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7. Initiale Diagnostik und Indikationsstellung zur Anti-Vascular-Endothelial Growth-Factor-Therapie bei Netzhauterkrankungen: Vergleich der Befundung durch Studienarzt versus Reading Center (ORCA/OCEAN-Studie)

Author

Brinkmann, Christian K., Chang, Petrus, Schick, Tina, Heimes, Britta, Vögeler, Jessica, Haegele, Birgit, Kirchhof, Bernd, Holz, Frank G., Pauleikhoff, Daniel, Ziemssen, Focke, Liakopoulos, Sandra, Spital, Georg, and Schmitz-Valckenberg, Steffen

Published
2019
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8. Surgical site infections are independently associated with the development of postoperative acute-on-chronic liver failure in liver cirrhosis

Author

Chang, Johannes, primary, Hoffstall, Schwiedhard, additional, Gödiker, Juliana, additional, Lehmann, Jennifer, additional, Schwind, Lea, additional, Lingohr, Philipp, additional, Manekeller, Steffen, additional, Wehner, Sven, additional, Strassburg, Christian P., additional, Chang, Petrus, additional, and Praktiknjo, Michael, additional

Published
2023
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9. Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration

Author

Saßmannshausen, Marlene, primary, Behning, Charlotte, additional, Weinz, Jonas, additional, Goerdt, Lukas, additional, Terheyden, Jan H., additional, Chang, Petrus, additional, Schmid, Matthias, additional, Poor, Stephen H., additional, Zakaria, Nadia, additional, Finger, Robert P., additional, Holz, Frank G., additional, Pfau, Maximilian, additional, Schmitz-Valckenberg, Steffen, additional, Thiele, Sarah, additional, Agostini, H., additional, Altay, L., additional, Atia, R., additional, Bandello, F., additional, Basile, P.G., additional, Behning, C., additional, Belmouhand, M., additional, Berger, M., additional, Binns, A., additional, Boon, C.J.F., additional, Böttger, M., additional, Bouchet, C., additional, Brazier, J.E., additional, Butt, T., additional, Carapezzi, C., additional, Carlton, J., additional, Carneiro, A., additional, Charil, A., additional, Coimbra, R., additional, Cozzi, M., additional, Crabb, D.P., additional, Cunha-Vaz, J., additional, Dahlke, C., additional, de Sisternes, L., additional, Dunbar, H., additional, Finger, R.P., additional, Fletcher, E., additional, Floyd, H., additional, Francisco, C., additional, Gutfleisch, M., additional, Hogg, R., additional, Holz, F.G., additional, Hoyng, C.B., additional, Kilani, A., additional, Krätzschmar, J., additional, Kühlewein, L., additional, Larsen, M., additional, Leal, S., additional, Lechanteur, Y.T.E., additional, Luhmann, U.F.O., additional, Lüning, A., additional, Marques, I., additional, Martinho, C., additional, Montesano, G., additional, Mulyukov, Z., additional, Paques, M., additional, Parodi, B., additional, Parravano, M., additional, Penas, S., additional, Peters, T., additional, Peto, T., additional, Pfau, M., additional, Poor, S., additional, Priglinger, S., additional, Rowen, D., additional, Rubin, G.S., additional, Sahel, J., additional, Sánchez, C., additional, Sander, O., additional, Saßmannshausen, M., additional, Schmid, M., additional, Schmitz-Valckenberg, S., additional, Schrinner-Fenske, H., additional, Siedlecki, J., additional, Silva, R., additional, Skelly, A., additional, Souied, E., additional, Staurenghi, G., additional, Stöhr, L., additional, Taylor, D.J., additional, Terheyden, J.H., additional, Thiele, S., additional, Tufail, A., additional, Varano, M., additional, Vieweg, L., additional, Wintergerst, L., additional, Wolf, A., additional, and Zakaria, N., additional

Published
2022
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10. The predictability of ocriplasmin treatment effects: is there consensus among retinal experts? Results from the EXPORT study

Author

Bertelmann, Thomas, Wachtlin, Joachim, Mennel, Stefan, Koss, Michael J., Maier, Mathias M., Schumann, Ricarda G., Kazerounian, Sara, Daniel, Hanna, Schmitz-Valckenberg, Steffen, Bertelmann, Thomas, Hoerauf, Hans, Feltgen, Nicolas, Wachtlin, Joachim, Kaymak, Hakan, Mennel, Stefan, Koss, Michael J., Fauser, Sascha, Maier, Mathias M., Schumann, Ricarda G., Müller, Simone, Chang, Petrus, Kazerounian, Sara, Lommatzsch, Albrecht, Daniel, Hanna, and on behalf of the EXPORT study group

Published
2017
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11. Associations with intraocular pressure across Europe: The European Eye Epidemiology (E3) Consortium

Author

Khawaja, Anthony P., Springelkamp, Henriët, Creuzot-Garcher, Catherine, Delcourt, Cécile, Hofman, Albert, Höhn, René, Iglesias, Adriana I., Wolfs, Roger C. W., Korobelnik, Jean-François, Silva, Rufino, Topouzis, Fotis, Williams, Katie M., Bron, Alain M., Buitendijk, Gabriëlle H. S., Cachulo, Maria da Luz, Cougnard-Grégoire, Audrey, Dartigues, Jean-François, Hammond, Christopher J., Pfeiffer, Norbert, Salonikiou, Angeliki, van Duijn, Cornelia M., Vingerling, Johannes R., Luben, Robert N., Mirshahi, Alireza, Lamparter, Julia, Klaver, Caroline C. W., Jansonius, Nomdo M., Foster, Paul J., Acar, Niyazi, Anastosopoulos, Eleftherios, Azuara-Blanco, Augusto, Bergen, Arthur, Bertelsen, Geir, Binquet, Christine, Bird, Alan, Brétillon, Lionel, Bron, Alain, Buitendijk, Gabrielle, Cachulo, Maria Luz, Chakravarthy, Usha, Chan, Michelle, Chang, Petrus, Colijn, Annemarie, Cougnard-Grégoire, Audrey, Creuzot-Garcher, Catherine, Cumberland, Philippa, Cunha-Vaz, José, Daien, Vincent, Deak, Gabor, Delcourt, Cécile, Delyfer, Marie-Noëlle, Hollander, Anneke den, Dietzel, Martha, Erke, Maja Gran, Fauser, Sascha, Finger, Robert, Fletcher, Astrid, Foster, Paul, Founti, Panayiota, Göbel, Arno, Gorgels, Theo, Grauslund, Jakob, Grus, Franz, Hammond, Christopher, Helmer, Catherine, Hense, Hans-Werner, Hermann, Manuel, Hoehn, René, Hogg, Ruth, Holz, Frank, Hoyng, Carel, Jansonius, Nomdo, Janssen, Sarah, Khawaja, Anthony, Klaver, Caroline, Korobelnik, Jean-François, Lamparter, Julia, Le Goff, Mélanie, Leal, Sergio, Lechanteur, Yara, Lehtimäki, Terho, Lotery, Andrew, Leung, Irene, Mauschitz, Matthias, Merle, Bénédicte, Meyer zu Westrup, Verena, Midena, Edoardo, Miotto, Stefania, Mirshahi, Alireza, Mohan-Saïd, Sadek, Muldrew, Alyson, Mueller, Michael, Nunes, Sandrina, Oexle, Konrad, Peto, Tunde, Piermarocchi, Stefano, Prokofyeva, Elena, Rahi, Jugnoo, Raitakari, Olli, Ribeiro, Luisa, Rougier, Marie-Bénédicte, Sahel, José, Salonikiou, Aggeliki, Sanchez, Clarisa, Schmitz-Valckenberg, Steffen, Schweitzer, Cédric, Segato, Tatiana, Shehata, Jasmin, Silva, Rufino, Silvestri, Giuliana, Simader, Christian, Souied, Eric, Springelkamp, Henriet, Tapp, Robyn, Topouzis, Fotis, Verhoeven, Virginie, Von Hanno, Therese, Vujosevic, Stela, Williams, Katie, Wolfram, Christian, Yip, Jennifer, Zerbib, Jennyfer, Zwiener, Isabella, and On behalf of the European Eye Epidemiology (E³) Consortium

Published
2016
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12. OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement

Author

Wu, Zhichao, primary, Pfau, Maximilian, additional, Blodi, Barbara A., additional, Holz, Frank G., additional, Jaffe, Glenn J., additional, Liakopoulos, Sandra, additional, Sadda, Srinivas R., additional, Staurenghi, Giovanni, additional, Bjelopera, Elvira, additional, Brown, Tyler, additional, Chang, Petrus, additional, Choong, John, additional, Corradetti, Giulia, additional, Corvi, Federico, additional, Domalpally, Amitha, additional, Hurtenbach, Cynthia, additional, Nittala, Muneeswar Gupta, additional, Olson, Anthony, additional, Pak, Jeong W., additional, Pappe, Judith, additional, Saßmannshausen, Marlene, additional, Skalak, Cindy, additional, Thiele, Sarah, additional, Guymer, Robyn H., additional, and Schmitz-Valckenberg, Steffen, additional

Published
2022
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13. Increased High-Density Lipoprotein Levels Associated with Age-Related Macular Degeneration

Author

Colijn, Johanna M., primary, den Hollander, Anneke I., additional, Demirkan, Ayse, additional, Cougnard-Grégoire, Audrey, additional, Verzijden, Timo, additional, Kersten, Eveline, additional, Meester-Smoor, Magda A., additional, Merle, Benedicte M.J., additional, Papageorgiou, Grigorios, additional, Ahmad, Shahzad, additional, Mulder, Monique T., additional, Costa, Miguel Angelo, additional, Benlian, Pascale, additional, Bertelsen, Geir, additional, Bron, Alain M., additional, Claes, Birte, additional, Creuzot-Garcher, Catherine, additional, Erke, Maja Gran, additional, Fauser, Sascha, additional, Foster, Paul J., additional, Hammond, Christopher J., additional, Hense, Hans-Werner, additional, Hoyng, Carel B., additional, Khawaja, Anthony P., additional, Korobelnik, Jean-Francois, additional, Piermarocchi, Stefano, additional, Segato, Tatiana, additional, Silva, Rufino, additional, Souied, Eric H., additional, Williams, Katie M., additional, van Duijn, Cornelia M., additional, Delcourt, Cécile, additional, Klaver, Caroline C.W., additional, Acar, Niyazi, additional, Altay, Lebriz, additional, Anastosopoulos, Eleftherios, additional, Azuara-Blanco, Augusto, additional, Berendschot, Tos, additional, Bergen, Arthur, additional, Binquet, Christine, additional, Bird, Alan, additional, Bobak, Martin, additional, Larsen, Morten Bøgelund, additional, Boon, Camiel, additional, Bourne, Rupert, additional, Brétillon, Lionel, additional, Broe, Rebecca, additional, Bron, Alain, additional, Buitendijk, Gabrielle, additional, Cachulo, Maria Luz, additional, Capuano, Vittorio, additional, Carrière, Isabelle, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cree, Angela, additional, Cumberland, Phillippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, De Jong, Eiko, additional, Deak, Gabor, additional, Delyfer, Marie-Noëlle, additional, Hollander, Anneke den, additional, Dietzel, Martha, additional, Faria, Pedro, additional, Farinha, Claudia, additional, Finger, Robert, additional, Fletcher, Astrid, additional, Foster, Paul, additional, Founti, Panayiota, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Heesterbeek, Thomas, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, de Jong, Eiko, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Korobelnik, Jean-François, additional, Lamparter, Julia, additional, Le Goff, Mélanie, additional, Lehtimäki, Terho, additional, Leung, Irene, additional, Lotery, Andrew, additional, Mauschitz, Matthias, additional, Meester, Magda, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Miotto, Stefania, additional, Mirshahi, Alireza, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Murta, Joaquim, additional, Nickels, Stefan, additional, Nunes, Sandrina, additional, Owen, Christopher, additional, Peto, Tunde, additional, Pfeiffer, Norbert, additional, Prokofyeva, Elena, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Rauscher, Franziska, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Rudnicka, Alicja, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schick, Tina, additional, Schmitz-Valckenberg, Steffen, additional, Schuster, Alexander, additional, Schweitzer, Cédric, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Speckauskas, Martynas, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, Topouzis, Fotis, additional, van Leeuwen, Elisa, additional, Verhoeven, Virginie, additional, Vingerling, Hans, additional, Von Hanno, Therese, additional, Williams, Katie, additional, Wolfram, Christian, additional, Yip, Jennifer, additional, Zerbib, Jennyfer, additional, Ajana, Soufiane, additional, Arango-Gonzalez, Blanca, additional, Arndt, Verena, additional, Bhatia, Vaibhav, additional, Bhattacharya, Shomi S., additional, Biarnés, Marc, additional, Borrell, Anna, additional, Bühren, Sebastian, additional, Calado, Sofia M., additional, Colijn, Johanna M., additional, Dammeier, Sascha, additional, de Jong, Eiko K., additional, De la Cerda, Berta, additional, Diaz-Corrales, Francisco J., additional, Diether, Sigrid, additional, Emri, Eszter, additional, Endermann, Tanja, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Heesterbeek, Thomas J., additional, Honisch, Sabina, additional, Kilger, Ellen, additional, Langen, Hanno, additional, Lengyel, Imre, additional, Luthert, Phil, additional, Maugeais, Cyrille, additional, Meester-Smoor, Magda, additional, Merle Inserm, Bénédicte M.J., additional, Monés, Jordi, additional, Nogoceke, Everson, additional, Pool, Frances M., additional, Rodríguez, Eduardo, additional, Ueffing, Marius, additional, Ulrich Bartz-Schmidt, Karl U., additional, van Leeuwen, Elisabeth M., additional, and Zumbansen, Markus, additional

Published
2019
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14. Initiale Diagnostik und Indikationsstellung zur Anti-Vascular-Endothelial Growth-Factor-Therapie bei Netzhauterkrankungen

Author

Brinkmann, Christian K., primary, Chang, Petrus, additional, Schick, Tina, additional, Heimes, Britta, additional, Vögeler, Jessica, additional, Haegele, Birgit, additional, Kirchhof, Bernd, additional, Holz, Frank G., additional, Pauleikhoff, Daniel, additional, Ziemssen, Focke, additional, Liakopoulos, Sandra, additional, Spital, Georg, additional, and Schmitz-Valckenberg, Steffen, additional

Published
2018
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16. Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population

Author

Mauschitz, Matthias M., primary, Bonnemaijer, Pieter W.M., additional, Diers, Kersten, additional, Rauscher, Franziska G., additional, Elze, Tobias, additional, Engel, Christoph, additional, Loeffler, Markus, additional, Colijn, Johanna Maria, additional, Ikram, M. Arfan, additional, Vingerling, Johannes R., additional, Williams, Katie M., additional, Hammond, Christopher J., additional, Creuzot-Garcher, Catherine, additional, Bron, Alain M., additional, Silva, Rufino, additional, Nunes, Sandrina, additional, Delcourt, Cécile, additional, Cougnard-Grégoire, Audrey, additional, Holz, Frank G., additional, Klaver, Caroline C.W., additional, Breteler, Monique M.B., additional, Finger, Robert P., additional, Acar, Niyazi, additional, Anastosopoulos, Eleftherios, additional, Azuara-Blanco, Augusto, additional, Berendschot, Tos, additional, Bergen, Arthur, additional, Bertelsen, Geir, additional, Binquet, Christine, additional, Bird, Alan, additional, Bobak, Martin, additional, Larsen, Morten Bøgelund, additional, Boon, Camiel, additional, Bourne, Rupert, additional, Brétillon, Lionel, additional, Broe, Rebecca, additional, Bron, Alain, additional, Buitendijk, Gabrielle, additional, Cachulo, Maria Luz, additional, Capuano, Vittorio, additional, Carrière, Isabelle, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cree, Angela, additional, Cumberland, Phillippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, De Jong, Eiko, additional, Deak, Gabor, additional, Delyfer, Marie-Noëlle, additional, Hollander, Anneke den, additional, Dietzel, Martha, additional, Erke, Maja Gran, additional, Faria, Pedro, additional, Farinha, Claudia, additional, Fauser, Sascha, additional, Finger, Robert, additional, Fletcher, Astrid, additional, Foster, Paul, additional, Founti, Panayiota, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Hense, Hans-Werner, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, Kersten, Eveline, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Korobelnik, Jean-François, additional, Lamparter, Julia, additional, Le Goff, Mélanie, additional, Lechanteur, Yara, additional, Lehtimäki, Terho, additional, Leung, Irene, additional, Lotery, Andrew, additional, Mauschitz, Matthias, additional, Meester, Magda, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Miotto, Stefania, additional, Mirshahi, Alireza, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Murta, Joaquim, additional, Nickels, Stefan, additional, Owen, Christopher, additional, Peto, Tunde, additional, Pfeiffer, Norbert, additional, Piermarocchi, Stefano, additional, Prokofyeva, Elena, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Rauscher, Franziska, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Rudnicka, Alicja, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schmitz-Valckenberg, Steffen, additional, Schuster, Alexander, additional, Schweitzer, Cédric, additional, Segato, Tatiana, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Speckauskas, Martynas, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, Topouzis, Fotis, additional, van Leeuwen, Elisa, additional, Verhoeven, Virginie, additional, Verzijden, Timo, additional, Von Hanno, Therese, additional, Wiedemann, Peter, additional, Williams, Katie, additional, Wolfram, Christian, additional, Yip, Jennifer, additional, and Zerbib, Jennyfer, additional

Published
2018
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17. The Decreasing Prevalence of Nonrefractive Visual Impairment in Older Europeans

Author

Delcourt, Cécile, primary, Le Goff, Mélanie, additional, von Hanno, Therese, additional, Mirshahi, Alireza, additional, Khawaja, Anthony P., additional, Verhoeven, Virginie J.M., additional, Hogg, Ruth E., additional, Anastosopoulos, Eleftherios, additional, Cachulo, Maria Luz, additional, Höhn, René, additional, Wolfram, Christian, additional, Bron, Alain, additional, Miotto, Stefania, additional, Carrière, Isabelle, additional, Colijn, Johanna M., additional, Buitendijk, Gabriëlle H.S., additional, Evans, Jennifer, additional, Nitsch, Dorothea, additional, Founti, Panayiota, additional, Yip, Jennifer L.Y., additional, Pfeiffer, Norbert, additional, Creuzot-Garcher, Catherine, additional, Silva, Rufino, additional, Piermarocchi, Stefano, additional, Topouzis, Fotis, additional, Bertelsen, Geir, additional, Foster, Paul J., additional, Fletcher, Astrid, additional, Klaver, Caroline C.W., additional, Korobelnik, Jean-François, additional, Acar, Niyazi, additional, Azuara-Blanco, Augusto, additional, Berendschot, Tos, additional, Bergen, Arthur, additional, Binquet, Christine, additional, Bird, Alan, additional, Bobak, Martin, additional, Boon, Camiel, additional, Brétillon, Lionel, additional, Broe, Rebecca, additional, Buitendijk, Gabrielle, additional, Capuano, Vittorio, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cougnard-Grégoire, Audrey, additional, Cree, Angela, additional, Cumberland, Phillippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, De Jong, Eiko, additional, Deak, Gabor, additional, Delcourt, Cécile, additional, Delyfer, Marie-Noëlle, additional, den Hollander, Anneke, additional, Dietzel, Martha, additional, Erke, Maja Gran, additional, Faria, Pedro, additional, Farinha, Claudia, additional, Fauser, Sascha, additional, Finger, Robert, additional, Foster, Paul, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Hansen, Morten, additional, Helmer, Catherine, additional, Hense, Hans-Werner, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, Kersten, Eveline, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Lamparter, Julia, additional, Lechanteur, Yara, additional, Lehtimäki, Terho, additional, Leung, Irene, additional, Lotery, Andrew, additional, Mauschitz, Matthias, additional, Meester, Magda, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Murta, Joaquim, additional, Nickels, Stefan, additional, Nunes, Sandrina, additional, Owen, Christopher, additional, Peto, Tunde, additional, Prokofyeva, Elena, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Rauscher, Franziska, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Rudnicka, Alicja, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schmitz-Valckenberg, Steffen, additional, Schouten, Johannes, additional, Schuster, Alexander, additional, Schweitzer, Cédric, additional, Segato, Tatiana, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Speckauskas, Martynas, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, van Leeuwen, Elisa, additional, Verhoeven, Virginie, additional, Verzijden, Timo, additional, Von Hanno, Therese, additional, Vujosevic, Stela, additional, Wiedemann, Peter, additional, Williams, Katie, additional, Yip, Jennifer, additional, and Zerbib, Jennyfer, additional

Published
2018
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18. Prevalence of Age-Related Macular Degeneration in Europe

Author

Colijn, Johanna M., primary, Buitendijk, Gabriëlle H.S., additional, Prokofyeva, Elena, additional, Alves, Dalila, additional, Cachulo, Maria L., additional, Khawaja, Anthony P., additional, Cougnard-Gregoire, Audrey, additional, Merle, Bénédicte M.J., additional, Korb, Christina, additional, Erke, Maja G., additional, Bron, Alain, additional, Anastasopoulos, Eleftherios, additional, Meester-Smoor, Magda A., additional, Segato, Tatiana, additional, Piermarocchi, Stefano, additional, de Jong, Paulus T.V.M., additional, Vingerling, Johannes R., additional, Topouzis, Fotis, additional, Creuzot-Garcher, Catherine, additional, Bertelsen, Geir, additional, Pfeiffer, Norbert, additional, Fletcher, Astrid E., additional, Foster, Paul J., additional, Silva, Rufino, additional, Korobelnik, Jean-François, additional, Delcourt, Cécile, additional, Klaver, Caroline C.W., additional, Ajana, Soufiane, additional, Arango-Gonzalez, Blanca, additional, Arndt, Verena, additional, Bhatia, Vaibhav, additional, Bhattacharya, Shomi S., additional, Biarnés, Marc, additional, Borrell, Anna, additional, Bühren, Sebastian, additional, Calado, Sofia M., additional, Colijn, Johanna M., additional, Cougnard-Grégoire, Audrey, additional, Dammeier, Sascha, additional, de Jong, Eiko K., additional, De la Cerda, Berta, additional, den Hollander, Anneke I., additional, Diaz-Corrales, Francisco J., additional, Diether, Sigrid, additional, Emri, Eszter, additional, Endermann, Tanja, additional, Ferraro, Lucia L., additional, Garcia, Míriam, additional, Heesterbeek, Thomas J., additional, Honisch, Sabina, additional, Hoyng, Carel B., additional, Kersten, Eveline, additional, Kilger, Ellen, additional, Langen, Hanno, additional, Lengyel, Imre, additional, Luthert, Phil, additional, Maugeais, Cyrille, additional, Meester-Smoor, Magda, additional, Monés, Jordi, additional, Nogoceke, Everson, additional, Peto, Tunde, additional, Pool, Frances M., additional, Rodríguez, Eduardo, additional, Ueffing, Marius, additional, Ulrich Bartz-Schmidt, Karl U., additional, van Leeuwen, Elisabeth M., additional, Verzijden, Timo, additional, Zumbansen, Markus, additional, Acar, Niyazi, additional, Anastosopoulos, Eleftherios, additional, Azuara-Blanco, Augusto, additional, Bergen, Arthur, additional, Binquet, Christine, additional, Bird, Alan, additional, Brétillon, Lionel, additional, Buitendijk, Gabrielle, additional, Cachulo, Maria Luz, additional, Chakravarthy, Usha, additional, Chan, Michelle, additional, Chang, Petrus, additional, Colijn, Johanna, additional, Cumberland, Philippa, additional, Cunha-Vaz, José, additional, Daien, Vincent, additional, Deak, Gabor, additional, Delyfer, Marie-Noëlle, additional, den Hollander, Anneke, additional, Dietzel, Martha, additional, Erke, Maja Gran, additional, Fauser, Sascha, additional, Finger, Robert, additional, Fletcher, Astrid, additional, Foster, Paul, additional, Founti, Panayiota, additional, Göbel, Arno, additional, Gorgels, Theo, additional, Grauslund, Jakob, additional, Grus, Franz, additional, Hammond, Christopher, additional, Helmer, Catherine, additional, Hense, Hans-Werner, additional, Hermann, Manuel, additional, Hoehn, René, additional, Hogg, Ruth, additional, Holz, Frank, additional, Hoyng, Carel, additional, Jansonius, Nomdo, additional, Janssen, Sarah, additional, Khawaja, Anthony, additional, Klaver, Caroline, additional, Lamparter, Julia, additional, Le Goff, Mélanie, additional, Leal, Sergio, additional, Lechanteur, Yara, additional, Lehtimäki, Terho, additional, Lotery, Andrew, additional, Leung, Irene, additional, Mauschitz, Matthias, additional, Merle, Bénédicte, additional, Meyer zu Westrup, Verena, additional, Midena, Edoardo, additional, Miotto, Stefania, additional, Mirshahi, Alireza, additional, Mohan-Saïd, Sadek, additional, Mueller, Michael, additional, Muldrew, Alyson, additional, Nunes, Sandrina, additional, Oexle, Konrad, additional, Rahi, Jugnoo, additional, Raitakari, Olli, additional, Ribeiro, Luisa, additional, Rougier, Marie-Bénédicte, additional, Sahel, José, additional, Salonikiou, Aggeliki, additional, Sanchez, Clarisa, additional, Schmitz-Valckenberg, Steffen, additional, Schweitzer, Cédric, additional, Shehata, Jasmin, additional, Silvestri, Giuliana, additional, Simader, Christian, additional, Souied, Eric, additional, Springelkamp, Henriet, additional, Tapp, Robyn, additional, Verhoeven, Virginie, additional, Von Hanno, Therese, additional, Vujosevic, Stela, additional, Williams, Katie, additional, Wolfram, Christian, additional, Yip, Jennifer, additional, Zerbib, Jennyfer, additional, and Zwiener, Isabella, additional

Published
2017
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19. Calculating the individual probability of successful ocriplasmin treatment in eyes with VMT syndrome: a multivariable prediction model from the EXPORT study

Author

Paul, Christoph, primary, Heun, Christine, additional, Müller, Hans-Helge, additional, Hoerauf, Hans, additional, Feltgen, Nicolas, additional, Wachtlin, Joachim, additional, Kaymak, Hakan, additional, Mennel, Stefan, additional, Koss, Michael Janusz, additional, Fauser, Sascha, additional, Maier, Mathias M, additional, Schumann, Ricarda G, additional, Mueller, Simone, additional, Chang, Petrus, additional, Schmitz-Valckenberg, Steffen, additional, Kazerounian, Sara, additional, Szurman, Peter, additional, Lommatzsch, Albrecht, additional, and Bertelmann, Thomas, additional

Published
2017
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21. Calculating the individual probability of successful ocriplasmin treatment in eyes with VMT syndrome: a multivariable prediction model from the EXPORT study.

Author

Paul, Christoph, Heun, Christine, Müller, Hans-Helge, Hoerauf, Hans, Feltgen, Nicolas, Wachtlin, Joachim, Kaymak, Hakan, Mennel, Stefan, Koss, Michael Janusz, Fauser, Sascha, Maier, Mathias M., Schumann, Ricarda G., Mueller, Simone, Chang, Petrus, Schmitz-Valckenberg, Steffen, Kazerounian, Sara, Szurman, Peter, Lommatzsch, Albrecht, and Bertelmann, Thomas

Abstract

Background/Aims To evaluate predictive factors for the treatment success of ocriplasmin and to use these factors to generate a multivariate model to calculate the individual probability of successful treatment. Methods Data were collected in a retrospective, multicentre cohort study. Patients with vitreomacular traction (VMT) syndrome without a full-thickness macular hole were included if they received an intravitreal injection (IVI) of ocriplasmin. Five factors (age, gender, lens status, presence of epiretinal membrane (ERM) formation and horizontal diameter of VMT) were assessed on their association with VMT resolution. A multivariable logistic regression model was employed to further analyse these factors and calculate the individual probability of successful treatment. Results 167 eyes of 167 patients were included. Univariate analysis revealed a significant correlation to VMT resolution for all analysed factors: age (years) (OR 0.9208; 95% CI 0.8845 to 0.9586; p<0.0001), gender (male) (OR 0.480; 95% CI 0.241 to 0.957; p=0.0371), lens status (phakic) (OR 2.042; 95% CI 1.054 to 3.958; p=0.0344), ERM formation (present) (OR 0.384; 95% CI 0.179 to 0.821; p=0.0136) and horizontal VMT diameter (μm) (OR 0.99812; 95% CI 0.99684 to 0.99941, p=0.0042). A significant multivariable logistic regression model was established with age and VMT diameter. Conclusion Known predictive factors for VMT resolution after ocriplasmin IVI were confirmed in our study. We were able to combine them into a formula, ultimately allowing the calculation of an individual probability of treatment success with ocriplasmin in patients with VMT syndrome without FTHM. [ABSTRACT FROM AUTHOR]

Published
2018
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23. Characteristics and Spatial Distribution of Structural Features in Age-Related Macular Degeneration

Author

Saßmannshausen, Marlene, Behning, Charlotte, Weinz, Jonas, Goerdt, Lukas, Terheyden, Jan H., Chang, Petrus, Schmid, Matthias, Poor, Stephen H., Zakaria, Nadia, Finger, Robert P., Holz, Frank G., Pfau, Maximilian, Schmitz-Valckenberg, Steffen, Thiele, Sarah, Agostini, H., Altay, L., Atia, R., Bandello, F., Basile, P.G., Behning, C., Belmouhand, M., Berger, M., Binns, A., Boon, C.J.F., Böttger, M., Bouchet, C., Brazier, J.E., Butt, T., Carapezzi, C., Carlton, J., Carneiro, A., Charil, A., Coimbra, R., Cozzi, M., Crabb, D.P., Cunha-Vaz, J., Dahlke, C., de Sisternes, L., Dunbar, H., Finger, R.P., Fletcher, E., Floyd, H., Francisco, C., Gutfleisch, M., Hogg, R., Holz, F.G., Hoyng, C.B., Kilani, A., Krätzschmar, J., Kühlewein, L., Larsen, M., Leal, S., Lechanteur, Y.T.E., Luhmann, U.F.O., Lüning, A., Marques, I., Martinho, C., Montesano, G., Mulyukov, Z., Paques, M., Parodi, B., Parravano, M., Penas, S., Peters, T., Peto, T., Pfau, M., Poor, S., Priglinger, S., Rowen, D., Rubin, G.S., Sahel, J., Sánchez, C., Sander, O., Saßmannshausen, M., Schmid, M., Schmitz-Valckenberg, S., Schrinner-Fenske, H., Siedlecki, J., Silva, R., Skelly, A., Souied, E., Staurenghi, G., Stöhr, L., Taylor, D.J., Terheyden, J.H., Thiele, S., Tufail, A., Varano, M., Vieweg, L., Wintergerst, L., Wolf, A., and Zakaria, N.

Abstract

To report the prevalence and topographic distribution of structural characteristics in study participants with age-related macular degeneration (AMD) and controls in the cross-sectional study part of the MACUSTAR study (ClinicalTrials.govIdentifier: NCT03349801).

Published
2023
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24. OCT Signs of Early Atrophy in Age-Related Macular Degeneration: Interreader Agreement

Author

Wu, Zhichao, Pfau, Maximilian, Blodi, Barbara A., Holz, Frank G., Jaffe, Glenn J., Liakopoulos, Sandra, Sadda, Srinivas R., Staurenghi, Giovanni, Bjelopera, Elvira, Brown, Tyler, Chang, Petrus, Choong, John, Corradetti, Giulia, Corvi, Federico, Domalpally, Amitha, Hurtenbach, Cynthia, Nittala, Muneeswar Gupta, Olson, Anthony, Pak, Jeong W., Pappe, Judith, Saßmannshausen, Marlene, Skalak, Cindy, Thiele, Sarah, Guymer, Robyn H., and Schmitz-Valckenberg, Steffen

Abstract

To determine the interreader agreement for incomplete retinal pigment epithelium (RPE) and outer retinal atrophy (iRORA) and complete RPE and outer retinal atrophy (cRORA) and their related features in age-related macular degeneration (AMD).

Published
2021
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25. [Use of artificial intelligence for recognition of biomarkers in intermediate age-related macular degeneration].

Author

von der Emde L, Künzel SH, Pfau M, Morelle O, Liermann Y, Chang P, Pfau K, Thiele S, and Holz FG

Subjects
Humans, Retinal Drusen diagnostic imaging, Retinal Drusen diagnosis, Retinal Drusen metabolism, Sensitivity and Specificity, Image Interpretation, Computer-Assisted methods, Algorithms, Macular Degeneration diagnosis, Macular Degeneration diagnostic imaging, Macular Degeneration pathology, Artificial Intelligence, Tomography, Optical Coherence methods, Biomarkers metabolism, Biomarkers analysis
Abstract

Advances in imaging and artificial intelligence (AI) have revolutionized the detection, quantification and monitoring for the clinical assessment of intermediate age-related macular degeneration (iAMD). The iAMD incorporates a broad spectrum of manifestations, which range from individual small drusen, hyperpigmentation, hypopigmentation up to early stages of geographical atrophy. Current high-resolution imaging technologies enable an accurate detection and description of anatomical features, such as drusen volumes, hyperreflexive foci and photoreceptor degeneration, which are risk factors that are decisive for prediction of the course of the disease; however, the manual annotation of these features in complex optical coherence tomography (OCT) scans is impractical for the routine clinical practice and research. In this context AI provides a solution by fully automatic segmentation and therefore delivers exact, reproducible and quantitative analyses of AMD-related biomarkers. Furthermore, the application of AI in iAMD facilitates the risk assessment and the development of structural endpoints for new forms of treatment. For example, the quantitative analysis of drusen volume and hyperreflective foci with AI algorithms has shown a correlation with the progression of the disease. These technological advances therefore improve not only the diagnostic precision but also support future targeted treatment strategies and contribute to the prioritized target of personalized medicine in the diagnostics and treatment of AMD., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)

Published
2024
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26. [Use of artificial intelligence in geographic atrophy in age-related macular degeneration].

Author

Chang P, von der Emde L, Pfau M, Künzel S, Fleckenstein M, Schmitz-Valckenberg S, and Holz FG

Subjects
Humans, Fluorescein Angiography, Sensitivity and Specificity, Geographic Atrophy diagnosis, Artificial Intelligence, Macular Degeneration diagnosis, Macular Degeneration pathology, Tomography, Optical Coherence
Abstract

The first regulatory approval of treatment for geographic atrophy (GA) secondary to age-related macular degeneration in the USA constitutes an important milestone; however, due to the nature of GA as a non-acute, insidiously progressing pathology, the ophthalmologist faces specific challenges concerning risk stratification, making treatment decisions, monitoring of treatment and patient education. Innovative retinal imaging modalities, such as fundus autofluorescence (FAF) and optical coherence tomography (OCT) have enabled identification of typical morphological alterations in relation to GA, which are also suitable for the quantitative characterization of GA. Solutions based on artificial intelligence (AI) enable automated detection and quantification of GA-specific biomarkers on retinal imaging data, also retrospectively and over time. Moreover, AI solutions can be used for the diagnosis and segmentation of GA as well as the prediction of structure and function without and under GA treatment, thereby making a valuable contribution to treatment monitoring and the identification of high-risk patients and patient education. The integration of AI solutions into existing clinical processes and software systems enables the broad implementation of informed and personalized treatment of GA secondary to AMD., (© 2024. The Author(s), under exclusive licence to Springer Medizin Verlag GmbH, ein Teil von Springer Nature.)

Published
2024
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27. [Baseline diagnostics and initial treatment decision for anti-vascular endothelial growth factor treatment in retinal diseases : Comparison between results by study physician and reading centers (ORCA/OCEAN study)].

Author

Brinkmann CK, Chang P, Schick T, Heimes B, Vögeler J, Haegele B, Kirchhof B, Holz FG, Pauleikhoff D, Ziemssen F, Liakopoulos S, Spital G, and Schmitz-Valckenberg S

Subjects
Angiogenesis Inhibitors, Humans, Intravitreal Injections, Ranibizumab, Reading, Tomography, Optical Coherence, Vascular Endothelial Growth Factor A, Retinal Diseases
Abstract

Background: The ORCA module of the non-interventional OCEAN study investigated the use of retinal imaging diagnostics in the clinical treatment of patients undergoing vascular endothelial growth factor (VEGF) inhibitor treatment as part of routine clinical care. This article analyzes the agreement between the diagnosis documented by the treating ophthalmologist and the evaluation of reading centers at baseline as well as the effect on the response to treatment during the course., Methods: A total of 396 patients (age 75.4 years) were enrolled in which ranibizumab treatment was indicated by the treating ophthalmologist due to either diabetic macular edema (DME), neovascular age-related macular degeneration (nvAMD) or retinal venous occlusion (RVO). Over a period of 24 months, patient and examination data, treatments and interpretation of retinal imaging data by the treating ophthalmologist were systematically recorded. Furthermore, retinal imaging data were also evaluated by three reading centers., Results: In 338 out of 396 (85.4%) study eyes, the baseline diagnosis of the treating ophthalmologist was confirmed by the reading centers (DME 87.5%, nvAMD 82.3%, RVO 94.9%). In 17 of the remaining 58 eyes with a discrepant diagnosis, there was at least a consensus with respect to the indications for VEGF inhibitor therapy. The differential diagnoses included a variety of different retinal diseases. During follow-up of up to 3 months, eyes with a consistent diagnosis showed a clear increase in visual acuity (6.4 versus 2.7 letters, p = 0.05) and greater decrease in central retinal thickness (-112.3 versus -24.4 μm, p < 0.0001)., Discussion: The initial treatment decision for anti-VEGF therapy with consideration of the differential diagnoses can be challenging. Accurate evaluation of the clinical and imaging findings along with appropriate expertise appear to be important. The observation of superior initial response in eyes with a consensus of the diagnosis at baseline underlines the relevance of an adequate initial assessment for a successful treatment outcome.

Published
2019
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28. Comparison of Green Versus Blue Fundus Autofluorescence in ABCA4 -Related Retinopathy.

Author

Müller PL, Pfau M, Mauschitz MM, Möller PT, Birtel J, Chang P, Gliem M, Schmitz-Valckenberg S, Fleckenstein M, Holz FG, and Herrmann P

Abstract

Purpose: To investigate the interreader and intermodality agreement for grading of retinal pigment epithelium (RPE) atrophy lesion size in ABCA4 -related retinopathy using green (GAF) and blue fundus autofluorescence (BAF) imaging., Methods: In this cross-sectional case series, 97 eyes of 49 patients with RPE atrophy secondary to ABCA4 -related retinopathy underwent GAF- (518 nm excitation light) and BAF- (488 nm excitation light) imaging using confocal scanning laser ophthalmoscopy (Spectralis HRA, Heidelberg Engineering, Heidelberg, Germany). Lesions with definitely decreased autofluorescence (DDAF) and questionably decreased autofluorescence (QDAF) in GAF and BAF imaging were analyzed separately by five independent readers using semiautomated software (RegionFinder, Heidelberg Engineering). Intermodality and interreader agreements were assessed for the square-root lesion size, lesion perimeter, and circularity., Results: GAF- and BAF-based measurements of DDAF and QDAF showed high intermodality and interreader agreement concerning square-root lesion size, as well as shape descriptive parameters (perimeter and circularity). Interreader agreement of square-root lesion size was slightly, hence not significantly higher for GAF-based grading ([95% coefficients of repeatability, intraclass correlation coefficient] DDAF: 0.215 mm, 0.997; QDAF: 0.712 mm, 0.981) compared to BAF-based grading (DDAF: 0.232 mm, 0.997; QDAF: 0.764 mm, 0.978). However, DDAF-measurements revealed distinctly more reproducible results than QDAF-measurements. Foveal sparing did not interfere with intermodality agreement., Conclusions: Both GAF- and BAF-based quantification of RPE atrophy showed very reliable results with possible superiority of GAF in the context of less energetic excitation light., Translational Relevance: The high interreader agreement qualifies the use of DDAF progression in GAF and BAF imaging as potential morphologic outcome measure for interventional clinical trials and disease monitoring.

Published
2018
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