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1. Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial

Author

Goldstein, Daniel J., Chang, Helena L., Mack, Michael J., Voisine, Pierre, Gammie, James S., Marks, Mary E., Iribarne, Alexander, Vengrenyuk, Yuliya, Raymond, Samantha, Taylor, Bradley S., Dagenais, François, Ailawadi, Gorav, Chu, Michael W.A., DiMaio, J. Michael, Narula, Jagat, Moquete, Ellen G., O'Sullivan, Karen, Williams, Judson B., Jr., Crestanello, Juan A., Scavo, Vincent, Puskas, John D., Acker, Michael A., Gillinov, Marc, Gelijns, Annetine C., O'Gara, Patrick T., Moskowitz, Alan J., Alexander, John H., and Bagiella, Emilia

Published
2024
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2. Hybrid Magnetic Resonance Positron Emission Tomography Is Associated With Cardiac-Related Outcomes in Cardiac Sarcoidosis

Author

Trivieri, Maria Giovanna, Robson, Philip M., Vergani, Vittoria, LaRocca, Gina, Romero-Daza, Angelica M., Abgral, Ronan, Devesa, Ana, Azoulay, Levi-Dan, Karakatsanis, Nicolas A., Parikh, Aditya, Panagiota, Christia, Palmisano, Anna, DePalo, Louis, Chang, Helena L., Rothstein, Joseph H., Fayad, Rima A., Miller, Marc A., Fuster, Valentin, Narula, Jagat, Dweck, Marc R., Morgenthau, Adam, Jacobi, Adam, Padilla, Maria, Kovacic, Jason C., and Fayad, Zahi A.

Published
2024
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3. Rationale and design of a randomized trial evaluating an external support device for saphenous vein coronary grafts

Author

Bagiella, Emilia, Puskas, John D., Moskowitz, Alan J., Gelijns, Annetine C., Alexander, John H., Narula, Jagat, Smith, Peter K., Hutcheson, Kelley, Chang, Helena L., Gammie, James S., Iribarne, Alexander, Marks, Mary E., Vengrenyuk, Yuliya, Yasumura, Keisuke, Raymond, Samantha, Taylor, Bradley S., Yarden, Orit, Orion, Eyal, Dagenais, François, Ailawadi, Gorav, Chu, Michael W.A., Gupta, Lopa, Levitan, Ronald G., Williams, Judson B., Jr., Crestanello, Juan A., Jessup, Mariell, Rose, Eric A., Scavo, Vincent, Acker, Michael A., Gillinov, Marc, O'Gara, Patrick T., Voisine, Pierre, Mack, Michael J., and Goldstein, Daniel J.

Published
2022
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4. Risk for non-home discharge following surgery for ischemic mitral valve disease

Author

DeRose, Joseph J., Wang, Alice, Smith, Peter K., Acker, Michael A., Ailawadi, Gorav, Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard D., Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Foo, James, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Williams, Deborah, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Lawrence, Rita, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Geither, Carrie, Doud, Kristen, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Mangusan, Ralph, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Jonathan Lacharité, Sophie Robichaud, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Villanueva, Robert, Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Kilcullen, Niamh, Hung, David, Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Lala, Anuradha, Chang, Helena L., Liu, Xiaoyu, Charles, Eric J., Yerokun, Babatunde A., Bowdish, Michael E., Mack, Michael J., and Stevenson, Lynne W.

Published
2021
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5. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Caulder, Ron, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Chen, Yingchun, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Dobrev, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Nielsen, Sten Lyager, Wiggers, Henrik, Malgaard, Henning, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Noiseux, Nicolas, Stevens, Louis-Mathieu, Prieto, Ignacio, Basile, Fadi, Dionne, Joannie, Fecteau, Julie, Blackstone, Eugene H., Gillinov, A. Marc, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Clarke, Pamela A., Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Berry, Mark F., Parsa, Cyrus J., Tong, Betty C., Williams, Judson B., Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Speir, Alan M., Magee, Patrick, Ad, Niv, Keyte, Sally, Dang, Minh, Slaughter, Mark, Headlee, Marsha, Moody, Heather, Solankhi, Naresh, Birks, Emma, Groh, Mark A., Shell, Leslie E., Shepard, Stephanie A., Trichon, Benjamin H., Nanney, Tracy, Hampton, Lynne C., Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevak, Daniel, Swayze, Roger, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismail, Denault, André, Demers, Philippe, Robichaud, Sophie, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Pagé, Pierre, Sirois, Carole, Latter, David, Leong-Poi, Howard, Bonneau, Daniel, Errett, Lee, Peterson, Mark D., Verma, Subodh, Feder-Elituv, Randi, Cohen, Gideon, Joyner, Campbell, Fremes, Stephen E., Moussa, Fuad, Christakis, George, Karkhanis, Reena, Yau, Terry, Farkouh, Michael, Woo, Anna, Cusimano, Robert James, David, Tirone, Feindel, Christopher, Garrard, Lisa, Fredericks, Suzanne, Mociornita, Amelia, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., Young, Cindi A., Beach, Dana, Acker, Michael A., Atluri, Pavan, Woo, Y. Joseph, Mayer, Mary Lou, Bowdish, Michael, Starnes, Vaughn A., Shavalle, David, Matthews, Ray, Javadifar, Shadi, Romar, Linda, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Keteyian, Stephen J., Brawner, Clinton A., Aldred, Heather, Hung, Judy, Zeng, Xin, Browndyke, Jeffrey, Toulgoat-Dubois, Yanne, Ferket, Bart S., Hohmann, Samuel F., Chang, Helena L., Mick, Stephanie L., Hung, Judy W., Overbey, Jessica R., and Lala, Anuradha

Published
2020
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7. Cortico-limbic interactions and carotid atherosclerotic burden during chronic stress exposure.

Author

Gharios, Charbel, Leent, Mandy M T van, Chang, Helena L, Abohashem, Shady, O'Connor, David, Osborne, Michael T, Tang, Cheuk Y, Kaufman, Audrey E, Robson, Philip M, Ramachandran, Sarayu, Calcagno, Claudia, Mani, Venkatesh, Trivieri, Maria Giovanna, Seligowski, Antonia V, Dekel, Sharon, Mulder, Willem J M, Murrough, James W, Shin, Lisa M, Tawakol, Ahmed, and Fayad, Zahi A

Subjects
PSYCHOLOGICAL stress, DIFFUSION tensor imaging, MAGNETIC resonance imaging, POSITRON emission tomography, DISEASE risk factors
Abstract

Background and Aims Chronic stress associates with cardiovascular disease, but mechanisms remain incompletely defined. Advanced imaging was used to identify stress-related neural imaging phenotypes associated with atherosclerosis. Methods Twenty-seven individuals with post-traumatic stress disorder (PTSD), 45 trauma-exposed controls without PTSD, and 22 healthy controls underwent 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI). Atherosclerotic inflammation and burden were assessed using 18F-FDG PET (as maximal target-to-background ratio, TBR max) and MRI, respectively. Inflammation was assessed using high-sensitivity C-reactive protein (hsCRP) and leucopoietic imaging (18F-FDG PET uptake in spleen and bone marrow). Stress-associated neural network activity (SNA) was assessed on 18F-FDG PET as amygdala relative to ventromedial prefrontal cortex (vmPFC) activity. MRI diffusion tensor imaging assessed the axonal integrity (AI) of the uncinate fasciculus (major white matter tract connecting vmPFC and amygdala). Results Median age was 37 years old and 54% of participants were female. There were no significant differences in atherosclerotic inflammation between participants with PTSD and controls; adjusted mean difference in TBR max (95% confidence interval) of the aorta 0.020 (−0.098, 0.138), and of the carotids 0.014 (−0.091, 0.119). Participants with PTSD had higher hsCRP, spleen activity, and aorta atherosclerotic burden (normalized wall index). Participants with PTSD also had higher SNA and lower AI. Across the cohort, carotid atherosclerotic burden (standard deviation of wall thickness) associated positively with SNA and negatively with AI independent of Framingham risk score. Conclusions In this study of limited size, participants with PTSD did not have higher atherosclerotic inflammation than controls. Notably, impaired cortico-limbic interactions (higher amygdala relative to vmPFC activity or disruption of their intercommunication) associated with carotid atherosclerotic burden. Larger studies are needed to refine these findings. [ABSTRACT FROM AUTHOR]

Published
2024
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8. Biatrial maze procedure versus pulmonary vein isolation for atrial fibrillation during mitral valve surgery: New analytical approaches and end points

Author

Miller, Marissa A., Taddei-Peters, Wendy C., Buxton, Dennis, Connolly, Amy, Geller, Nancy L., Gordon, David, Jeffries, Neal O., Lee, Albert, Moy, Claudia S., Gombos, Ilana Kogan, Ralph, Jennifer, Weisel, Richard, Gardner, Timothy J., O'Gara, Patrick T., Rose, Eric A., Gelijns, Annetine C., Parides, Michael K., Ascheim, Deborah D., Moskowitz, Alan J., Bagiella, Emilia, Moquete, Ellen, Chang, Helena, Chase, Melissa, Goldfarb, Seth, Gupta, Lopa, Kirkwood, Katherine, Kumbarce, Edlira, Levitan, Ron, O'Sullivan, Karen, Overbey, Jessica, Santos, Milerva, Weglinski, Michael, Williams, Paula, Wood, Carrie, Ye, Xia, Mack, Michael, Adame, Tracine, Settele, Natalie, Adams, Jenny, Ryan, William, Smith, Robert L., Grayburn, Paul, Chen, Frederick Y., Nohria, Anju, Cohn, Lawrence, Shekar, Prem, Aranki, Sary, Couper, Gregory, Davidson, Michael, Bolman, R. Morton, III, Burgess, Anne, Conboy, Debra, Blackwell, Ray, Kerzner, Roger, Banbury, Michael, Squire, Andrea M., Gillinov, A. Marc, Blackstone, Eugene H., Lytle, Bruce, Mihaljevic, Tomislav, Lackner, Pamela, Berroteran, Leoma, Dolney, Diana, Fleming, Suzanne, Palumbo, Roberta, Whitman, Christine, Sankovic, Kathy, Sweeney, Denise Kosty, Pattakos, Gregory, Argenziano, Michael, Williams, Mathew, Goldsmith, Lyn, Smith, Craig R., Naka, Yoshifumi, Stewart, Allan, Schwartz, Allan, Bell, Daniel, Van Patten, Danielle, Sreekanth, Sowmya, Smith, Peter K., Alexander, John H., Milano, Carmelo A., Glower, Donald D., Mathew, Joseph P., Harrison, J. Kevin, Welsh, Stacey, Ferguson, T. Bruce, Kypson, Alan P., Rodriguez, Evelio, Harris, Malissa, Akers, Brenda, O'Neal, Allison, Puskas, John D., Thourani, Vinod H., Guyton, Robert, Baer, Jefferson, Baio, Kim, Neill, Alexis A., Voisine, Pierre, Senechal, Mario, Dagenais, François, O'Connor, Kim, Dussault, Gladys, Ballivian, Tatiana, Keilani, Suzanne, Michler, Robert E., D'Alessandro, David A., DeRose, Joseph J., Jr., Goldstein, Daniel J., Bello, Ricardo, Jakobleff, William, Garcia, Mario, Taub, Cynthia, Spevack, Daniel, Swayze, Roger, Sookraj, Nadia, Perrault, Louis P., Basmadjian, Arsène-Joseph, Bouchard, Denis, Carrier, Michel, Cartier, Raymond, Pellerin, Michel, Tanguay, Jean François, El-Hamamsy, Ismael, Denault, André, Lacharité, Jonathan, Robichaud, Sophie, Adams, David H., Varghese, Robin, Mandel-Portnoy, Yael, Horvath, Keith A., Corcoran, Philip C., Siegenthaler, Michael P., Murphy, Mandy, Iraola, Margaret, Greenberg, Ann, Sai-Sudhakar, Chittoor, Hasan, Ayseha, McDavid, Asia, Kinn, Bradley, Mullen, John C., Choy, Jonathan, Meyer, Steven, Kuurstra, Emily, Gammie, James S., DeFilippi, Christopher R., Gaetani, Dino T., Young, Cindi A., Beach, Dana, Collins, Julia, Bolling, Steven F., Pagani, Francis D., Bloem, Cathie, Acker, Michael A., Woo, Y. Joseph, Mayer, Mary Lou, Bavaria, Joseph E., Szeto, Wilson Y., Margulies, Kenneth, Keane, Martin, Glassberg, Helene, Jagasia, Dinesh, Kirkpatrick, James, Kron, Irving L., Ailawadi, Gorav, Johnston, Karen, Dent, John M., Kern, John, Keim, Jessica, Burks, Sandra, Gahring, Kim, Mangi, Abeel, Akar, Joseph, Yuh, David, Wilson, Lynn, Bull, David A., Desvigne-Nickens, Patrice, Dixon, Dennis O., Haigney, Mark, Holubkov, Richard, Jacobs, Alice, Miller, Frank, Murkin, John M., Spertus, John, Wechsler, Andrew S., Sellke, Frank, McDonald, Cheryl L., Byington, Robert, Dickert, Neal, Ikonomidis, John S., Williams, David O., Yancy, Clyde W., Canty, John M., Jr., Fang, James C., Giannetti, Nadia, Richenbacher, Wayne, Rao, Vivek, Furie, Karen L., Miller, Rachel, Pinney, Sean, Roberts, William C., Walsh, Mary N., Hung, Judy, Zeng, Xin, Couderc, Jean-Philippe, Balda, Dan, Bowen, Wayne, Wilson, Mauri, Schering, Anne, Chang, Helena L., Rajeswaran, Jeevanantham, Ishwaran, Hemant, Li, Liang, Ehrlinger, John, Couderc, Jean-Phillipe, and Mack, Michael J.

Published
2019
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9. A Prospective Multi-Institutional Cohort Study of Mediastinal Infections After Cardiac Operations

Author

Perrault, Louis P., Kirkwood, Katherine A., Chang, Helena L., Mullen, John C., Gulack, Brian C., Argenziano, Michael, Gelijns, Annetine C., Ghanta, Ravi K., Whitson, Bryan A., Williams, Deborah L., Sledz-Joyce, Nancy M., Lima, Brian, Greco, Giampaolo, Fumakia, Nishit, Rose, Eric A., Puskas, John D., Blackstone, Eugene H., Weisel, Richard D., and Bowdish, Michael E.

Published
2018
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11. Pneumonia after cardiac surgery: Experience of the National Institutes of Health/Canadian Institutes of Health Research Cardiothoracic Surgical Trials Network

Author

Ailawadi, Gorav, Chang, Helena L., O'Gara, Patrick T., O'Sullivan, Karen, Woo, Y. Joseph, DeRose, Joseph J., Jr., Parides, Michael K., Thourani, Vinod H., Robichaud, Sophie, Gillinov, A. Marc, Taddei-Peters, Wendy C., Miller, Marissa A., Perrault, Louis P., Smith, Robert L., Goldsmith, Lyn, Horvath, Keith A., Doud, Kristen, Baio, Kim, Gelijns, Annetine C., Moskowitz, Alan J., Bagiella, Emilia, Alexander, John H., and Iribarne, Alexander

Published
2017
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13. A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe Acute Respiratory Distress Syndrome from COVID-19

Author

Bowdish, Michael E., primary, Barkauskas, Christina E., additional, Overbey, Jessica R., additional, Gottlieb, Robert L., additional, Osman, Keren, additional, Duggal, Abhijit, additional, Marks, Mary E., additional, Hupf, Jonathan, additional, Fernandes, Eustace, additional, Leshnower, Bradley G., additional, Golob, Jonathan L., additional, Iribarne, Alexander, additional, Rassias, Athos J., additional, Moquete, Ellen G., additional, O’Sullivan, Karen, additional, Chang, Helena L., additional, Williams, Judson B., additional, Parnia, Sam, additional, Patel, Nirav C., additional, Desai, Nimesh D., additional, Vekstein, Andrew M., additional, Hollister, Beth A., additional, Possemato, Tammie, additional, Romero, Christian, additional, Hou, Peter C., additional, Burke, Elizabeth, additional, Hayes, Jack, additional, Grossman, Fred, additional, Itescu, Silviu, additional, Gillinov, Marc, additional, Pagani, Francis D., additional, O’Gara, Patrick T., additional, Mack, Michael J., additional, Smith, Peter K., additional, Bagiella, Emilia, additional, Moskowitz, Alan J., additional, and Gelijns, Annetine C., additional

Published
2023
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14. Cost-Effectiveness of Mitral Valve Repair Versus Replacement for Severe Ischemic Mitral Regurgitation: A Randomized Clinical Trial From the Cardiothoracic Surgical Trials Network

Author

Ferket, Bart S., Ailawadi, Gorav, Gelijns, Annetine C., Acker, Michael A., Hohmann, Samuel F., Chang, Helena L., Bouchard, Denis, Meltzer, David O., Michler, Robert E., Moquete, Ellen G., Voisine, Pierre, Mullen, John C., Lala, Anuradha, Mack, Michael J., Gillinov, A. Marc, Thourani, Vinod H., Miller, Marissa A., Gammie, James S., Parides, Michael K., Bagiella, Emilia, Smith, Robert L., Smith, Peter K., Hung, Judy W., Gupta, Lopa N., Rose, Eric A., O’Gara, Patrick T., and Moskowitz, Alan J.

Published
2018
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15. Intimal hyperplasia, saphenous vein graft disease, and clinical outcomes: Insights from the CTSN VEST randomized trial

Author

Goldstein, Daniel J., primary, Chang, Helena L., additional, Mack, Michael J., additional, Voisine, Pierre, additional, Gammie, James S., additional, Marks, Mary E., additional, Iribarne, Alexander, additional, Vengrenyuk, Yuliya, additional, Raymond, Samantha, additional, Taylor, Bradley S., additional, Dagenais, François, additional, Ailawadi, Gorav, additional, Chu, Michael W.A., additional, DiMaio, J. Michael, additional, Narula, Jagat, additional, Moquete, Ellen G., additional, O'Sullivan, Karen, additional, Williams, Judson B., additional, Crestanello, Juan A., additional, Scavo, Vincent, additional, Puskas, John D., additional, Acker, Michael A., additional, Gillinov, Marc, additional, Gelijns, Annetine C., additional, O'Gara, Patrick T., additional, Moskowitz, Alan J., additional, Alexander, John H., additional, and Bagiella, Emilia, additional

Published
2022
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16. External Support for Saphenous Vein Grafts in Coronary Artery Bypass Surgery

Author

Goldstein, Daniel J., primary, Puskas, John D., additional, Alexander, John H., additional, Chang, Helena L., additional, Gammie, James S., additional, Marks, Mary E., additional, Iribarne, Alexander, additional, Vengrenyuk, Yuliya, additional, Raymond, Samantha, additional, Taylor, Bradley S., additional, Yarden, Orit, additional, Orion, Eyal, additional, Dagenais, François, additional, Ailawadi, Gorav, additional, Chu, Michael W. A., additional, DiMaio, J. Michael, additional, Narula, Jagat, additional, Moquete, Ellen G., additional, O’Sullivan, Karen, additional, Williams, Judson B., additional, Crestanello, Juan A., additional, Jessup, Mariell, additional, Rose, Eric A., additional, Scavo, Vincent, additional, Acker, Michael A., additional, Gillinov, Marc, additional, Mack, Michael J., additional, Gelijns, Annetine C., additional, O’Gara, Patrick T., additional, Moskowitz, Alan J., additional, Bagiella, Emilia, additional, and Voisine, Pierre, additional

Published
2022
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18. Two-Year Outcomes of Surgical Treatment of Moderate Ischemic Mitral Regurgitation

Author

Michler, Robert E., Smith, Peter K., Parides, Michael K., Ailawadi, Gorav, Thourani, Vinod, Moskowitz, Alan J., Acker, Michael A., Hung, Judy W., Chang, Helena L., Perrault, Louis P., Gillinov, A. Marc, Argenziano, Michael, Bagiella, Emilia, Overbey, Jessica R., Moquete, Ellen G., Gupta, Lopa N., Miller, Marissa A., Taddei-Peters, Wendy C., Jeffries, Neal, Weisel, Richard D., Rose, Eric A., Gammie, James S., DeRose, Joseph J., Jr., Puskas, John D., Dagenais, François, Burks, Sandra G., El-Hamamsy, Ismail, Milano, Carmelo A., Atluri, Pavan, Voisine, Pierre, OʼGara, Patrick T., and Gelijns, Annetine C.

Published
2016
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19. A Randomized Trial of Mesenchymal Stromal Cells for Moderate to Severe ARDS From COVID-19.

Author

Bowdish, Michael E., Barkauskas, Christina E., Overbey, Jessica R., Gottlieb, Robert L., Osman, Keren, Duggal, Abhijit, Marks, Mary E., Hupf, Jonathan, Fernandes, Eustace, Leshnower, Bradley G., Golob, Jonathan L., Iribarne, Alexander, Rassias, Athos J., Moquete, Ellen G., O’Sullivan, Karen, Chang, Helena L., Williams, Judson B., Parnia, Sam, Patel, Nirav C., and Desai, Nimesh D.

Subjects
STROMAL cells, ARTIFICIAL respiration, ADULT respiratory distress syndrome
Abstract

Rationale: There are limited therapeutic options for patients with COVID-19-related acute respiratory distress syndrome (ARDS) with inflammation-mediated lung injury. Mesenchymal stromal cells offer promise as immunomodulatory agents.Objectives: Evaluation of efficacy and safety of allogeneic mesenchymal cells in mechanically-ventilated patients with moderate or severe COVID-induced respiratory failure.Methods: Patients were randomized to two infusions of 2 million cells/kg or sham infusions, in addition to standard of care. We hypothesized that cell therapy would be superior to sham-control for the primary endpoint of 30-day mortality. The key secondary endpoint was ventilator-free survival within 60 days, accounting for deaths and withdrawals in a ranked analysis.Measurements and Main Results: At the third interim analysis, the Data and Safety Monitoring Board recommended that the trial halt enrollment as the pre-specified mortality reduction from 40% to 23% was unlikely to be achieved (n=222 out of planned 300). Thirty-day mortality was 37.5% (42/112) in cell recipients versus 42.7% (47/110) in control patients (RR 0.88;95% CI 0.64,1.21;p=0.43). There were no significant differences in days alive off ventilation within 60 days (median rank 117.3 [IQR:60.0,169.5] in cell patients and 102.0 [IQR:54.0,162.5] in controls; higher is better). Resolution or improvement of ARDS at 30-days was observed in 51/104 (49.0%) cell recipients and 46/106 (43.4%) of control patients (OR 1.36;95% CI 0.57, 3.21). There were no infusion-related toxicities and overall serious adverse events over 30 days were similar.Conclusions: Mesenchymal cells, while safe, did not improve 30-day survival or 60-day ventilator-free days in patients with moderate/severe COVID-related acute respiratory distress syndrome. Clinical trial registration available at www.Clinicaltrials: gov, ID:NCT04371393. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/). [ABSTRACT FROM AUTHOR]

Published
2023
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20. Evaluating the association between hybrid magnetic resonance positron emission tomography and cardiac-related outcomes in cardiac sarcoidosis

Author

Trivieri, Maria Giovanna, primary, Robson, Philip M., additional, Vergani, Vittoria, additional, LaRocca, Gina, additional, Romero-Daza, Angelica M., additional, Abgral, Ronan, additional, Karakatsanis, Nicolas A., additional, Parikh, Aditya, additional, Panagiota, Christia, additional, Palmisano, Anna, additional, DePalo, Louis, additional, Chang, Helena L., additional, Rothstein, Joseph H., additional, Fayad, Rima A., additional, Miller, Marc A., additional, Fuster, Valentin, additional, Narula, Jagat, additional, Dweck, Marc R., additional, Jacobi, Adam, additional, Padilla, Maria, additional, Kovacic, Jason C., additional, and Fayad, Zahi A., additional

Published
2022
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21. Risk for non-home discharge following surgery for ischemic mitral valve disease

Author

Lala, Anuradha, primary, Chang, Helena L., additional, Liu, Xiaoyu, additional, Charles, Eric J., additional, Yerokun, Babatunde A., additional, Bowdish, Michael E., additional, Thourani, Vinod H., additional, Mack, Michael J., additional, Miller, Marissa A., additional, O'Gara, Patrick T., additional, Blackstone, Eugene H., additional, Moskowitz, Alan J., additional, Gelijns, Annetine C., additional, Mullen, John C., additional, Stevenson, Lynne W., additional, DeRose, Joseph J., additional, Wang, Alice, additional, Smith, Peter K., additional, Acker, Michael A., additional, Ailawadi, Gorav, additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard D., additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Moquete, Ellen, additional, Chang, Helena, additional, Chase, Melissa, additional, Foo, James, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, O'Sullivan, Karen, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Williams, Deborah, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Lawrence, Rita, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Gillinov, A. Marc, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Geither, Carrie, additional, Doud, Kristen, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, Dagenais, François, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, Mangusan, Ralph, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Perrault, Louis P., additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Jonathan Lacharité, Sophie Robichaud, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, Young, Cindi A., additional, Beach, Dana, additional, Villanueva, Robert, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Kilcullen, Niamh, additional, Hung, David, additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional

Published
2021
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22. Surgical Ablation of Atrial Fibrillation during Mitral-Valve Surgery

Author

Gillinov, Marc A., Gelijns, Annetine C., Parides, Michael K., DeRose, Joseph J., Jr., Moskowitz, Alan J., Voisine, Pierre, Ailawadi, Gorav, Bouchard, Denis, Smith, Peter K., Mack, Michael J., Acker, Michael A., Mullen, John C., Rose, Eric A., Chang, Helena L., Puskas, John D., Couderc, Jean-Philippe, Gardner, Timothy J., Varghese, Robin, Horvath, Keith A., Bolling, Steven F., Michler, Robert E., Geller, Nancy L., Ascheim, Deborah D., Miller, Marissa A., Bagiella, Emilia, Moquete, Ellen G., Williams, Paula, Taddei-Peters, Wendy C., OʼGara, Patrick T., Blackstone, Eugene H., and Argenziano, Michael

Published
2015
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24. Hospitalized patients with HIV and COVID‑19 receiving convalescent plasma: A case series.

Author

SILVERA, RICHARD J., LIN, HUNG‑MO, RAHMAN, FARAH, ARVIND, VARUN, CHANG, HELENA L., BAINE, IAN, ARINSBURG, SUZANNE A., BOUVIER, NICOLE M., ABERG, JUDITH A., and LIU, SEAN T. H.

Subjects
CONVALESCENT plasma, COVID-19, HIV, SARS-CoV-2, HOSPITAL patients
Abstract

The use of convalescent plasma in coronavirus disease 2019 (COVID‑19) in the general population has not been shown to have a clear benefit. However, there are limited data available on its use in specific populations, such as in persons with human immunodeficiency virus (HIV; PWH). The present case series study describes 12 hospitalized PWH who received convalescent plasma for severe COVID‑19 between March 2020 and July 2020. Demographics, pre‑existing comorbidities, HIV status, and COVID‑19 management were reported and examined in a multivariate analysis. A high mortality rate of 58%, (7 out of 12 PWH) was observed in those receiving the convalescent plasma. By contrast, a brief review of 13 previously published cohorts of PWH hospi‑ talized with COVID‑19 revealed a cumulative mortality of 19% (85 of 439 PWH). In the present case series study, PWH had a significantly higher relative risk for in‑hospital COVID‑19‑associated mortality compared with individuals without HIV (unadjusted range, 2.10‑2.52; and adjusted range, 1.79‑2.08; P<0.02 in all analyses). Covariate‑adjustments were made for patient demographics, pre‑existing co‑morbidities, and mechanical ventilation needs. The high mortality rate of the present case series may be related to random sampling or an adverse effect of convalescent plasma in PWH and severe COVID‑19. Additional research is thus required to investigate the risks and benefits of the use of COVID‑19 convalescent plasma in PWH. [ABSTRACT FROM AUTHOR]

Published
2022
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25. Anticoagulation, Bleeding, Mortality, and Pathology in Hospitalized Patients With COVID-19

Author

Nadkarni, Girish N., primary, Lala, Anuradha, additional, Bagiella, Emilia, additional, Chang, Helena L., additional, Moreno, Pedro R., additional, Pujadas, Elisabet, additional, Arvind, Varun, additional, Bose, Sonali, additional, Charney, Alexander W., additional, Chen, Martin D., additional, Cordon-Cardo, Carlos, additional, Dunn, Andrew S., additional, Farkouh, Michael E., additional, Glicksberg, Benjamin S., additional, Kia, Arash, additional, Kohli-Seth, Roopa, additional, Levin, Matthew A., additional, Timsina, Prem, additional, Zhao, Shan, additional, Fayad, Zahi A., additional, and Fuster, Valentin, additional

Published
2020
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27. Cost-effectiveness of coronary artery bypass grafting plus mitral valve repair versus coronary artery bypass grafting alone for moderate ischemic mitral regurgitation

Author

Ferket, Bart S., primary, Thourani, Vinod H., additional, Voisine, Pierre, additional, Hohmann, Samuel F., additional, Chang, Helena L., additional, Smith, Peter K., additional, Michler, Robert E., additional, Ailawadi, Gorav, additional, Perrault, Louis P., additional, Miller, Marissa A., additional, O'Sullivan, Karen, additional, Mick, Stephanie L., additional, Bagiella, Emilia, additional, Acker, Michael A., additional, Moquete, Ellen, additional, Hung, Judy W., additional, Overbey, Jessica R., additional, Lala, Anuradha, additional, Iraola, Margaret, additional, Gammie, James S., additional, Gelijns, Annetine C., additional, O'Gara, Patrick T., additional, Moskowitz, Alan J., additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Caulder, Ron, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Parides, Michael K., additional, Ascheim, Deborah D., additional, Chang, Helena, additional, Chase, Melissa, additional, Chen, Yingchun, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Dobrev, Edlira, additional, Levitan, Ron, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Nielsen, Sten Lyager, additional, Wiggers, Henrik, additional, Malgaard, Henning, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Noiseux, Nicolas, additional, Stevens, Louis-Mathieu, additional, Prieto, Ignacio, additional, Basile, Fadi, additional, Dionne, Joannie, additional, Fecteau, Julie, additional, Blackstone, Eugene H., additional, Gillinov, A. Marc, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Clarke, Pamela A., additional, Argenziano, Michael, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Berry, Mark F., additional, Parsa, Cyrus J., additional, Tong, Betty C., additional, Williams, Judson B., additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Senechal, Mario, additional, Dagenais, François, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Speir, Alan M., additional, Magee, Patrick, additional, Ad, Niv, additional, Keyte, Sally, additional, Dang, Minh, additional, Slaughter, Mark, additional, Headlee, Marsha, additional, Moody, Heather, additional, Solankhi, Naresh, additional, Birks, Emma, additional, Groh, Mark A., additional, Shell, Leslie E., additional, Shepard, Stephanie A., additional, Trichon, Benjamin H., additional, Nanney, Tracy, additional, Hampton, Lynne C., additional, D'Alessandro, David A., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevak, Daniel, additional, Swayze, Roger, additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismail, additional, Denault, André, additional, Demers, Philippe, additional, Robichaud, Sophie, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Pagé, Pierre, additional, Sirois, Carole, additional, Latter, David, additional, Leong-Poi, Howard, additional, Bonneau, Daniel, additional, Errett, Lee, additional, Peterson, Mark D., additional, Verma, Subodh, additional, Feder-Elituv, Randi, additional, Cohen, Gideon, additional, Joyner, Campbell, additional, Fremes, Stephen E., additional, Moussa, Fuad, additional, Christakis, George, additional, Karkhanis, Reena, additional, Yau, Terry, additional, Farkouh, Michael, additional, Woo, Anna, additional, Cusimano, Robert James, additional, David, Tirone, additional, Feindel, Christopher, additional, Garrard, Lisa, additional, Fredericks, Suzanne, additional, Mociornita, Amelia, additional, Mullen, John C., additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Young, Cindi A., additional, Beach, Dana, additional, Atluri, Pavan, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bowdish, Michael, additional, Starnes, Vaughn A., additional, Shavalle, David, additional, Matthews, Ray, additional, Javadifar, Shadi, additional, Romar, Linda, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Keteyian, Stephen J., additional, Brawner, Clinton A., additional, Aldred, Heather, additional, Hung, Judy, additional, Zeng, Xin, additional, Browndyke, Jeffrey, additional, and Toulgoat-Dubois, Yanne, additional

Published
2020
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29. Pacemaker Implantation After Mitral Valve Surgery With Atrial Fibrillation Ablation

Author

DeRose, Joseph J., primary, Mancini, Donna M., additional, Chang, Helena L., additional, Argenziano, Michael, additional, Dagenais, François, additional, Ailawadi, Gorav, additional, Perrault, Louis P., additional, Parides, Michael K., additional, Taddei-Peters, Wendy C., additional, Mack, Michael J., additional, Glower, Donald D., additional, Yerokun, Babatunde A., additional, Atluri, Pavan, additional, Mullen, John C., additional, Puskas, John D., additional, O’Sullivan, Karen, additional, Sledz, Nancy M., additional, Tremblay, Hugo, additional, Moquete, Ellen, additional, Ferket, Bart S., additional, Moskowitz, Alan J., additional, Iribarne, Alexander, additional, Gelijns, Annetine C., additional, O’Gara, Patrick T., additional, Blackstone, Eugene H., additional, Gillinov, A. Marc, additional, Miller, Marissa A., additional, Buxton, Dennis, additional, Connolly, Amy, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Chang, Helena, additional, Chase, Melissa, additional, Dobrev, Edlira, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Levitan, Ron, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Blackwell, Ray, additional, Kerzner, Roger, additional, Banbury, Michael, additional, Squire, Andrea M., additional, Lytle, Bruce, additional, Mihaljevic, Tomislav, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Smith, Peter K., additional, Alexander, John H., additional, Milano, Carmelo A., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Thourani, Vinod H., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, O’Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, DeRose, Joseph J., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevack, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismael, additional, Denault, André, additional, Lacharité, Jonathan, additional, Robichaud, Sophie, additional, Adams, David H., additional, Varghese, Robin, additional, Mandel-Portnoy, Yael, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, DeFilippi, Christopher R., additional, Gaetani, Dino T., additional, Young, Cindi A., additional, Beach, Dana, additional, Collins, Julia, additional, Bolling, Steven F., additional, Pagani, Francis D., additional, Bloem, Cathie, additional, Acker, Michael A., additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bavaria, Joseph E., additional, Szeto, Wilson Y., additional, Margulies, Kenneth, additional, Keane, Martin, additional, Glassberg, Helene, additional, Jagasia, Dinesh, additional, Kirkpatrick, James, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Mangi, Abeel, additional, Akar, Joseph, additional, Yuh, David, additional, Wilson, Lynn, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Canty, John M., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Couderc, Jean-Philippe, additional, Balda, Dan, additional, Bowen, Wayne, additional, Wilson, Mauri, additional, and Schering, Anne, additional

Published
2019
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30. Biatrial maze procedure versus pulmonary vein isolation for atrial fibrillation during mitral valve surgery: New analytical approaches and end points

Author

Blackstone, Eugene H., primary, Chang, Helena L., additional, Rajeswaran, Jeevanantham, additional, Parides, Michael K., additional, Ishwaran, Hemant, additional, Li, Liang, additional, Ehrlinger, John, additional, Gelijns, Annetine C., additional, Moskowitz, Alan J., additional, Argenziano, Michael, additional, DeRose, Joseph J., additional, Couderc, Jean-Phillipe, additional, Balda, Dan, additional, Dagenais, François, additional, Mack, Michael J., additional, Ailawadi, Gorav, additional, Smith, Peter K., additional, Acker, Michael A., additional, O'Gara, Patrick T., additional, Gillinov, A. Marc, additional, Miller, Marissa A., additional, Taddei-Peters, Wendy C., additional, Buxton, Dennis, additional, Connolly, Amy, additional, Geller, Nancy L., additional, Gordon, David, additional, Jeffries, Neal O., additional, Lee, Albert, additional, Moy, Claudia S., additional, Gombos, Ilana Kogan, additional, Ralph, Jennifer, additional, Weisel, Richard, additional, Gardner, Timothy J., additional, Rose, Eric A., additional, Ascheim, Deborah D., additional, Bagiella, Emilia, additional, Moquete, Ellen, additional, Chang, Helena, additional, Chase, Melissa, additional, Goldfarb, Seth, additional, Gupta, Lopa, additional, Kirkwood, Katherine, additional, Kumbarce, Edlira, additional, Levitan, Ron, additional, O'Sullivan, Karen, additional, Overbey, Jessica, additional, Santos, Milerva, additional, Weglinski, Michael, additional, Williams, Paula, additional, Wood, Carrie, additional, Ye, Xia, additional, Mack, Michael, additional, Adame, Tracine, additional, Settele, Natalie, additional, Adams, Jenny, additional, Ryan, William, additional, Smith, Robert L., additional, Grayburn, Paul, additional, Chen, Frederick Y., additional, Nohria, Anju, additional, Cohn, Lawrence, additional, Shekar, Prem, additional, Aranki, Sary, additional, Couper, Gregory, additional, Davidson, Michael, additional, Bolman, R. Morton, additional, Burgess, Anne, additional, Conboy, Debra, additional, Blackwell, Ray, additional, Kerzner, Roger, additional, Banbury, Michael, additional, Squire, Andrea M., additional, Blackstone, Eugene H., additional, Lytle, Bruce, additional, Mihaljevic, Tomislav, additional, Lackner, Pamela, additional, Berroteran, Leoma, additional, Dolney, Diana, additional, Fleming, Suzanne, additional, Palumbo, Roberta, additional, Whitman, Christine, additional, Sankovic, Kathy, additional, Sweeney, Denise Kosty, additional, Pattakos, Gregory, additional, Williams, Mathew, additional, Goldsmith, Lyn, additional, Smith, Craig R., additional, Naka, Yoshifumi, additional, Stewart, Allan, additional, Schwartz, Allan, additional, Bell, Daniel, additional, Van Patten, Danielle, additional, Sreekanth, Sowmya, additional, Alexander, John H., additional, Milano, Carmelo A., additional, Glower, Donald D., additional, Mathew, Joseph P., additional, Harrison, J. Kevin, additional, Welsh, Stacey, additional, Ferguson, T. Bruce, additional, Kypson, Alan P., additional, Rodriguez, Evelio, additional, Harris, Malissa, additional, Akers, Brenda, additional, O'Neal, Allison, additional, Puskas, John D., additional, Thourani, Vinod H., additional, Guyton, Robert, additional, Baer, Jefferson, additional, Baio, Kim, additional, Neill, Alexis A., additional, Voisine, Pierre, additional, Senechal, Mario, additional, O'Connor, Kim, additional, Dussault, Gladys, additional, Ballivian, Tatiana, additional, Keilani, Suzanne, additional, Michler, Robert E., additional, D'Alessandro, David A., additional, Goldstein, Daniel J., additional, Bello, Ricardo, additional, Jakobleff, William, additional, Garcia, Mario, additional, Taub, Cynthia, additional, Spevack, Daniel, additional, Swayze, Roger, additional, Sookraj, Nadia, additional, Perrault, Louis P., additional, Basmadjian, Arsène-Joseph, additional, Bouchard, Denis, additional, Carrier, Michel, additional, Cartier, Raymond, additional, Pellerin, Michel, additional, Tanguay, Jean François, additional, El-Hamamsy, Ismael, additional, Denault, André, additional, Lacharité, Jonathan, additional, Robichaud, Sophie, additional, Adams, David H., additional, Varghese, Robin, additional, Mandel-Portnoy, Yael, additional, Horvath, Keith A., additional, Corcoran, Philip C., additional, Siegenthaler, Michael P., additional, Murphy, Mandy, additional, Iraola, Margaret, additional, Greenberg, Ann, additional, Sai-Sudhakar, Chittoor, additional, Hasan, Ayseha, additional, McDavid, Asia, additional, Kinn, Bradley, additional, Mullen, John C., additional, Choy, Jonathan, additional, Meyer, Steven, additional, Kuurstra, Emily, additional, Gammie, James S., additional, DeFilippi, Christopher R., additional, Gaetani, Dino T., additional, Young, Cindi A., additional, Beach, Dana, additional, Collins, Julia, additional, Bolling, Steven F., additional, Pagani, Francis D., additional, Bloem, Cathie, additional, Woo, Y. Joseph, additional, Mayer, Mary Lou, additional, Bavaria, Joseph E., additional, Szeto, Wilson Y., additional, Margulies, Kenneth, additional, Keane, Martin, additional, Glassberg, Helene, additional, Jagasia, Dinesh, additional, Kirkpatrick, James, additional, Kron, Irving L., additional, Johnston, Karen, additional, Dent, John M., additional, Kern, John, additional, Keim, Jessica, additional, Burks, Sandra, additional, Gahring, Kim, additional, Mangi, Abeel, additional, Akar, Joseph, additional, Yuh, David, additional, Wilson, Lynn, additional, Bull, David A., additional, Desvigne-Nickens, Patrice, additional, Dixon, Dennis O., additional, Haigney, Mark, additional, Holubkov, Richard, additional, Jacobs, Alice, additional, Miller, Frank, additional, Murkin, John M., additional, Spertus, John, additional, Wechsler, Andrew S., additional, Sellke, Frank, additional, McDonald, Cheryl L., additional, Byington, Robert, additional, Dickert, Neal, additional, Ikonomidis, John S., additional, Williams, David O., additional, Yancy, Clyde W., additional, Canty, John M., additional, Fang, James C., additional, Giannetti, Nadia, additional, Richenbacher, Wayne, additional, Rao, Vivek, additional, Furie, Karen L., additional, Miller, Rachel, additional, Pinney, Sean, additional, Roberts, William C., additional, Walsh, Mary N., additional, Hung, Judy, additional, Zeng, Xin, additional, Couderc, Jean-Philippe, additional, Bowen, Wayne, additional, Wilson, Mauri, additional, and Schering, Anne, additional

Published
2019
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31. A Generalized Deep Learning Approach for Evaluating Secondary Pulmonary Tuberculosis on Chest Computed Tomography

Author

Wang, Ye, primary, Mei, Xueyan, additional, Liu, Chenyu, additional, Deyer, Timothy, additional, Zeng, Jingyi, additional, Xia, Chunchao, additional, Schefflein, Javin, additional, Jia, Lian, additional, Yu, He, additional, Jiang, Faming, additional, Yang, Chen, additional, Zhou, Ping, additional, Chang, Helena L., additional, Robson, Philip, additional, Doshi, Amish, additional, Mendelson, David, additional, Zhu, Hui, additional, Powell, Charles, additional, Yang, Yang, additional, Fayad, Zahi, additional, and Li, Weimin, additional

Published
2019
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33. 17 - Improved Quality of Care and Quality of Life for IBD Patients using Healthpromise App: A Randomized, Control Trial

Author

Atreja, Ashish, primary, Szigethy, Eva, additional, Otobo, Emamuzo, additional, Chang, Helena L., additional, Keefer, Laurie, additional, Rogers, Jason, additional, Kohli, Akshay, additional, Ullman, Thomas A., additional, Marion, James F., additional, Cohen, Benjamin L., additional, Maser, Elana, additional, Itzkowitz, Steven, additional, Colombel, Jean Frederic, additional, and Sands, Bruce E., additional

Published
2018
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36. Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular Assist Device Support in Patients With Advanced Heart Failure: A Randomized Clinical Trial.

Author

Yau, Terrence M., Pagani, Francis D., Mancini, Donna M., Chang, Helena L., Lala, Anuradha, Woo, Y. Joseph, Acker, Michael A., Selzman, Craig H., Soltesz, Edward G., Kern, John A., Maltais, Simon, Charbonneau, Eric, Pan, Stephanie, Marks, Mary E., Moquete, Ellen G., O'Sullivan, Karen L., Taddei-Peters, Wendy C., McGowan, Lydia K., Green, China, and Rose, Eric A.

Subjects
HEART failure treatment, STEM cell transplantation, HEART ventricle diseases, GASTROINTESTINAL hemorrhage, LEFT heart ventricle, HEART failure, INJECTIONS, LONGITUDINAL method, MYOCARDIUM, NOSEBLEED, PROBABILITY theory, COMPLICATIONS of prosthesis, RESEARCH funding, STATISTICAL sampling, RANDOMIZED controlled trials, TREATMENT effectiveness, MEDICAL device removal, HEART assist devices, STROKE volume (Cardiac output)
Abstract

Importance: Left ventricular assist device (LVAD) therapy improves myocardial function, but few patients recover sufficiently for explant, which has focused attention on stem cells to augment cardiac recovery.Objective: To assess efficacy and adverse effects of intramyocardial injections of mesenchymal precursor cells (MPCs) during LVAD implant.Design, Setting, and Participants: A randomized phase 2 clinical trial involving patients with advanced heart failure, undergoing LVAD implant, at 19 North American centers (July 2015-August 2017). The 1-year follow-up ended August 2018.Interventions: Intramyocardial injections of 150 million allogeneic MPCs or cryoprotective medium as a sham treatment in a 2:1 ratio (n = 106 vs n = 53).Main Outcomes and Measures: The primary efficacy end point was the proportion of successful temporary weans (of 3 planned assessments) from LVAD support within 6 months of randomization. This end point was assessed using a Bayesian analysis with a predefined threshold of a posterior probability of 80% to indicate success. The 1-year primary safety end point was the incidence of intervention-related adverse events (myocarditis, myocardial rupture, neoplasm, hypersensitivity reactions, and immune sensitization). Secondary end points included readmissions and adverse events at 6 months and 1-year survival.Results: Of 159 patients (mean age, 56 years; 11.3% women), 155 (97.5%) completed 1-year of follow-up. The posterior probability that MPCs increased the likelihood of successful weaning was 69%; below the predefined threshold for success. The mean proportion of successful temporary weaning from LVAD support over 6 months was 61% in the MPC group and 58% in the control group (rate ratio [RR], 1.08; 95% CI, 0.83-1.41; P = .55). No patient experienced a primary safety end point. Of 10 prespecified secondary end points reported, 9 did not reach statistical significance. One-year mortality was not significantly different between the MPC group and the control group (14.2% vs 15.1%; hazard ratio [HR], 0.89; 95%, CI, 0.38-2.11; P = .80). The rate of serious adverse events was not significantly different between groups (70.9 vs 78.7 per 100 patient-months; difference, -7.89; 95% CI, -39.95 to 24.17; P = .63) nor was the rate of readmissions (0.68 vs 0.75 per 100 patient-months; difference, -0.07; 95% CI, -0.41 to 0.27; P = .68).Conclusions and Relevance: Among patients with advanced heart failure, intramyocardial injections of mesenchymal precursor cells, compared with injections of a cryoprotective medium as sham treatment, did not improve successful temporary weaning from left ventricular assist device support at 6 months. The findings do not support the use of intramyocardial mesenchymal stem cells to promote cardiac recovery as measured by temporary weaning from device support.Trial Registration: clinicaltrials.gov Identifier: NCT02362646. [ABSTRACT FROM AUTHOR]

Published
2019
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45. Permanent Pacemaker Implantation and Long-Term Outcomes of Patients Undergoing Concomitant Mitral and Tricuspid Valve Surgery.

Author

Iribarne, Alexander, Alabbadi, Sundos H., Moskowitz, Alan J., Ailawadi, Gorav, Badhwar, Vinay, Gillinov, Marc, Thourani, Vinod H., Allen, Keith B., Halkos, Michael E., Patel, Nirav C., Kramer, Robert S., D'Alessandro, David, Raymond, Samantha, Chang, Helena L., Gupta, Lopa, Fenton, Kathleen N., Taddei-Peters, Wendy C., Chu, Michael W.A., Falk, Volkmar, and Chikwe, Joanna

Subjects
*MITRAL valve surgery, *CARDIAC pacemakers, *TRICUSPID valve surgery, *TRICUSPID valve, *MITRAL valve, *STROKE, *HOSPITAL admission & discharge
Abstract

Tricuspid valve annuloplasty (TA) during mitral valve repair (MVr) is associated with increased risk of permanent pacemaker (PPM) implantation, but the magnitude of risk and long-term clinical consequences have not been firmly established. This study assesses the incidence rates of PPM implantation after isolated MVr and following MVr with TA as well as the associated long-term clinical consequences of PPM implantation. State-mandated hospital discharge databases of New York and California were queried for patients undergoing MVr (isolated or with concomitant TA) between 2004 and 2019. Patients were stratified by whether or not they received a PPM within 90 days of index surgery. After weighting by propensity score, survival, heart failure hospitalizations (HFHs), endocarditis, stroke, and reoperation were compared between patients with or without PPM. A total of 32,736 patients underwent isolated MVr (n = 28,003) or MVr + TA (n = 4,733). Annual MVr + TA volumes increased throughout the study period (P < 0.001, trend), and PPM rates decreased (P < 0.001, trend). The incidence of PPM implantation <90 days after surgery was 7.7% for MVr and 14.0% for MVr + TA. In 90-day conditional landmark-weighted analyses, PPMs were associated with reduced long-term survival among MVr (HR: 1.96; 95% CI: 1.75-2.19; P < 0.001) and MVr + TA recipients (HR: 1.65; 95% CI: 1.28-2.14; P < 0.001). In both surgical groups, PPMs were also associated with an increased risk of HFH (HR: 1.56; 95% CI: 1.27-1.90; P < 0.001) and endocarditis (HR: 1.95; 95% CI: 1.52-2.51; P < 0.001), but not with stroke or reoperation. Compared to isolated MVr, adding TA to MVr was associated with a higher risk of 90-day PPM implantation. In both surgical groups, PPM implantation was associated with an increase in mortality, HFH, and endocarditis. [Display omitted] [ABSTRACT FROM AUTHOR]

Published
2024
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46. Efficacy and safety study of tazarotene cream 0.1% for the treatment of brittle nail syndrome.

Author

Sherber NS, Hoch AM, Coppola CA, Carter EL, Chang HL, Barsanti FR, and Mackay-Wiggan JM

Subjects
Administration, Topical, Aged, Female, Humans, Keratolytic Agents administration & dosage, Male, Middle Aged, Nicotinic Acids administration & dosage, Pilot Projects, Treatment Outcome, Keratolytic Agents therapeutic use, Nail Diseases drug therapy, Nicotinic Acids therapeutic use
Abstract

Brittle nail syndrome refers to nails that exhibit surface roughness, raggedness, and peeling. It is a common problem, with a higher prevalence among elderly patients. The goal of this study was to determine if tazarotene cream 0.1% ameliorates the signs and symptoms of brittle nails. In this open-label, single-center trial, participants applied tazarotene cream to the nails twice daily for 24 weeks. Signs and symptoms were rated by the investigators and by the participants during treatment and 12 weeks after discontinuation. Twenty participants were enrolled in the study; 1 participant withdrew prior to the 4-week followup visit. Of the 18 participants available for analysis (1 participant was excluded because baseline photographs were not available) for the primary end point of improvement in the physician global improvement assessment (PGIA), all 18 participants achieved improvement of the target nails at week 12 as well as 16 participants (88.9%) at week 24. All 18 participants had improvement in the PGIA score 12 weeks posttreatment at week 36. The physician global assessment (PGA) improved for 14 of 19 participants (73.7%) at both weeks 12 and 24; at week 24, 4 of 19 participants had achieved a PGA score of none. At week 36, 17 of 19 participants (89.5%) agreed that their nails had improved overall. Only 1 participant (5.3%) reported mild local irritation. This study demonstrated that tazarotene improves some of the changes noted in conjunction with brittle nail syndrome with minimal to no irritation.

Published
2011

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