142 results on '"Chang, Leon"'
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2. JNJ-77242113, a highly potent, selective peptide targeting the IL-23 receptor, provides robust IL-23 pathway inhibition upon oral dosing in rats and humans
3. Gene expression and metabolism in malignant hyperthermia susceptible and normal skeletal muscle
4. An Association between OXPHOS-Related Gene Expression and Malignant Hyperthermia Susceptibility in Human Skeletal Muscle Biopsies
5. Unravelling the unseen metabolic changes in patients with malignant hyperthermia
6. Efecto 2020 en la siniestralidad laboral de la República del Ecuador: un año atípico por COVID-19
7. Anesthesia for the Obese Parturient
8. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation
9. Comparison of Transcriptomic Changes in Survivors of Exertional Heat Illness with Malignant Hyperthermia Susceptible Patients
10. S1028 Characterization of a First-in-Class Oral Therapy Selectively Targeting the IL-23 Pathway
11. Adaptive Complex Contagions and Threshold Dynamical Systems
12. IL-23 regulation of myeloid cell biology during inflammation
13. Permeabilised skeletal muscle reveals mitochondrial deficiency in malignant hyperthermia-susceptible individuals
14. Identification of highly selective SIK1/2 inhibitors that modulate innate immune activation and suppress intestinal inflammation.
15. A Novel Approach for Modeling Biphasic Dose–Response Curves
16. Operating Room Management Case Scenarios
17. Discovery of JNJ-64264681: A Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase
18. The mitochondrial bioenergetics in primary myotubes from mouse models of malignant hyperthermia are not directly related to increased sarcoplasmic calcium concentrations
19. Efecto 2020 en la siniestralidad laboral de la República del Ecuador: un año atípico por COVID-19
20. Mo1504: IN SILICO EVALUATION AND PRE-CLINICAL EFFICACY OF ANTI-TNF AND ANTI-IL-23 COMBINATION THERAPY IN INFLAMMATORY BOWEL DISEASE
21. Su1738 JNJ-77242113, AN ORAL PEPTIDE SELECTIVELY TARGETING THE IL-23 RECEPTOR, DEMONSTRATES PHARMACODYNAMIC ACTIVITY IN RAT AND HUMAN COLON TISSUE EXPLANTS FOLLOWING ORAL DOSING
22. Discovery of a Potent and Selective Covalent Inhibitor of Bruton’s Tyrosine Kinase with Oral Anti-Inflammatory Activity
23. Operating Room Management Case Scenarios
24. Heteroarylureas with fused bicyclic diamine cores as inhibitors of fatty acid amide hydrolase
25. Bioenergetic defects in muscle fibers of RYR1 mutant knock-in mice associated with malignant hyperthermia
26. Heat Transfer Optimization in TV Glass Furnaces
27. Anti‐MDA5‐associated dermatomyositis
28. The ex utero intrapartum treatment procedure: anesthetic considerations
29. Hyperpolarization-Activated, Cation-Nonselective, Cyclic Nucleotide-Modulated Channel Blockade Alleviates Mechanical Allodynia and Suppresses Ectopic Discharge in Spinal Nerve Ligated Rats
30. Inhibition of fatty acid amide hydrolase produces analgesia by multiple mechanisms
31. Work-related musculoskeletal disorders - Official data study in the Republic of Ecuador
32. Analysis of integrated inflammatory bowel disease mouse models to assess their disease driving pathways and relevance for Crohn’s disease and Ulcerative colitis
33. Incompressible Navier-Stokes Calculations in Pump Flows
34. Computation of incompressible viscous flows through turbopump components
35. Multigrid convergence of an implicit symmetric relaxation scheme
36. Incompressible Navier-Stokes computations of rotating flows
37. Mitochondrial Dysfunction in Malignant Hyperthermia Susceptible Skeletal Muscle
38. Real-time Magnetic Resonance Imaging-Guided Biopsy Using SmartFrame® Stereotaxis in the Setting of a Conventional Diagnostic Magnetic Resonance Imaging Suite
39. Safety of stereotactic laser ablations performed as treatment for glioblastomas in a conventional magnetic resonance imaging suite
40. Stereotactic laser ablation as treatment for brain metastases that recur after stereotactic radiosurgery: a multiinstitutional experience
41. 1-Aryl-2-((6-aryl)pyrimidin-4-yl)amino)ethanols as competitive inhibitors of fatty acid amide hydrolase
42. Heteroarylureas with spirocyclic diamine cores as inhibitors of fatty acid amide hydrolase
43. A Single Amino Acid Difference between Mouse and Human 5-Lipoxygenase Activating Protein (FLAP) Explains the Speciation and Differential Pharmacology of Novel FLAP Inhibitors
44. Preclinical Characterization of the FAAH Inhibitor JNJ-42165279
45. Phenotyping drug polypharmacology via eicosanoid profiling of blood
46. Mannose-binding lectin and innate immunity in bronchiectasis
47. Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH)
48. Aryl Piperazinyl Ureas as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) in Rat, Dog, and Primate
49. Lessons learned from the institution of the Surgical Care Improvement Project at a teaching medical center
50. Biochemical and Biological Properties of 4-(3-phenyl-[1,2,4] thiadiazol-5-yl)-piperazine-1-carboxylic acid phenylamide, a Mechanism-Based Inhibitor of Fatty Acid Amide Hydrolase
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