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Introduction: Variation laws of dynamic response and settlement deformation at different depths of soil roadbed were investigated and summarized in this study through a simulation test with a dynamic model groove in soft clay foundation of low road embankment. Materials and Methods: In this test, the traffic load was simulated by single-point and double-point shock excitation. Besides, loading frequency, intensity and duration were adjusted by a single variable control method. Research results show that peak values of soil pressure and pore water pressure decrease with the increase of buried depth, but they are unrelated to loading intensity and frequency. Conclusion: Nevertheless, settlement deformation does not increase linearly with the increase of frequency or time difference. The accumulative settlement at a depth varies as the loading time increases.

Basing on highway bridge construction technique and management features, this paper conducts analysis and establishment to construction safety risk factor, index system, etc. of actual engineering, after using vague synthetic judgment method, analytic hierarchy process, implement research via integrated evaluation method, makes out argument to different safety risk factors, establishes bridge safety risk factor collection via method of comprehensive assessment, confirms bridge safety risk incidence value, judges matrix by using MATLAB construction vagueness, finally calculates concrete risk gradation sort, and gets highway bridge construction safety risk grade. Through practice it has proved that the construction safety risk assessment method is based on the method of quantification, can find out biggest influence factors on the safety of Bridges in engineering, and can also reduce the misjudgment caused by subjective factors. The safety of the bridge has a positive practical significance.

In order to improve the quality of the project, we adopt the intelligent compaction control system and collect CMV values through experiments. In the experiment using finite element simulation software to simulate and analyze. From the simulation results to analyze the road surface displacement and stress trends, derived from the displacement of the pressed material in the fifth pass, the sixth pass is almost the same, the rate of change close to 0, can be considered pressed material has the desired pressure. The actual degree is in good agreement with the actual compaction of sand filling, indicating that the compaction state of the pressed material can also be verified from the stress angle of the pressed material. The stress change from the weak vibration to the strong vibration load increases first and then decreases rapidly, and the reduction of strong vibration is more obvious. Therefore, the simulation result also shows that the strong vibration has the better compaction effect than the weak vibration.

In order to monitor and forecast the deformation of the brick-concrete building, by taking a brick-concrete building as research object, fiber grating sensors were used to collect the monitoring data and double logarithmic curve of limit value characteristic and monitoring data were obtained based on the fractal theory. Constant dimension fractal method cannot be used to analyze the data directly. With the method of variable dimension fractal, we accumulate data, and the double logarithmic curve is smooth. Piecewise fractal dimensions are close. The outer interpolation method is used to calculate the fractal dimension of the next point and then back calculate the vertical displacement. The relative errors are calculated by comparing the forecast values and monitoring values, and the maximum relative error is 5.76%. The result shows that the fractal theory is suitable to use in the forecast of the deformation and the accuracy is good.

Background/Aims: Hearts from diabetic subjects are susceptible to myocardial ischemia reperfusion (I/R) injury. Propofol has been shown to protect against myocardial I/R injury due to its antioxidant properties while the underlying mechanism remained incompletely understood. Thus, this study aimed to determine whether or not propofol could attenuate myocardial I/R injury by attenuating mitochondrial dysfunction/damage through upregulating Caveolin (Cav)-3 under hyperglycemia. Methods: Cultured rat cardiomyocyte H9C2 cells were subjected to hypoxia/reoxygenation (H/R) in the absence or presence of propofol under high glucose (HG), and cell viability, lactate dehydrogenase (LDH) and mitochondrial viability as well as creatine kinase-MB (CK-MB), cardiac troponin I (cTnI) and intracellular adenosine triphosphate (ATP) content were measured with colorimetric Enzyme-Linked Immunosorbent Assays. Intracellular levels of oxidative stress was assessed using 2,7-dichlorodihydrofluorescein diacetate (DCF-DA) fluorescent staining and mitochondrial-dependent apoptosis was assessed by detecting mitochondrial membrane potential and the activation of apoptotic caspases 3 and 9. Results: Exposure of cells to HG without or with H/R both significantly increased cell injury, cell apoptosis and enhanced oxidative stress that were associated with mitochondrial dysfunction and decreased Cav-3 protein expression. All these changes were further exacerbated following H/R under HG. Administration of propofol at concentrations from 12.5 to 50 µM but not 100 µM significantly attenuated H/R injury that was associated with increased Cav-3 expression and activation of the prosurvival proteins Akt and STAT3 with the optimal protective effects seen at 50 µM of propofol (P25). The beneficial effects of propofol(P25) were abrogated by Cav-3 disruption with β-methyl-cyclodextrin. Conclusion: Propofol counteracts cardiomyocyte H/R injury by attenuating mitochondrial damage and improving mitochondrial biogenesis through upregulating Cav-3 during hyperglycemia.

To explore the situation of HIV infection among currently married MSM and the features of related sexual behavior on both males and females in Gansu province.By "Place the recruitment" methodology, 297 currently married MSM were recruited in Lanzhou and Tianshui cities of Gansu province. Participants filled in a questionnaire and underwent HIV antibody testing. SPSS 17.0 software was used to analyze the result and differences between positive HIV MSM and negative HIV MSM. Possible factors that influencing the HIV infection among currently married MSM were analyzed.Among those currently married MSM, the HIV positive rate was 4.7%. 94.6% participants admitted having had anal sex with male partners in the past 6 months while 30.9% participants had more than 2 male sex partners in the past week, with the rate of condoms use as 45.9%. 69.0% of the participants had sex with females in the past 6 months, with the rate of condoms use as 24.9%. 59.0% of the participants did not use condoms when having sexual relations with partners. Among HIV positive married MSM, the rate of AIDS awareness was 64.3% and 7.1% of them ever having had HIV testing last year and 92.9% of them had anal sex with males. In the recent 6 months, 14.3% had ever used condom each time when having anal sex with males. 35.7% of the cases ever having had sex with females, with the rate of condom use as 60.0%.HIV prevalence, low AIDS awareness, low HIV rate of testing and high rate of unprotected sex behavior with either sex partners were found among currently married MSM in Gansu province.of this study called for behavioral intervention and HIV testing measures should be taken immediately.