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The roles of rainfall with various intensities in hydraulic erosion processes are obviously different. In-depth knowledge about the spatiotemporal variation in extreme rainfall erosivity is critical for soil erosion risk assessment and formulation of response measures. In the period of 1961–2020, more than 390,000 erosive rainfall data from 212 meteorological stations were collected to explore the erosion characteristics of different intensities of rainfall erosivity across southern China. The asymmetric characteristic of extreme rainfall erosion was analyzed and expressed by an asymmetric change index (ACI) defined in this study. Correlation analysis was applied to study the impact of global extreme climate events on the ACI. The results showed that different patterns of precipitation had evident asymmetric characteristics in rainfall erosivity, and fewer high-intensity precipitation events contributed to much higher total rainfall erosivity, particularly for rainstorms (≥100 mm). The ACI of the rainfall erosivity exhibited evident spatial heterogeneity; insignificant increasing trends were found in the ACIs for heavy rainfall, torrential, and rainstorm erosivities over the past 60 years. The change rate of ACI varied greatly on both monthly and interdecadal scales, and the ACI of rainstorms showed the maximum linear increasing trend on the long-time scale. There were significantly high correlations between the ACI and erosive rainfall days and the ACI and erosive rainfall (p < 0.01), and the correlation coefficients were relatively higher from May to October, where the precipitation was concentrated. Additionally, the El Niño-Southern Oscillation and tropical cyclones clearly influenced the spatiotemporal distribution of the ACI and rainfall erosivity but were limited to specific periods and regions. These results could provide a reference for extreme soil erosion event monitoring and control in southern China. [ABSTRACT FROM AUTHOR]

Background: Silence of the tumor suppressor miR-34c is implicated in the development of colorectal cancer (CRC). For the past few years, Resveratrol (Res) has been introduced to oncotherapies alone or with traditional chemotherapeutic drugs. However, the study of molecular mechanism involved in the anti-CRC effect of Res is still ongoing.Methods: The anti-CRC effect of Res alone or with Oxaliplatin (Oxa) was determined by cell viability assay, soft agar colony formation assay, flow cytometry and real-time cellular analyzer in HT-29 (p53+) and HCT-116 (p53-) CRC cell lines. Expressions of miR-34c and its targets were detected by qPCR and/or western blot. To evaluate the role of miR-34c in anti-CRC effect by Res alone or with Oxa, miR-34c was up or down-regulated by lentiviral mediation or specific inhibitor, respectively. To investigate how miR-34c was increased by Res, the methylation status of miR-34c promoter was detected by MSP. The tumor bearing mouse model was established by subcutaneous injection of HCT-116 cells to assess anti-CRC effect of Res alone or with Oxa in vivo. IL-6 and TNF-α in xenografts were detected by ELISA.Results: Res inhibited cell viability, proliferation, migration and invasion as well as promoted apoptosis both in HT-29 and HCT-116 CRC cells. The anti-CRC effect of Res was partially but specifically through up-regulating miR-34c which further knocked down its target KITLG; and the effect was enhanced in the presence of p53 probably through inactivating PI3K/Akt pathway. Besides, Res sensitized CRC cells to Oxa in a miR-34c dependent manner. The xenograft experiments showed that exposure to Res or Oxa suppressed tumor growth; and the efficacy was evidently augmented by the co-treatment of Res and Oxa. Likewise, miR-34c level was elevated in xenografts of Res-treated mice while the KITLG was decreased. Finally, Res clearly reduced IL-6 in xenografts.Conclusion: Res suppressed CRC by specifically activating miR-34c-KITLG in vitro and in vivo; and the effect was strengthened in the presence of p53. Besides, Res exerted a synergistic effect with Oxa in a miR-34c dependent manner. We also suggested that Res-increased miR-34c could interfere IL-6-triggered CRC progression. [ABSTRACT FROM AUTHOR]