Search

Your search keyword '"Chang, Guodong"' showing total 14 results
Start Over Author "Chang, Guodong"
14 results on '"Chang, Guodong"'

7. Accuracy of HAS‐BLED and other bleeding risk assessment tools in predicting major bleeding events in atrial fibrillation: A network meta‐analysis

Author

Guangyan Mu, Yimin Cui, Chang Guodong, Kun Hu, Lingyue Ma, Qiufen Xie, and Zhuo Zhang

Subjects
medicine.medical_specialty, Network Meta-Analysis, Hemorrhage, Risk management tools, 030204 cardiovascular system & hematology, Risk Assessment, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Atrial Fibrillation, medicine, Humans, HAS-BLED, business.industry, Anticoagulants, Atrial fibrillation, Hematology, medicine.disease, Predictive value, Thrombosis, Stroke, Meta-analysis, business, Risk assessment, Major bleeding
Abstract

Background Preventing thrombosis is an important part of atrial fibrillation (AF) treatment. However, it may increase the risk of bleeding, and bleeding risk assessment tools' predictive value remains unclear. This network meta-analysis investigated the sensitivity and specificity of HAS-BLED, and other bleeding risk assessment tools, to predict major bleeding events in AF patients. Methods The PubMed, EMBASE, and Cochrane Central Register of Controlled Trials databases were searched using keywords, including "AF," "bleeding," and "HAS-BLED," for results published through 30 November 2018. The predictive sensitivity and specificity of each bleeding risk assessment tool was analyzed by network meta-analysis. Results Our analysis included 18 studies, recruiting a total of 321 888 people. The bleeding risk assessment tools analyzed in this study included the ABC-bleeding score, ATRIA, European score, GARFIELD-AF, HAS-BLED, HEMORR2HAGES, ORBIT, Shireman, and mOBRI. A comprehensive analysis of sensitivity and specificity, based on an inconsistency model, showed that European score, ABC, and mOBRI have relatively high-sensitivity but low-specificity tools, whereas HAS-BLED and HEMORR2HAGES have balanced sensitivity and specificity. ORBIT, ATRIA, Shireman, and GARFIELD-AF had relatively high specificity but low sensitivity. A consistency model analysis showed similar results. Conclusions HAS-BLED is a balanced bleeding risk assessment tool in terms of sensitivity and specificity, whereas the European score, ABC, and mOBRI are high-sensitivity tools and ORBIT, ATRIA, Shireman, and GARFIELD-AF are high-specificity tools.

Published
2020

13. Interpretation of the tenfold symmetry in electron-diffraction pattern.

Author

Min Lequan, Zhang Xiaodan, and Chang Guodong

Subjects
*ELECTRON diffraction, *QUASICRYSTALS
Abstract

The electron-diffraction pattern (EDP) of the Al-Co-Cu decagonal phase is scanned with high accuracy and processed via the recognizing operator. The calculated center position of the diffraction spots of the processed EDP can be interpreted via the integral lattice points in an oblique coordinate system with the different unit lengths. A periodic filing presented in this paper can generate the diffraction pattern, in which the positions of the diffraction spots are exactly located at the same integral lattice points. Consequently, the EDP of the Al-Co-Cu decagonal phase may be produced by a periodic structure. [ABSTRACT FROM AUTHOR]

Published
2000

14. IL-6-miR-210 Suppresses Regulatory T Cell Function and Promotes Atrial Fibrosis by Targeting Foxp3.

Author

Chen Y, Chang G, Chen X, Li Y, Li H, Cheng D, Tang Y, and Sang H

Subjects
Atrial Fibrillation genetics, Cells, Cultured, Fibrosis, Forkhead Transcription Factors metabolism, Gene Expression Regulation, Humans, Immune Tolerance, Interleukin-2 Receptor alpha Subunit metabolism, Interleukin-6 metabolism, Atrial Fibrillation immunology, Forkhead Transcription Factors genetics, Heart Atria pathology, Interleukin-6 genetics, MicroRNAs genetics, T-Lymphocytes, Regulatory immunology
Abstract

The aim of this study was to explore the role of IL-6-miR-210 in the regulation of Tregs function and atrial fibrosis in atrial fibrillation (AF). The levels of interleukin (IL)-6 and IL-10 in AF patients were detected by using ELISA. Proportions of Treg cells were detected by fluorescence activated cell sorting analysis in AF patients. The expression of Foxp3, α-SMA, collagen I and collagen III were determined by western blot. The atrial mechanocytes were authenticated by vimentin immunostaining. The expression of miR-210 was performed by quantitative real-time polymerase chain reaction (qRT-PCR). TargetScan was used to predict potential targets of miR-210. The cardiomyocyte transverse sections in AF model group were observed by H&E staining. The myocardial filaments were observed by masson staining. The level of IL-6 was highly increased while the level of IL-10 (Tregs) was significantly decreased in AF patients as compared to normal control subjects, and IL-6 suppressed Tregs function and promoted the expression of α-SMA, collagen I and collagen III. Furthermore, miR-210 regulated Tregs function by targeting Foxp3, and IL-6 promoted expression of miR-210 via regulating hypoxia inducible factor-1α (HIF-1α). IL-6-miR-210 suppresses regulatory T cell function and promotes atrial fibrosis by targeting Foxp3.

Published
2020
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results