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2. High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California

Author

Fong, Tse-Ling, Lee, Brian T., Chang, Mimi, Nasanbayar, Khishigsuren, Tsogtoo, Enkhjargal, Boldbaatar, Delgerbat, Dashdorj, Esugen D., Clifford, Namuun E., Dashdorj, Arghun N., Bang, Bo-Ram, Chida, Takeshi, Lim, Carolina, Sugiyama, Masaya, Mizokami, Masashi, Dashdorj, Naranjargal J., Liu, Ping, Glenn, Jeffrey S., Dashdorj, Naranbaatar D., and Saito, Takeshi more...

Published
2021
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15. High Prevalence of Chronic Viral Hepatitis and Liver Fibrosis Among Mongols in Southern California

Author

Fong, Tse-Ling, primary, Lee, Brian T., additional, Chang, Mimi, additional, Nasanbayar, Khishigsuren, additional, Tsogtoo, Enkhjargal, additional, Boldbaatar, Delgerbat, additional, Dashdorj, Esugen D., additional, Clifford, Namuun E., additional, Dashdorj, Arghun N., additional, Bang, Bo-Ram, additional, Chida, Takeshi, additional, Lim, Carolina, additional, Sugiyama, Masaya, additional, Mizokami, Masashi, additional, Dashdorj, Naranjargal J., additional, Liu, Ping, additional, Glenn, Jeffrey S., additional, Dashdorj, Naranbaatar D., additional, and Saito, Takeshi, additional more...

Published
2020
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17. Effect of Achieving Minimal Disease Activity on the Progression of Subclinical Atherosclerosis and Arterial Stiffness: A Prospective Cohort Study in Psoriatic Arthritis

Author

Cheng, Isaac T., primary, Shang, Qing, additional, Li, Edmund K., additional, Wong, Priscilla C., additional, Kun, Emily W., additional, Law, Mei Yan, additional, Yip, Ronald M., additional, Yim, Isaac C., additional, Lai, Billy T., additional, Ying, Shirley K., additional, Kwok, Kitty Y., additional, Li, Martin, additional, Li, Tena K., additional, Zhu, Tracy Y., additional, Lee, Jack J., additional, Chang, Mimi M., additional, Szeto, Cheuk‐Chun, additional, Yan, Bryan P., additional, Lee, Alex P., additional, and Tam, Lai‐Shan, additional more...

Published
2019
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18. Precision Medicine and the Practice of Trichiatry: Adapting the Concept

Author

Trüeb, Ralph M., primary, Jolliffe, Vicky M.L., additional, Régnier, Antonia Fellas, additional, Dutra Rezende, Hudson, additional, Vañó-Galván, Sergio, additional, Kopera, Daisy, additional, Ioannides, Demetrios, additional, Gavazzoni Dias, Maria Fernanda Reis, additional, Macpherson, Melanie, additional, Gadzhigoroeva, Aida, additional, Ovcharenko, Julya, additional, Lee, Won-Soo, additional, Murugusundram, Sundaram, additional, Kurata, Sotaro, additional, Chang, Mimi, additional, and Tanglertsampan, Chuchai, additional more...

Published
2019
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19. Bone and renal safety profile at 72 weeks after switching to tenofovir alafenamide in chronic hepatitis B patients.

Author

Lee, Brian T, Chang, Mimi, Lim, Carolina, Bae, Ho S, and Fong, Tse‐Ling

Subjects
TENOFOVIR, HEPATITIS B, BONE density
Abstract

Background and Aim: Tenofovir disoproxil fumarate (TDF) has been efficacious in treating chronic hepatitis B (CHB), but long‐term use is accompanied by a decline in renal function and bone mineral density (BMD). Tenofovir alefanamide (TAF) is a prodrug of tenofovir, with similar efficacy in CHB but with fewer side effects than TDF. Recent studies on patients who underwent the switch from TDF to TAF have shown improved bone and renal profiles from 24 to 48 weeks of follow‐up. Methods: This study provides follow‐up at 72 weeks in a real‐world cohort of 61 Asian CHB patients who were switched from TDF to TAF. All patients had been treated with TDF for at least 12 months with hepatitis B virus DNA <21 IU/mL prior to switch. Results: Improvements in proximal tubular function, measured by urine beta‐2‐microglobulin to creatinine and retinol‐binding protein to creatinine ratios, were sustained at 72 weeks (P < 0.01). Renal function showed decline at 72 weeks compared to baseline (GFRCG 90.9 vs 96.3 mL/min, P < 0.01). Improvement in hip BMD was sustained at 72 weeks (mean % change of 17.7% from baseline, P < 0.01). However, spine BMD showed discordance, with initial improvement at 24 weeks (3.3% from week 0, P < 0.01) but regression at 72 weeks (−0.6% from week 0, P = NS). Interestingly, there was a slight increase in weight and BMI after 72 weeks (P < 0.01). Conclusions: CHB patients who switch from long‐term TDF to TAF therapy show sustained improvement in proximal tubular function and hip BMD. Weight gain was noted, and long‐term studies are needed to evaluate its effect on patient outcomes. [ABSTRACT FROM AUTHOR] more...

Published
2021
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21. Trichologist, Dermatotrichologist, or Trichiatrist? A Global Perspective on a Strictly Medical Discipline

Author

Trüeb, Ralph Michel, primary, Vañó-Galván, Sergio, additional, Kopera, Daisy, additional, Jolliffe, Vicky M.L., additional, Ioannides, Demetrios, additional, Gavazzoni Dias, Maria ;Fernanda Reis, additional, Macpherson, Melanie, additional, Ruíz Ávila, Javier, additional, Gadzhigoroeva, Aida, additional, Ovcharenko, Julya, additional, Lee, Won-Soo, additional, Murugusundram, Sundaram, additional, Kurata, Sotaro, additional, Chang, Mimi, additional, and Tanglertsampan, Chuchai, additional more...

Published
2018
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22. Underestimation of Risk of Carotid Subclinical Atherosclerosis by Cardiovascular Risk Scores in Patients with Psoriatic Arthritis

Author

Shen, Jiayun, primary, Lam, Steven H., additional, Shang, Qing, additional, Wong, Chun-Kwok, additional, Li, Edmund K., additional, Wong, Priscilla, additional, Kun, Emily W., additional, Cheng, Isaac T., additional, Li, Martin, additional, Li, Tena K., additional, Zhu, Tracy Y., additional, Lee, Jack Jock-Wai, additional, Chang, Mimi, additional, Lee, Alex Pui-Wai, additional, and Tam, Lai-Shan, additional more...

Published
2017
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23. Increased prevalence of coronary plaque in patients with psoriatic arthritis without prior diagnosis of coronary artery disease

Author

Shen, Jiayun, primary, Wong, Ka-Tak, additional, Cheng, Isaac T, additional, Shang, Qing, additional, Li, Edmund K, additional, Wong, Priscilla, additional, Kun, Emily W, additional, Law, Mei Yan, additional, Yip, Ronald, additional, Yim, Isaac, additional, Ying, Shirley, additional, Li, Martin, additional, Li, Tena K, additional, Wong, Chun-Kwok, additional, Zhu, Tracy Y, additional, Lee, Jack Jock-Wai, additional, Chang, Mimi, additional, Lee, Alex Pui-Wai, additional, and Tam, Lai-Shan, additional more...

Published
2017
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24. Prospective evidence of a circulating microRNA signature as a non-invasive marker of hepatocellular carcinoma in HBV patients

Author

Wang, Chun, primary, Hann, Hie-Won, additional, Ye, Zhong, additional, Hann, Richard S., additional, Wan, Shaogui, additional, Ye, Xishan, additional, Block, Peter D., additional, Li, Bingshan, additional, Myers, Ronald E., additional, Wang, Xiaowei, additional, Juon, Hee-Soon, additional, Civan, Jesse, additional, Chang, Mimi, additional, Bae, Ho S., additional, Xing, Jinliang, additional, and Yang, Hushan, additional more...

Published
2016
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25. The Medication Risk of Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis in Asians: The Major Drug Causality and Comparison With the US FDA Label.

Author

Wang, Yu‐Hsin, Chen, Chun‐Bing, Tassaneeyakul, Wichittra, Saito, Yoshiro, Aihara, Michiko, Choon, Siew Eng, Lee, Haur Yueh, Chang, Mimi Mee, Roa, Francisca D., Wu, Cheng‐Wei, Zhang, Jing, Nakkam, Nontaya, Konyoung, Parinya, Okamoto‐Uchida, Yoshimi, Cheung, Christina Man‐tung, Huang, Jin‐wen, Ji, Chao, Cheng, Bo, Hui, Rosaline Chung‐Yee, and Chu, Chia‐Yu more...

Subjects
STEVENS-Johnson Syndrome, ASIANS, STRONTIUM, BETA-lactamase inhibitors
Abstract

Specific ethnic genetic backgrounds are associated with the risk of Stevens–Johnson syndrome / toxic epidermal necrolysis (SJS/TEN) especially in Asians. However, there have been no large cohort, multiple‐country epidemiological studies of medication risk related to SJS/TEN in Asian populations. Thus, we analyzed the registration databases from multiple Asian countries who were treated during 1998–2017. A total 1,028 SJS/TEN cases were identified with the algorithm of drug causality for epidermal necrolysis. Furthermore, those medications labeled by the US Food and Drug Administration (FDA) as carrying a risk of SJS/TEN were also compared with the common causes of SJS/TEN in Asian countries. Oxcarbazepine, sulfasalazine, COX‐II inhibitors, and strontium ranelate were identified as new potential causes. In addition to sulfa drugs and beta‐lactam antibiotics, quinolones were also a common cause. Only one acetaminophen‐induced SJS was identified, while several medications (e.g., oseltamivir, terbinafine, isotretinoin, and sorafenib) labeled as carrying a risk of SJS/TEN by the FDA were not found to have caused any of the cases in the Asian countries investigated in this study. [ABSTRACT FROM AUTHOR] more...

Published
2019
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26. Cultural differences in parenting styles and their effects on teens' self-esteem, perceived parental relationship satisfaction, and self-satisfaction

Author

Chang, Mimi

Subjects
FOS: Psychology, 170102 Developmental Psychology and Ageing
Abstract

It is commonly understood that adolescence can be a time when teens attempt to reconcile their own desires and needs with the wishes of their parents. While some adolescents get through this period of time without many problems, others tend to experience many negative effects. It is possible that the parent’s role in the relationship may play a part in the development of teenager’s self-esteem and self-satisfaction. Cultural values such as the Asian American emphasis on interdependence and family harmony may influence the type of parenting style these parents may choose to adopt. A study was performed with 156 teenagers from central New Jersey to determine the effects of parenting styles on teenagers’ self-esteem and overall satisfaction with their parents and themselves. Results indicated that there were no significant differences between race and authoritative parenting style, however, significant differences were found in that Asian American parents tended to be more authoritarian than their Caucasian counterparts. Furthermore, authoritative parenting was found to be associated with higher self esteem and satisfaction. Findings from the study are discussed in terms of the impact of cultural expectations on adolescents’ satisfaction with self and with their parents. more...

Published
2007
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27. Underestimation of Risk of Carotid Subclinical Atherosclerosis by Cardiovascular Risk Scores in Patients with Psoriatic Arthritis.

Author

Jiayun Shen, Lam, Steven H., Qing Shang, Chun-Kwok Wong, Li, Edmund K., Wong, Priscilla, Kun, Emily W., Cheng, Isaac T., Li, Martin, Li, Tena K., Zhu, Tracy Y., Lee, Jack Jock-Wai, Chang, Mimi, Pui-Wai Lee, Alex, Lai-Shan Tam, Shen, Jiayun, Shang, Qing, Wong, Chun-Kwok, Lee, Alex Pui-Wai, and Tam, Lai-Shan more...

Published
2018
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31. Underestimation of Risk of Carotid Subclinical Atherosclerosis by Cardiovascular Risk Scores in Patients with Psoriatic Arthritis

Author

Shen, Jiayun, Lam, Steven H., Shang, Qing, Wong, Chun-Kwok, Li, Edmund K., Wong, Priscilla, Kun, Emily W., Cheng, Isaac T., Li, Martin, Li, Tena K., Zhu, Tracy Y., Lee, Jack Jock-Wai, Chang, Mimi, Lee, Alex Pui-Wai, and Tam, Lai-Shan more...

Abstract

Objective.To test the performances of established cardiovascular (CV) risk scores in discriminating subclinical atherosclerosis (SCA) in patients with psoriatic arthritis.Methods.These scores were calculated: Framingham risk score (FRS), QRISK2, Systematic COronary Risk Evaluation (SCORE), 10-year atherosclerotic cardiovascular disease risk algorithm (ASCVD) from the American College of Cardiology and the American Heart Association, and the European League Against Rheumatism (EULAR)–recommended modified versions (by 1.5 multiplication factor, m-). Carotid intima-media thickness > 0.9 mm and/or the presence of plaque determined by ultrasound were classified as SCA+.Results.We recruited 146 patients [49.4 ± 10.2 yrs, male: 90 (61.6%)], of whom 142/137/128/118 patients were eligible to calculate FRS/QRISK2/SCORE/ASCVD. Further, 62 (42.5%) patients were SCA+ and were significantly older, with higher systolic blood pressure and higher low-density lipoprotein cholesterol (all p < 0.05). All CV risk scores were significantly higher in patients with SCA+ [FRS: 7.8 (3.9–16.5) vs 2.7 (1.1–7.8), p < 0.001; QRISK2: 5.5 (3.1–10.2) vs 2.9 (1.2–6.3), p < 0.001; SCORE: 1 (0–2) vs 0 (0–1), p < 0.001; ASCVD: 5.6 (2.6–12.4) vs 3.4 (1.4–6.1), p = 0.001]. The Hosmer-Lemeshow test revealed moderate goodness of fit for the 4 CV scores (p ranged from 0.087 to 0.686). However, of the patients with SCA+, those identified as high risk were only 44.1% (by FRS > 10%), 1.8% (QRISK2 > 20%), 10.9% (SCORE > 5%), and 43.6% (ASCVD > 7.5%). By applying the EULAR multiplication factor, 50.8%/14.3%/14.5%/54.5% of the patients with SCA+ were identified as high risk by m-FRS/m-QRISK2/m-SCORE/m-ASCVD, respectively. EULAR modification increased the sensitivity of FRS and ASCVD in discriminating SCA+ from 44% to 51%, and 44% to 55%, respectively.Conclusion.All CV risk scores underestimated the SCA+ risk. EULAR–recommended modification improved the sensitivity of FRS and ASCVD only to a moderate level. more...

Published
2018
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39. Perceived HBV-Related Stigma Is Associated With Lower Antiviral Medication Adherence in Patients With Chronic Hepatitis B.

Author

Juon HS, Yang D, Fang CX, Hann HW, Bae H, Chang M, and Klassen AC

Subjects
Humans, Male, Female, Middle Aged, Adult, Aged, Philadelphia, Asian psychology, Asian statistics & numerical data, Los Angeles, Young Adult, Antiviral Agents therapeutic use, Medication Adherence psychology, Hepatitis B, Chronic drug therapy, Hepatitis B, Chronic psychology, Social Stigma
Abstract

Medication nonadherence among patients with chronic hepatitis B (CHB) can lead to severe liver disease progression, including liver cirrhosis and hepatocellular carcinoma (HCC). Yet the factors that influence adherence in high-risk groups, like Korean Americans, remain unclear. Thus, this study explored the psychosocial and clinical factors affecting medication adherence in CHB patients. A cohort of 365 Korean American patients with CHB from two clinics in Philadelphia and Los Angeles was studied. The 8-item Morisky Medication Adherence Scale (MMAS-8) gauged their adherence to antiviral medication. Using descriptive and multivariable logistic regression analyses, we identified factors associated with MMAS-8 scores. Of the participants, 78% were undergoing antiviral therapy, with over two-thirds (69%) reporting medium to high adherence levels. The multivariable logistic regression analysis revealed that age, knowledge of sequalae of CHB, perceived HBV stigma and possession of pharmacy plan were associated with medication adherence. Older participants had higher medication adherence than younger. High knowledge of sequalae of CHB and low perceived HBV stigma were associated with higher medication adherence. Having pharmacy plans was also associated with higher medication adherence to antiviral therapy. These findings highlight the critical role of person-related factors (e.g., knowledge and stigma) and healthcare factors in medication adherence. Future research should focus on developing targeted educational interventions focusing on personal factors to improve medication adherence among Korean American patients with CHB., (© 2025 The Author(s). Journal of Viral Hepatitis published by John Wiley & Sons Ltd.) more...

Published
2025
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