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195 results on '"Chang, Lun-Ching"'

5. Older molecular brain age in severe mental illness

Author

Lin, Chien-Wei, Chang, Lun-Ching, Ma, Tianzhou, Oh, Hyunjung, French, Beverly, Puralewski, Rachel, Mathews, Fasil, Fang, Yusi, Lewis, David A., Kennedy, James L., Mueller, Daniel, Marshe, Victoria S., Jaffe, Andrew, Chen, Qiang, Ursini, Gianluca, Weinberger, Daniel, Newman, Anne B., Lenze, Eric J., Nikolova, Yuliya S., Tseng, George C., and Sibille, Etienne

Published
2021
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6. Gut flora metagenomic analysis coupled with metabolic and deep immune profiling in chronic kidney disease.

Author

Wu, I-Wen, Chang, Lun-Ching, Wu, Yi-Lun, Yang, Huang-Yu, Twu, Yuh-Ching, Tsai, Po-Yu, Paulus, Skyler, Resnick, Rhian, Chung, Wen-Hung, Yang, Chih-Wei, Hsieh, Wen-Ping, and Su, Shih-Chi

Subjects
*SHORT-chain fatty acids, *GUT microbiome, *CHRONIC kidney failure, *KIDNEY physiology, *BILE acids
Abstract

Background Perturbation of gut microbiota has been linked to chronic kidney disease (CKD), which was correlated with a sophisticated milieu of metabolic and immune dysregulation. Methods To clarify the underlying host–microbe interaction in CKD, we performed multi-omics measurements, including systems-level gut microbiome, targeted serum metabolome and deep immunotyping, in a cohort of patients and non-CKD controls. Results Our analyses on functional profiles of the gut microbiome showed a decrease in the diversity and abundance of carbohydrate-active enzyme (CAZyme) genes but an increase in the abundance of antibiotic resistance, nitrogen cycling enzyme and virulence factor genes in CKD. Moreover, models generated using measurements of serum metabolites (amino acids, bile acids and short-chain fatty acids) or immunotypes were predictive of renal impairment but less so than many of the functional profiles derived from gut microbiota, with the CAZyme genes being the top-performing model to accurately predict the early stage of diseases. In addition, co-occurrence analyses revealed coordinated host–microbe relationships in CKD. Specifically, the highest fractions of significant correlations were identified with circulating metabolites by several taxonomic and functional profiles of gut microbiome, while immunotype features were moderately associated with the abundance of microbiome-encoded metabolic pathways and serum levels of amino acids (e.g. B cell cluster tryptophan and B cell cluster tryptophan metabolism). Conclusion Overall, our multi-omics integration revealed several signatures of systems-level gut microbiome in robust associations with host–microbe co-metabolites and renal function, which may have aetiological and diagnostic implications in CKD. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Cognitive Assessment with Cognivue Clarity®: Psychometric Properties and Normative Ranges in a Diverse Population.

Author

Galvin, James E., Chang, Lun-Ching, Estes, Paul, Harris, Heather M., and Fung, Ernest

Subjects
*PSYCHOMETRICS, *EXPLORATORY factor analysis, *ALZHEIMER'S disease, *NEUROPSYCHOLOGICAL tests, *PSYCHOPHYSICS, *OLDER people
Abstract

Background: Detecting cognitive impairment in clinical practice is challenging as most instruments do not perform well in diverse samples of older adults. These same instruments are often used for eligibility into clinical trials making it difficult to recruit minoritized adults into Alzheimer's disease (AD) studies. Cognivue Clarity® is an FDA-cleared computerized 10-minute cognitive screening platform using adaptive psychophysics to detect cognitive impairment. Objective: Test the ability of Cognivue Clarity to measure cognitive performance in a diverse community sample compared with the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). Methods: This study enrolled 452 participants across 6 US study sites and completed both Cognivue Clarity device and RBANS. Psychometric properties and exploratory factor analysis of Cognivue Clarity were explored and comparisons against RBANS across different age, sex, education, and ethnoracial groups were conducted. Results: Participants had a mean age of 47.9±16.1 years (range: 18–85), 63.6% were female, 45.9% had ≤12 years of education, 31.2% were African American and 9.2% were Hispanic. Cognivue Clarity had strong internal consistency, test-retest reliability and minimal practice effects. A 4-factor structure (Memory, Attention, Visuomotor, and Discrimination) had excellent goodness-of-fit. Normalizing age effects improved performance. Race and education effects were similar to those seen with RBANS. Cognivue Clarity had strong correlations with RBANS. Conclusions: Our study supports the use of Cognivue Clarity as an easy-to-use, brief, and valid cognitive assessment that measures cognitive performance. In the correct clinical setting, Cognivue Clarity may identify individuals with likely cognitive impairment who could be candidates for AD research studies. [ABSTRACT FROM AUTHOR]

Published
2024
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10. MAOB expression correlates with a favourable prognosis in prostate cancer, and its genetic variants are associated with the metastasis of the disease.

Author

Huang, Hsiang‐Ching, Hsieh, Yi‐Hsien, Hsiao, Chi‐Hao, Lin, Chia‐Yen, Wang, Shian‐Shiang, Ho, Kuo‐Hao, Chang, Lun‐Ching, Huang, Huei‐Mei, Yang, Shun‐Fa, and Chien, Ming‐Hsien

Subjects
PROSTATE cancer prognosis, PROSTATE cancer, GENETIC variation, GENE expression, TAIWANESE people, MONOAMINE oxidase
Abstract

Monoamine oxidase B (MAOB), a neurotransmitter‐degrading enzyme, was reported to reveal conflicting roles in various cancers. However, the functional role of MAOB and impacts of its genetic variants on prostate cancer (PCa) is unknown. Herein, we genotyped four loci of MAOB single‐nucleotide polymorphisms (SNPs), including rs1799836 (A/G), rs3027452 (G/A), rs6651806 (A/C) and rs6324 (G/A) in 702 PCa Taiwanese patients. We discovered that PCa patients carrying the MAOB rs6324 A‐allele exhibited an increased risk of having a high initial prostate‐specific antigen (iPSA) level (>10 ng/mL). Additionally, patients with the rs3027452 A‐allele had a higher risk of developing distal metastasis, particularly in the subpopulation with high iPSA levels. In a subpopulation without postoperative biochemical recurrence, patients carrying the rs1799836 G‐allele had a higher risk of developing lymph node metastasis and recurrence compared to those carrying the A‐allele. Furthermore, genotype screening in PCa cell lines revealed that cells carrying the rs1799836 G‐allele expressed lower MAOB levels than those carrying the A‐allele. Functionally, overexpression and knockdown of MAOB in PCa cells respectively suppressed and enhanced cell motility and proliferation. In clinical observations, correlations of lower MAOB expression levels with higher Gleason scores, advanced clinical T stages, tumour metastasis, and poorer prognosis in PCa patients were noted. Our findings suggest that MAOB may act as a suppressor of PCa progression, and the rs3027452 and rs1799836 genetic variants of MAOB are linked to PCa metastasis within the Taiwanese population. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Phenotype-specific signatures of fecal metabolome and systems-level gut microbiome associated with childhood airway allergies

Author

Chang, Lun-Ching and Shih-Chi Su

Subjects
Mite sensitization, allergic rhinitis, allergy, carbohydrate active enzyme, virulome, resistome, fecal metabolomics, Copy Number Variation
Abstract

Our integrative analyses reveal several signatures of systems-level gut microbiome in robust associations with fecal metabolites and disease phenotypes, which may be of etiological and diagnostic implications in childhood airway allergies.

Published
2022
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26. Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors

Author

Do, Khanh, Speranza, Giovanna, Chang, Lun-Ching, Polley, Eric C., Bishop, Rachel, Zhu, Weimin, Trepel, Jane B., Lee, Sunmin, Lee, Min-Jung, Kinders, Robert J., Phillips, Larry, Collins, Jerry, Lyons, John, Jeong, Woondong, Antony, Ramya, Chen, Alice P., Neckers, Len, Doroshow, James H., and Kummar, Shivaani

Published
2015
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32. Deep immune profiling of patients with renal impairment unveils distinct immunotypes associated with disease severity.

Author

Wu, I-Wen, Wu, Yi-Lun, Yang, Huang-Yu, Hsu, Cheng-Kai, Chang, Lun-Ching, Twu, Yuh-Ching, Chang, Ya-Ling, Chung, Wen-Hung, Yang, Chih-Wei, Hsieh, Wen-Ping, and Su, Shih-Chi

Subjects
MONONUCLEAR leukocytes, STEM cell factor, IMMUNOREGULATION, CHRONIC kidney failure
Abstract

Background Chronic kidney disease (CKD) is pathologically correlated with a sophisticated milieu of innate and adaptive immune dysregulation, but the underlying immunological disturbances remain poorly understood. Methods To address this, we comprehensively interrogated cellular and soluble elements of the immune system by using high-dimensional flow cytometry to analyze peripheral blood mononuclear cells and performing cytokine/chemokine profiling of serum samples, respectively, in a cohort of 69 patients and 19 non-CKD controls. Results Altered serum levels of several cytokines/chemokines were identified, among which concentrations of stem cell factor (SCF) were found to be elevated with the progression of CKD and inversely correlated with estimated glomerular filtration rate (eGFR). Deep immunophenotyping analyses reveal a global change in immune modulation associated with CKD severity. Specifically, a decrease in the subsets of CD56dim natural killer (NK) cells (KLRG-1+CD38+CD64+CD15+CD197+) and monocytes (KLRG-1+CD38+PD-1+) was detected in severe CKD compared with controls and mild CKD. In addition, comparisons between mild and severe CKD demonstrated a loss of a mature B cell population (PD-1+CD197+IgD+HLA-DR+) in the advanced stages of disease. Further, we identified immunophenotypic markers to discriminate mild CKD from the controls, among which the portion of CD38+ monocytes was of particular value in early diagnosis. Conclusions Our data unveil severity-specific immunological signatures perturbed in CKD patients. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Longitudinal Associations between the Neighborhood Built Environment and Cognition in US Older Adults: The Multi-Ethnic Study of Atherosclerosis

Author

Besser, Lilah M., primary, Chang, Lun-Ching, additional, Hirsch, Jana A., additional, Rodriguez, Daniel A., additional, Renne, John, additional, Rapp, Stephen R., additional, Fitzpatrick, Annette L., additional, Heckbert, Susan R., additional, Kaufman, Joel D., additional, and Hughes, Timothy M., additional

Published
2021
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36. Associations Between Neighborhood Park Access and Longitudinal Change in Cognition in Older Adults: The Multi-Ethnic Study of Atherosclerosis

Author

Besser, Lilah M., primary, Chang, Lun-Ching, additional, Evenson, Kelly R., additional, Hirsch, Jana A., additional, Michael, Yvonne L., additional, Galvin, James E., additional, Rapp, Stephen R., additional, Fitzpatrick, Annette L., additional, Heckbert, Susan R., additional, Kaufman, Joel D., additional, and Hughes, Timothy M., additional

Published
2021
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37. Combined Impacts of Genetic Variants of Long Non-Coding RNA MALAT1 and the Environmental Carcinogen on the Susceptibility to and Progression of Oral Squamous Cell Carcinoma

Author

Ding, Yi-Fang, primary, Wen, Yu-Ching, additional, Chuang, Chun-Yi, additional, Lin, Chiao-Wen, additional, Yang, Yi-Chieh, additional, Liu, Yu-Fan, additional, Chang, Wei-Min, additional, Chang, Lun-Ching, additional, Yang, Shun-Fa, additional, and Chien, Ming-Hsien, additional

Published
2021
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41. Characterization of dementia with Lewy bodies (DLB) and mild cognitive impairment using the Lewy body dementia module (LBD‐MOD)

Author

Galvin, James E., primary, Chrisphonte, Stephanie, additional, Cohen, Iris, additional, Greenfield, Keri K., additional, Kleiman, Michael J., additional, Moore, Claudia, additional, Riccio, Mary Lou, additional, Rosenfeld, Amie, additional, Shkolnik, Niurka, additional, Walker, Marcia, additional, Chang, Lun‐Ching, additional, and Tolea, Magdalena I., additional

Published
2021
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42. Potential Impacts of Interleukin-17A Promoter Polymorphisms on the EGFR Mutation Status and Progression of Non-Small Cell Lung Cancer in Taiwan

Author

Lee, Kai-Ling, primary, Lai, Tsung-Ching, additional, Wang, Yao-Chen, additional, Shih, Pei-Chun, additional, Yang, Yi-Chieh, additional, Tsao, Thomas Chang-Yao, additional, Liu, Tu-Chen, additional, Wen, Yu-Ching, additional, Chang, Lun-Ching, additional, Yang, Shun-Fa, additional, and Chien, Ming-Hsien, additional

Published
2021
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47. Compositional and Functional Adaptations of Intestinal Microbiota and Related Metabolites in CKD Patients Receiving Dietary Protein Restriction

Author

Wu, I-Wen, primary, Lee, Chin-Chan, additional, Hsu, Heng-Jung, additional, Sun, Chiao-Yin, additional, Chen, Yuen-Chan, additional, Yang, Kai-Jie, additional, Yang, Chi-Wei, additional, Chung, Wen-Hun, additional, Lai, Hsin-Chih, additional, Chang, Lun-Ching, additional, and Su, Shih-Chi, additional

Published
2020
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48. Integration of metagenomics‐metabolomics reveals specific signatures and functions of airway microbiota in mite‐sensitized childhood asthma

Author

Chiu, Chih‐Yung, primary, Chou, Hsin‐Cheng, additional, Chang, Lun‐Ching, additional, Fan, Wen‐Lang, additional, Dinh, Michael Cong Vinh, additional, Kuo, Yu‐Lun, additional, Chung, Wen‐Hung, additional, Lai, Hsin‐Chih, additional, Hsieh, Wen‐Ping, additional, and Su, Shih‐Chi, additional

Published
2020
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49. Older molecular brain age in severe mental illness

Author

Lin, Chien-Wei, primary, Chang, Lun-Ching, additional, Ma, Tianzhou, additional, Oh, Hyunjung, additional, French, Beverly, additional, Puralewski, Rachel, additional, Mathews, Fasil, additional, Fang, Yusi, additional, Lewis, David A., additional, Kennedy, James L., additional, Mueller, Daniel, additional, Marshe, Victoria S., additional, Jaffe, Andrew, additional, Chen, Qiang, additional, Ursini, Gianluca, additional, Weinberger, Daniel, additional, Newman, Anne B., additional, Lenze, Eric J., additional, Nikolova, Yuliya S., additional, Tseng, George C., additional, and Sibille, Etienne, additional

Published
2020
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