126 results on '"Chang, Chiehying"'
Search Results
2. X-Ray Crystal Structure of Bone Marrow Kinase in the X Chromosome: A Tec Family Kinase
3. Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1)
4. Biologic-like In Vivo Efficacy with Small Molecule Inhibitors of TNFα Identified Using Scaffold Hopping and Structure-Based Drug Design Approaches
5. Identification of N-Methyl Nicotinamide and N-Methyl Pyridazine-3-Carboxamide Pseudokinase Domain Ligands as Highly Selective Allosteric Inhibitors of Tyrosine Kinase 2 (TYK2)
6. Identification of Imidazo[1,2-b]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors
7. Using yeast surface display to engineer a soluble and crystallizable construct of hematopoietic progenitor kinase 1 (HPK1).
8. Discovery of furo[2,3-d][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors
9. Design and synthesis of carbazole carboxamides as promising inhibitors of Bruton’s tyrosine kinase (BTK) and Janus kinase 2 (JAK2)
10. Purine derivatives as potent Bruton’s tyrosine kinase (BTK) inhibitors for autoimmune diseases
11. Discovery of furo[2,3- d ][1,3]thiazinamines as beta amyloid cleaving enzyme-1 (BACE1) inhibitors
12. Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton’s Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers
13. Discovery of S3-Truncated, C-6 Heteroaryl Substituted Aminothiazine β-Site APP Cleaving Enzyme-1 (BACE1) Inhibitors
14. Small Molecule Reversible Inhibitors of Bruton’s Tyrosine Kinase (BTK): Structure–Activity Relationships Leading to the Identification of 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxo-3,4-dihydroquinazolin-3-yl)phenyl]-9H-carbazole-1-carboxamide (BMS-935177)
15. Discovery and Preclinical Evaluation of BMS-711939, an Oxybenzylglycine Based PPARα Selective Agonist
16. Targeting the BACE1 Active Site Flap Leads to a Potent Inhibitor That Elicits Robust Brain Aβ Reduction in Rodents
17. Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2- f][1,2,4]triazine inhibitors of IGF-1R kinase and IR kinase
18. Synthesis and structure–activity relationships of 2-aryl-4-oxazolylmethoxy benzylglycines and 2-aryl-4-thiazolylmethoxy benzylglycines as novel, potent PPARα selective activators- PPARα and PPARγ selectivity modulation
19. The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor
20. Design, synthesis and structure–activity relationships of azole acids as novel, potent dual PPAR α/γ agonists
21. Discovery of azetidinone acids as conformationally-constrained dual PPARα/γ agonists
22. Image Annotation and Database Mining to Create a Novel Screen for the Chemotype-Dependent Crystallization of HCV NS3 Protease
23. Small Molecule Antagonist of Leukocyte Function Associated Antigen-1 (LFA-1): Structure−Activity Relationships Leading to the Identification of 6-((5S,9R)-9-(4-Cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic Acid (BMS-688521)
24. Discovery of an Oxybenzylglycine Based Peroxisome Proliferator Activated Receptor α Selective Agonist 2-((3-((2-(4-Chlorophenyl)-5-methyloxazol-4-yl)methoxy)benzyl)(methoxycarbonyl)amino)acetic Acid (BMS-687453)
25. Discovery of a 2,4-Disubstituted Pyrrolo[1,2-f][1,2,4]triazine Inhibitor (BMS-754807) of Insulin-like Growth Factor Receptor (IGF-1R) Kinase in Clinical Development
26. Discovery and initial SAR of 3-(1 H-benzo[ d]imidazol-2-yl)pyridin-2(1 H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)
27. Design of LFA-1 antagonists based on a 2,3-dihydro-1 H-pyrrolizin-5(7aH)-one scaffold
28. Novel 1 H-(benzimidazol-2-yl)-1 H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase
29. Design of LFA-1 antagonists based on a 2,3-dihydro-1H-pyrrolizin-5(7aH)-one scaffold
30. Discovery and initial SAR of 3-(1H-benzo[d]imidazol-2-yl)pyridin-2(1H)-ones as inhibitors of insulin-like growth factor 1-receptor (IGF-1R)
31. Structure of the complex of trypsin with a highly potent synthetic inhibitor at 0.97 Å resolution
32. Novel 1H-(benzimidazol-2-yl)-1H-pyridin-2-one inhibitors of insulin-like growth factor I (IGF-1R) kinase
33. Discovery of a 1H-Benzoimidazol-2-yl)-1H-pyridin-2-one (BMS-536924) Inhibitor of Insulin-like Growth Factor I Receptor Kinase with in Vivo Antitumor Activity
34. De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold
35. Molecular design and structure–Activity relationships leading to the potent, selective, and orally active thrombin active site inhibitor BMS-189664
36. Crystallization and preliminary X-ray analysis of CTLA-4 (CD152) membrane-external domain
37. Kinetic and crystallographic studies ofEscherichia coliUDP-N-acetylmuramate:L-alanine ligase
38. X-ray Structure of the Uncomplexed Anti-tumor Antibody BR96 and Comparison with its Antigen-bound Form
39. Crystallographic determination of the structures of human α-thrombin complexed with BMS-186282 and BMS-189090
40. The Crystal Structure of the Antibody N10-Staphylococcal Nuclease Complex at 2.9 Å Resolution
41. The X-ray structure of an anti-tumour antibody in complex with antigen
42. Structure of a Retro-binding Peptide Inhibitor Complexed with Human α-Thrombin
43. Structure and specificity of the anti-digoxinantibody 40–50
44. Human mannose-binding protein carbohydrate recognition domain trimerizes through a triple α-helical coiled-coil
45. Crystallization and Preliminary X-ray Analysis of a Trimeric Form of Human Mannose Binding Protein
46. Crystallization and Preliminary X-ray Analysis of an Anti-Staphylococcal Nuclease-Staphylococcal Nuclease Complex and of a Second Anti-Staphylococcal Nuclease Antibody
47. Molecular, biological, and preliminary structural analysis of recombinant bryodin 1, a...
48. Structure and Specificity of the Anti-Digoxin Antibody 40-50
49. Identification of Imidazo[1,2- b ]pyridazine Derivatives as Potent, Selective, and Orally Active Tyk2 JH2 Inhibitors.
50. Small molecule antagonist of leukocyte function associated antigen-1 (LFA-1): structure-activity relationships leading to the identification of 6-((5S,9R)-9-(4-cyanophenyl)-3-(3,5-dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]nonan-7-yl)nicotinic acid (BMS-688521).
Catalog
Books, media, physical & digital resources
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.