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230 results on '"Chang, Qinghua"'

6. Tumor‐targeted and microenvironment‐activatable iron‐based nMOF for synergistic inducing ferroptosis.

Author

Gao, Fangxin, Xie, Yaqing, Zhang, Pan, Chang, Qinghua, Zhang, Enli, Shen, Jingyi, Liang, Lili, and Zong, Zhihui

Subjects
IRON overload, INHIBITION of cellular proliferation, REACTIVE oxygen species, IRON ions, TUMOR treatment
Abstract

Ferroptosis is a new form of cell death that relies on iron and involves an imbalance of intracellular reactive oxygen species (ROS), which is expected to help alleviate bottlenecks in tumor treatment. Herein, a sorafenib‐loaded folic acid‐armored iron‐based nMOF was designed for synergistic inducing ferroptosis of tumors. The particle size of the synthesized SM@F is about 210nm, and the drug loading rate is 24.74%. SM@F can be degraded and releases sorafenib and iron ions slowly, resulting in intracellular drug release and iron overload after being highly uptaken by SMMC‐7721 cells. SM@F can effectively inhibit the proliferation of SMMC‐7721 cells, and this effect can be significantly attenuated by ferroptosis inhibitors. Mechanistic investigations revealed that SM@F could increase the content of ROS, and lipid peroxides; decrease the content of glutathione (GSH); and down‐regulate the GXP4 expression in SMMC‐7721 cells. The results indicate that the synthesized SM@F could effectively inhibit the proliferation of tumor cells with synergistic inducing ferroptosis. [ABSTRACT FROM AUTHOR]

Published
2024
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48. Study on Interface Structure of Cu/Al Clad Plates by Roll Casting

Author

Wang Wenyan, Chang Qinghua, Xie Jingpei, and Mao Aixia

Subjects
lcsh:TN1-997, Materials science, Scanning electron microscope, Diffusion, chemistry.chemical_element, 02 engineering and technology, 01 natural sciences, Tetragonal crystal system, Condensed Matter::Materials Science, Lattice constant, 0103 physical sciences, Atom, Physics::Atomic and Molecular Clusters, General Materials Science, Composite material, lcsh:Mining engineering. Metallurgy, LAMMPS, 010302 applied physics, Metals and Alloys, 021001 nanoscience & nanotechnology, casting process, Casting, Copper, molecular dynamics, chemistry, Transmission electron microscopy, interface, 0210 nano-technology, copper and aluminum composite panels
Abstract

Large scale Atomic/Molecular dynamic Parallel Simulator (LAMMPS) molecular dynamics simulation software was used to simulate the copper and aluminum atom diffusion and changes of interface during heating and cooling process of copper and aluminum composite panels. The structures of the interface were characterized through scanning electron microscope (SEM), X-ray diffraction (XRD), and transmission electron microscope (TEM), and the mechanical properties were also tested. The simulation results show that the diffusion rate of copper atom is higher than that of aluminum atom, and that the CuAl2 radial distribution function of the interface at 300 K is consistent with that of pure CuAl2 at room temperature. At 930 K, t = 50 ps Cu atoms spread at a distance of approximately four Al lattice constants around the Al layer, and Al atoms spread to about half a lattice constant distance to the Cu layer. The experimental results show that the thickness of the interface in copper&ndash, aluminum composite plate is about 1 &mu, m, and only one kind of CuAl2 with tetragonal phase structure is generated in the interface, which corresponds with the result of molecular dynamics simulation.

Published
2018
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