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This study proposes new strategies for the information technology (IT) industry in South Korea, provides objectives for the South Korean IT industry and articulates the roles of the Korean government agencies, companies and users. Specifically, it covers South Korean IT strategies employed during several periods, including a stagnant period and a more recent period reflecting new successful IT environments of developed countries. South Korean IT companies should recognize the importance of user interface and user experience technologies as a next key global IT industry trend. Raising this awareness is critical in increasing the global competitiveness of the Korean IT industry. Furthermore, South Korean government agencies should take more active role in constructing and improving interactive environments that would benefit both companies and users. For future research, it is imperative to investigate the specific roles of companies, users and government agencies with respect to IT usage. [ABSTRACT FROM PUBLISHER]

Amyloid fibrils are responsible for pathogenesis of various diseases and exhibit the structural feature of an ordered, hierarchical structure such as multi-stranded helical structure. As the multi-strandedness of amyloid fibrils has recently been found to be highly correlated with their toxicity and infectivity, it is necessary to study how the hierarchical (i.e. multi-stranded) structure of amyloid fibril is formed. Moreover, although it has recently been reported that the nanomechanics of amyloid proteins plays a key role on the amyloid-induced pathogenesis, a critical role that the multi-stranded helical structure of the fibrils plays in their nanomechanical properties has not fully characterized. In this work, we characterize the morphology and mechanical properties of multi-stranded amyloid fibrils by using equilibrium molecular dynamics simulation and elastic network model. It is shown that the helical pitch of multi-stranded amyloid fibril is linearly proportional to the number of filaments comprising the amyloid fibril, and that multi-strandedness gives rise to improving the bending rigidity of the fibril. Moreover, we have also studied the morphology and mechanical properties of a single protofilament (filament) in order to understand the effect of cross-β structure and mutation on the structures and mechanical properties of amyloid fibrils. Our study sheds light on the underlying design principles showing how the multi-stranded amyloid fibril is formed and how the structure of amyloid fibrils governs their nanomechanical properties.