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7. One Network to Solve Them All --- Solving Linear Inverse Problems using Deep Projection Models

Author

Chang, J. H. Rick, Li, Chun-Liang, Poczos, Barnabas, Kumar, B. V. K. Vijaya, and Sankaranarayanan, Aswin C.

Subjects
Computer Science - Computer Vision and Pattern Recognition, I.4.5
Abstract

While deep learning methods have achieved state-of-the-art performance in many challenging inverse problems like image inpainting and super-resolution, they invariably involve problem-specific training of the networks. Under this approach, different problems require different networks. In scenarios where we need to solve a wide variety of problems, e.g., on a mobile camera, it is inefficient and costly to use these specially-trained networks. On the other hand, traditional methods using signal priors can be used in all linear inverse problems but often have worse performance on challenging tasks. In this work, we provide a middle ground between the two kinds of methods --- we propose a general framework to train a single deep neural network that solves arbitrary linear inverse problems. The proposed network acts as a proximal operator for an optimization algorithm and projects non-image signals onto the set of natural images defined by the decision boundary of a classifier. In our experiments, the proposed framework demonstrates superior performance over traditional methods using a wavelet sparsity prior and achieves comparable performance of specially-trained networks on tasks including compressive sensing and pixel-wise inpainting.

Published
2017

16. Adhesion patterns of Neisseria lactamica and its implications

Author

Chang, J. H.

Subjects
618.92
Abstract

Neisseria Meningitidis is a pathogenic bacteria responsible for a wide range of serious disease, including septsis and meningitis especially in children and infants. In contrast Neisseria lac/arnica which resides m the same ecological niche as N.meningitidis, the nasopharynx, does not cause disease and is commensal. It was found that the two species of Neisseria have converse carriage rates where N.lactamica has a protecthe role

Published
2006

17. Erdafitinib in patients with advanced solid tumours with FGFR alterations (RAGNAR): an international, single-arm, phase 2 study

Author

Pant, S, Schuler, M, Iyer, G, Witt, O, Doi, T, Qin, S, Tabernero, J, Reardon, D, Massard, C, Minchom, A, Lugowska, I, Carranza, O, Arnold, D, Gutierrez, M, Winter, H, Stuyckens, K, Crow, L, Najmi, S, Hammond, C, Thomas, S, Santiago-Walker, A, Triantos, S, Sweiti, H, Loriot, Y, Greco, M, Coward, J, Joshua, A, Karapetis, C, Hart, C, Zhang, A, Prenen, H, Goeminne, J, Machiels, J, Rottey, S, Corassa, M, Molin, G, Tiscoski, K, Jardim, D, Mak, M, Fu, W, Yao, H, Huang, J, Jiang, H, Chen, B, Yan, D, Yang, Y, Le Tourneau, C, Penel, N, Salas, S, Blay, J, Brachet, P, Durando, X, Emambux, S, Ravaud, A, Folprecht, G, Ahrens, M, Golf, A, Haag, G, Lordick, F, Desuki, A, Cazzaniga, M, Ciardiello, F, Milella, M, Koyama, T, Hirooka, Y, Okamoto, W, Aogi, K, Kuboki, Y, Lee, J, Kim, S, Ahn, M, Chang, J, Kim, Y, Nam, D, Park, J, Paz-Ares, L, Moreno, V, Cervantes, A, Calvo, M, Falcon, A, Gonzalez, A, Martinez Bueno, A, Garcia-Corbacho, J, Longo, F, Yen, C, Chen, J, Hou, M, Chao, Y, Rau, K, Chiu, T, Feng, Y, Hsu, C, Huang, W, Lai, K, Yeh, S, Palmer, D, Welsh, L, Plummer, R, Bilen, M, Arrowsmith, E, Spigel, D, Zandberg, D, Doroshow, D, Lu-Emerson, C, Moezi, M, Paulson, S, Ward, P, Chaves, J, Grigg, C, Hussein, A, Manda, S, Monticelli, M, Qamar, R, Richey, S, Tamura, D, Wilks, S, Pant S., Schuler M., Iyer G., Witt O., Doi T., Qin S., Tabernero J., Reardon D. A., Massard C., Minchom A., Lugowska I., Carranza O., Arnold D., Gutierrez M., Winter H., Stuyckens K., Crow L., Najmi S., Hammond C., Thomas S., Santiago-Walker A., Triantos S., Sweiti H., Loriot Y., Greco M. A., Coward J., Joshua A., Karapetis C., Hart C., Zhang A., Prenen H., Goeminne J. -C., Machiels J. -P., Rottey S., Corassa M., Molin G. Z. D., Tiscoski K., Jardim D. L. F., Mak M., Fu W., Yao H., Huang J., Jiang H., Chen B., Yan D., Yang Y., Le Tourneau C., Penel N., Salas S., Blay J. -Y., Brachet P. -E., Durando X., Emambux S., Ravaud A., Folprecht G., Ahrens M., Golf A., Haag G. M., Lordick F., Desuki A., Cazzaniga M., Ciardiello F., Milella M., Koyama T., Hirooka Y., Okamoto W., Aogi K., Kuboki Y., Lee J., Kim S. -B., Ahn M. -J., Chang J. H., Kim Y. -M., Nam D. -H., Park J. -S., Paz-Ares L., Moreno V., Cervantes A., Calvo M., Falcon A., Gonzalez A., Martinez Bueno A., Garcia-Corbacho J., Longo F., Yen C. -J., Chen J. -S., Hou M. -F., Chao Y., Rau K. -M., Chiu T. -J., Feng Y. -H., Hsu C. -H., Huang W. -T., Lai K. -M., Yeh S. -P., Palmer D., Welsh L., Plummer R., Bilen M., Arrowsmith E., Spigel D. R., Zandberg D. P., Doroshow D., Lu-Emerson C., Moezi M., Paulson S., Reardon D., Ward P., Chaves J., Grigg C., Hussein A., Manda S., Monticelli M., Qamar R., Richey S. L., Tamura D., Wilks S., Pant, S, Schuler, M, Iyer, G, Witt, O, Doi, T, Qin, S, Tabernero, J, Reardon, D, Massard, C, Minchom, A, Lugowska, I, Carranza, O, Arnold, D, Gutierrez, M, Winter, H, Stuyckens, K, Crow, L, Najmi, S, Hammond, C, Thomas, S, Santiago-Walker, A, Triantos, S, Sweiti, H, Loriot, Y, Greco, M, Coward, J, Joshua, A, Karapetis, C, Hart, C, Zhang, A, Prenen, H, Goeminne, J, Machiels, J, Rottey, S, Corassa, M, Molin, G, Tiscoski, K, Jardim, D, Mak, M, Fu, W, Yao, H, Huang, J, Jiang, H, Chen, B, Yan, D, Yang, Y, Le Tourneau, C, Penel, N, Salas, S, Blay, J, Brachet, P, Durando, X, Emambux, S, Ravaud, A, Folprecht, G, Ahrens, M, Golf, A, Haag, G, Lordick, F, Desuki, A, Cazzaniga, M, Ciardiello, F, Milella, M, Koyama, T, Hirooka, Y, Okamoto, W, Aogi, K, Kuboki, Y, Lee, J, Kim, S, Ahn, M, Chang, J, Kim, Y, Nam, D, Park, J, Paz-Ares, L, Moreno, V, Cervantes, A, Calvo, M, Falcon, A, Gonzalez, A, Martinez Bueno, A, Garcia-Corbacho, J, Longo, F, Yen, C, Chen, J, Hou, M, Chao, Y, Rau, K, Chiu, T, Feng, Y, Hsu, C, Huang, W, Lai, K, Yeh, S, Palmer, D, Welsh, L, Plummer, R, Bilen, M, Arrowsmith, E, Spigel, D, Zandberg, D, Doroshow, D, Lu-Emerson, C, Moezi, M, Paulson, S, Ward, P, Chaves, J, Grigg, C, Hussein, A, Manda, S, Monticelli, M, Qamar, R, Richey, S, Tamura, D, Wilks, S, Pant S., Schuler M., Iyer G., Witt O., Doi T., Qin S., Tabernero J., Reardon D. A., Massard C., Minchom A., Lugowska I., Carranza O., Arnold D., Gutierrez M., Winter H., Stuyckens K., Crow L., Najmi S., Hammond C., Thomas S., Santiago-Walker A., Triantos S., Sweiti H., Loriot Y., Greco M. A., Coward J., Joshua A., Karapetis C., Hart C., Zhang A., Prenen H., Goeminne J. -C., Machiels J. -P., Rottey S., Corassa M., Molin G. Z. D., Tiscoski K., Jardim D. L. F., Mak M., Fu W., Yao H., Huang J., Jiang H., Chen B., Yan D., Yang Y., Le Tourneau C., Penel N., Salas S., Blay J. -Y., Brachet P. -E., Durando X., Emambux S., Ravaud A., Folprecht G., Ahrens M., Golf A., Haag G. M., Lordick F., Desuki A., Cazzaniga M., Ciardiello F., Milella M., Koyama T., Hirooka Y., Okamoto W., Aogi K., Kuboki Y., Lee J., Kim S. -B., Ahn M. -J., Chang J. H., Kim Y. -M., Nam D. -H., Park J. -S., Paz-Ares L., Moreno V., Cervantes A., Calvo M., Falcon A., Gonzalez A., Martinez Bueno A., Garcia-Corbacho J., Longo F., Yen C. -J., Chen J. -S., Hou M. -F., Chao Y., Rau K. -M., Chiu T. -J., Feng Y. -H., Hsu C. -H., Huang W. -T., Lai K. -M., Yeh S. -P., Palmer D., Welsh L., Plummer R., Bilen M., Arrowsmith E., Spigel D. R., Zandberg D. P., Doroshow D., Lu-Emerson C., Moezi M., Paulson S., Reardon D., Ward P., Chaves J., Grigg C., Hussein A., Manda S., Monticelli M., Qamar R., Richey S. L., Tamura D., and Wilks S.

Abstract

Background: FGFR alterations are reported across various malignancies and might act as oncogenic drivers in multiple histologies. Erdafitinib is an oral, selective pan-FGFR tyrosine kinase inhibitor with activity in FGFR-altered advanced urothelial carcinoma. We aimed to evaluate the safety and activity of erdafitinib in previously treated patients with FGFR-altered advanced solid tumours. Methods: The single-arm, phase 2 RAGNAR study was conducted at 156 investigative centres (hospitals or oncology practices that are qualified oncology study centres) across 15 countries. The study consisted of four cohorts based on tumour histology and patient age; the results reported in this Article are for the primary cohort of the study, defined as the Broad Panel Cohort, which was histology-agnostic. We recruited patients aged 12 years or older with advanced or metastatic tumours of any histology (except urothelial cancer) with predefined FGFR1–4 alterations (mutations or fusions according to local or central testing). Eligible patients had disease progression on at least one previous line of systemic therapy and no alternative standard therapy available to them, and an Eastern Cooperative Oncology Group performance status of 0–1 (or equivalent for adolescents aged 12–17 years). Patients received once-daily oral erdafitinib (8 mg/day with provision for pharmacodynamically guided up-titration to 9 mg/day) on a continuous 21-day cycle until disease progression or intolerable toxicity. The primary endpoint was objective response rate by independent review committee according to Response Evaluation Criteria In Solid Tumors (RECIST), version 1.1, or Response Assessment In Neuro-Oncology (RANO). The primary analysis was conducted on the treated population of the Broad Panel Cohort. This ongoing study is registered with ClinicalTrials.gov, number NCT04083976. Findings: Patients were recruited between Dec 5, 2019, and Feb 15, 2022. Of 217 patients treated with erdafitinib, 97 (45%) pa

Published
2023

18. Electrolytes for Zn Batteries: Deep Eutectic Solvents in Polymer Gels

Author

European Commission, Gregorio, Víctor, Jankowski, Piotr, García García, Nuria, Garcia Lastra, J. M., Tiemblo, Pilar, Chang, J. H., European Commission, Gregorio, Víctor, Jankowski, Piotr, García García, Nuria, Garcia Lastra, J. M., Tiemblo, Pilar, and Chang, J. H.

Abstract

Gel polymer electrolytes composed of deep eutectic solvent acetamide:Zn(TFSI) and poly(ethylene oxide) (PEO) are prepared by using a fast, solvent-free procedure. The effect of the PEO molecular weight and its concentration on the physicochemical and electrochemical properties of the electrolytes are studied. Gels prepared with ultrahigh molecular-weight PEO present pseudo-solid behavior and ionic conductivity even higher than that of the original liquid electrolyte. A decrease in the dendritic growth in soft gels with PEO contents up to 1 wt % is demonstrated. The changes in the chemical structure of the electrolyte produced by the strong interactions between ethylene oxide units and Zn have also been studied. The addition of PEO takes the electrolyte out of its original eutectic composition, producing blend crystallization. However, it is possible to retain the eutectic point of the electrolyte in a gel form if the addition of PEO is accompanied by the reduction of acetamide.

Published
2023

22. 346 The Coronavirus Disease (COVID-19) May Change Trends of Outcomes Post Out-of-Hospital Cardiac Arrest in Different Hospital Levels: An Updated Trend from 2017 to 2021

Author

Fan, C.-Y., primary, Sung, C.-W., additional, Chen, C.-H., additional, Chen, C.-Y., additional, Chen, Y.-C., additional, Chen, J.-W., additional, Chang, J.-H., additional, Chang, W.-T., additional, Chiang, W.-C., additional, Huang, C.-H., additional, and Huang, E., additional

Published
2022
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26. List of contributors

Author

Abdul Khalil, H.P.S., primary, Abdulkareem, A., additional, Abolhasani, M.M., additional, Abraham, J., additional, Al-Thani, N., additional, Azimi, S., additional, Bhadra, J., additional, Chang, J.-H., additional, Cherusseri, J., additional, Denchev, Z.Z., additional, Dencheva, N.V., additional, Dungani, R., additional, Hemanth, R., additional, Jayanarayanan, K., additional, Joseph, K., additional, Kelnar, I., additional, Loganathan, S., additional, Maria, H.J., additional, Mishra, R.K., additional, Mishra, J., additional, Nayak, G.C., additional, Owolabi, A.F., additional, Ramesan, M.T., additional, Saurabh, Chaturbhuj K., additional, Seo, B.-S., additional, Shaji, A., additional, Sharika, T., additional, Suhailath, K., additional, Suresha, B., additional, Thomas, S., additional, and Tiwari, S.K., additional

Published
2017
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28. Constructivist Self-Construal: A Cross-Cultural Comparison

Author

Ge, F, Syropoulos, S, Gensler, J, Leidner, B, Loughnan, S, Chang, J, Harada, C, Mari, S, Paladino, M, Shi, J, Yeung, V, Kuo, C, Tsuchiya, K, Ge F., Syropoulos S., Gensler J., Leidner B., Loughnan S., Chang J. -H., Harada C., Mari S., Paladino M. P., Shi J., Yeung V. W. L., Kuo C. -Y., Tsuchiya K., Ge, F, Syropoulos, S, Gensler, J, Leidner, B, Loughnan, S, Chang, J, Harada, C, Mari, S, Paladino, M, Shi, J, Yeung, V, Kuo, C, Tsuchiya, K, Ge F., Syropoulos S., Gensler J., Leidner B., Loughnan S., Chang J. -H., Harada C., Mari S., Paladino M. P., Shi J., Yeung V. W. L., Kuo C. -Y., and Tsuchiya K.

Abstract

Building on independent versus interdependent self-construal theory, three studies provide initial empirical evidence for a third way of construing the self: the constructivist self-construal. People with a constructivist view perceive the self as constantly changing (impermanence), as a collection of distinct phenomena from moment to moment (discontinuity), as lacking an essence (disentification), and as psychologically overlapping with other people and things in the universe (boundlessness/boundaries). In Study 1, we piloted a new Constructivist Self-Construal Scale and established preliminary evidence for the discriminant validity of the scale. Studies 2 and 3 found that across seven countries with diverse cultural backgrounds, the self was consistently cognitively represented on the four dimensions of constructivist self. People from collectivistic cultures where Buddhist philosophy is more prevalent tended to endorse the dimensions of the constructivist self-construal to a greater degree than people from other cultures. Implications regarding the development of the constructivist self-construal and future research recommendations are discussed.

Published
2022

30. Historical Aspects

Author

Chang, J. H. T., Angerpointner, T. A., editor, Gauderer, Michael W. L., editor, Hecker, W. Ch., editor, Prévot, J., editor, Spitz, L., editor, Stauffer, U. G., editor, Wurnig, P., editor, Myers, Nathaniel A., editor, and Angerpointner, Thomas A., editor

Published
1991
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39. Impediments to eye transplantation: ocular viability following optic-nerve transection or enucleation

Author

Ellenberg, D., Shi, J., Jain, S., Chang, J.-H., Ripps, H., Brady, S., Melhem, E.R., Lakkis, F., Adamis, A., Chen, D.-F., Ellis-Behnke, R., Langer, R.S., Strittmatter, S.M., and Azar, D.T.

Subjects
Neurotrophic functions -- Physiological aspects, Neurotrophic functions -- Research, Optic nerve -- Physiological aspects, Optic nerve -- Research, Eye -- Enucleation, Eye -- Patient outcomes, Eye -- Complications and side effects, Eye -- Research, Cornea -- Transplantation, Cornea -- Patient outcomes, Cornea -- Complications and side effects, Cornea -- Research, Retina -- Blood-vessels, Retina -- Physiological aspects, Retina -- Research, Health
Published
2009

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