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485 results on '"Chang, Hung-Yu"'

7. The impact of the COVID-19 pandemic on heart failure management: Global experience of the OPTIMIZE Heart Failure Care network

Author

Cowie, Martin R., Mourilhe-Rocha, Ricardo, Chang, Hung-Yu, Volterrani, Maurizio, Ban, Ha Ngoc, Campos de Albuquerque, Denilson, Chung, Edward, Fonseca, Cândida, Lopatin, Yuri, Magaña Serrano, José Antonio, Mircheva, Lilyana, Moncada-Paz, Gustavo Adolfo, Pagava, Zurab, Reyes, Eugenio B., Saldarriaga, Clara, Schwartzmann, Pedro, Sim Kheng Leng, David, Trivi, Marcelo, Yotov, Yoto Trifonov, and Zieroth, Shelley

Published
2022
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8. Modeling Biological Membrane and Red Blood Cells by Coarse- Grained Particle Method

Author

Li, He, Chang, Hung-yu, Yang, Jun, Lu, Lu, and Lykotrafitis, George

Subjects
Condensed Matter - Soft Condensed Matter
Abstract

In this work, we review previously developed coarse-grained (CG) particle models for biological membrane and red blood cells (RBCs) and discuss the advantages of the CG particle method over the continuum and atomic simulations on modeling biological phenomena. CG particle models can largely increase the length scale and time scale of atomic simulations by eliminating fast degrees of freedom while preserving the mesoscopic structures and properties of the simulated system. One the other hand, CG particle models can be used to capture microstructural alternations in diseased RBCs and simulate topological changes of biological membrane and RBCs, which are major challenges to typical continuum representations of membrane and RBCs. The power and versatility of the CG particle methods are demonstrated through simulating the dynamical processes involving significant topological changes, such as lipid self-assembly, vesicle fusion and membrane budding.

Published
2017

21. Penalized Model‐Based Unsupervised Phenomapping Unravels Distinctive HFrEF Phenotypes With Improved Outcomes Discrimination From Sacubitril/Valsartan Treatment Independent of MAGGIC Score

Author

Sung, Kuo‐Tzu, primary, Chang, Hung‐Yu, additional, Hsu, Nai‐Wei, additional, Huang, Wen‐Hung, additional, Lin, Yueh‐Hung, additional, Yun, Chun‐Ho, additional, Hsiao, Chih‐Chung, additional, Hsu, Chien‐Yi, additional, Tsai, Shin‐Yi, additional, Chen, Ying‐Ju, additional, Tsai, Cheng‐Ting, additional, Su, Cheng‐Huang, additional, Hung, Ta‐Chuan, additional, Hou, Charles Jia‐Yin, additional, Yeh, Hung‐I, additional, and Hung, Chung‐Lieh, additional

Published
2023
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28. Theoretical Investigation of DIBL Characteristics for Scaled Tri-Gate InGaAs-OI n-MOSFETs Including Sensitivity to Process Variations

Author

Shu-Hua Wu, Chien-Lin Yu, Chang-Hung Yu, and Pin Su

Subjects
III-V channel, tri-gate MOSFET, quantum confinement, drain-induced barrier lowering (DIBL), process variation, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

This paper investigates the intrinsic drain-induced barrier lowering (DIBL) characteristics of highly-scaled tri-gate n-MOSFETs with InGaAs channel based on ITRS 2021 technology node through numerical simulation corroborated with theoretical calculation. This paper indicates that, when studying short-channel effects in III-V FETs, one has to account for quantum-confinement, or else predictions will be pessimistic. Due to 2-D quantum-confinement, the DIBL of the InGaAs tri-gate devices can be significantly suppressed and be comparable to the Si counterpart. Besides, for highly-scaled InGaAs tri-gate NFETs, the impact of buried-oxide thickness on DIBL becomes minor, and the DIBL sensitivity to the fin-width and gate-length variations can also be suppressed by the quantum-confinement effect. This paper may provide insights for tri-gate device design using III-V high-mobility channel materials.

Published
2017
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33. New Findings on the Drain-Induced Barrier Lowering Characteristics for Tri-Gate Germanium-on-Insulator p-MOSFETs

Author

Shu-Hua Wu, Chang-Hung Yu, and Pin Su

Subjects
tri-gate MOSFET, multi-gate MOSFET, GeOI, SOI, DIBL, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
Abstract

This paper investigates the intrinsic drain-induced barrier lowering (DIBL) characteristics for tri-gate germanium-on-insulator (GeOI) p-MOSFETs through theoretical calculation by analytical solution of 3-D Poisson's equation corroborated with TCAD numerical simulation. It is found that, relative to the silicon-on-insulator counterpart, there exists a build-in negative substrate bias in the GeOI PFET. This built-in substrate bias, stemming mainly from the large discrepancy in bandgap between Ge and Si, pulls the carriers toward the channel/BOX interface and thus degrades the DIBL of the GeOI PFET beyond what permittivity predicts. This new mechanism has to be considered when designing or benchmarking tri-gate GeOI p-MOSFETs.

Published
2015
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34. Economic evaluation of new blood pressure target for hypertensive patients in Taiwan according to the 2022 hypertension clinical practice guidelines of the Taiwan society of cardiology: a simulation modeling study

Author

Liao, Chia-Te, primary, Toh, Han Siong, additional, Yang, Chun-Ting, additional, Hsu, Chien-Yi, additional, Lee, Mei-Chuan, additional, Chang, Wei-Ting, additional, Chen, Zhih-Cherng, additional, Chang, Hung-Yu, additional, and Strong, Carol, additional

Published
2022
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39. Permanent Pacemaker Implantation for Late Atrioventricular Block in Patients Receiving Catheter Ablation for Atrioventricular Nodal Reentrant Tachycardia

Author

Liao, Jo-Nan, Hu, Yu-Feng, Wu, Tsu-Juey, Fong, Ann-Ning, Lin, Wei-Shiang, Lin, Yenn-Jiang, Chang, Shih-Lin, Lo, Li-Wei, Tuan, Ta-Chuan, Chang, Hung-Yu, Li, Cheng-Hung, Chao, Tze-Fan, Chung, Fa-Po, Hanafy, Dicky Armein, Lin, Wen-Yu, Huang, Jin-Long, Huang, Chin-Chou, Leu, Hsin-Bang, Lee, Pi-Chang, Chiang, Chern-En, and Chen, Shih-Ann

Published
2013
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47. The Characteristics and Outcomes of Patients with Heart Failure and Reduced Ejection Fraction: The Eligibility of Novel Heart Failure Medications

Author

Fong, Man-Cai, Chang, Hung-Yu, Wang, Chun-Chieh, Feng, An-Ning, Lin, Wei-Shiang, Wu, Yen-Wen, Sung, Shih-Hsien, Huang, Jin-Long, Kuo, Jen-Yuan, and Yin, Wei-Hsian

Subjects
Original Article
Abstract

BACKGROUND: Renin-angiotensin system inhibitors and beta-blockers are the initial treatment of choice for heart failure with reduced ejection fraction (HFrEF), whereas sacubitril/valsartan (SAC/VAL) and ivabradine are considered to second-line therapies. The eligibility of SAC/VAL and ivabradine according to the U.S. Food and Drug Administration (FDA), European Medicines Agency (EMA) labels, Taiwan National Health Insurance (TNHI) reimbursement regulations, and European Society of Cardiology (ESC) heart failure (HF) guidelines are diverse, and they may not fulfill the needs of real-world HFrEF patients. METHODS: Patients hospitalized for HF with left ventricular ejection fraction (LVEF) ≤ 40% were recruited from 21 hospitals in Taiwan between 2013 and 2014. The criteria for SAC/VAL and ivabradine according to the different regulations were applied. RESULTS: Of 1,474 patients, 86.8%, 29.4%, and 9.5% met the EMA/FDA label criteria, TNHI-regulation, and ESC guidelines for SAC/VAL, compared to 47.1%, 37.2%, and 45.6% for ivabradine, respectively. Ineligible reasons for the TNHI regulations included LVEF > 35% (19.9%, for SAC/VAL and ivabradine) and sinus rate < 75 beats per minute (bpm) (29.9%, for ivabradine). Although not meeting the TNHI regulations, patients with LVEF 35-40% had a similar 1-year mortality rate (15.6% vs. 15.8%, p = 0.876) to those with LVEF ≤ 35%, whereas patients with a sinus rate 70-74 bpm had a similar 1-year mortality rate (15.3% vs. 16.1%, p = 0.805) to those with a sinus rate ≥ 75 bpm. CONCLUSIONS: Approximately 70% and 63% of TSOC-HFrEF registry patients were ineligible for SAC/VAL and ivabradine, respectively, according to current TNHI regulations. Regardless of the eligibility for novel HFrEF medications, the high incidence of adverse events suggests that all patients should be treated cautiously.

Published
2021

49. Cost-Effectiveness Evaluation of Add-on Empagliflozin in Patients With Heart Failure and a Reduced Ejection Fraction From the Healthcare System's Perspective in the Asia-Pacific Region

Author

Liao, Chia-Te, primary, Yang, Chun-Ting, additional, Kuo, Fang-Hsiu, additional, Lee, Mei-Chuan, additional, Chang, Wei-Ting, additional, Tang, Hsin-Ju, additional, Hua, Yi-Ming, additional, Chang, Hung-Yu, additional, Chen, Zhih-Cherng, additional, Strong, Carol, additional, Ou, Huang-Tz, additional, and Toh, Han Siong, additional

Published
2021
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50. Prediction of Recurrent Atrial Tachyarrhythmia After Receiving Atrial Flutter Ablation in Patients With Prior Cardiac Surgery for Valvular Heart Disease

Author

Chou, Ching-Yao, primary, Chung, Fa-Po, additional, Chang, Hung-Yu, additional, Lin, Yenn-Jiang, additional, Lo, Li-Wei, additional, Hu, Yu-Feng, additional, Chao, Tze-Fan, additional, Liao, Jo-Nan, additional, Tuan, Ta-Chuan, additional, Lin, Chin-Yu, additional, Chang, Ting-Yung, additional, Liu, Chih-Min, additional, Wu, Cheng-I, additional, Huang, Sung-Hao, additional, Chen, Chun-Chao, additional, Cheng, Wen-Han, additional, Liu, Shin-Huei, additional, Lugtu, Isaiah Carlos, additional, Jain, Ankit, additional, Feng, An-Ning, additional, Chang, Shih-Lin, additional, and Chen, Shih-Ann, additional

Published
2021
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