Search

Your search keyword '"Chang, Yoon-Hee"' showing total 128 results
Start Over Author "Chang, Yoon-Hee"
128 results on '"Chang, Yoon-Hee"'

1. Adult Strabismus Preferred Practice Pattern®

Author

Dagi, Linda R., Velez, Federico G., Holmes, Jonathan M., Archer, Steven M., Strominger, Mitchell B., Pineles, Stacy L., Paysse, Evelyn A., Pihlblad, Matthew Simon, Atalay, Hatice Tuba, Campolattaro, Brian N., and Chang, Yoon-Hee

Published
2024
Full Text
View/download PDF

3. Complex or Incomitant Strabismus

Author

Dagi, Linda R., Chang, Yoon-Hee, Silverstein, Evan, Chiang, Michael, Section editor, Albert, Daniel M., editor, Miller, Joan W., editor, Azar, Dimitri T., editor, and Young, Lucy H., editor

Published
2022
Full Text
View/download PDF

5. Two siblings with GAPO syndrome: Ophthalmic presentation and histopathologic findings.

Author

Falcone, Michelle M., Chang, Yoon-Hee, Lidov, Hart, Stagner, Anna M., and Dagi, Linda R.

Subjects
*GROWTH disorders, *EYELASHES, *SYNDROMES, *SIBLINGS, *EXTRACELLULAR matrix, *CONNECTIVE tissues
Abstract

GAPO syndrome (growth retardation, alopecia, pseudoanodontia, optic atrophy) is a rare, autosomal recessive connective tissue disorder with only 60 reported cases. Ophthalmic manifestations vary and include hypertelorism, optic atrophy, and glaucoma. There have been three reported cases of GAPO syndrome with craniosynostosis. We describe two new siblings with GAPO syndrome and craniosynostosis and the first histopathologic analysis of Tenon's capsule and extraocular muscle in this syndrome. Both siblings presented with papilledema and V-pattern strabismus in addition to the alopecia, brittle eyelashes, growth retardation, and pseudoanodontia that characterize GAPO syndrome. Cranial vault expansion, though successful, was complicated by lack of distinct periosteal layers, thin dural adherence to bone, and extensive venous bleeding. Tenons encountered during strabismus surgery was inelastic and highly vascular. Histopathological analysis revealed hyalinization of Tenon's and a thickened, homogenized, amorphous appearance, similar to the extracellular matrix abnormalities described in skin and other organs Histopathological analysis of extraocular muscle was, in contrast, unremarkable. GAPO impacts the extracellular matrix of Tenon's resulting in inelasticity and hypervascularity. Ophthalmologists should be mindful of these aberrant characteristics when planning surgery in this population. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

10. The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A

Author

Faul, Christian, Donnelly, Mary, Merscher-Gomez, Sandra, Chang, Yoon Hee, Franz, Stefan, Delfgaauw, Jacqueline, Chang, Jer-Ming, Choi, Hoon Young, Campbell, Kirk N., Kim, Kwanghee, Reiser, Jochen, and Mundel, Peter

Subjects
Calcineurin -- Health aspects, Cyclosporine -- Physiological aspects, Cyclosporine -- Health aspects, Cyclosporine -- Research, Cytoskeleton -- Physiological aspects, Cytoskeleton -- Health aspects, Proteinuria -- Care and treatment, Proteinuria -- Research
Abstract

The immunosuppressive action of the calcineurin inhibitor cyclosporine A (CsA) stems from the inhibition of nuclear factor of activated T cells (NFAT) signaling in T cells. CsA is also used for the treatment of proteinuric kidney diseases. As it stands, the antiproteinuric effect of CsA is attributed to its immunosuppressive action. Here we show that the beneficial effect of CsA on proteinuria is not dependent on NFAT inhibition in T cells, but rather results from the stabilization of the actin cytoskeleton in kidney podocytes. CsA blocks the calcineurin-mediated dephosphorylation of synaptopodin, a regulator of Rho GTPases in podocytes, thereby preserving the phosphorylation-dependent synaptopodin-14-3-3[beta] interaction. Preservation of this interaction, in turn, protects synaptopodin from cathepsin L-mediated degradation. These results represent a new view of calcineurin signaling and shed further light on the treatment of proteinuric kidney diseases. Novel calcineurin substrates such as synaptopodin may provide promising starting points for antiproteinuric drugs that avoid the serious side effects of long-term CsA treatment., The kidney glomerulus is a highly specialized structure that ensures the selective ultrafiltration of plasma so that essential proteins are retained in the blood. The common denominator in a variety [...]

Published
2008

Catalog

Books, media, physical & digital resources
See catalog results