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Open in new tab Download slide Open in new tab Download slide OBJECTIVES The aim of this study was to compare the outcomes of tricuspid valve (TV) repair versus replacement for patients with infective endocarditis (IE). METHODS In this nationwide population-based cohort study, we identified 704 patients from Taiwan National Health Insurance Research Database who underwent TV surgery due to IE between 2000 and 2013. Of them, 412 (58.5%) underwent TV repair and 292 (41.5%) underwent TV replacement, and their perioperative and late outcomes were analysed. Confounding was reduced using the inverse probability of treatment weighting on propensity score. RESULTS After inverse probability of treatment weighting, the in-hospital mortality rate between the 2 groups was not significantly different. However, patients who received TV repair had lower rates of perioperative complications, including massive blood transfusion, de novo dialysis and deep wound infection; longer ICU and hospital stays; and higher hospital cost. Regarding late outcomes, TV repair was associated with lower risks of all-cause readmission [subdistribution hazard ratio (HR) 0.68, 95% confidence interval (CI) 0.60–0.78; P  <   0.001], readmission for adverse liver outcomes (subdistribution HR 0.75, 95% CI 0.58–0.97; P  =   0.025), new permanent pacemaker implantation (subdistribution HR 0.27, 95% CI 0.15–0.48; P  <   0.001) and all-cause mortality (HR 0.60, 95% CI 0.51–0.71; P  <   0.001) than TV replacement. CONCLUSIONS For IE, TV repair is associated with better early and late outcomes than TV replacement. A repair-first strategy is recommended for patients with IE for whom TV surgery is indicated. [ABSTRACT FROM AUTHOR]