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1,221 results on '"Chang, Kai‐Ping"'

3. Tobacco-Smoking, Alcohol-Drinking, and Betel-Quid-Chewing Behaviors: Development and Use of a Web-Based Survey System

Author

Hsu, Kuo-Yao, Tsai, Yun-Fang, Huang, Chu-Ching, Yeh, Wen-Ling, Chang, Kai-Ping, Lin, Chen-Chun, Chen, Ching-Yen, and Lee, Hsiu-Lan

Subjects
Information technology, T58.5-58.64, Public aspects of medicine, RA1-1270
Abstract

BackgroundSmoking tobacco, drinking alcohol, and chewing betel quid are health-risk behaviors for several diseases, such as cancer, cardiovascular disease, and diabetes, with severe impacts on health. However, health care providers often have limited time to assess clients’ behaviors regarding smoking tobacco, drinking alcohol, and chewing betel quid and intervene, if needed. ObjectiveThe objective of this study was to develop a Web-based survey system; determine the rates of tobacco-smoking, alcohol-drinking, and betel-quid-chewing behaviors; and estimate the efficiency of the system (time to complete the survey). MethodsPatients and their family members or friends were recruited from gastrointestinal medical–surgical, otolaryngology, orthopedics, and rehabilitation clinics or wards at a medical center in northern Taiwan. Data for this descriptive, cross-sectional study were extracted from a large series of research studies. A Web-based survey system was developed using a Linux, Apache, MySQL, PHP stack solution. The Web survey was set up to include four questionnaires: the Chinese-version Fagerstrom Tolerance Questionnaire, the Chinese-version Alcohol Use Disorders Identification Test, the Betel Nut Dependency Scale, and a sociodemographic form with several chronic diseases. After the participants completed the survey, the system automatically calculated their score, categorized their risk level for each behavior, and immediately presented and explained their results. The system also recorded the time each participant took to complete the survey. ResultsOf 782 patient participants, 29.6% were addicted to nicotine, 13.3% were hazardous, harmful, or dependent alcohol drinkers, and 1.5% were dependent on chewing betel quid. Of 425 family or friend participants, 19.8% were addicted to nicotine, 5.6% were hazardous, harmful, or dependent alcohol drinkers, and 0.9% were dependent on chewing betel quid. Regarding the mean time to complete the survey, patients took 7.9 minutes (SD 3.0; range 3-20) and family members or friends took 7.7 minutes (SD 2.8; range 3-18). Most of the participants completed the survey within 5-10 minutes. ConclusionsThe Web-based survey was easy to self-administer. Health care providers can use this Web-based survey system to save time in assessing these risk behaviors in clinical settings. All smokers had mild-to-severe nicotine addiction, and 5.6%-12.3% of patients and their family members or friends were at risk of alcohol dependence. Considering that these three behaviors, particularly in combination, dramatically increase the risk of esophageal cancer, appropriate and convenient interventions are necessary for preserving public health in Taiwan.

Published
2018
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6. Nasopharyngeal carcinoma patient-derived xenograft mouse models reveal potential drugs targeting cell cycle, mTOR, and autophagy pathways

Author

Li, Hsin-Pai, Huang, Chen-Yang, Lui, Kar-Wai, Chao, Yin-Kai, Yeh, Chun-Nan, Lee, Li-Yu, Huang, Yenlin, Lin, Tung-Liang, Kuo, Yung-Chia, Huang, Mei-Yuan, Fan, Hsien-Chi, Lin, An-Chi, Hsieh, Chia-Hsun, Chang, Kai-Ping, Lin, Chien-Yu, Wang, Hung-Ming, Chao, Mei, Liu, Jai-Shin, Chang, Yu-Sun, and Hsu, Cheng-Lung

Published
2023
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16. Clinical Outcomes of Taiwanese Patients with Resected Oral Cavity Squamous Cell Carcinoma Who Underwent Reconstruction with Free Versus Local Flaps

Author

Liao, Chun-Ta, Wen, Yu-Wen, Lee, Shu-Ru, Ng, Shu-Hang, Liu, Tsang-Wu, Tsai, Sen-Tien, Tsai, Ming-Hsui, Lin, Jin-Ching, Chien, Chih-Yen, Lou, Pei-Jen, Wang, Cheng-Ping, Chu, Pen-Yuan, Leu, Yi-Shing, Tsai, Kuo-Yang, Terng, Shyuang-Der, Chen, Tsung-Ming, Wang, Cheng-Hsu, Chen, Wen-Cheng, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Fang, Tuan-Jen, Huang, Shiang-Fu, Kang, Chung-Jan, Chang, Kai-Ping, Yen, Tzu-Chen, Yang, Lan-Yan, and Lin, Chih-Hung

Published
2022
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26. Precision Adjuvant Therapy Based on Detailed Pathologic Risk Factors for Resected Oral Cavity Squamous Cell Carcinoma: Long-Term Outcome Comparison of CGMH and NCCN Guidelines

Author

Lin, Chien-Yu, Fan, Kang-Hsing, Lee, Li-Yu, Hsueh, Chuen, Yang, Lan Yan, Ng, Shu-Hang, Wang, Hung-Ming, Hsieh, Chia-Hsun, Lin, Chih-Hung, Tsao, Chung-Kan, Kang, Chung-Jan, Fang, Tuan-Jen, Lee, Li-Ang, Huang, Shiang-Fu, Chang, Kai-Ping, Yen, Tzu-Chen, Tay, Ze Yun, Wen, Yu-Wen, Lee, Shu Ru, and Liao, Chun-Ta

Published
2020
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28. Salivary Biomarkers for Detection of Oral Squamous Cell Carcinoma in a Taiwanese Population

Author

Gleber-Netto, Frederico Omar, Yakob, Maha, Li, Feng, Feng, Ziding, Dai, Jianliang, Kao, Huang-Kai, Chang, Yu-Liang, Chang, Kai-Ping, and Wong, David TW

Subjects
Dental/Oral and Craniofacial Disease, Cancer, Clinical Research, Rare Diseases, Digestive Diseases, Adult, Aged, Biomarkers, Tumor, Carcinoma, Squamous Cell, Dual Specificity Phosphatase 1, Early Detection of Cancer, Enzyme-Linked Immunosorbent Assay, Female, Head and Neck Neoplasms, Humans, Interleukin-1beta, Interleukin-8, Male, Middle Aged, Mouth Neoplasms, Proteomics, Risk Factors, Saliva, Squamous Cell Carcinoma of Head and Neck, Taiwan, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeThis study evaluated the discriminatory power of salivary transcriptomic and proteomic biomarkers in distinguishing oral squamous cell carcinoma cases from controls and potentially malignant oral disorders (PMOD).Experimental designA total of 180 samples (60 OSCC patients, 60 controls, and 60 PMOD patients) were used in the study. Seven transcriptomic markers (IL8, IL1β, SAT1, OAZ1, DUSP1, S100P, and H3F3A) were measured using qPCR, and two proteomic markers (IL8 and IL1β) were evaluated by ELISA.ResultsAmong 7 transcriptomic markers, transcript level of DUSP1 was significantly lower in OSCC patients than in controls and PMOD patients. Between the proteomic markers, the protein concentration of IL8 and IL1β was significantly higher in OSCC patients than controls and dysplasia patients. Univariate fractional polynomial (FP) models revealed that salivary IL8 protein (IL8p) has the highest AUC value between OSCC patients and controls (0.74) and between OSCC and PMOD patients (0.72). Applying a 2-marker FP model, salivary IL8p combined with IL1β gave the best AUC value for discrimination between OSCC patients and controls, as well as the IL8p combined with H3F3A mRNA, which gave the best AUC value for discrimination between OSCC and PMOD patients. Multivariate models analysis combining salivary analytes and risk factor exposure related to oral carcinogenesis formed the best combinatory variables for differentiation between OSCC versus PMOL (AUC = 0.80), OSCC versus controls (AUC = 0.87), and PMOD versus controls (AUC = 0.78).ConclusionsThe combination of transcriptomic and proteomic salivary markers is of great value for oral cancer detection and differentiation from PMOD patients and controls. Clin Cancer Res; 22(13); 3340-7. ©2016 AACR.

Published
2016

33. A combined analysis of maximum standardized uptake value on FDG-PET, genetic markers, and clinicopathological risk factors in the prognostic stratification of patients with resected oral cavity squamous cell carcinoma

Author

Liao, Chun-Ta, Hsieh, Chia-Hsun, Fan, Wen-Lang, Ng, Shu-Hang, Cheng, Nai-Ming, Lee, Li-Yu, Hsueh, Chuen, Lin, Chien-Yu, Fan, Kang-Hsing, Wang, Hung-Ming, Lin, Chih-Hung, Tsao, Chung-Kan, Kang, Chung-Jan, Fang, Tuan-Jen, Huang, Shiang-Fu, Chang, Kai-Ping, Lee, Li-Ang, Fang, Ku-Hao, Wang, Yu-Chien, Yang, Lan-Yan, and Yen, Tzu-Chen

Published
2020
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34. Tumor Depth of Invasion (Tumor > 4 cm/Depth > 10 mm and Depth > 20 mm) and Through Cortex/Skin Invasion are Both Valid Criteria for Classifying Tumors as pT4a in AJCC 2018 Oral Cavity Cancer Staging System

Author

Liao, Chun-Ta, Lee, Li-Yu, Hsueh, Chuen, Lin, Chien-Yu, Fan, Kang-Hsing, Wang, Hung-Ming, Hsieh, Chia-Hsun, Ng, Shu-Hang, Lin, Chih-Hung, Tsao, Chung-Kan, Kang, Chung-Jan, Fang, Tuan-Jen, Huang, Shiang-Fu, Chang, Kai-Ping, Lee, Li-Ang, Fang, Ku-Hao, Wang, Yu-Chien, Lin, Wan-Ni, Hsin, Li-Jen, Yang, Lan Yan, and Yen, Tzu-Chen

Published
2019
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42. Parenting stress in parents of children with refractory epilepsy before and after vagus nerve stimulation implantation

Author

Wang, Chuan-Yu, Kuo, Yung-Ting, Wang, Huei-Shyong, Lin, Kuang-Lin, Hung, Po-Cheng, Chang, Ying-Chao, Hung, Pi-Lien, Fan, Pi-Chuan, Lee, Wang-Tso, Yang, Rei-Cheng, Ko, Fang-Jong, Lin, Lung-Chang, Chou, Po-Ching, Tsai, Jeng-Dau, Hung, Kun-Long, Chen, Hui-Ju, Chang, Kai-Ping, Hsu, Ting-Rong, Ho, Che-Sheng, Chiu, Nan-Chang, Chen, Shyi-Jou, Fan, Hueng-Chuen, Lee, Hsu-Tung, Shen, Ein-Yiao, Kuo, Huang-Tsung, Chang, Ming-Yuh, Chang, Tung-Ming, Li, Sung-Tse, Yeh, Geng-Chang, Tsai, Pei-Chieh, Wu, Wen-Hsiang, and Chen, Juei-Chao

Published
2017
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44. Clinical validation of a saliva-based matrix Metalloproteinase-1 rapid strip test for detection of oral cavity cancer

Author

Chu, Lichieh Julie, primary, Chang, Ya-Ting, additional, Chien, Chih-Yen, additional, Chung, Hui-Ching, additional, Wu, Shu-Fang, additional, Chen, Chih-Jou, additional, Liu, Yen-Chun, additional, Liao, Wei-Chao, additional, Chen, Chien-Hua, additional, Chiang, Wei-Fan, additional, Chang, Kai-Ping, additional, Wang, Jun-Sheng, additional, and Yu, Jau-Song, additional

Published
2023
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45. Saliva protein biomarkers to detect oral squamous cell carcinoma in a high-risk population in Taiwan

Author

Yu, Jau-Song, Chen, Yi-Ting, Chiang, Wei-Fan, Hsiao, Yung-Chin, Chu, Lichieh Julie, See, Lai-Chu, Wu, Chi-Sheng, Tu, Hui-Tzu, Chen, Hsiao-Wei, Chen, Chia-Chun, Liao, Wei-Chao, Chang, Ya-Ting, Wu, Chih-Ching, Lin, Che-Yi, Liu, Shyun-Yeu, Chiou, Shu-Ti, Chia, Shu-Li, Chang, Kai-Ping, Chien, Chih-Yen, Chang, Su-Wei, Chang, Chee-Jen, Young, John D., Pao, Chia C., Chang, Yu-Sun, and Hartwell, Leland H.

Published
2016

46. Comparative clinical outcomes of Taiwanese patients with resected buccal and tongue squamous cell carcinomas

Author

Liao, Chun-Ta, Wen, Yu-Wen, Yang, Lan Yan, Lee, Shu Ru, Ng, Shu-Hang, Liu, Tsang-Wu, Tsai, Sen-Tien, Tsai, Ming-Hsui, Lin, Jin-Ching, Chen, Peir-Rong, Lou, Pei-Jen, Wang, Cheng Ping, Chu, Pen-Yuan, Hwang, Tzer-Zen, Leu, Yi-Shing, Tsai, Kuo-Yang, Terng, Shyuang-Der, Chen, Tsung-Ming, Wang, Cheng-Hsu, Chien, Chih-Yen, Chen, Wen-Cheng, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Hsieh, Chia-Hsun, Tsao, Chung-Kan, Fang, Tuan-Jen, Huang, Shiang-Fu, Kang, Chung-Jan, Chang, Kai-Ping, and Yen, Tzu-Chen

Published
2017
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47. Association between the diagnosis-to-treatment interval and overall survival in Taiwanese patients with oral cavity squamous cell carcinoma

Author

Liao, Chun-Ta, Chen, Hsin-Ni, Wen, Yu-Wen, Lee, Shu Ru, Ng, Shu-Hang, Liu, Tsang-Wu, Tsai, Sen-Tien, Tsai, Ming-Hsui, Lin, Jin-Ching, Lou, Pei-Jen, Wang, Cheng Ping, Chu, Pen-Yuan, Leu, Yi-Shing, Tsai, Kuo-Yang, Terng, Shyuang-Der, Chen, Tsung-Ming, Wang, Cheng-Hsu, Chien, Chih-Yen, Chen, Wen-Cheng, Lee, Li-Yu, Lin, Chien-Yu, Wang, Hung-Ming, Lin, Chih-Hung, Fang, Tuan-Jen, Huang, Shiang-Fu, Kang, Chung-Jan, Chang, Kai-Ping, Yang, Lan Yan, and Yen, Tzu-Chen

Published
2017
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