1. Association of same-day urinary phenol levels and cardiac electrical alterations: analysis of the Fernald Community Cohort
- Author
-
Jack Rubinstein, Susan M. Pinney, Changchun Xie, and Hong-Sheng Wang
- Subjects
Environmental chemicals ,Phenol ,Bisphenol ,Human population ,Heart electrical properties ,Industrial medicine. Industrial hygiene ,RC963-969 ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Exposure to phenols has been linked in animal models and human populations to cardiac function alterations and cardiovascular diseases, although their effects on cardiac electrical properties in humans remains to be established. This study aimed to identify changes in electrocardiographic (ECG) parameters associated with environmental phenol exposure in adults of a midwestern large cohort known as the Fernald Community Cohort (FCC). Methods During the day of the first comprehensive medical examination, urine samples were obtained, and electrocardiograms were recorded. Cross-sectional linear regression analyses were performed. Results Bisphenol A (BPA) and bisphenol F (BPF) were both associated with a longer PR interval, an indication of delayed atrial-to-ventricle conduction, in females (p
- Published
- 2024
- Full Text
- View/download PDF