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2,777 results on '"Chang-Chin Chen"'

1. AQP0 is a novel surface marker for deciphering abnormal erythropoiesis

Author

Tso-Fu Wang, Guan-Ling Lin, Sung-Chao Chu, Chang-Chin Chen, Yu-Shan Liou, Hsin-Hou Chang, and Der-Shan Sun

Subjects
Aquaporin 0 (AQP0), Erythropoiesis, Dyserythropoiesis, Hematopoiesis, Bone marrow, Flow cytometry, Medicine (General), R5-920, Biochemistry, QD415-436
Abstract

Abstract Background Hematopoiesis occurs in the bone marrow, producing a complete spectrum of blood cells to maintain homeostasis. In addition to light microscopy, chromosome analysis, and polymerase chain reaction, flow cytometry is a feasible and fast method for quantitatively analyzing hematological diseases. However, because sufficient specific cell markers are scarce, dyserythropoietic diseases are challenging to identify through flow cytometry. Methods Bone marrow samples from C57BL/B6 mice and one healthy donor were analyzed using traditional two-marker (CD71 and glycophorin A) flow cytometry analysis. After cell sorting, the gene expressions of membrane proteins in early and late erythropoiesis precursors and in nonerythroid cells were characterized using microarray analysis. Results Among characterized gene candidates, aquaporin 0 (AQP0) expressed as a surface protein in early- and late-stage erythropoiesis precursors and was not expressed on nonerythroid cells. With the help of AQP0 staining, we could define up to five stages of erythropoiesis in both mouse and human bone marrow using flow cytometry. In addition, because patients with dyserythropoiesis generally exhibited a reduced population of APQ0high cells relative to healthy participants, the analysis results also suggested that the levels of APQ0high cells in early erythropoiesis serve as a novel biomarker that distinguishes normal from dysregulated erythropoiesis. Conclusions AQP0 was successfully demonstrated to be a marker of erythroid differentiation. The expression levels of AQP0 are downregulated in patients with dyserythropoiesis, indicating a critical role of AQP0 in erythropoiesis. Accordingly, the level of AQP0high in early erythroid precursor cells may serve as a reference parameter for diagnosing diseases associated with dyserythropoiesis.

Published
2021
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2. Sinopyrophorinae, a new subfamily of Elateridae (Coleoptera, Elateroidea) with the first record of a luminous click beetle in Asia and evidence for multiple origins of bioluminescence in Elateridae

Author

Wen-Xuan Bi, Jin-Wu He, Chang-Chin Chen, Robin Kundrata, and Xue-Yan Li

Subjects
Zoology, QL1-991
Abstract

The new subfamily Sinopyrophorinae within Elateridae is proposed to accommodate a bioluminescent species, Sinopyrophorus schimmeli Bi & Li, gen. et sp. nov., recently discovered in Yunnan, China. This lineage is morphologically distinguished from other click-beetle subfamilies by the strongly protruding frontoclypeal region, which is longitudinally carinate medially, the pretarsal claws without basal setae, the hind wing venation with a well-defined wedge cell, the abdomen with seven (male) or six (female) ventrites, the large luminous organ on the abdominal sternite II, and the male genitalia with median lobe much shorter than parameres, and parameres arcuate, with the inner margin near its apical third dentate. Molecular phylogeny based on the combined 14 mitochondrial and two nuclear genes supports the placement of this taxon far from other luminescent click-beetle groups, which provides additional evidence for the multiple origin of bioluminescence in Elateridae. Illustrations of habitus and main diagnostic features of S. schimmeli Bi & Li, gen. et sp. nov. are provided, as well as the brief description of its luminescent behavior.

Published
2019
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12. First record of Jacobsoniidae (Coleoptera) from China with description of a new species of Sarothrias Grouvelle

Author

Wen-Xuan Bi, Chang-Chin Chen, and Mei-Ying Lin

Subjects
Zoology, QL1-991
Abstract

The family Jacobsoniidae Heller (短跗甲科) is newly recorded from China upon the discovery of Sarothrias sinicus Bi & Chen, sp. n. (中华短跗甲) from Motuo, Southeast Xizang. Description and illustrations of the habitus and major diagnostic features of the new taxon are provided. A key to the species of Sarothrias and some ecological notes on the new species are presented.

Published
2015
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15. A Survey on Federated Learning Poisoning Attacks and Defenses

Author

Lianga, Junchuan, Wang, Rong, Feng, Chaosheng, and Chang, Chin-Chen

Subjects
Computer Science - Cryptography and Security
Abstract

As one kind of distributed machine learning technique, federated learning enables multiple clients to build a model across decentralized data collaboratively without explicitly aggregating the data. Due to its ability to break data silos, federated learning has received increasing attention in many fields, including finance, healthcare, and education. However, the invisibility of clients' training data and the local training process result in some security issues. Recently, many works have been proposed to research the security attacks and defenses in federated learning, but there has been no special survey on poisoning attacks on federated learning and the corresponding defenses. In this paper, we investigate the most advanced schemes of federated learning poisoning attacks and defenses and point out the future directions in these areas.

Published
2023

18. A blockchain-based secure storage scheme for medical information

Author

Sun, Zhijie, Han, Dezhi, Li, Dun, Wang, Xiangsheng, Chang, Chin-Chen, and Wu, Zhongdai

Subjects
Computer Science - Cryptography and Security
Abstract

Medical data involves a large amount of personal information and is highly privacy sensitive. In the age of big data, the increasing informatization of healthcare makes it vital that medical information is stored securely and accurately. However, current medical information is subject to the risk of privacy leakage and difficult to share. To address these issues, this paper proposes a healthcare information security storage solution based on Hyperledger Fabric and the Attribute-Based Access Control (ABAC) framework. The scheme first utilizes attribute-based access control, which allows dynamic and fine-grained access to medical information, and then stores the medical information in the blockchain, which can be secured and tamper-proof by formulating corresponding smart contracts. In addition, this solution also incorporates IPFS technology to relieve the storage pressure of the blockchain. Experiments show that the proposed scheme combining access control of attributes and blockchain technology in this paper can not only ensure the secure storage and integrity of medical information but also has a high throughput when accessing medical information.

Published
2022

19. Spontaneous Rupture of Renal Pelvis

Author

Te-Li Chen, Yu-Jang Su, Lap-Ming Tang, Wen-Han Chang, and Chang-Chin Chen

Subjects
renal pelvis, spontaneous rupture, Geriatrics, RC952-954.6
Abstract

Spontaneous renal pelvis rupture is a rare situation. It is nearly always related to underlying renal abnor-malities caused by calculus, infection, tumor or pregnancy, resulting in hydronephrosis. In some situations, it is iatrogenic, such as fluid overload during diagnostic or therapeutic interventions. Here, we present a case of spontaneous renal pelvis rupture with no predisposing factor found.

Published
2007
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32. Strategies for subtyping primary aldosteronism

Author

Yang, Yun-Hsuan, Chang, Yu-Ling, Lee, Bo-Ching, Lu, Ching-Chu, Wang, Wei-Ting, Hu, Ya-Hui, Liu, Han-Wen, Lin, Yung-Hsiang, Chang, Chin-Chen, Wu, Wan-Chen, Tseng, Fen-Yu, Lin, Yen-Hung, Wu, Vin-Cent, and Hwu, Chii-Min

Published
2024
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41. A New Study of Integration Between Social Robotic Systems and the Metaverse for Dealing with Healthcare in the Post-COVID-19 Situations

Author

Kerdvibulvech, Chutisant, Chang, Chin-Chen, Goos, Gerhard, Founding Editor, Hartmanis, Juris, Founding Editor, Bertino, Elisa, Editorial Board Member, Gao, Wen, Editorial Board Member, Steffen, Bernhard, Editorial Board Member, Yung, Moti, Editorial Board Member, Cavallo, Filippo, editor, Cabibihan, John-John, editor, Fiorini, Laura, editor, Sorrentino, Alessandra, editor, He, Hongsheng, editor, Liu, Xiaorui, editor, Matsumoto, Yoshio, editor, and Ge, Shuzhi Sam, editor

Published
2022
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