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In order to ascertain the influencing factors and rules of the inner corrosion on the insulating joint unprotected side of the buried pipelines, a model of the buried pipeline’s insulating joint protected side and unprotected side cathodic protection system was established using the BEASY software with the help of the coupling calculation method for finite element and boundary element. The influences of different internal dielectric conductivity, potential difference between the protected side and the unprotected side as well as the damage rate of the inner coating on the internal corrosion of the unprotected side of the insulating joint were studied by numerical simulations, and the influence laws of various factors on the internal corrosion of the non - protected side of the insulating joint were analyzed with the help of analytical method. Results showed that the main factors affecting the internal corrosion of the unprotected side of the insulating joint were potential difference between the protected side and unprotected side, dielectric conductivity and the damage rate of the internal coating on the unprotected side. Furthermore, the corrosion rate was proportional to the potential difference between the protected side and the unprotected side, and to the dielectric conductivity, and were inversely proportional to the damage rate of the inner coating on the non - protected side.

BackgroundAs the second primary type of cognitive impairment worldwide, vascular cognitive impairment (VCI) is closely associated with cerebrovascular risks, which imposes a heavy burden on the society and families. Early diagnosis and treatment are important for intervening and reversing VCI. And formulating high-quality clinical guidelines is an effective way to improve diagnosis and treatment levels of VCI.ObjectiveTo assess the quality of guidelines for VCI, aiming at offering support for making clinical decisions for VCI.MethodsFrom August to November 2021, we searched literature databases and websites in China and abroad to identify guidelines for VCI, and assessed them using the Appraisal of Guidelines for Research & Evaluation (AGREE) Ⅱ.ResultsA total of 18 guidelines were enrolled, 12 of which are Chinese guidelines and 6 are foreign guidelines; 9 of which are evidence-based guidelines, and the other 9 are not. The intraclass correlation coefficient was 0.935, indicating a high degree of agreement between raters. The overall quality of these guidelines was relatively low, since in the six domains, only the average score of Clarity of Presentation was greater than 60% (64.04%) , and the average scores of Scope and Purpose (52.31%) and Editorial Independence (42.01%) were between 30% and 60%, and those for other three domains, Stakeholder Involvement (27.24%) , Rigor of Development (20.05%) and Applicability (13.83%) , were all less than 30%. The grade of recommendation for 6 guidelines was B, and that for other 12 guidelines was C.ConclusionThe overall quality of the included guidelines was rated relatively low, especially their average score for each of the three domains, Stakeholder Involvement, Rigor of Development, and Applicability, was below the average level. It is suggested to enhance the quality of VCI guidelines via improving the details of guidelines strictly under the evidence-based principle.

Hepatitis B virus (HBV) infection is a major global public health problem and a serious threat to human health. The assembly of the HBV outer shell protein is an important step in the HBV life cycle. Influencing the assembly of core proteins to block viral DNA replication has become a popular target for anti‐HBV drug development. In this study, 47 heteroarylpyrimidine (HAP) compounds were investigated by QSAR, and Topomer CoMFA and HQSAR models with strong predictive ability were developed. Eight new compounds with high activity were successfully designed by searching R groups in Topomer Search. The results of molecular docking and ADMET performance prediction showed that all these compounds have good docking scores and potential medicinal values. To further understand the possible conformations and interactions of the compounds at the protein active site, we performed molecular dynamics simulations of the four compounds with high docking scores and confirmed that these complexes have stable binding conformations by free energy mapping. The free energy calculations verified the stable binding results. These results provide an important reference and theoretical basis for the design and development of effective heteroaryldihydropyrimidine analogs as potential HBV capsid inhibitors. [ABSTRACT FROM AUTHOR]