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4. Future directions in psychiatric neurosurgery: Proceedings of the 2022 American Society for Stereotactic and Functional Neurosurgery meeting on surgical neuromodulation for psychiatric disorders

Author

Hitti, Frederick L, Widge, Alik S, Riva-Posse, Patricio, Malone, Donald A, Okun, Michael S, Shanechi, Maryam M, Foote, Kelly D, Lisanby, Sarah H, Ankudowich, Elizabeth, Chivukula, Srinivas, Chang, Edward F, Gunduz, Aysegul, Hamani, Clement, Feinsinger, Ashley, Kubu, Cynthia S, Chiong, Winston, Chandler, Jennifer A, Carbunaru, Rafael, Cheeran, Binith, Raike, Robert S, Davis, Rachel A, Halpern, Casey H, Vanegas-Arroyave, Nora, Markovic, Dejan, Bick, Sarah K, McIntyre, Cameron C, Richardson, R Mark, Dougherty, Darin D, Kopell, Brian H, Sweet, Jennifer A, Goodman, Wayne K, Sheth, Sameer A, and Pouratian, Nader

Subjects
Biomedical and Clinical Sciences, Rehabilitation, Neurosciences, Brain Disorders, Good Health and Well Being, Humans, United States, Neurosurgery, Deep Brain Stimulation, Neurosurgical Procedures, Mental Disorders, Psychosurgery, Deep brain stimulation, Treatment resistant depression, Obsessive compulsive disorder, Tourette syndrome, Neuromodulation, Medical and Health Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences
Abstract

ObjectiveDespite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a potential therapy for persistent disabling disease, however it has not yet gained widespread adoption. In 2016, the American Society for Stereotactic and Functional Neurosurgery (ASSFN) convened a meeting with leaders in the field to discuss a roadmap for the path forward. A follow-up meeting in 2022 aimed to review the current state of the field and to identify critical barriers and milestones for progress.DesignThe ASSFN convened a meeting on June 3, 2022 in Atlanta, Georgia and included leaders from the fields of neurology, neurosurgery, and psychiatry along with colleagues from industry, government, ethics, and law. The goal was to review the current state of the field, assess for advances or setbacks in the interim six years, and suggest a future path forward. The participants focused on five areas of interest: interdisciplinary engagement, regulatory pathways and trial design, disease biomarkers, ethics of psychiatric surgery, and resource allocation/prioritization. The proceedings are summarized here.ConclusionThe field of surgical psychiatry has made significant progress since our last expert meeting. Although weakness and threats to the development of novel surgical therapies exist, the identified strengths and opportunities promise to move the field through methodically rigorous and biologically-based approaches. The experts agree that ethics, law, patient engagement, and multidisciplinary teams will be critical to any potential growth in this area.

Published
2023

5. Proceedings of the 10th annual deep brain stimulation think tank: Advances in cutting edge technologies, artificial intelligence, neuromodulation, neuroethics, interventional psychiatry, and women in neuromodulation

Author

Wong, Joshua K, Mayberg, Helen S, Wang, Doris D, Richardson, R Mark, Halpern, Casey H, Krinke, Lothar, Arlotti, Mattia, Rossi, Lorenzo, Priori, Alberto, Marceglia, Sara, Gilron, Ro’ee, Cavanagh, James F, Judy, Jack W, Miocinovic, Svjetlana, Devergnas, Annaelle D, Sillitoe, Roy V, Cernera, Stephanie, Oehrn, Carina R, Gunduz, Aysegul, Goodman, Wayne K, Petersen, Erika A, Bronte-Stewart, Helen, Raike, Robert S, Malekmohammadi, Mahsa, Greene, David, Heiden, Petra, Tan, Huiling, Volkmann, Jens, Voon, Valerie, Li, Luming, Sah, Pankaj, Coyne, Terry, Silburn, Peter A, Kubu, Cynthia S, Wexler, Anna, Chandler, Jennifer, Provenza, Nicole R, Heilbronner, Sarah R, San Luciano, Marta, Rozell, Christopher J, Fox, Michael D, de Hemptinne, Coralie, Henderson, Jaimie M, Sheth, Sameer A, and Okun, Michael S

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Psychology, Bioengineering, Neurosciences, Assistive Technology, Depression, Rehabilitation, Mental Health, Mental health, deep brain stimulation, artificial intelligence, neuroethics, Parkinson's disease, dystonia, interventional psychiatry, adaptive DBS, epilepsy, Parkinson’s disease, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology
Abstract

The deep brain stimulation (DBS) Think Tank X was held on August 17-19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme women in neuromodulation. Dr. Helen Mayberg from Mt. Sinai, NY was the keynote speaker. She discussed milestones and her experiences in developing depression DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging DBS technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank X speakers was that DBS has continued to expand in scope however several indications have reached the "trough of disillusionment." DBS for depression was considered as "re-emerging" and approaching a slope of enlightenment. DBS for depression will soon re-enter clinical trials. The group estimated that globally more than 244,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. This year's meeting was focused on advances in the following areas: neuromodulation in Europe, Asia, and Australia; cutting-edge technologies, closed loop DBS, DBS tele-health, neuroethics, lesion therapy, interventional psychiatry, and adaptive DBS.

Published
2023

7. Changing interactions, relationships and behaviour : exploring the use of child-directed play and coaching skills in the primary classroom

Author

Chandler, Jennifer and McAleese, Maria

Subjects
social, behavioural, emotional wellbeing, child-directed play, coaching skills, teacher-child relationship, teacher training, child-directed interaction skills, primary-aged children
Abstract

Rates of social, behavioural, emotional and wellbeing difficulties among primary-aged pupils in Northern Ireland are rising. Providing school staff with training in how to support children displaying externalising behaviours is, therefore, an increasingly important role for educational psychologists. This study investigates the effects of a twilight training session in the use of child-directed play and coaching skills on teacher-reported interactions, teacher-child relationships and pupil behaviour. An embedded pretest-posttest design was employed, with forty-four primary school teachers and support staff completing baseline and post-training measures. Measures included a non-standardised questionnaire regarding participants' use of child-directed play and coaching skills, the Student Teacher Relationship Scale and the Sutter-Eyberg Student Behaviour Inventory-Revised. Four supplementary, open-ended questions were used to gain insight into participants' experiences of implementing child-directed play and coaching skills in the classroom. Thematic analysis and a range of statistical tests were employed to analyse the wealth of data. Findings indicate that educational psychologists' delivery of a single twilight training session has the potential to produce small but meaningful change in how school staff interact and relate to primary-aged children experiencing needs associated with social, behavioural, emotional and wellbeing difficulties. The impact of the twilight training session on wider markers of school inclusion is proposed as an area worthy of further investigation.

Published
2022

8. Future Developments in Brain/Neural–Computer Interface Technology

Author

Soekadar, Surjo R., Vermehren, Mareike, Colucci, Annalisa, Haslacher, David, Bublitz, Christoph, Ienca, Marcello, Chandler, Jennifer A., Blankertz, Benjamin, Dubljević, Veljko, Series Editor, Jotterand, Fabrice, Series Editor, Jox, Ralf J., Series Editor, Racine, Eric, Series Editor, and Coin, Allen, editor

Published
2023
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11. A brain-based definition of death and criteria for its determination after arrest of circulation or neurologic function in Canada: a 2023 clinical practice guideline

Author

Shemie, Sam D., Wilson, Lindsay C., Hornby, Laura, Basmaji, John, Baker, Andrew J., Bensimon, Cécile M., Chandler, Jennifer A., Chassé, Michaël, Dawson, Rosanne, Dhanani, Sonny, Mooney, Owen T., Sarti, Aimee J., Simpson, Christy, Teitelbaum, Jeanne, Torrance, Sylvia, Boyd, J. Gordon, Brennan, Joanne, Brewster, Heather, Carignan, Robert, Dawe, Kirk J., Doig, Christopher J., Elliott-Pohl, Kennedy, Gofton, Teneille E., Hartwick, Michael, Healey, Andrew, Honarmand, Kimia, Hornby, Karen, Isac, George, Kanji, Aly, Kawchuk, Joann, Klowak, Jennifer A., Kramer, Andreas H., Kromm, Julie, LeBlanc, Allana E., Lee-Ameduri, Katarina, Lee, Laurie A., Leeies, Murdoch, Lewis, Ariane, Manara, Alex, Matheson, Shauna, McKinnon, Nicole K. A., Murphy, Nicholas, Briard, Joel Neves, Pope, Thaddeus M., Sekhon, Mypinder S., Shanker, Jai Jai S., Singh, Gurmeet, Singh, Jeffrey, Slessarev, Marat, Soliman, Karim, Sutherland, Stephanie, Weiss, Matthew J., Shaul, Randi Zlotnik, Zuckier, Lionel S., Zorko, David J., and Rochwerg, Bram

Published
2023
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13. Death determination by neurologic criteria—what do families understand?

Author

Sarti, Aimee J., Sutherland, Stephanie, Meade, Maureen, Hornby, Laura, Wilson, Lindsay C., Landriault, Angele, Vanderspank-Wright, Brandi, Valiani, Sabira, Keenan, Sean, Weiss, Matthew J., Werestiuk, Kim, Beed, Stephen, Kramer, Andreas H., Kawchuk, Joann, Cardinal, Pierre, Dhanani, Sonny, Lotherington, Ken, Pagliarello, Giuseppe, Chassé, Michaël, Gatien, Mary, Parsons, Kim, Chandler, Jennifer A., Nickerson, Peter, and Shemie, Sam D.

Published
2023
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18. Inequities in organ and tissue donation and transplantation for sexual orientation and gender identity diverse people: A scoping review

Author

Leeies, Murdoch, Collister, David, Ho, Julie, Trachtenberg, Aaron, Gruber, Jackie, Weiss, Matthew J., Chandler, Jennifer A., Mooney, Owen, Carta, Tricia, Klassen, Ben, Draenos, Chris, Sutha, Ken, Randell, Shane, Strang, Matthew, Partain, Billy, Whitley, Cameron T., Cuvelier, Susan, MacKenzie, Lauren J., Shemie, Sam D., and Hrymak, Carmen

Published
2023
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23. Correction: Death determination by neurologic criteria—what do families understand?

Author

Sarti, Aimee J., Sutherland, Stephanie, Meade, Maureen, Hornby, Laura, Wilson, Lindsay C., Landriault, Angele, Vanderspank-Wright, Brandi, Valiani, Sabira, Keenan, Sean, Weiss, Matthew J., Werestiuk, Kim, Beed, Stephen, Kramer, Andreas H., Kawchuk, Joann, Cardinal, Pierre, Dhanani, Sonny, Lotherington, Ken, Pagliarello, Giuseppe, Chassé, Michaël, Gatien, Mary, Parsons, Kim, Chandler, Jennifer A., Nickerson, Peter, and Shemie, Sam D.

Published
2023
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33. Single‐cell transcriptomics identifies aberrant glomerular angiogenic signalling in the early stages of WT1 kidney disease.

Author

Chandler, Jennifer C, Jafree, Daniyal J, Malik, Saif, Pomeranz, Gideon, Ball, Mary, Kolatsi‐Joannou, Maria, Piapi, Alice, Mason, William J, Benest, Andrew V, Bates, David O, Letunovska, Aleksandra, Al‐Saadi, Reem, Rabant, Marion, Boyer, Olivia, Pritchard‐Jones, Kathy, Winyard, Paul J, Mason, Andrew S, Woolf, Adrian S, Waters, Aoife M, and Long, David A

Subjects
TRANSCRIPTION factors, KIDNEY glomerulus diseases, ENDOTHELIAL cells, JUVENILE diseases, ADRENOMEDULLIN
Abstract

WT1 encodes a podocyte transcription factor whose variants can cause an untreatable glomerular disease in early childhood. Although WT1 regulates many podocyte genes, it is poorly understood which of them are initiators in disease and how they subsequently influence other cell‐types in the glomerulus. We hypothesised that this could be resolved using single‐cell RNA sequencing (scRNA‐seq) and ligand‐receptor analysis to profile glomerular cell–cell communication during the early stages of disease in mice harbouring an orthologous human mutation in WT1 (Wt1R394W/+). Podocytes were the most dysregulated cell‐type in the early stages of Wt1R394W/+ disease, with disrupted angiogenic signalling between podocytes and the endothelium, including the significant downregulation of transcripts for the vascular factors Vegfa and Nrp1. These signalling changes preceded glomerular endothelial cell loss in advancing disease, a feature also observed in biopsy samples from human WT1 glomerulopathies. Addition of conditioned medium from murine Wt1R394W/+ primary podocytes to wild‐type glomerular endothelial cells resulted in impaired endothelial looping and reduced vascular complexity. Despite the loss of key angiogenic molecules in Wt1R394W/+ podocytes, the pro‐vascular molecule adrenomedullin was upregulated in Wt1R394W/+ podocytes and plasma and its further administration was able to rescue the impaired looping observed when glomerular endothelium was exposed to Wt1R394W/+ podocyte medium. In comparative analyses, adrenomedullin upregulation was part of a common injury signature across multiple murine and human glomerular disease datasets, whilst other gene changes were unique to WT1 disease. Collectively, our study describes a novel role for altered angiogenic signalling in the initiation of WT1 glomerulopathy. We also identify adrenomedullin as a proangiogenic factor, which despite being upregulated in early injury, offers an insufficient protective response due to the wider milieu of dampened vascular signalling that results in endothelial cell loss in later disease. © 2024 The Author(s). The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland. [ABSTRACT FROM AUTHOR]

Published
2024
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35. A unique subset of pericystic endothelium associates with aberrant microvascular remodelling and impaired blood perfusion early in polycystic kidney disease

Author

Jafree, Daniyal J, primary, Perera, Charith, additional, Ball, Mary, additional, Tolomeo, Daniele, additional, Pomeranz, Gideon, additional, Wilson, Laura, additional, Davis, Benjamin, additional, Mason, William J, additional, Funk, Eva Maria, additional, Kolatsi-Joannou, Maria, additional, Polschi, Radu, additional, Malik, Saif, additional, Stewart, Benjamin J, additional, Price, Karen L, additional, Mitchell, Hannah, additional, Motallebzadeh, Reza, additional, Muto, Yoshiharu, additional, Lees, Robert, additional, Needham, Sarah R, additional, Moulding, Dale, additional, Chandler, Jennifer C, additional, Walsh, Claire L, additional, Woolf, Adrian S, additional, Winyard, Paul JD, additional, Scambler, Peter J, additional, Hagerling, Rene, additional, Clatworthy, Menna R, additional, Humphreys, Benjamin, additional, Lythgoe, Mark F, additional, Walker-Samuel, Simon, additional, and Long, David A, additional

Published
2024
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37. Pseudouridylation defect due to DKC1 and NOP10 mutations causes nephrotic syndrome with cataracts, hearing impairment, and enterocolitis

Author

Balogh, Eszter, Chandler, Jennifer C., Varga, Máté, Tahoun, Mona, Menyhárd, Dóra K., Schay, Gusztáv, Goncalves, Tomas, Hamar, Renáta, Légrádi, Regina, Szekeres, Akos, Gribouval, Olivier, Kleta, Robert, Stanescu, Horia, Bockenhauer, Detlef, Kerti, Andrea, Williams, Hywel, Kinsler, Veronica, Di, Wei-Li, Curtis, David, Kolatsi-Joannou, Maria, Hammid, Hafsa, Szőcs, Anna, Perczel, Kristóf, Maka, Erika, Toldi, Gergely, Sava, Florentina, Arrondel, Christelle, Kardos, Magdolna, Fintha, Attila, Hossain, Ahmed, D’Arco, Felipe, Kaliakatsos, Mario, Koeglmeier, Jutta, Mifsud, William, Moosajee, Mariya, Faro, Ana, Jávorszky, Eszter, Rudas, Gábor, Saied, Marwa H., Marzouk, Salah, Kelen, Kata, Götze, Judit, Reusz, George, Tulassay, Tivadar, Dragon, François, Mollet, Géraldine, Motameny, Susanne, Thiele, Holger, Dorval, Guillaume, Nürnberg, Peter, Perczel, András, Szabó, Attila J., Long, David A., Tomita, Kazunori, Antignac, Corinne, Waters, Aoife M., and Tory, Kálmán

Published
2020

48. Deep brain stimulation for refractory obsessive-compulsive disorder (OCD): emerging or established therapy?

Author

Wu, Hemmings, Hariz, Marwan, Visser-Vandewalle, Veerle, Zrinzo, Ludvic, Coenen, Volker A., Sheth, Sameer A., Bervoets, Chris, Naesström, Matilda, Blomstedt, Patric, Coyne, Terry, Hamani, Clement, Slavin, Konstantin, Krauss, Joachim K., Kahl, Kai G., Taira, Takaomi, Zhang, Chencheng, Sun, Bomin, Toda, Hiroki, Schlaepfer, Thomas, Chang, Jin Woo, Régis, Jean, Schuurman, Rick, Schulder, Michael, Doshi, Paresh, Mosley, Philip, Poologaindran, Anujan, Lázaro-Muñoz, Gabriel, Pepper, Joshua, Schechtmann, Gaston, Fytagoridis, Anders, Huys, Daniel, Gonçalves-Ferreira, Antonio, D’Haese, Pierre-François, Neimat, Joseph, Broggi, Giovanni, Vilela-Filho, Osvaldo, Voges, Jürgen, Alkhani, Ahmed, Nakajima, Takeshi, Richieri, Raphaelle, Djurfeldt, Diana, Fontaine, Philippe, Martinez-Alvarez, Roberto, Okamura, Yasushi, Chandler, Jennifer, Watanabe, Katsushige, Barcia, Juan A., Reneses, Blanca, Lozano, Andres, Gabriëls, Loes, De Salles, Antonio, Halpern, Casey H., Matthews, Keith, Fins, Joseph J., and Nuttin, Bart

Published
2021
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