oxide shows promise as an alternative to iridium oxide catalysts in PEMWE but suffers from severe anodic corrosion. Herein, a pluralistic electronic structure modulation approach is presented to address the instability issue of Ru, by in situ growing MnxRu1−xO2 solid solution on MnO2, coated carbon fibers (MnxRu1−xO2/MnO2/CFs). Due to higher ion electronegativity, Mn dopants in the MnxRu1−xO2 solid solution accept electrons, activating the Ru site. Simultaneously, the MnO2 support donates electrons to prevent Ru site overoxidation and dissolution due to its lower work function than the MnxRu1−xO2 solid solution. As a result, the MnxRu1−xO2/MnO2/CFs catalyst exhibits a low overpotential of 161 mV at 10 mA cm−2 and a remarkable stability exceeding 600 h. Profiting by its improved oxygen evolution reaction (OER) kinetic activity, the MnxRu1−xO2/MnO2/CF‐based PEMWE shows a low cell voltage of 1.9 V at 2 A cm−2, and stably operate at current density of 500 mA cm−2 for 24 h. This work shows the potential of the pluralistic electronic structure modulation to boost activity and stability of Ru‐based acidic OER electrocatalysts.

Abstract Background It has been confirmed that the ApoB/ApoA1 ratio is closely associated with the incidence of cardiometabolic diseases (CMD). However, due to uncontrolled confounding factors in observational studies, the causal relationship of this association remains unclear. Methods In this study, we extracted the ApoB/ApoA1 ratio and data on CMD and its associated risk factors from the largest European Genome-Wide Association Study. The purpose was to conduct Mendelian Randomization (MR) analysis. The causal relationship between the ApoB/ApoA1 ratio and CMD was evaluated using both univariable and multivariable MR analyses. Furthermore, bidirectional MR analysis was performed to estimate the causal relationship between the ApoB/ApoA1 ratio and risk factors for CMD. The final verification confirmed whether the ApoB/ApoA1 ratio exhibits a mediating effect in CMD and related risk factors. Results In terms of CMD, a noteworthy correlation was observed between the increase in the ApoB/ApoA1 ratio and various CMD, including ischemic heart disease, major adverse cardiovascular events, aortic aneurysm, cerebral ischemic disease and so on (all P FDR

Access to off-farm employment has been expected to be a critical approach to ending hunger and all forms of malnutrition, two important targets of achieving Zero Hunger. This study aims to investigate the role of off-farm employment in improving dietary diversity through substitution effect and complementary effect with agricultural production activities and income effect. This study adopts Poisson/Tobit/Probit/OLS regressions and the instrument variable method based on the primary survey data collected among 1,282 households at 12 sites in environmentally and economically vulnerable areas of China, Nepal, Cambodia, Thailand, and Myanmar in 2019. The results show that off-farm employment is positively associated with household dietary diversity and the consumption of flesh meat, fish and other aquatic animals, fruits, and milk and dairy products, which are rich in protein and micronutrients. The results of mechanism analysis show that off-farm employment contributes to household dietary diversity by improving crop diversity, especially for poor households, boosting the probability of livestock raising for households with the middle one-third disposal income, and increasing household income. The positive association between off-farm employment and household dietary diversity is much higher for households with the bottom one-third disposal income, low illiteracy, and from upper-middle income countries. These findings imply that off-farm employment does play a vital role in achieving multiple benefits of poverty alleviation, malnutrition reduction, and agrobiodiversity conservation in environmentally and economically vulnerable areas. However, it may enlarge the gaps in dietary diversity between households with low human capital and from low and lower-middle income countries and those with high human capital and from middle-high countries.

Energy storage systems based on virtual synchronous control provide virtual inertia to the power system to stabilize the frequency of the grid while smoothing out system power fluctuations, and the constraining effect of the energy storage state of charge (SOC) has a significant impact on regulating virtual inertia and damping. For this reason, this paper proposes a method for fuzzy adaptive virtual inertia control of energy storage systems considering SOC to avoid deep over-charging and over-discharging of energy storage units, which can effectively extend the working life of energy storage. Finally, the effectiveness of the proposed control strategy is verified by hardware-in-the-loop experiments.

The high sodium content in meat products poses health risks to consumers and does not align with modern green and healthy living standards. Current strategies for directly reducing the sodium content in meat products are limited by their negative impact on the sensory or quality attributes of the products. In recent years, there has been great interest in applying ultrasound technology to reduce sodium content. This paper discusses the advantages and disadvantages of current mainstream strategies for reducing the sodium content in meat products, as well as the potential mechanisms by which ultrasound-assisted marination improves the quality of low-salt meat products. The main findings indicate that ultrasound, through its cavitation and mechanical effects, facilitates the transition of proteins from stable insoluble aggregates to stable soluble complexes, exposing more hydrophilic groups and, thus, enhancing protein solubility. At the same time, ultrasound promotes a greater number of proteins to participate in the formation of interfacial layers, thereby increasing emulsifying activity. Furthermore, ultrasound treatment promotes the interaction between proteins and water, leading to partial unfolding of protein chains, which allows polar residues to more readily capture water in the gel, thereby improving the water-holding capacity of the gel. These effects will contribute to the formation of high-quality low-salt meat products. However, variations in the frequency, intensity, and duration of ultrasound treatment can lead to differing effects on the quality improvement of low-salt meat products.

Short-chain dehydrogenase/reductases (SDRs) are the largest NAD(H)-dependent oxidoreductase superfamilies and are involved in diverse metabolisms. This study presents a comprehensive genomic analysis of the SDR superfamily in Cinnamomum camphora, a species that is one of the most significant woody essential oil plants in southern China. We identify a total of 222 CcSDR proteins and classify them into five types based on their cofactor-binding and active sites: ‘atypical’, ‘classic’, ‘divergent’, ‘extended’, and ‘unknown’. Phylogenetic analysis reveals three evolutionary branches within the CcSDR proteins, and further categorization using the SDR-initiative Hidden Markov model resulted in 46 families, with the CcSDR110C, CcSDR108E, and CcSDR460A families being the most populous. Collinearity analysis identified 34 pairs of CcSDR paralogs in C. camphora, 141 pairs of SDR orthologs between C. camphora and Populus trichocarpa, and 59 pairs between C. camphora and Oryza sativa. Expression profile analysis indicates a preference for the expression of 77 CcSDR genes in specific organs such as flowers, bark, twigs, roots, leaves, or fruits. Moreover, 77 genes exhibit differential expression patterns during the four developmental stages of leaves, while 130 genes show variance across the five developmental stages of fruits. Additionally, to explore the biosynthetic mechanism of methyl eugenol, a key component of the leaf essential oil in the methyl eugenol chemotype, this study also identifies eugenol synthase (EGS) within the CcSDR460A family through an integrated strategy. Real-time quantitative PCR analysis demonstrates that the expression of CcEGS in the leaves of the methyl eugenol chemotype is more than fourfold higher compared to other chemotypes. When heterologously expressed in Escherichia coli, it catalyzes the conversion of coniferyl acetate into a mixture predominantly composed of eugenol (71.44%) and isoeugenol (21.35%). These insights pave the way for future research into the functional diversity of CcSDR genes, with a focus on secondary metabolism.

Prior research has identified trust trait, trust expectation, trust risk and trust behavior as integral components of interpersonal trust. However, there still lack an in-depth exploration of the structural relationships among these integral components—how these integral components collectively constitute interpersonal trust. The current study innovatively proposed that interpersonal trust is anchored by individual trust trait, mediated by the dynamic equilibrium between trust risk and trust expectation, and culminates in trust behavior as the outcome. Interpersonal trust results from the synergistic interplay of individual and environmental factors. We called such structural relationships as the pyramid structure model of interpersonal trust, and proved its rationality by empirical evidence.

ObjectiveThis study utilized computed tomography angiography (CTA) to assess the risk of acute type A aortic dissection (ATAAD) by analyzing the imaging morphology indicators of the ascending aorta, along with the relevant risk factors associated with aortic dissection.MethodsThe study utilized a retrospective observational research design. The population consisted of 172 patients who received treatment in the Department of Cardiothoracic Surgery at Qilu Hospital, Shandong University, from January 2018 to December 2022. The patients were divided into two groups: the ATAAD group (n = 97) and the thoracic aortic aneurysm group (TAA, n = 75). Demographic data and ascending aorta CTA measurements were collected from all patients. Single factor and multivariate logistic regression were employed to analyze the statistical differences in clinical data and ascending aorta CTA imaging morphology indicators between the two groups.ResultsThe variables were included in logistic multivariate analysis for further screening, indicating that the length of the ascending aorta (LAA) before ATAAD (OR = 3.365; 95% CI :1.742–6.500, P

BackgroundThere is currently insufficient data to validate adult-based US risk stratification systems (RSSs) for the identification of malignant thyroid nodules in a pediatric population.MethodsFrom October 2016 and May 2023, 173 thyroid nodules of pediatric patients (age ≤ 18 years) with definitive pathology results and ultrasound (US) examination within 1 month before surgery or fine-needle aspiration (FNA) biopsy in our institution were enrolled in this study. The clinical and US characteristics of these nodules were retrospectively reviewed and categorized according to the ACR-TIRADS, C-TIRADS, and ATA guidelines. The diagnostic performance of US-based FNA criteria (original and simulating) of the three guidelines in thyroid cancer detection was estimated.ResultsThe three RSSs had similar AUC according to the categories(0.849-0.852, all P > 0.05). When combined with the original FNA criteria of the three RSSs to manage the nodules, the FNA rate of ACR-TIRADS and C-TIRADS were significantly less than ATA guidelines (53.18% vs. 64.63%, P < 0.05, and 52.60% vs. 64.63%, P < 0.05). The missed malignancy rate (MMR) and unnecessary FNA rate (UFR) of ATA guidelines (50.00%, 35.85%) was highest among the three RSSs, followed by the C-TIRADS (37.80%, 19.57%) and the ACR-TIRADS (37.04%, 19.57%). When nodules < 1 cm with the highest category in each RSS biopsied, that is when using the simulating FNA thresholds, the MMR was reduced overall (all P < 0.001), without a change in the UFR (all P > 0.05). All the three RSSs showed a substantial improvement in accuracy and malignant detection rate (all P < 0.05).ConclusionThe ACR-TIRADS, C-TIRADS, and ATA guidelines showed high missed malignancy rates when using their original recommended FNA criteria. When nodules < 1 cm with the highest category in each RSS biopsied, the missed malignancy rate of each RSS was decreased. Decreasing the FNA thresholds for highly suspicious malignant nodules may therefore be an effective means of managing malignant thyroid nodules in pediatric patients.

The Pan-Third Pole region comprises multiple nations affected by climate vulnerability and energy inequality, wherein promoting energy transitions in rural households would provide a path to combat climate change. Identifying the factors that drive rural household energy consumption and the transition is important. This study performed a micro-survey of 1060 rural households in five countries in the Pan-Third Pole region and empirically analyzed the relationships between off-farm income, energy consumption, and energy transitions. The off-farm income of rural households was found to have a significantly positive effect (p

Deep-water oil and gas is currently the hot spot and difficulty of global oil and gas exploration, and the complex flow process inside the turbidite channels of deep-water canyons makes it difficult to characterize reservoir structures, identify barriers and interlayers and clarify the spatial distribution laws of reservoirs, which restricts the development of deep-water oil and gas. Taking the Central Canyon of the Qiongdongnan Basin as an example, this paper identifies and characterizes the barriers and interlayers of composite channel scale by means of seismic sedimentology, based on three-dimensional seismic and core data. Then, based on the turbidite filling process, barriers and interlayers are classified, and their genesis and control factors are analyzed. Finally, a development model of deep-water barriers and interlayers is established based on the quantitative analysis of sediment transportation system parameters. And the following research results are obtained. First, based on sedimentary genesis, barriers and interlayers are classified into four types, namely mudstone interlayers of lateral (aggradational) turbidite channel genesis (type A), mudstone interlayers of fine-grained turbidite channel genesis (type B), barriers of hemipelagic deep-water sediment genesis (type C), and calcareous petrophysical interlayers (type D). Second, based on the filling stage, barriers and interlayers are divided into four combination sequences, i.e., the initial canyon formation stage with strong sediment supply conditions (type A + type C and type B+ type C), the initial canyon formation stage with weak sediment supply conditions (type B + type C), the stable canyon development/late reworking stage with strong sediment supply conditions (types A + type D), and the stable canyon development/late reworking stage with weak sediment supply conditions (type D). Third, the development types and combination sequences of barriers and interlayers are controlled by the change of sediment transportation volume and terrain slope in the canyon. In the initial canyon formation stage, there is sufficient space for the development of turbidite, and the development of thin barriers and interlayers is controlled by sediment dischage volume, while the development of thick barriers and interlayers is controlled by terrain slope change. In the stable canyon development/late reworking stage, turbidite undergoes superimposed development and overbank. The sediment supply is the primary control factor of barrier and interlayer thickness, and the terrain slope change is the secondary factor. In conclusion, the development model of barriers and interlayers can be used to describe and predict the reservoir structure models under the same sedimentary background and provides a technical support for the exploration and development of deep-water oil and gas.

The rotating blade is a key component of an aero-engine, and its vibration characteristics have an important impact on the performance of the engine and are vital for condition monitoring. This paper reviews the research progress of blade dynamics, including three main aspects: modeling of blades, solution methods, and vibration characteristics. Firstly, three popular structural dynamics models for blades are reviewed, namely lumped-mass model, finite element model, and semi-analytical model. Then, the solution methods for the blade dynamics are comprehensively described. The advantages and limitations of these methods are summarized. In the third part, this review summarizes the properties of the modal and vibration responses of aero-engine blades and discusses the typical forms and mechanisms of blade vibration. Finally, the deficiencies and limitations in the current research on blade modeling and vibration analysis are summarized, and the directions for future efforts are pointed out. The purpose of this review is to provide meaningful insights to researchers and engineers in the field of aero-engine blade modeling and dynamic characteristics analysis.

The Guodian Fe deposit is representative of the newly discovered Qihe–Yucheng high-grade Fe skarn ore cluster, Luxi Block, eastern North China Craton (NCC). The age of the Pandian Fe deposit remains elusive, which hinders the understanding of its metallogenic tectonic background. Phlogopites are recognized in syn-ore stages, and they are closely associated with magnetite in the Guodian skarn Fe deposit. Here, we carried out 40Ar/39Ar dating of phlogopite, which can place a tight constraint on the timing of Guodian iron mineralization and shed light on the geodynamic framework under which the Guodian Fe deposit formed. Ore-related phlogopite 40Ar/39Ar dating yielded 40Ar/39Ar plateau ages of 131.6 ± 1.7 Ma at 890–1400 °C, with the corresponding isochron age being 131.1 ± 2.6 Ma. These two ages are consistent within the error, indicating that they can represent the formation age of the Guodian iron deposit. The mineralization age overlaps the zircon U-Pb age of 124.4 Ma for ore-related Pandian pluton. This age consistency confirms that the iron skarn mineralization is temporally and likely genetically related to Pandian diorite. The present results, coupled with existing isotopic age data, indicate the Guodian skarn Fe deposit formed contemporaneously with large-scale skarn iron mineralization over the Luxi Block in the Late Mesozoic. The available data demonstrated that the eastern NCC was “destructed” in the Late Mesozoic, as marked by voluminous igneous rocks, faulted-basin formation, high crustal heat flow, and widespread metamorphic core complexes in the eastern part of the NCC. It is thus suggested that the Guodian Fe skarn deposits, together with other deposits of similar ages in the Luxi Block and even in the eastern NCC, were products of this craton destruction. Lithospheric extension and extensive magmatism related to the craton destruction may have provided sufficient heat energy, fluid, chlorine, and Fe for the formation of the Fe deposit.

This paper endeavors to investigate the characteristics of the transient dynamic response of a generally shaped arch when influenced by uncertain parameters while being subjected to specific external excitation. The equations of motion of the generally shaped arches are derived by the differential quadrature (DQ) method, and the deterministic dynamic responses are calculated using the Newmark-β method. By employing the Chebyshev inclusive function, an interval method based on a non-intrusive polynomial surrogate model is developed, and the uncertain dynamic responses are reckoned by enabling numerical simulations. The results of the proposed interval method are compared with those obtained from the scanning method for validation. The effects of various shapes and rise span ratios on the dynamic responses are investigated through a parametric study. The results suggest that the degree of fluctuation in the uncertain dynamic behavior is influenced by the type of parameter. Additionally, the responses of each shaped arch decrease with the increase in the rise span ratios, and with the same rise span ratio, the deterministic responses and corresponding uncertain responses are also affected by the shape of the arch, and they are considered to be at a minimum when the arch shape is parabolic. This study will enhance understanding of the dynamic properties of arches with uncertainties and provide some basis for the assessment and health monitoring of arch structures.

Developing advanced underwater welding technology for titanium, which is the key structural material for underwater applications, is of great significance for the design, fabrication, and maintenance of submarine equipment. In this study, in order to investigate the underwater welding microstructure and mechanical properties of Ti-4Al-2V alloy, underwater wet laser welding was conducted on Ti-4Al-2V alloy using varying laser power. The microstructure and properties of the welding joints were characterized and analyzed. The microstructure of the heat-affected zone and fusion zone in the welding joints are not significantly different from those of welding in air, but a mixed oxide layer composed of Al2O3 and TiO2 is formed on the surface of the fusion zone. Due to internal stress, a large number of cracks initiate on the oxide layer and propagate to the joints. In the 4 kW and 5 kW joints, a penetrating crack formed due to the excessive accumulation of internal stress breaking up the α phase. The mechanical properties of the joints are significantly affected by the laser power. The tensile strength of the 3 kW and 4 kW joints is comparable to that of the base metal, which is about 600 MPa, while the 5 kW joint shows brittle fracture with no plastic deformation and 228 MPa strength. This research lays a solid foundation for understanding the underwater wet laser welding behavior of titanium alloys.

This paper introduces a simultaneous optimization approach to synthesizing work and heat exchange networks (WHENs). The proposed work and heat integration (WHI) superstructure enables different thermodynamic paths of pressure and temperature-changing streams. The superstructure is connected to a heat exchanger network (HEN) superstructure, enabling the heat integration of hot and cold streams identified within the WHI superstructure. A two-step solution strategy is proposed, consisting of initialization and design steps. In the first step, a thermodynamic path model based on the WHI superstructure is combined with a model for simultaneous optimization and heat integration. This nonlinear programming (NLP) model aims to minimize operating expenditures and provide an initial solution for the second optimization step. In addition, hot and cold streams are identified, enabling additional model reduction. In the second step of the proposed solution approach, a thermodynamic path model is combined with the modified HEN model to minimize the network’s total annualized cost (TAC). The proposed mixed integer nonlinear programming (MINLP) model is validated by several examples, exploring the impact of the equipment costing and annualization factor on the optimal network design. The results from these case studies clearly indicate that the new synthesis approach proposed in this paper produces solutions that are consistently similar to or better than the designs presented in the literature using other methodologies.

Laser welding of the near α-phase titanium alloy Ti-4Al-2V, used for complex components in the nuclear industry, has been rarely reported. In this study, butt weld joints made of Ti-4Al-2V alloy plates under different parameters, including the laser power, the welding speed, and the defocus distance, were manufactured and analyzed. The results showed that adjusting the combination of 4.2 kW of laser power, a 20 mm/s welding speed, and a −2 mm defocus distance could achieve a penetration depth exceeding 6 mm. Porosity defects were prone to forming in the middle and bottom parts of the fusion zone, due to rapid cooling. The microstructure of the fusion zone was mainly needle-like α martensite, which precipitated in the form of specific clusters. The interior of a cluster was composed of three types of variants with /60° phase interfaces to achieve the lower boundary’s energy. Affected by the microstructure and welding defects, the strength of the weld joint was basically similar under different welding conditions, namely about 720 MPa, slightly higher than that of the base metal, while the rupture elongation at breaking decreased by more than 50%. The micro-Vickers hardness of the weld joints was about 50–60 HV higher than that of the base metal, while the impact toughness was about 40 KJ, almost half that of the base metal. This research lays a solid foundation for the engineering application of laser welding of Ti-4Al-2V alloys.

The pulp and paper industry has an important role in the industrial transition towards net zero or negative emissions, given its renewable biomass-based feedstock and energy supply. In particular, pulp and paper mills have large existing sources of biogenic CO2, with a high potential to contribute to carbon dioxide removal through carbon capture and storage (CCS). To effectively navigate anticipated changes in feedstock and energy markets, there is a need for a better understanding of how different technology pathways for the pulp and paper industry interact with one another, for instance, how enhanced valorization of biomass side streams may affect the potential for carbon capture. This paper aims to investigate the effect of combining carbon capture with lignin extraction in a chemical pulp mill. Pinch analysis is used to study how the targets for heat recovery, fuel usage and electricity generation, are affected by different mill and capture configurations. Based on these results, the effect on carbon flows is evaluated. The results show that when carbon capture technology is implemented and fuel use is minimized at the case-study mill, there is still enough heat available from the recovery boilers to supply the process needs without requiring usage of a utility boiler. However, when carbon capture is combined with lignin extraction, the heat production of the recovery boilers is no longer sufficient to cover the process demands, and additional heat from a utility boiler is required. However, this case implies that some of the carbon leaves the mill embedded in the extracted lignin product, which can be expected to have a higher value than captured carbon dioxide. When back-pressure electricity production was maximized for the different mill configurations, a very high fuel-to-electricity efficiency could be achieved, but since the CO2 emissions from the utility boiler were not assumed to be captured, this would lead to more carbon being emitted compared to the capture scenarios with minimized fuel use.

As an important component of the air-breathing combined precooling cycle engine of the hypersonic aircraft, the compact heat exchanger plays an important role in precooling the incoming air. However, the compact heat exchanger is easy to frosting during the precooling operation, which leads to an extremely unfavorable result, that is, the specific impulse and specific thrust of the engine significantly decrease. Therefore, in order to maintain the performance of the engine, some measures should be taken to defrosting the compact heat exchanger of the engine. In order to carried out the frosting and defrosting experiments on the compact heat exchanger that operating at relatively low altitudes, the frosting and defrosting performance of the compact heat exchanger are experimentally studied in the wind tunnel under the conditions of moderate airflow humidity value (6.4 g/kg), as well as the flow velocity and the temperature of the mainstream are 10 m/s and 50 °C, respectively. In the defrosting experiments, anhydrous methanol and anhydrous ethanol are sprayed into the mainstream as the defrosting solvents, respectively, and the mass ratios of anhydrous methanol to water and anhydrous ethanol to water are 0.75, 1.0 and 1.25. The experimental results indicate that for the frosting experiment, after coolant flows through the inside of the heat exchanger tube bundles, the frost layer quickly condenses on the outside of tube bundles. However, in the defrosting experiments, once a certain mass ratio of anhydrous methanol or anhydrous ethanol is sprayed into the main flow, the wall temperature of the heat exchanger tube bundles increases significantly, and the wall temperature is close to or higher than the freezing point of water. Furthermore, the defrosting effect and the heat transfer rate are obviously improved, and the pressure loss coefficient drops sharply. Through the analyzation of the defrosting experimental results, it is found that the defrosting performance of anhydrous methanol and anhydrous ethanol are obvious different, and the defrosting effect of anhydrous methanol is significantly higher than that of anhydrous ethanol with the same mass ratio. Within the range of experimental study parameters, for anhydrous methanol, the best defrosting performance can be obtained when the mass ratio is 1.0; and for anhydrous ethanol, the best defrosting effect can be realized when the mass ratio is 1.25. However, the defrosting performance of anhydrous ethanol with the mass ratio of 1.25 is still slightly lower than that of anhydrous methanol with the mass ratio of 0.75. Moreover, in order to achieve the best defrosting performance of the compact heat exchanger, the optimal mass ratio of anhydrous methanol to water may be in the range of between 1.0 and 1.25; and the optimal mass ratio of anhydrous ethanol to water should be greater than 1.25.

ObjectiveTo explore the advantages of dosimetry and the treatment efficiency of tangent-arc technology in deep inspiration breath-hold radiotherapy for breast cancer.MethodsForty patients with left-sided breast cancer who were treated in our hospital from May 2020 to June 2021 were randomly selected and divided into two groups. The first group’s plan was a continuous semi-arc that started at 145° ( ± 5°) and stopped at 325° ( ± 5°). The other group’s plan, defined as the tangent-arc plan, had two arcs: the first arc started at 145° ( ± 5°) and stopped at 85° ( ± 5°), and the second arc started at 25° ( ± 5°) and stopped at 325° ( ± 5°). We compared the target dose, dose in organs at risk (OARs), and treatment time between the two groups.ResultsThe target dose was similar between the continuous semiarc and tangent-arc groups. The V5 of the right lung was significantly different between the two groups (Dif 5.52, 95% confidence interval 1.92-9.13, t=3.10, P=0.004), with the patients in the continuous semi-arc and tangent-arc groups having lung V5 values of (9.16 ± 1.62)%, and (3.64 ± 0.73)%, respectively. The maximum dose to the spinal cord was (1835.88 ± 222.17) cGy in the continuous semi-arc group and (599.42 ± 153.91) cGy in the tangent-arc group, yielding a significant difference between the two groups (Dif 1236.46, 95% confidence interval 689.32-1783.6, t=4.57, P

Concrete made from rice husk ash (RHA) is stronger and more durable than normal concrete. It can also help reduce greenhouse gas emissions. A feasible prediction model to rapidly determine the compressive strength of RHA concrete can save resources and time, and the properties and characteristics of RHA concrete can be more accurately determined. In this study, the compressive strength of RHA concrete is predicted by using support vector regression (SVR) in conjunction with three optimization algorithms, namely firefly algorithm (FA), particle swarm optimization (PSO), and grey wolf optimization (GWO). The coefficient of determination (R2), root mean square error (RMSE), mean absolute error (MAE), a10-index and adjusted R2 are used to assess the predictive accuracy of models. The results show that all the three optimization algorithms can significantly improve the prediction performance of support vector regression. The prediction accuracy is also substantially higher than that of the classical machine learning models like the random forest (RF) model and the back propagation neural network (BPNN) model. The FA-SVR model with R2 values of 0.9544 and 0.9614, adjusted R2 values of 0.9530 and 0.9560, RMSE values of 3.7506 and 3.6571, MAE values of 2.2880 and 3.0732, and a10-index values of 0.8584 and 0.8793 corresponding to the training and test sets, respectively. The FA-SVR model outperforms the other two hybrid models in terms of prediction performance. The sensitivity analysis reveals that the fine aggregate content is the key factor in predicting the compressive strength of RHA concrete.

ObjectiveTo evaluate whether the categorization methods of risk stratification systems (RSSs) is a decisive factor that influenced the diagnostic performances and unnecessary FNA rates in order to choose optimal RSS for the management of thyroid nodules.MethodsFrom July 2013 to January 2019, 2667 patients with 3944 thyroid nodules had undergone pathological diagnosis after thyroidectomy and/or US-guided FNA. US categories were assigned according to the six RSSs. The diagnostic performances and unnecessary FNA rates were calculated and compared according to the US-based final assessment categories and the unified size thresholds for biopsy proposed by ACR-TIRADS, respectively.ResultsA total of 1781 (45.2%) thyroid nodules were diagnosed as malignant after thyroidectomy or biopsy. Significantly lowest specificity and accuracy, along with the highest unnecessary FNA rates were seen in EU-TIRADS for both US categories (47.9%, 70.2%, and 39.4%, respectively, all P < 0.05) and indications for FNA (54.2%, 50.0%, and 55.4%, respectively, all P < 0.05). Diagnostic performances for US-based final assessment categories exhibited similar accuracy for AI-TIRADS, Kwak-TIRADS, C-TIRADS, and ATA guidelines (78.0%, 77.8%, 77.9%, and 76.3%, respectively, all P > 0.05), while the lowest unnecessary FNA rate was seen in C-TIRADS (30.9%) and without significant differences to that of AI-TIRADS, Kwak-TIRADS, and ATA guideline (31.5%, 31.7%, and 33.6%, respectively, all P > 0.05). Diagnostic performance for US-FNA indications showed similar accuracy for ACR-TIRADS, Kwak-TIRADS, C-TIRADS and ATA guidelines (58.0%, 59.7%, 58.7%, and 57.1%, respectively, all P > 0.05). The highest accuracy and lowest unnecessary FNA rate were seen in AI-TIRADS (61.9%, 38.6%) and without significant differences to that of Kwak-TIRADS(59.7%, 42.9%) and C-TIRADS 58.7%, 43.9%, all P > 0.05).ConclusionThe different US categorization methods used by each RSS were not determinant influential factors in diagnostic performance and unnecessary FNA rate. For daily clinical practice, the score-based counting RSS was an optimal choice.

Based on the Doppler radar, wind profile radar, FY-4A black body temperature (TBB), ground-based microwave radiomter, automatic ground stations and ERA5 reanalysis data, the process evolution and abnormal characteristics of the location, direction of movement and long life of the pre-TC squall line caused by typhoon Lekima (2019) are analysed. Results are as follows. (1) The evolution of the pre-TC squall line experiences three stages: development and formation, strengthening and maturation, and weakening and extinction. In the second stage, the influence area is the most extensive and the intensity is the strongest, and the changes of meteorological parameters caused by the pre-TC squall line crossing have extreme characteristics. The characteristics of mesoscale thunderstorm high pressure, pre-squall hot depression, cold pool and warm center are obvious. (2) The pre-TC squall line occurs in the humid zone between the enhanced continental high pressure and typhoon Lekima. Typhoon provides abundant water vapor and strong unstable environment to generate large convective available potential energy (CAPE) and convergence of northeast airflow during the pre-TC squall line event. Under the weather background of middle-level dry air and low-level wet air thermal unstable stratification and the low-level strong vertical wind shear, the pre-TC squall line is generated. (3) After the pre-TC squall line enters Fujian, the significantly enhanced unstable structure of middle-level dry air and low-level wet air, the abnormal enhancement of low-level vertical wind shear, and the convective storm generated by the pre-TC squall line incorporates into the pre-TC squall line and promotes the development and enhancement of the pre-TC squall line, which are favorable for ground wind increase. (4) The enhanced northeast airflow guides the pre-TC squall line to move toward the southwest, which has a large angle with the guidance air flow. Their moving directions are consistent with each other, which causes the high moving speed and ground wind increase. (5) The peak values of thermodynamic convection parameters (K, TT and A index) calculated from the ground-based microwave radiometer data have a good correspondence with the extreme values of the gale caused by pre-TC squall line. The indices K≥37 ℃ and A≥11 ℃ have certain reference value for severe convection weather warning.

The dynamic characteristics of a structure serve as a crucial foundation for structural assessment, fault diagnosis, and ensuring structural safety. Therefore, it is imperative to investigate the impacts of uncertain parameters on the dynamic performance of structures. The dynamic characteristics of arches with uncertain parameters are analyzed in this paper. The uncertain parameters are regarded as non-probabilistic uncertainties and represented as interval variables. A model of an arch considering interval-uncertain parameters is built, and kinematic equations are established. The natural frequencies are obtained using the differential quadrature (DQ) method, and the relationships between natural frequency, radius, and central angle are also analyzed. On this basis, the Chebyshev polynomial surrogate (CPS) model is employed to solve the uncertain dynamic problem, and the natural frequencies are seen to be the objective functions of the CPS model. The accuracy verification of the model is achieved by comparison with the Monte Carlo simulation (MCS). Simulations are carried out considering different uncertainties, and the results show that the bounds of natural frequencies are influenced not only by the types of uncertain parameters, but also by their combinations.

The Daliuhang gold deposit in the Qipengfu (Qixia–Penglai–Fushan) ore concentration area is a typical gold deposit of medium-low temperature hydrothermal veins. Uncertainties regarding the primary sources of ore-forming fluids, as well as whether host rocks contribute materials to the mineralization of the gold deposits in the Jiaodong Peninsula, are still subject to intense debate. Hydrogen–oxygen isotope results show that atmospheric water is involved in ore-forming fluids. According to the results of the helium–argon isotopes of pyrite, it is hypothesized that the initial fluid source was located in the oceanic crust or upper mantle lithosphere above the Early Cretaceous Paleo-Pacific Plate, as it was subducted into the eastern part of the eastern North China Craton. In situ sulfur isotope results show that high δ34S values characterize the pyrite in the main mineralization period. It is inferred that during the thinning and melting process of the lithospheric mantle, the volatile components enriched in pyrite contributed to the release of δ34S. At the same time, when the fluids ascended to the weak zones, such as fissures of ore-endowed peripheral rocks, the δ34S in the peripheral rocks were extracted, and the two processes acted together to cause high δ34S values to occur. Similarly, the lead and strontium isotopic compositions indicate a crust–mantle mixing attribute of the mineralized material source. The zircon U–Pb age of the ore-hosting granodiorite was 130.35 ± 0.55 Ma, and the Rb–Sr isochron age of the pyrite from the main mineralization period was 117.60 ± 0.10 Ma, which represents the timing of felsic magmatism and gold mineralization, respectively, with at least 10 Ma between the magmatism and mineralization. The magma gradually cooled over time after its formation, and when the granodiorite cooled down to 300 ± 50 °C, the temperature and pressure conditions were most conducive to the precipitation of gold. It is inferred that gold-rich initial mantle fluids with volatile components, rising along tectonically weak zones, such as fractures, underwent fluid phase separation in the fractured position of the granite and extracted the gold from the granodiorite, forming gold deposits.

Abstract Purpose To investigate the efficacy and safety of pyrotinib in treating patients with human epidermal growth factor receptor type 2 (HER2)‐positive breast cancers with brain metastasis. Patients and Methods This is a multicenter retrospective study, and the HER2‐positive breast cancer patients with brain metastasis were studied. The enrolled patients were given pyrotinib 400 mg orally once per day for 21 days as one cycle, and evaluated every two cycles. All relevant data were detected for final assessments including medical history, clinical examination, histopathology, immunohistochemistry, radiographic imaging, treatment outcome, and adverse events. Results Forty‐two female patients in total were enrolled in this study. The objective response rate (ORR) and disease control rate (DCR) of central nervous system (CNS), were found in 20 of 42 (47.6%) and in 39 of 42 (92.8%), respectively, while for extra‐CNS, the respective ORR and DCR were in 9 of 38 (23.6%) and in 36 of 38 (94.7%), respectively. The compounded ORR and DCR were seen in 17 of 42 (40.4%) and in 39 of 42 (92.8%), respectively. The improvement rate of craniocerebral symptoms after treatment was (19/19) 100% and the median duration was 15 months. The median effective time of brain metastases and other metastases was 43 and 50 days. The median follow‐up time was 22 months (interquartile range, 16.0–24.3 months). The median time for progression in brain metastasis was 16.6 months. The median time to progress for our group patients was 11.1 months. Sixteen patients (36%) with adverse reactions were recorded in the study. Conclusion Pyrotinib combined with chemotherapy/radiotherapy or alone showed significantly greater local control rates and progression free survival (PFS), with manageable toxicity for patients with HER2‐positive breast cancer with brain metastases, and further follow‐up will provide an overall survival (OS) data.

Abstract The collectors of electronic transformers has the problem of electromagnetic incompatibility under the operation of disconnecting switches, which limits their wide application in smart grids. To evaluate the maximum level of disturbance that collectors are able to withstand in the stochastic process of switching operation, this work introduces a quantitative approach based on limited test measurements, which can quantify the level of disturbance in the signal acquisition ports of electronic voltage transformers (EVT) in different gas‐insulated switchgears (GIS). Based on large numbers of experimental statistical data of the true type simulation experimental platform, the Spearman rank correlation coefficient is used to prove that the amplitude of the disturbance voltage pulse at the secondary side port and the breakdown voltage between the primary side fracture approximately satisfy a linear relationship. Subsequently, the quantile regression model is used to quantify and verify the maximum disturbance level of the secondary side port. Moreover, a solution is proposed to tackle the difficulty in obtaining the breakdown voltage at breaks in the GIS substation field applicatvion, under which the quantified maximum disturbance voltage deviation of secondary ports is only −4.34% by comparison. The research work can further explore the practical value of the measured data in a few tests under GIS substation field conditions and provide references for the subsequent revision of EVT‐related standards.

Urban healthcare operations continuously generate large amounts of electronic medical record data. Combined with urban regional factors, a comprehensive data model is established to conduct a multidimensional visual analysis, which is helpful in extracting and analyzing the correlations between regional factors and residents’ health. This paper establishes data models for regional factors such as regional diet, industrial economy, climate, and regional epidemics and introduces an Apriori association algorithm to find disease association relationships, a one-mode projection algorithm for bipartite networks to perform disease clustering, and a collaborative filtering recommendation algorithm to predict patients’ potential high-risk diseases. Combined with the general analysis process for the visual exploration of regional health impact factors proposed in this paper, a visual analysis system is designed, and through the collaborative interaction of multiple visual interfaces, the multidimensional visual presentation of the association pattern between regional factors and residents’ health is achieved. Taking a sample size of 24,626 electronic medical records in a city as an example, the case study proves that the exploration of regional factors such as catering, climate and regional epidemics can provide an analytical basis and decision support for improving the health level of urban residents.

ObjectivesTo estimate the feasibility of decreasing the original thresholds for biopsy in the Kwak Thyroid Imaging Reporting and Data System (Kwak TIRADS) and Chinese Thyroid Imaging Reporting and Data System (C TIRADS).MethodsThis retrospective study included 3,201 thyroid nodules from 2,146 patients with a pathological diagnosis. We lowered the original fine-needle aspiration (FNA) thresholds with the TR4a-TR5 in Kwak and C TIRADSs and calculated the ratio of additional benign-to-malignant nodules being biopsied (RABM). If the RABM is less than 1, the decreased FNA thresholds could be accepted and used to the modified TIRADSs (modified C and Kwak TIRADSs). Then, we estimated and compared the diagnostic performance between the modified TIRADS and the original TIRADS to determine if the decreased thresholds could be an effective strategy.ResultsA total of 1,474 (46.0%) thyroid nodules were diagnosed as malignant after thyroidectomy. The TR4c-TR5 in Kwak TIRADS and TR4b-TR5 in C TIRADS had a rational RABM (RABM < 1). The modified Kwak TIRADS had higher sensitivity, a positive predictive value, a negative predictive value, lower specificity, an unnecessary biopsy rate, and a missed malignancy rate compared with the original Kwak TIRADS (94.1% vs. 42.6%, 59.4% vs. 44.6%, 89.9% vs. 52.8%, 45.0% vs. 54.9%, 40.6% vs. 55.4%, and 10.1% vs. 47.1%, respectively, P < 0.05 for all). Similar trends were seen in the modified C TIRADS versus the original C TIRADS (95.1% vs. 38.7%, 61.7% vs. 47.8%, 92.3% vs. 55.0%, 49.7% vs. 64.0%, 38.3% vs. 52.2%, and 7.7% vs. 44.9%, respectively, P < 0.05 for all).ConclusionsThe biopsy of all nodules with TR4C-TR5 in the Kwak TIRADS and TR4B-TR5 in the C TIRADS might be an effective strategy. This paper contributes to the contradiction concerning whether to perform FNA for the nodules smaller than 10 mm.

Based on the equivalent bending stiffness of the viscoelastic cracked beam with open cracks, the corresponding complex frequency characteristic equations of a Timoshenko viscoelastic cracked beam are obtained by using the method of separation of variables and the Laplace transform. The vibration characteristics of a viscoelastic Timoshenko cracked beams with the standard linear solid model and Kelvin-Voigt model are investigated. By numerical examples, the effects of the crack location, crack number, crack depth, and slenderness ratio on the vibration characteristics of the viscoelastic cracked beams are revealed.

Located in the Penglai-Qixia-Fushan Gold Belt, the Yangjiakuang gold deposit formed in the marble of the Paleoproterozoic Fenzishan Group is different from the previous altered rock-type gold deposits whose host gold-bearing rocks are Archean gneiss and Mesozoic granite. Two gold orebodies have been explored within the Yangjiakuang gold deposit, and both of them were controlled by the Yangjiakuang syncline. Three ore-forming stages have been recognized, including the pyrite-sericite stage (I), the gold, polymetallic sulfide, and quartz stage (II), and quartz-calcite stage (III). The calcites, which represent the main metallogenic stage (II) at Yangjiakuang gold deposit, yielded a Sm-Nd isochron age of 123.5 ± 8.1 Ma (MSWD = 0.042). Subsequent geologic events were recorded by quartz diorite porphyrite dyke which are dated at 122.75 ± 0.66 Ma (MSWD = 1.5) by zircon LA-ICP-MS U-Pb dating. It is suggested that the gold mineralization took place in the early period of Early Cretaceous. The in situ δ34S values of pyrites from two stages have a narrow range from + 5.65 to + 9.63‰ with an average value of 8.14‰, which indicate that the source of δ34S is related to the Guojialing granite and the Fenzishan Group. The lead isotopic compositions of pyrites (206Pb/204Pb = 16.615 to 16.832; 207Pb/204Pb = 15.275 to 15.403; 208Pb/204Pb = 36.829–37.470) show a consistent origin of the lower crust. The measured 3He/4He (40Ar/36Ar) of hydrothermal fluids in pyrites are 0.641–1.132 Ra (637.5–1162.7), indicating that the ore-forming fluid originating from a mixing of crustal and mantle components. It is suggested that the gold mineralization is associated with extensional tectonic inversion caused by the rollback of the subducting Izanagi Plate during the early Cretaceous, which triggered partial melting of mantle and lower crust, and subsequent magma mixing and exsolution of ore-bearing fluids. These fluids extracted ore-forming materials from the enclosing rocks of the Jiaodong Group, the Fenzishan Group, and the Guojialing granite to form the ore-forming fluids.

Emission reductions in power generation for offshore oil and gas activities are key in order to reach climate targets in regions with this industry. This study presents a review of both established and immature low carbon power generation concepts, an analysis of their potential for greenhouse gas (GHG) emission reduction, and an evaluation of their offshore applicability. The potential for GHG emission reduction is quantified by estimating CO2 equivalent intensity for implementation on the Norwegian Continental Shelf. The offshore applicability is evaluated with emphasis on weight, infrastructure requirements, process heat availability, technical maturity, as well as health, safety, and environment (HSE). It is shown that power from shore is the only technically mature concept with potential for very high emission reductions (>95 %, provided that low GHG electric power is available). There are several alternative concepts under development that also can give significant emission reductions (>70 %), including fuel switching, CO2 capture and storage, and renewable power combined with energy storage. Combined cycle gas turbines and offshore wind power combined with gas turbines are technically mature and can achieve partial emission reductions (around 15–50 %, with the assumed system configurations). Other concepts offering partial emission reductions are under development, but do not show clear advantages over those already mentioned. It is pointed out that, to enable reaching the net zero emission targets, only efficiency improvements and power from shore are not enough, and there is a need to develop additional low emission technologies not yet on the market. The present study has compiled a large database of specifications for assessing low carbon power production concepts and proposes a methodology that is valuable in screening a large number of commercial and immature technologies.

The relationship between the in-stent neoatherosclerosis (ISNA) formation and the plaque’s characteristic changes in the non-culprit lesion is unclear. We aim to investigate the plaque characteristics changes at non-culprit lesions between patients with ISNA and without ISNA formation at 1-year follow-up. We retrospectively enrolled patients who had DES implantation in de novo lesion and underwent immediately after stenting and 1-year follow-up optical coherence tomography (OCT) examination. OCT-defined ISNA was defined as the presence of lipid-laden neointima or calcification within the culprit stent with a longitudinal extension of ≥1 mm. Non-culprit lesions were divided into two groups: ISNA group (with ISNA) and non-ISNA group (without ISNA). Plaque characteristics of non-culprit lesions were evaluated at baseline and 1-year follow-up. In total, 89 patients with 89 non-culprit lesions (ISNA: n = 37; non-ISNA: n = 52) were included in the analyses. The lesions in the ISNA group show a smaller minimum lumen area compared to the non-ISNA group at 1-year follow-up (2.57 ± 1.08 mm2 versus 3.20 ± 1.62 mm2, p = 0.044). The lesions of the ISNA group show a significant decrease in minimum lumen area changes percent (–7.25% versus 6.46%, p = 0.039). And there are more lesions with minimum lumen area (64.9% versus 38.5%, p = 0.014) and minimum lumen diameter (64.9% versus 40.4%, p = 0.023) decrease in the ISNA group. Furthermore, the lesions in ISNA group have more plaques with lipid core length increase (25.0% versus 10.0%, p = 0.040), more plaques with FCT decrease (50.0% versus 74.0%, p = 0.027) and less TCFA change to non-TCFA (33.3% versus 87.5%, p = 0.010). The plaque characteristic changes in non-culprit lesions are closely related to ISNA formation. The ISNA formation may accompany by a tardier plaque stabilization process in non-culprit lesions.

District solar assists cooling systems can make full use of local renewable resources, and reduce the fossil fuel consumption and greenhouse gas emissions. After modelling and validation of solar cooling systems, the exergo-economic method is carried out to explore the economic performance by considering the lowest heat transfer areas of two chiller types based on the yearly ambient parameters in Beijing, China. The sensitivity analysis of key parameters is searched to depict the impacts of initialized parameters. The results show that the solar cooling system coupled to parallel chiller needs the lowest solar installation area, 602 m2, and corresponds to the highest coefficient of performance, 1.15, and exergy efficiency, 21.91%. However, due to the higher heat transfer areas of parallel chiller, the specific exergo-economic cost of chilled water, 3.93 $/kWh, is higher than the one of series cooling system, 3.78 $/kWh. The sensitivity analysis demonstrates that except for temperatures of cooling water, returned chilled water, and temperature difference of driving steam from solar unit, other parameters have positive impact on exergo-economic performance.

Continuously improving heat transfer efficiency is one of the important goals in the field of energy. Compact heat exchangers characterized by microscale flow and heat transfer have successfully provided solutions for this purpose. However, as the characteristic scale of the channels decreases, the flow and heat transfer characteristics may differ from those at the conventional scale. When considering the influence of scale effects and changes in special fluid properties, the flow and heat transfer process becomes more complex. The conclusions of the relevant studies have not been unified, and there are even disagreements on some aspects. Therefore, further research is needed to obtain a sufficient understanding of flow structure and heat transfer mechanisms in microchannels. This article systematically reviews the research about microscale flow and heat transfer, focusing on the flow and heat transfer mechanisms in microchannels, which is elaborated in the following two perspectives: one is the microscale single-phase flow and heat transfer that only considers the influence of scale effects, the other is the special heat transfer phenomena brought about by the coupling of microscale flow with special fluids (fluid with phase change (pseudophase change)). The microscale flow and heat transfer mechanisms under the influence of multiple factors, including scale effects (such as rarefaction, surface roughness, axial heat conduction, and compressibility) and special fluids, are investigated, which can meet the specific needs for the design of various microscale heat exchangers.

In this study, we investigated the electronic properties and selective adsorption for CO2 of nickel boride clusters (NiB)n, (n = 1~10) using the first principles method. We optimized the structures of the clusters and analyzed their stability based on binding energy per atom. It was observed that (NiB)n clusters adopt 3D geometries from n = 4, which were more stable compared to the plane clusters. The vertical electron affinity, vertical ionization energy, chemical potential, and highest occupied molecular orbital (HOMO)–lowest unoccupied molecular orbital (LUMO) gap were calculated. Our results revealed that (NiB)6 and (NiB)10, with high chemical potential, exhibit a higher affinity for CO2 adsorption due to a charge delivery channel that forms along the Ni→B→CO2 path. Notably, (NiB)10 demonstrated a more practical CO2 desorption temperature, as well as a broader window for the selective adsorption of CO2 over N2. The density of states analysis showed that the enhanced CO2 adsorption on (NiB)10 can be attributed to the synergistic effect between Ni and B, which provides more active sites for CO2 adsorption and promotes the electron transfer from the surface to the CO2 molecule. Our theoretical results imply that (NiB)10 should be a promising candidate for CO2 capture.

In order to study the influence of typical coal-fired flue gas components on the supersaturation characteristics in a multisection growth tube, a two-dimensional heat and mass transfer model was used to predict the supersaturation profiles formed by the cool saturated flow into a warm-walled growth tube (Method 1) and the warm saturated flow into a cold-walled growth tube (Method 2). The calculated results show that the increase in the concentration of the three typical components CO2, SO2, and RH (relative humidity) of the flue gas is beneficial for the achievement of the supersaturated environment in Method 1. Additionally, having too many sections of the growth tube has a disadvantage in achieving the supersaturation profiles. When the content of the gas of lower Le is higher, having more sections of the growth tube is beneficial to achieving a supersaturated environment, while a lower number of sections is necessary when the gas content is lower in Method 2. In a word, the appropriate number of sections in a growth tube is significantly important for the achievement of a favorable supersaturated environment.

The engine system is critical for a marine vehicle, and its performance significantly affects the efficiency and safety of the whole ship. Due to the harsh working environment and the complex system structure, a marine system is prone to have many kinds of novelties and faults. Timely detection of faults via effective condition monitoring is vital for such systems, avoiding serious damage and economic loss. However, it is difficult to realize online monitoring because of the limitations of measurement and health monitoring methods. In this paper, a marine engine system simulator is set up with enhanced sensory placement for static and dynamic data collection. The test rig and processing for static and dynamic data are described. Then, a physics-based multivariate modeling method is proposed for the health monitoring of the system. Case studies are carried out considering the misfire fault and the exhaust valve leakage fault. In the misfire fault test, the exhaust gas temperature of the misfired cylinder dropped from the confidence interval 100–150 °C to 70–80 °C and the head vibration features decreased from the confidence interval 900–1300 m/s2 to around 200–300 m/s2. For the exhaust valve leakage fault, the engine body vibration main bearing impact RMS increased nearly 10 times. Comparisons between the model-predicted confidence interval and measured data reveal that the proposed model based on the fault-related static and dynamic features successfully identified the two faults and their positions, proving the effectiveness of the proposed framework.