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To link to full-text access for this article, visit this link: http://dx.doi.org/10.1016/j.ejor.2007.03.003 Byline: Hung-Tso Lin, Wen-Ling Chang Keywords: Production; Order selection; Pricing; Fuzzy sets Abstract: This paper presents the methods for order selection and pricing of manufacturer (supplier) with make-to-order basis when orders exceed production capacity. By quoting the concepts of triangular fuzzy numbers and linguistic variables, a fuzzy approach to evaluating buyers by taking into account both positive and negative criteria is proposed. According to the classified results of buyers, the orders will be produced with priority, declined, or determined by MIP model. The fixed quantity MIP model and flexible quantity MIP model are employed to determine the produced orders along with the production quantity and the reference amount for price reduction. By applying the concept of TOPSIS, the closeness coefficients for satisfaction grades of orders and for ranking values of buyers are used as the adjusting rates in the final pricing MIP model to set segmented price. Author Affiliation: Department of Distribution Management, National Chin-Yi University of Technology, 35, Lane 215, Chung-Shan Road, Section 1 Taiping City, Taichung Country, Taiwan, Republic of China Article History: Received 19 October 2006; Accepted 7 March 2007

Background: Remote cardiac rhythm monitoring and recording, using hand-carried electrocardiogram (ECG) device had been widely used in telemedicine. The feasibility and accuracy analysis on the data recorded by a new miniature ECG system-on-chip (SoC) system has not been explored before., Methods: This study evaluated the accuracy of the ECG recordings captured by CardioChip - a single-channeled, low-powered, miniature ECG SoC designed for mobile applications; comparing against Philips Pagewriter Trim III - a Food and Drug Administration certified, widely-used standard 12-lead ECG recording device, within Mackay Memorial Hospital in Taiwan., Results: Total of 111 participants, age ranging from 39 to 87years old [mean age: 61.2 ± 13.4, 57 male (51.3%)] were enrolled. Two experienced cardiologists rated and scored the ECG morphology to be the same between the two devices, while CardioChip ECG was more sensitive to baseline noise. R-peak amplitudes measured both devices using single lead information (CardioChip ECG vs. Lead 1 in standard 12-lead ECG) showed statistical consistency. Offline analysis of signal correlation coefficients and coherence showed good correlation with both over 0.94 in average (0.94 ± 0.04 and 0.95 ± 0.04, respectively), high agreement between raters (94% agreement) for detecting abnormal cardiac rhythm with excellent R-peak amplitude (r = 0.98, p < 0.001) and PR interval (r = 0.91, p < 0.001) correlations, indicating excellent correlation between ECG recordings derived from two different modalities., Conclusions: The results suggested that CardioChip ECG is comparable to medical industry standard ECG. The future implementation of wearable ECG device embedded with miniature ECG system-on-chip (SoC) system is ready for clinical use, which will potentially enhance efficacy on identifying subjects with suspected cardiac arrhythmias.

Electronic health record (EHR) systems have been used widely in research. However, most of the EHRs are highly dimensional and it is challenging to analyze such large data set. Bioinformatics is an interdisciplinary science with a focus on data management and interpretation for complex biological phenomena. We investigated biomarkers of nutrition from 3001 patients. Multivariate-adjusted hazard ratios of mortality were calculated according to both albumin and sodium levels. We explore the association of aging predicted by all-cause mortality in future.

Interactions between infiltrating macrophages in the tumor microenvironment (TME) and tumor cells contribute to tumor progression. The potential impacts of recruited macrophages to the upper urinary tract urothelial cell carcinomas (UUTUCs) progression remain unclear. Here we found human UUTUCs might recruit more macrophages than surrounding normal urothelial cells in human clinical specimens and in in vitro co-culture experiments with UUTUC cells and macrophages. The consequences of recruiting more macrophages to UUTUCs might then enhance UUTUC cell growth, migration and invasion. Further investigation found that the androgen receptor (AR) not only enhanced UUTUC cells capacity to recruit more macrophages, it could also promote the macrophages-enhanced UUTUC cells growth, migration and invasion. Downstream AR target cytokine search found AR might function through modulating CCL5 expression to influence UTTUC progression. Interruption of CCL5 partially reversed the AR-regulated macrophage-enhanced UUTUC progression. AR in UUTUC cells also increased tumor formation in vivo . Taken together, these results suggest that macrophages recruitment may enhance UUTUC progression, modulated by AR-CCL5 signal through alterations in chromatin state to establish a tumor microenvironment with recruited macrophages and cytokines to facilitate cell growth, migration and invasion.