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941 results on '"Chan, Wai-Man"'

1. A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders

Author

Lee, Arthur S., Ayers, Lauren J., Kosicki, Michael, Chan, Wai-Man, Fozo, Lydia N., Pratt, Brandon M., Collins, Thomas E., Zhao, Boxun, Rose, Matthew F., Sanchis-Juan, Alba, Fu, Jack M., Wong, Isaac, Zhao, Xuefang, Tenney, Alan P., Lee, Cassia, Laricchia, Kristen M., Barry, Brenda J., Bradford, Victoria R., Jurgens, Julie A., England, Eleina M., Lek, Monkol, MacArthur, Daniel G., Lee, Eunjung Alice, Talkowski, Michael E., Brand, Harrison, Pennacchio, Len A., and Engle, Elizabeth C.

Published
2024
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2. Noncoding variants alter GATA2 expression in rhombomere 4 motor neurons and cause dominant hereditary congenital facial paresis

Author

Tenney, Alan P, Di Gioia, Silvio Alessandro, Webb, Bryn D, Chan, Wai-Man, de Boer, Elke, Garnai, Sarah J, Barry, Brenda J, Ray, Tammy, Kosicki, Michael, Robson, Caroline D, Zhang, Zhongyang, Collins, Thomas E, Gelber, Alon, Pratt, Brandon M, Fujiwara, Yuko, Varshney, Arushi, Lek, Monkol, Warburton, Peter E, Van Ryzin, Carol, Lehky, Tanya J, Zalewski, Christopher, King, Kelly A, Brewer, Carmen C, Thurm, Audrey, Snow, Joseph, Facio, Flavia M, Narisu, Narisu, Bonnycastle, Lori L, Swift, Amy, Chines, Peter S, Bell, Jessica L, Mohan, Suresh, Whitman, Mary C, Staffieri, Sandra E, Elder, James E, Demer, Joseph L, Torres, Alcy, Rachid, Elza, Al-Haddad, Christiane, Boustany, Rose-Mary, Mackey, David A, Brady, Angela F, Fenollar-Cortés, María, Fradin, Melanie, Kleefstra, Tjitske, Padberg, George W, Raskin, Salmo, Sato, Mario Teruo, Orkin, Stuart H, Parker, Stephen CJ, Hadlock, Tessa A, Vissers, Lisenka ELM, van Bokhoven, Hans, Jabs, Ethylin Wang, Collins, Francis S, Pennacchio, Len A, Manoli, Irini, and Engle, Elizabeth C

Subjects
Biological Sciences, Genetics, 2.1 Biological and endogenous factors, Animals, Mice, Facial Paralysis, GATA2 Transcription Factor, Motor Neurons, Neurogenesis, Neurons, Efferent, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Hereditary congenital facial paresis type 1 (HCFP1) is an autosomal dominant disorder of absent or limited facial movement that maps to chromosome 3q21-q22 and is hypothesized to result from facial branchial motor neuron (FBMN) maldevelopment. In the present study, we report that HCFP1 results from heterozygous duplications within a neuron-specific GATA2 regulatory region that includes two enhancers and one silencer, and from noncoding single-nucleotide variants (SNVs) within the silencer. Some SNVs impair binding of NR2F1 to the silencer in vitro and in vivo and attenuate in vivo enhancer reporter expression in FBMNs. Gata2 and its effector Gata3 are essential for inner-ear efferent neuron (IEE) but not FBMN development. A humanized HCFP1 mouse model extends Gata2 expression, favors the formation of IEEs over FBMNs and is rescued by conditional loss of Gata3. These findings highlight the importance of temporal gene regulation in development and of noncoding variation in rare mendelian disease.

Published
2023

3. A recurrent missense variant in the E3 ubiquitin ligase substrate recognition subunit FEM1B causes a rare syndromic neurodevelopmental disorder

Author

Lecoquierre, François, Punt, A. Mattijs, Ebstein, Frédéric, Wallaard, Ilse, Verhagen, Rob, Studencka-Turski, Maja, Duffourd, Yannis, Moutton, Sébastien, Tran Mau-Them, Frédédic, Philippe, Christophe, Dean, John, Tennant, Stephen, Brooks, Alice S., van Slegtenhorst, Marjon A., Jurgens, Julie A., Barry, Brenda J., Chan, Wai-Man, England, Eleina M., Martinez Ojeda, Mayra, Engle, Elizabeth C., Robson, Caroline D., Morrow, Michelle, Innes, A. Micheil, Lamont, Ryan, Sanderson, Matthea, Krüger, Elke, Thauvin, Christel, Distel, Ben, Faivre, Laurence, Elgersma, Ype, and Vitobello, Antonio

Published
2024
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5. Expanding the genetics and phenotypes of ocular congenital cranial dysinnervation disorders

Author

Abarca-Barriga, Hugo, Al-Haddad, Christiane, Berman, Jeffrey L., Bothun, Erick D., Capasso, Jenina, Chacon-Camacho, Oscar Francisco, Chang, Lan, Christiansen, Stephen P., Ciccarelli, Maria Laura, Cordonnier, Monique, Cox, Gerald F., Curry, Cynthia J., Dagi, Linda R., Lee Dahm, Thomas, David, Karen L., Davitt, Bradley V., De Berardinis, Teresa, Demer, Joseph L., Désir, Julie, D’Esposito, Fabiana, Drack, Arlene V., Eggenberger, Eric, Elder, James E., Elliott, Alexandra T., Epley, K. David, Feldman, Hagit Baris, Ferreira, Carlos R., Flaherty, Maree P., Fulton, Anne B., Gerth-Kahlert, Christina, Gottlob, Irene, Grill, Stephen, Halliday, Dorothy J., Hanisch, Frank, Hay, Eleanor, Heidary, Gena, Holder, Christopher, Horton, Jonathan C., Iannaccone, Alessandro, Isenberg, Sherwin J., Johnston, Suzanne C., Kahana, Alon, Katowitz, James A., Kazlas, Melanie, Kerr, Natalie C., Kimonis, Virginia, Ko, Melissa W., Koc, Feray, Larsen, Dorte Ancher, Lay-Son, Guillermo, Ledoux, Danielle M., Levin, Alex V., Levy, Richard L., Lyons, Christopher J., Mackey, David A., Magli, Adriano, Mantagos, Iason S., Marti, Candice, Maystadt, Isabelle, McKenzie, Fiona, Menezes, Manoj P., Mikail, Claudia N., Miller, David T., Miller, Kathryn Bisceglia, Mills, Monte D., Miyana, Kaori, Moller, H.U., Mullineaux, Lisa, Nishimura, Julie K., Noble, A. Gwendolyn, Pandey, Pramod Kumar, Pavone, Piero, Penzien, Johann, Petersen, Robert, Phalen, James A., Poduri, Annapurna, Polo, Claudia R., Prasov, Lev, Ramos, Feliciano J., Ramos-Caceres, Maria, Robb, Richard M., Rossillion, Béatrice, Sahin, Mustafa, Singer, Harvey S., Smith, Lois E.H., Sorkin, Jeffrey A., Soul, Janet S., Staffieri, Sandra E., Stalker, Heather J., Stasheff, Steven F., Strassberg, Sonya, Strominger, Mitchell B., Taranath, Deepa Ajay, Thomas, Ioan Talfryn, Traboulsi, Elias I., Ugrin, Maria Cristina, VanderVeen, Deborah K., Vincent, Andrea L., Vogel G, Marlene C., Wabbels, Bettina, Wong, Agnes M.F., Woods, C. Geoffrey, Wu, Carolyn, Yang, Edward, Yeung, Alison, Young, Terri L., Zenteno, Juan C., Zubcov-Iwantscheff, Alexandra A., Zwaan, Johan, Jurgens, Julie A., Barry, Brenda J., Chan, Wai-Man, MacKinnon, Sarah, Whitman, Mary C., Matos Ruiz, Paola M., Pratt, Brandon M., England, Eleina M., Pais, Lynn, Lemire, Gabrielle, Groopman, Emily, Glaze, Carmen, Russell, Kathryn A., Singer-Berk, Moriel, Di Gioia, Silvio Alessandro, Lee, Arthur S., Andrews, Caroline, Shaaban, Sherin, Wirth, Megan M., Bekele, Sarah, Toffoloni, Melissa, Bradford, Victoria R., Foster, Emma E., Berube, Lindsay, Rivera-Quiles, Cristina, Mensching, Fiona M., Sanchis-Juan, Alba, Fu, Jack M., Wong, Isaac, Zhao, Xuefang, Wilson, Michael W., Weisburd, Ben, Lek, Monkol, Brand, Harrison, Talkowski, Michael E., MacArthur, Daniel G., O’Donnell-Luria, Anne, Robson, Caroline D., Hunter, David G., and Engle, Elizabeth C.

Published
2024
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7. Well-Being of Hong Kong DSE Students in the Post-COVID-19 Age: Opportunities and Challenges for Mental Health Education and Promotion

Author

Chun, Derek Wai Sun, Yau, Siu Ho, Chan, Wai Man, Fung, Ting Ting, Filipe, Joaquim, Editorial Board Member, Ghosh, Ashish, Editorial Board Member, Prates, Raquel Oliveira, Editorial Board Member, Zhou, Lizhu, Editorial Board Member, Li, Hongxiu, editor, Ghorbanian Zolbin, Maehed, editor, Krimmer, Robert, editor, Kärkkäinen, Jukka, editor, Li, Chenglong, editor, and Suomi, Reima, editor

Published
2022
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8. Suicidality and Intellectual Disability: A Systematic Review.

Author

Chan, Wai Man Raymond and Bhandarkar, Ritesh

Subjects
*PARASUICIDE, *DEVELOPMENTAL disabilities, *ATTEMPTED suicide, *SUICIDE prevention, *MENTAL illness, *INTELLECTUAL disabilities
Abstract

BackgroundMethodsResultsConclusionsSuicidality in individuals with intellectual disability is a critical but under-researched area. This systematic review aims to synthesize existing literature on the prevalence, risk factors, and interventions for suicidality among individuals with intellectual disability.Adhering to the PRISMA guidelines, a comprehensive review of databases was conducted for empirical studies on suicidality in intellectual disability. Data were extracted on sample characteristics, methodologies, and key findings.Nineteen studies met the inclusion criteria. Consistent risk factors, notably comorbid psychiatric disorders, emerged. Passive suicide methods predominated with a positive correlation between higher intellectual functioning and increased suicidal behaviors.The increased vulnerability to suicide in this population highlights the need for targeted interventions and comprehensive risk assessments. Much future research is required in the face of paucity of data with the priority on developing specific suicide prevention tools while addressing cultural stigmas to enhance support for this population. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Pathway-Based Meta-Analysis for Partially Paired Transcriptomics Analysis

Author

Fung, Wing Tung, Wu, Joseph T., Chan, Wai Man Mandy, Chan, Henry H., and Pang, Herbert

Abstract

Pathway-based differential expression analysis allows the incorporation of biological domain knowledge into transcriptomics analysis to enhance our understanding of disease mechanisms. To integrate information among multiple studies at the pathway level, pathway-based meta-analysis can be performed. Paired or partially paired samples are common in biomedical research. However, there are currently no existing pathway-based meta-analysis methods appropriate for paired or partially paired study designs. In this study, we developed a pathway-based meta-analysis approach for paired or partially paired samples. Meta-analysis on the transcriptomics profiles were conducted using p-value-based, rank-based, and effect size-based algorithms. The application of our approach was demonstrated using partially paired data from psoriasis transcriptomics studies. Upon combining six transcriptomics studies, genes related to the cell cycle and DNA replication pathways are found to be highly perturbed in psoriatic lesional skin samples. Results were validated externally with independent RNA-Seq data. Comparison with existing pathway meta-analysis methods revealed consistent results, with our method showing higher detection power. This study demonstrated the utility of our newly developed pathway-based meta-analysis that allows the incorporation of partially paired or paired samples. The proposed framework can be applied to omics data including but not limited to transcriptomics data.

Published
2020
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10. TUBB3 Arg262His causes a recognizable syndrome including CFEOM3, facial palsy, joint contractures, and early-onset peripheral neuropathy

Author

Whitman, Mary C., Barry, Brenda J., Robson, Caroline D., Facio, Flavia M., Van Ryzin, Carol, Chan, Wai-Man, Lehky, Tanya J., Thurm, Audrey, Zalewski, Christopher, King, Kelly A., Brewer, Carmen, Almpani, Konstantinia, Lee, Janice S., Delaney, Angela, FitzGibbon, Edmond J., Lee, Paul R., Toro, Camilo, Paul, Scott M., Abdul-Rahman, Omar A., Webb, Bryn D., Jabs, Ethylin Wang, Moller, Hans Ulrik, Larsen, Dorte Ancher, Antony, Jayne H., Troedson, Christopher, Ma, Alan, Ragnhild, Glad, Wirgenes, Katrine V., Tham, Emma, Kvarnung, Malin, Maarup, Timothy James, MacKinnon, Sarah, Hunter, David G., Collins, Francis S., Manoli, Irini, and Engle, Elizabeth C.

Published
2021
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13. Biallelic mutations in human DCC cause developmental split-brain syndrome

Author

Jamuar, Saumya S, Schmitz-Abe, Klaus, D'Gama, Alissa M, Drottar, Marie, Chan, Wai-Man, Peeva, Maya, Servattalab, Sarah, Lam, Anh-Thu N, Delgado, Mauricio R, Clegg, Nancy J, Zayed, Zayed Al, Dogar, Mohammad Asif, Alorainy, Ibrahim A, Jamea, Abdullah Abu, Abu-Amero, Khaled, Griebel, May, Ward, Wendy, Lein, Ed S, Markianos, Kyriacos, Barkovich, A James, Robson, Caroline D, Grant, P Ellen, Bosley, Thomas M, Engle, Elizabeth C, Walsh, Christopher A, and Yu, Timothy W

Subjects
Agricultural, Veterinary and Food Sciences, Biological Sciences, Bioinformatics and Computational Biology, Genetics, Agricultural Biotechnology, Perinatal Period - Conditions Originating in Perinatal Period, Neurosciences, Pediatric, Brain Disorders, Clinical Research, Intellectual and Developmental Disabilities (IDD), Neurological, Brain, Central Nervous System, Colorectal Neoplasms, Female, Gene Expression Regulation, Developmental, Humans, Intellectual Disability, Loss of Heterozygosity, Male, Mutation, Neurons, Phenotype, Polymorphism, Single Nucleotide, Receptors, Cell Surface, Medical and Health Sciences, Developmental Biology, Agricultural biotechnology, Bioinformatics and computational biology
Abstract

Motor, sensory, and integrative activities of the brain are coordinated by a series of midline-bridging neuronal commissures whose development is tightly regulated. Here we report a new human syndrome in which these commissures are widely disrupted, thus causing clinical manifestations of horizontal gaze palsy, scoliosis, and intellectual disability. Affected individuals were found to possess biallelic loss-of-function mutations in the gene encoding the axon-guidance receptor 'deleted in colorectal carcinoma' (DCC), which has been implicated in congenital mirror movements when it is mutated in the heterozygous state but whose biallelic loss-of-function human phenotype has not been reported. Structural MRI and diffusion tractography demonstrated broad disorganization of white-matter tracts throughout the human central nervous system (CNS), including loss of all commissural tracts at multiple levels of the neuraxis. Combined with data from animal models, these findings show that DCC is a master regulator of midline crossing and development of white-matter projections throughout the human CNS.

Published
2017

14. Novel variants in TUBA1A cause congenital fibrosis of the extraocular muscles with or without malformations of cortical brain development

Author

Jurgens, Julie A., Barry, Brenda J., Lemire, Gabrielle, Chan, Wai-Man, Whitman, Mary C., Shaaban, Sherin, Robson, Caroline D., MacKinnon, Sarah, England, Eleina M., McMillan, Hugh J., Kelly, Christopher, Pratt, Brandon M., O’Donnell-Luria, Anne, MacArthur, Daniel G., Boycott, Kym M., Hunter, David G., and Engle, Elizabeth C.

Published
2021
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15. A cell type-aware framework for nominating non-coding variants in Mendelian regulatory disorders

Author

Lee, Arthur S, primary, Ayers, Lauren J, additional, Kosicki, Michael, additional, Chan, Wai-Man, additional, Fozo, Lydia N, additional, Pratt, Brandon M, additional, Collins, Thomas E, additional, Zhao, Boxun, additional, Rose, Matthew F, additional, Sanchis-Juan, Alba, additional, Fu, Jack M, additional, Wong, Isaac, additional, Zhao, Xuefang, additional, Tenney, Alan P, additional, Lee, Cassia, additional, Laricchia, Kristen M, additional, Barry, Brenda J, additional, Bradford, Victoria R, additional, Lek, Monkol, additional, MacArthur, Daniel G, additional, Lee, Eunjung Alice, additional, Talkowski, Michael E, additional, Brand, Harrison, additional, Pennacchio, Len A, additional, and Engle, Elizabeth C, additional

Published
2023
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19. Implementation of Electronic Health Monitoring Systems at the Community Level in Hong Kong

Author

Chan, Wai Man, Zhao, Yang, Tsui, Kwok Leung, Hutchison, David, Series editor, Kanade, Takeo, Series editor, Kittler, Josef, Series editor, Kleinberg, Jon M., Series editor, Mattern, Friedemann, Series editor, Mitchell, John C., Series editor, Naor, Moni, Series editor, Pandu Rangan, C., Series editor, Steffen, Bernhard, Series editor, Terzopoulos, Demetri, Series editor, Tygar, Doug, Series editor, Weikum, Gerhard, Series editor, Chen, Hsinchun, editor, Zeng, Daniel Dajun, editor, Karahanna, Elena, editor, and Bardhan, Indranil, editor

Published
2017
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20. Intelligent conceptual mould layout design system (ICMLDS) : innovation report

Author

Chan, Wai Man Ivan

Subjects
620, TP Chemical technology
Abstract

Family Mould Cavity Runner Layout Design (FMCRLD) is the most demanding and critical task in the early Conceptual Mould Layout Design (CMLD) phase. Traditional experience-dependent manual FCMRLD workflow results in long design lead time, non-optimum designs and costs of errors. However, no previous research, existing commercial software packages or patented technologies can support FMCRLD automation and optimisation. The nature of FMCRLD is non-repetitive and generative. The complexity of FMCRLD optimisation involves solving a complex two-level combinatorial layout design optimisation problem. This research first developed the Intelligent Conceptual Mould Layout Design System (ICMLDS) prototype based on the innovative nature-inspired evolutionary FCMRLD approach for FMCRLD automation and optimisation using Genetic Algorithm (GA) and Shape Grammar (SG). The ICMLDS prototype has been proven to be a powerful intelligent design tool as well as an interactive design-training tool that can encourage and accelerate mould designers’ design alternative exploration, exploitation and optimisation for better design in less time. This previously unavailable capability enables the supporting company not only to innovate the existing traditional mould making business but also to explore new business opportunities in the high-value low-volume market (such as telecommunication, consumer electronic and medical devices) of high precision injection moulding parts. On the other hand, the innovation of this research also provides a deeper insight into the art of evolutionary design and expands research opportunities in the evolutionary design approach into a wide variety of new application areas including hot runner layout design, ejector layout design, cooling layout design and architectural space layout design.

Published
2012

22. Mutations in a Human ROBO Gene Disrupt Hindbrain Axon Pathway Crossing and Morphogenesis

Author

Jen, Joanna C., Chan, Wai-Man, Bosley, Thomas M., Wan, Jijun, Carr, Janai R., Rüb, Udo, Shattuck, David, Salamon, Georges, Kudo, Lili C., Ou, Jing, Kansu, Tülay, al Dhalaan, Hesham, al Zayed, Zayed, MacDonald, David B., Stigsby, Bent, Plaitakis, Andreas, Dretakis, Emmanuel K., Gottlob, Irene, Pieh, Christina, Traboulsi, Elias I., Wang, Qing, Wang, Lejin, Andrews, Caroline, Yamada, Koki, Demer, Joseph L., Karim, Shaheen, Alger, Jeffry R., Geschwind, Daniel H., Deller, Thomas, Sicotte, Nancy L., Nelson, Stanley F., Baloh, Robert W., and Engle, Elizabeth C.

Published
2004

26. Mutant [alpha]2-chimaerin signals via bidirectional ephrin pathways in Duane retraction syndrome

Author

Nugen, Alicia A., Park, Jong G., Wei, Yan, Tenney, Alan P., Gilette, Nicole M., DeLisle, Michelle M., Chan, Wai-Man, Cheng, Long, and Engle, Elizabeth C.

Subjects
Gene mutation -- Research, Cellular signal transduction -- Research, Neurons -- Research, Duane retraction syndrome -- Research, Health care industry
Abstract

Duane retraction syndrome (DRS) is the most common form of congenital paralytic strabismus in humans and can result from [alpha]2-chimaerin (CHN1) missense mutations. We report a knockin [alpha]2-chimaerin mouse ([Chn1.sup.KI/KI]) that models DRS. Whole embryo imaging of [Chn1.sup.KI/KI] mice revealed stalled abducens nerve growth and selective trochlear and first cervical spinal nerve guidance abnormalities. Stalled abducens nerve bundles did not reach the orbit, resulting in secondary aberrant misinnervation of the lateral rectus muscle by the oculomotor nerve. By contrast, [Chn1.sup.KO/KO] mice did not have DRS, and embryos displayed abducens nerve wandering distinct from the [Chn1.sup.KI/KI] phenotype. Murine embryos lacking EPH receptor A4 ([Epha4.sup.KO/KO]), which is upstream of [alpha]2-chimaerin in corticospinal neurons, exhibited similar abducens wandering that paralleled previously reported gait alterations in [Chn1.sup.KO/KO] and [Epha4.sup.KO/KO] adult mice. Findings from [Chn1.sup.KI/KI] [Epha4.sup.KO/KO] mice demonstrated that mutant [alpha]2-chimaerin and EphA4 have different genetic interactions in distinct motor neuron pools: abducens neurons use bidirectional ephrin signaling via mutant [alpha]2-chimaerin to direct growth, while cervical spinal neurons use only ephrin forward signaling, and trochlear neurons do not use ephrin signaling. These findings reveal a role for ephrin bidirectional signaling upstream of mutant [alpha]2-chimaerin in DRS, which may contribute to the selective vulnerability of abducens motor neurons in this disorder., Introduction Despite the complexity of axon guidance during neurodevelopment and its importance for proper circuit formation and normal behavior, few human disorders have been shown with certainty to result from [...]

Published
2017
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36. Three-year visual and anatomic results of administrating intravitreal bevacizumab in inflammatory ocular neovascularization

Author

Mansour, Ahmad M., Arevalo, J. Fernando, Fardeau, Christine, Hrisomalos, Emily N., Chan, Wai-Man, Lai, Timothy Y.Y., Ziemssen, Focke, Ness, Thomas, Sibai, Abla Mehio, Mackensen, Friederike, Wolf, Armin, Hrisomalos, Nicholas, Heiligenhaus, Arnd, Spital, Georg, Jo, Yukari, Gomi, Fumi, Ikuno, Yasushi, Akesbi, Jad, LeHoang, Phuc, Adan, Alfredo, Mahendradas, Padmamalini, Khairallah, Moncef, Guthoff, Rainer, Ghandour, Blanche, Küçükerdönmez, Cem, and Kurup, Shree K.

Published
2012
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37. Recessive variants in COL25A1 gene as novel cause of arthrogryposis multiplex congenita with ocular congenital cranial dysinnervation disorder

Author

Natera‐de Benito, Daniel, primary, Jurgens, Julie A., additional, Yeung, Alison, additional, Zaharieva, Irina T., additional, Manzur, Adnan, additional, DiTroia, Stephanie P., additional, Di Gioia, Silvio Alessandro, additional, Pais, Lynn, additional, Pini, Veronica, additional, Barry, Brenda J., additional, Chan, Wai‐Man, additional, Elder, James E., additional, Christodoulou, John, additional, Hay, Eleanor, additional, England, Eleina M., additional, Munot, Pinki, additional, Hunter, David G., additional, Feng, Lucy, additional, Ledoux, Danielle, additional, O'Donnell‐Luria, Anne, additional, Phadke, Rahul, additional, Engle, Elizabeth C., additional, Sarkozy, Anna, additional, and Muntoni, Francesco, additional

Published
2022
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38. Human CHN1 Mutations Hyperactivate α2-Chimaerin and Cause Duane's Retraction Syndrome

Author

Miyake, Noriko, Chilton, John, Psatha, Maria, Cheng, Long, Andrews, Caroline, Chan, Wai-Man, Law, Krystal, Crosier, Moira, Lindsay, Susan, Cheung, Michelle, Allen, James, Gutowski, Nick J., Ellard, Sian, Young, Elizabeth, Iannaccone, Alessandro, Appukuttan, Binoy, Stou, J. Timothy, Christiansen, Stephen, Ciccarelli, Maria Laura, Baldi, Altonso, Campioni, Mara, Zenteno, Juan C., Davenport, Dominic, Mariani, Laura E., Sahin, Mustafa, Guthrie, Sarah, and Engle, Elizabeth C.

Published
2008
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45. Long-term Visual Outcomes of Intravitreal Bevacizumab in Inflammatory Ocular Neovascularization

Author

Mansour, Ahmad M., Arevalo, J. Fernando, Ziemssen, Focke, Mehio-Sibai, Abla, Mackensen, Friederike, Adan, Alfredo, Chan, Wai-Man, Ness, Thomas, Banker, Alay S., Dodwell, David, Chau Tran, Thi Ha, Fardeau, Christine, LeHoang, Phuc, Mahendradas, Padmamalini, Berrocal, Maria, Tabbarah, Zuheir, Hrisomalos, Nicholas, Hrisomalos, Frank, Al-Salem, Khalil, and Guthoff, Rainer

Published
2009
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49. Physical distancing implementation, ambient temperature and Covid-19 containment: An observational study in the United States

Author

Guo, Cui, Chan, Shin Heng Teresa, Lin, Changqing, Zeng, Yiqian, Bo, Yacong, Zhang, Yumiao, Hossain, Md Shakhaoat, Chan, Wai Man, Yeung, David W., Lau, Alexis Kai Hon, Lao, Xiang Qian, Guo, Cui, Chan, Shin Heng Teresa, Lin, Changqing, Zeng, Yiqian, Bo, Yacong, Zhang, Yumiao, Hossain, Md Shakhaoat, Chan, Wai Man, Yeung, David W., Lau, Alexis Kai Hon, and Lao, Xiang Qian

Abstract

Governments may relax physical distancing interventions for coronavirus disease 2019 (Covid-19) containment in warm seasons/areas to prevent economic contractions. However, it is not clear whether higher temperature may offset the transmission risk posed by this relaxation. This study aims to investigate the associations of the effective reproductive number (Rt) of Covid-19 with ambient temperature and the implementation of physical distancing interventions in the United States (US). This study included 50 states and one territory of the US with 4,532,650 confirmed cases between 29 January and 31 July 2020. We used an interrupted time-series model with a state-level random intercept for data analysis. An interaction term of ‘physical distancing×temperature’ was included to examine their interactions. Stratified analyses by temperature and physical distancing implementation were also performed to analyse the modifying effects. The overall median (interquartile range) Rt was 1.2 (1.0–2.3). The implementation of physical distancing was associated with a 12% decrease in the risk of Rt (relative risk [RR]: 0.88, 95% confident interval [CI]: 0.86–0.89), and each 5 °C increase in temperature was associated with a 2% decrease (RR: 0.98, 95%CI: 0.97–0.98). We observed a statistically significant interaction between temperature and physical distancing implementation, but all the RRs were small (close to one). The containing effects of high temperature were attenuated by 5.1% when physical distancing was implemented. The association of COVID-19 Rt with physical distancing implementation was more stable (0.88 vs. 0.89 in days when temperature was low and high, respectively). Increased temperature did not offset the risk of Covid-19 Rt posed by the relaxation of physical distancing implementation. Our study does not recommend relaxing the implementation of physical distancing interventions in warm seasons/areas. © 2021 Elsevier B.V.

Published
2021

50. Meteorological factors and COVID-19 incidence in 190 countries: an observational study

Author

Guo, Cui, Bo, Yacong, Lin, Changqing, Li, Hao Bi, Zeng, Yiqian, Zhang, Yumiao, Hossain, Md Shakhaoat, Chan, Wai Man, Yeung, David W., Kwok, Kin-On, Wong, Samuel Y.S., Lau, Alexis Kai Hon, Lao, Xiangqian, Guo, Cui, Bo, Yacong, Lin, Changqing, Li, Hao Bi, Zeng, Yiqian, Zhang, Yumiao, Hossain, Md Shakhaoat, Chan, Wai Man, Yeung, David W., Kwok, Kin-On, Wong, Samuel Y.S., Lau, Alexis Kai Hon, and Lao, Xiangqian

Abstract

Novel corona virus disease 2019 (COVID-19), which first emerged in December 2019, has become a pandemic. This study aimed to investigate the associations between meteorological factors and COVID-19 incidence and mortality worldwide. This study included 1,908,197 confirmed cases of and 119,257 deaths from COVID-19 from 190 countries between 23 January and 13 April, 2020. We used a distributed lag non-linear model with city-/country-level random intercept to investigate the associations between COVID19 incidence and daily temperature, relative humidity, and wind speed. A series of confounders were considered in the analysis including demographics, socioeconomics, geographic locations, and political strategies. Sensitivity analyses were performed to examine the robustness of the associations. The COVID-19 incidence showed a stronger association with temperature than with relative humidity or wind speed. An inverse association was identified between the COVID-19 incidence and temperature. The corresponding 14-day cumulative relative risk was 1.28 [95% confidence interval (CI), 1.20–1.36] at 5 °C, and 0.75 (95% CI, 0.65–0.86) at 22 °C with reference to the risk at 11 °C. An inverse J-shaped association was observed between relative humidity and the COVID-19 incidence, with the highest risk at 72%. A higher wind speed was associated with a generally lower incidence of COVID-19, although the associations were weak. Sensitivity analyses generally yielded similar results. The COVID-19 incidence decreased with the increase of temperature. Our study suggests that the spread of COVID-19 may slow during summer but may increase during winter.

Published
2021

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