Search

Your search keyword '"Chan, Kai En"' showing total 169 results
Start Over Author "Chan, Kai En"
169 results on '"Chan, Kai En"'

2. 919 GLOBAL EPIDEMIOLOGY OF CIRRHOSIS: CHANGING ETIOLOGICAL BASIS AND DISEASE BURDEN BETWEEN FEMALES AND MALES

Author

Zeng, Rebecca Wenling, Xiao, Jieling, Fu, Clarissa E, Tan, Darren J, Chan, Kai En, Ng, Cheng Han, Lim, Wen Hui, Muthiah, Mark, Koh, Benjamin, Tan, Eunice X, Teng, Margaret LP, Dan, Yock Young, Siddiqui, Mohammad Shadab, Loomba, Rohit, and Huang, Daniel

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Nutrition and Dietetics, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Published
2023

3. 400 QUALITY ASSESSMENT OF LIVER VISUALISATION THROUGH IMAGING FOR DETECTION AND SURVEILLANCE OF HEPATOCELLULAR CARCINOMA: SYSTEMATIC REVIEW AND META-ANALYSIS

Author

Quek, Jingxuan, Xiao, Jieling, Fu, Clarissa E, Tan, Darren J, Chan, Kai En, Lim, Wen Hui, Ng, Cheng Han, Syn, Nicholas L, Teng, Margaret LP, Muthiah, Mark, Loomba, Rohit, and Huang, Daniel

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Good Health and Well Being, Neurosciences, Paediatrics and Reproductive Medicine, Gastroenterology & Hepatology, Clinical sciences, Nutrition and dietetics
Published
2023

4. Placebo Adverse Events in Non-alcoholic Steatohepatitis Clinical Trials: A Pooled Analysis of 2,944 Participants

Author

Tay, Phoebe Wen Lin, Ng, Cheng Han, Lin, Snow Yunni, Chin, Yip Han, Xiao, Jieling, Lim, Wen Hui, Lim, Sze Yinn, Fu, Clarissa Elysia, Chan, Kai En, Quek, Jingxuan, Tan, Darren Jun Hao, Chew, Nicholas, Syn, Nicholas, Keitoku, Taisei, Tamaki, Nobuharu, Siddiqui, Mohammad Shadab, Noureddin, Mazen, Muthiah, Mark, Huang, Daniel Q, and Loomba, Rohit

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Hepatitis, Clinical Research, Digestive Diseases, Clinical Trials and Supportive Activities, Liver Disease, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Humans, Non-alcoholic Fatty Liver Disease, Bile Acids and Salts, Randomized Controlled Trials as Topic, Gastroenterology & Hepatology, Clinical sciences
Abstract

IntroductionIn the absence of an effective treatment for non-alcoholic steatohepatitis (NASH), a randomized, placebo-controlled trial (RCT) remains the current gold standard study design in NASH. As NASH is a largely asymptomatic disease, the side effects of potential therapies require careful evaluation, therefore a pooled rate of the adverse events (AEs) in placebo-treated patients serves as a useful comparator for safety. Therefore, we performed a systematic review and meta-analysis to estimate the rate of AEs among participants in the placebo arm of NASH RCTs.MethodsMedline, Embase and Cochrane Central Register of Controlled Trials were searched to include clinical trials in phase 2-4 NASH RCTs with placebo treatment arms. A pooled proportions of AEs were analyzed using a generalized linear mixed model with Clopper-Pearson intervals.ResultsA total of 41 RCTs (2,944 participants on placebo) were included in this meta-analysis. A total of 68% (confidence interval [CI] 55%-77%) of participants on placebo experienced an AE, 7.8% (5.7%-10%) experienced serious AEs and 3.1% (CI: 1.9%-5.1%) experienced AEs leading to discontinuation. A significantly higher proportion of participants experienced serious AEs in phase 3 studies compared to in phase 2 studies ( P < 0.01) and in pharmaceutical funded studies as compared to studies which were federal-funded studies ( P < 0.01). An analysis of clinical trials evaluating bile acid modulating agents determined that 10% (CI: 5.5%-18%) of participants receiving placebo developed pruritus.DiscussionThe present study summarizes the AEs with NASH placebo. Among participants in the placebo arm in NASH, two-third experienced an AE, and nearly 10% experienced a serious AE.

Published
2023

5. Meta‐analysis: Chemoprevention of hepatocellular carcinoma with statins, aspirin and metformin

Author

Zeng, Rebecca W, Yong, Jie Ning, Tan, Darren JH, Fu, Clarissa E, Lim, Wen Hui, Xiao, Jieling, Chan, Kai En, Tan, Caitlyn, Goh, Xin Lei, Chee, Douglas, Syn, Nicholas, Tan, Eunice X, Muthiah, Mark D, Ng, Cheng Han, Tamaki, Nobuharu, Lee, Sung Won, Kim, Beom Kyung, Nguyen, Mindie H, Loomba, Rohit, and Huang, Daniel Q

Subjects
Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Sciences, Digestive Diseases, Liver Cancer, Prevention, Liver Disease, Chronic Liver Disease and Cirrhosis, Patient Safety, Rare Diseases, Cancer, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Good Health and Well Being, Humans, Carcinoma, Hepatocellular, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Liver Neoplasms, Aspirin, Metformin, Chemoprevention, hepatoma, incidence, liver cancer, prevention, Gastroenterology & Hepatology, Clinical sciences, Pharmacology and pharmaceutical sciences
Abstract

BackgroundEmerging data suggest that statins, aspirin and metformin may protect against hepatocellular carcinoma (HCC) development. However, prior meta-analyses were limited by heterogeneity and inclusion of studies without adequate adjustment for baseline risks.AimTo examine by an updated meta-analysis the association between these medications and HCC risk.MethodsMedline and Embase databases were searched from inception to March 2022 for studies that balanced baseline risks between study groups via propensity score matching or inverse probability of treatment weighting, that reported the impact of statins, aspirin or metformin on HCC risk. Multivariable-adjusted hazard ratios (HRs) for HCC were pooled using a random effects model.ResultsStatin use was associated with reduced HCC risk overall (HR: 0.52; 95% CI: 0.37-0.72) (10 studies, 1,774,476), and in subgroup analyses for cirrhosis, hepatitis B/C, non-alcoholic fatty liver disease, studies accounting for concurrent aspirin and metformin consumption and lipophilic statins. Aspirin use was associated with reduced HCC risk overall (HR: 0.48; 95% CI: 0.27-0.87) (11 studies, 2,190,285 patients) but not in studies accounting for concurrent statin and metformin use. Metformin use was not associated with reduced HCC risk overall (HR: 0.57; 95% CI: 0.31-1.06) (3 studies, 125,458 patients). Most analyses had moderate/substantial heterogeneity, except in follow-up

Published
2023

6. Efficacy and safety of tirzepatide for treatment of overweight or obesity. A systematic review and meta-analysis

Author

Tan, Bryan, Pan, Xin-Hui, Chew, Han Shi Jocelyn, Goh, Rachel Sze Jen, Lin, Chaoxing, Anand, Vickram Vijay, Lee, Ethan Cheng Zhe, Chan, Kai En, Kong, Gwyneth, Ong, Christen En Ya, Chung, Hui Charlotte, Young, Dan Yock, Chan, Mark Y., Khoo, Chin Meng, Mehta, Anurag, Muthiah, Mark Dhinesh, Noureddin, Mazen, Ng, Cheng Han, Chew, Nicholas W. S., and Chin, Yip Han

Published
2023
Full Text
View/download PDF

7. Longitudinal Outcomes Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease: A Meta-analysis of 129 Studies

Author

Chan, Kai En, Ong, Elden Yen Hng, Chung, Charlotte Hui, Ong, Christen En Ya, Koh, Benjamin, Tan, Darren Jun Hao, Lim, Wen Hui, Yong, Jie Ning, Xiao, Jieling, Wong, Zhen Yu, Syn, Nicholas, Kaewdech, Apichat, Teng, Margaret, Wang, Jiong-Wei, Chew, Nicholas, Young, Dan Yock, Know, Alfred, Siddiqui, Mohammad Shadab, Huang, Daniel Q., Tamaki, Nobuharu, Wong, Vincent Wai-Sun, Mantzoros, Christos S., Sanyal, Arun, Noureddin, Mazen, Ng, Cheng Han, and Muthiah, Mark

Published
2024
Full Text
View/download PDF

8. Management of corneal neovascularization: Current and emerging therapeutic approaches

Author

Wu, Duoduo, Chan, Kai En, Lim, Blanche Xiao Hong, Lim, Dawn Ka-Ann, Wong, Wendy Meihua, Chai, Charmaine, Manotosh, Ray, and Lim, Chris Hong Long

Subjects
Verteporfin -- Health aspects, Stem cells -- Health aspects, Vascular endothelial growth factor -- Health aspects, Pegaptanib -- Health aspects, Company business management, Health
Abstract

Corneal neovascularization (CoNV) is a sight-threatening condition affecting an estimated 1.4 million people per year, and the incidence is expected to rise. It is a complication of corneal pathological diseases such as infective keratitis, chemical burn, corneal limbal stem cell deficiency, mechanical trauma, and immunological rejection after keratoplasties. CoNV occurs due to a disequilibrium in proangiogenic and antiangiogenic mediators, involving a complex system of molecular interactions. Treatment of CoNV is challenging, and no therapy thus far has been curative. Anti-inflammatory agents such as corticosteroids are the mainstay of treatment due to their accessibility and well-studied safety profile. However, they have limited effectiveness and are unable to regress more mature neovascularization. With the advent of advanced imaging modalities and an expanding understanding of its pathogenesis, contemporary treatments targeting a wide array of molecular mechanisms and surgical options are gaining traction. This review aims to summarize evidence regarding conventional and emerging therapeutic options for CoNV. Keywords: Anti-VEGF, cornea, corneal neovascularization, gene therapy, Author(s): Duoduo Wu [1]; Kai En Chan [2]; Blanche Xiao Hong Lim [1,2]; Dawn Ka-Ann Lim [1,2]; Wendy Meihua Wong [1,2]; Charmaine Chai [1,2]; Ray Manotosh [1,2]; Chris Hong Long [...]

Published
2024
Full Text
View/download PDF

9. The Spectrum and Impact of Metabolic Dysfunction in MAFLD: A Longitudinal Cohort Analysis of 32,683 Overweight and Obese Individuals

Author

Chan, Kai En, Ng, Cheng Han, Fu, Clarissa Elysia, Quek, Jingxuan, Kong, Gwyneth, Goh, Yi Jie, Zeng, Rebecca Wenling, Tseng, Michael, Aggarwal, Manik, Nah, Benjamin, Chee, Douglas, Wong, Zhen Yu, Zhang, Sitong, Wang, Jiong-Wei, Chew, Nicholas W.S., Dan, Yock Young, Siddiqui, Mohammad Shadab, Noureddin, Mazen, Sanyal, Arun J., and Muthiah, Mark

Published
2023
Full Text
View/download PDF

10. Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD – An Umbrella Overview of Systematic Review of Meta-Analysis

Author

Xiao, Jieling, Ng, Cheng Han, Chan, Kai En, Fu, Clarissa, Tay, Phoebe, Yong, Jie Ning, Lim, Wen Hui, Tan, Darren Jun Hao, Syn, Nicholas, Wong, Zhen Yu, Tseng, Michael, Chew, Nicholas, Huang, Daniel Q., Dan, Yock Yong, Wong, Vincent Wai-Sun, Loomba, Rohit, Siddiqui, Mohammad S., Sanyal, Arun J., Noureddin, Mazen, and Muthiah, Mark D.

Published
2023
Full Text
View/download PDF

11. Comparative Burden of Metabolic Dysfunction in Lean NAFLD vs Non-lean NAFLD - A Systematic Review and Meta-analysis

Author

Tang, Ansel, Ng, Cheng Han, Phang, Poh Hui, Chan, Kai En, Chin, Yip Han, Fu, Clarissa Elysia, Zeng, Rebecca Wenling, Xiao, Jieling, Tan, Darren Jun Hao, Quek, Jingxuan, Lim, Wen Hui, Mak, Lung Yi, Wang, Jiong-wei, Chew, Nicholas W.S., Syn, Nicholas, Huang, Daniel Q., Siddiqui, Mohammad Shadab, Sanyal, Arun, Muthiah, Mark, and Noureddin, Mazen

Published
2023
Full Text
View/download PDF

13. The global syndemic of metabolic diseases in the young adult population: A consortium of trends and projections from the Global Burden of Disease 2000–2019

Author

Chong, Bryan, Kong, Gwyneth, Shankar, Kannan, Chew, H.S. Jocelyn, Lin, Chaoxing, Goh, Rachel, Chin, Yip Han, Tan, Darren Jun Hao, Chan, Kai En, Lim, Wen Hui, Syn, Nicholas, Chan, Siew Pang, Wang, Jiong-Wei, Khoo, Chin Meng, Dimitriadis, Georgios K., Wijarnpreecha, Karn, Sanyal, Arun, Noureddin, Mazen, Siddiqui, Mohammad Shadab, Foo, Roger, Mehta, Anurag, Figtree, Gemma A., Hausenloy, Derek J., Chan, Mark Y., Ng, Cheng Han, Muthiah, Mark, Mamas, Mamas A., and Chew, Nicholas W.S.

Published
2023
Full Text
View/download PDF

14. Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019

Author

Chong, Bryan, Jayabaskaran, Jayanth, Kong, Gwyneth, Chan, Yiong Huak, Chin, Yip Han, Goh, Rachel, Kannan, Shankar, Ng, Cheng Han, Loong, Shaun, Kueh, Martin Tze Wah, Lin, Chaoxing, Anand, Vickram Vijay, Lee, Ethan Cheng Zhe, Chew, H.S. Jocelyn, Tan, Darren Jun Hao, Chan, Kai En, Wang, Jiong-Wei, Muthiah, Mark, Dimitriadis, Georgios K., Hausenloy, Derek J., Mehta, Anurag J., Foo, Roger, Lip, Gregory, Chan, Mark Y., Mamas, Mamas A., le Roux, Carel W., and Chew, Nicholas W.S.

Published
2023
Full Text
View/download PDF

15. Clinical Course, Immunogenicity, and Efficacy of BNT162b2 mRNA Vaccination Against SARS-CoV-2 Infection in Liver Transplant Recipients

Author

Tan, Eunice X., Lim, Wen Hui, Thong, Elizabeth, Chavatte, Jean-Marc, Zhang, Jinyan, Lim, Jonathan, Jin, Jocelyn Y., Lim, Daniel R.X., Kang, Jaclyn Y.T., Tang, Ansel Shao Pin, Chan, Kai En, Tan, Caitlyn, Tan, Shi Ni, Nah, Benjamin, Huang, Daniel Q., Wang, Lin-Fa, Tambyah, Paul A., Somani, Jyoti, Young, Barnaby, and Muthiah, Mark D.

Published
2023
Full Text
View/download PDF

16. Global prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in the overweight and obese population: a systematic review and meta-analysis

Author

Quek, Jingxuan, Chan, Kai En, Wong, Zhen Yu, Tan, Caitlyn, Tan, Bryan, Lim, Wen Hui, Tan, Darren Jun Hao, Tang, Ansel Shao Pin, Tay, Phoebe, Xiao, Jieling, Yong, Jie Ning, Zeng, Rebecca Wenling, Chew, Nicholas W S, Nah, Benjamin, Kulkarni, Anand, Siddiqui, Mohammad Shadab, Dan, Yock Young, Wong, Vincent Wai-Sun, Sanyal, Arun J, Noureddin, Mazen, Muthiah, Mark, and Ng, Cheng Han

Published
2023
Full Text
View/download PDF

17. Type 2 diabetes mellitus in metabolic-associated fatty liver disease vs. type 2 diabetes mellitus non-alcoholic fatty liver disease: a longitudinal cohort analysis

Author

Muthiah, Mark, Ng, Cheng Han, Chan, Kai En, Fu, Clarissa Elysia, Lim, Wen Hui, Tan, Darren Jun Hao, Nah, Benjamin, Kong, Gwyneth, Xiao, Jieling, Yong, Jie Ning, Tan, Bryan, Syn, Nicholas, Wang, Jiong-Wei, Sayed, Nilofer, Tan, Eunice, Chew, Nicholas WS, Dan, Yock Young, Siddiqui, Mohammad Shadab, Sanyal, Arun J., and Noureddin, Mazen

Published
2023
Full Text
View/download PDF

18. The placebo response rate and nocebo events in obesity pharmacological trials. A systematic review and meta-analysis

Author

Chin, Yip Han, Ng, Cheng Han, Chew, Nicholas WS, Kong, Gwyneth, Lim, Wen Hui, Tan, Darren Jun Hao, Chan, Kai En, Tang, Ansel, Huang, Daniel Q, Chan, Mark Y, Figtree, Gemma, Wang, Jiong-Wei, Shabbir, Asim, Khoo, Chin Meng, Wong, Vincent Wai-Sun, Young, Dan Yock, Siddiqui, Mohammad Shadab, Noureddin, Mazen, Sanyal, Arun, Cummings, David E., Syn, Nicholas, and Muthiah, Mark Dhinesh

Published
2022
Full Text
View/download PDF

19. Global Epidemiology of Cirrhosis: Changing Etiological Basis and Comparable Burden of Nonalcoholic Steatohepatitis between Males and Females

Author

Tan, Darren, primary, Chan, Kai En, additional, Wong, Zhen Yu, additional, Ng, Cheng Han, additional, Xiao, Jieling, additional, Lim, Wen Hui, additional, Tay, Phoebe, additional, Tang, Ansel, additional, Fu, Clarissa Elysia, additional, Muthiah, Mark, additional, Nah, Benjamin, additional, Tan, Eunice X., additional, Teng, Margaret L.P., additional, Siddiqui, Mohammad Shadab, additional, Dan, Yock Young, additional, Lim, Seng Gee, additional, Loomba, Rohit, additional, and Huang, Daniel Q., additional

Published
2023
Full Text
View/download PDF

20. Longitudinal Outcomes Associated with Metabolic Dysfunction-Associated Steatotic Liver Disease. A Meta Analysis of 129 Studies

Author

Chan, Kai En, primary, Ong, Elden Yen Hng, additional, Chung, Charlotte Hui, additional, Ong, Christen En Ya, additional, Koh, Benjamin, additional, Tan, Darren Jun Hao, additional, Lim, Wen Hui, additional, Yong, Jie Ning, additional, Xiao, Jieling, additional, Wong, Zhen Yu, additional, Syn, Nicholas, additional, Kaewdech, Apichat, additional, Teng, Margaret, additional, Wang, Jiong-Wei, additional, Chew, Nicholas, additional, Young, Dan Yock, additional, Kow, Alfred, additional, Siddiqui, Mohammad Shadab, additional, Huang, Daniel Q., additional, Tamaki, Nobuharu, additional, Wong, Vincent Wai-Sun, additional, Mantzoros, Christos S., additional, Sanyal, Arun, additional, Noureddin, Mazen, additional, Ng, Cheng Han, additional, and Muthiah, Mark, additional

Published
2023
Full Text
View/download PDF

21. Non-alcoholic fatty liver disease and the longitudinal risks of clinical outcomes: a meta-analysis

Author

Chan, Kai En, primary, Hng Ong, Elden Yen, additional, Hui Ong, Charlotte Chung, additional, Ya Ong, Christen En, additional, Feng Koh, Benjamin Wei, additional, Tang, Ansel, additional, Teng, Margaret, additional, Lim, Wen Hui, additional, Hao Tan, Darren Jun, additional, Huang, Daniel, additional, Siddiqui, Mohammad Shadab, additional, Noureddin, Mazen, additional, Sanyal, Arun, additional, Ng, Cheng Han, additional, and Muthiah, Mark, additional

Published
2023
Full Text
View/download PDF

22. Mortality, Cardiovascular, and Medication Outcomes in Patients With Myocardial Infarction and Underweight in a Meta-Analysis of 6.3 Million Patients

Author

Lin, Chaoxing, primary, Loke, Wan Hsien, additional, Ng, Bing Han, additional, Chin, Yip Han, additional, Chong, Bryan, additional, Goh, Rachel Sze Jen, additional, Kong, Gwyneth, additional, Ong, Christen En Ya, additional, Chan, Kai En, additional, Fu, Clarissa, additional, Idnani, Tasha, additional, Muthiah, Mark D., additional, Khoo, Chin Meng, additional, Foo, Roger, additional, Loh, Poay Huan, additional, Chan, Mark Y., additional, Brown, Adrian, additional, Dimitriadis, Georgios K., additional, and Chew, Nicholas W.S., additional

Published
2023
Full Text
View/download PDF

23. Higher Risk of Adverse Cardiovascular Outcomes in Females with Type 2 Diabetes Mellitus: An Umbrella Review of Systematic Reviews

Author

Yaow, Clyve Yu Leon, primary, Chong, Bryan, additional, Chin, Yip Han, additional, Kueh, Martin Tze Wah, additional, Ng, Cheng Han, additional, Chan, Kai En, additional, Tang, Ansel Shao Pin, additional, Chung, Charlotte, additional, Goh, Rachel, additional, Kong, Gwyneth, additional, Muthiah, Mark, additional, Sukmawati, Indah, additional, Lukito, Antonia Anna, additional, Chan, Mark Y, additional, Khoo, Chin Meng, additional, Mehta, Anurag, additional, Mamas, Mamas A, additional, Dimitriadis, Georgios K, additional, and Chew, Nicholas W S, additional

Published
2023
Full Text
View/download PDF

24. Meta‐analysis: Prevalence of significant or advanced fibrosis in adults with alpha‐1‐antitrypsin deficiency

Author

Huang, Daniel Q., primary, Chan, Kai En, additional, Tan, Caitlyn, additional, Zeng, Rebecca Wenling, additional, Koh, Benjamin, additional, Ong, Elden Yen Hng, additional, Ong, Charlotte Chung Hui, additional, Ong, Christen En Ya, additional, Tan, Darren J. H., additional, Lim, Wen Hui, additional, Cho, Elina, additional, Tan, Eunice X. X., additional, Teng, Margaret L. P., additional, Ng, Cheng Han, additional, Nah, Benjamin, additional, Lim, Mei Chin, additional, Muthiah, Mark, additional, Clark, Virginia C., additional, and Loomba, Rohit, additional

Published
2023
Full Text
View/download PDF

25. Quality Assessment of Ultrasound and Magnetic Resonance Imaging for Hepatocellular Carcinoma Surveillance: A Systematic Review and Meta-Analysis.

Author

Quek, Jingxuan, Tan, Darren Jun Hao, Chan, Kai En, Lim, Wen Hui, Ng, Cheng Han, Ren, Yi Ping, Koh, Teng Kiat, Teh, Readon, Xiao, Jieling, Fu, Clarissa, Syn, Nicholas, Teng, Margaret, Muthiah, Mark, Fowler, Kathryn J., Sirlin, Claude B., Loomba, Rohit, and Huang, Daniel Q.

Subjects
FATTY liver, MAGNETIC resonance imaging, HEPATOCELLULAR carcinoma, NON-alcoholic fatty liver disease, ULTRASONIC imaging
Abstract

Introduction: To achieve early detection and curative treatment options, surveillance imaging for hepatocellular carcinoma (HCC) must remain of quality and without substantial limitations in liver visualization. However, the prevalence of limited liver visualization during HCC surveillance imaging has not been systematically assessed. Utilizing a systematic review and meta-analytic approach, we aimed to determine the prevalence of limited liver visualization during HCC surveillance imaging. Methods: MEDLINE and Embase electronic databases were searched to identify published data on liver visualization limitations of HCC surveillance imaging. An analysis of proportions was pooled using a generalized linear mixed model with Clopper-Pearson intervals. Risk factors were analysed using a generalized mixed model with a logit link and inverse variance weightage. Results: Of 683 records, 10 studies (7,131 patients) met inclusion criteria. Seven studies provided data on liver visualization limitations on ultrasound (US) surveillance exams: prevalence of limited liver visualization was 48.9% (95% CI: 23.5–74.9%) in the overall analysis and 59.2% (95% CI: 24.2–86.9%) in a sensitivity analysis for cirrhotic patients. Meta-regression determined that non-alcoholic fatty liver disease was associated with limited liver visualization on US. Four studies provided data for liver visualization limitations in abbreviated magnetic resonance imaging (aMRI), with inadequate visualization ranging from 5.8% to 19.0%. One study provided data for complete MRI and none for computed tomography. Conclusion: A substantial proportion of US exams performed for HCC surveillance provide limited liver visualization, especially in cirrhosis, which may hinder detection of small observations. Alternative surveillance strategies including aMRI may be appropriate for patients with limited US visualization. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

27. Safety and tolerability of obeticholic acid in chronic liver disease: a pooled analysis of 1878 individuals

Author

Ng, Cheng Han, primary, Tang, Ansel Shao Pin, additional, Xiao, Jieling, additional, Wong, Zhen Yu, additional, Yong, Jie Ning, additional, Fu, Clarissa E., additional, Zeng, Rebecca W., additional, Tan, Caitlyn, additional, Wong, Gabriel Hong Zhe, additional, Teng, Margaret, additional, Chee, Douglas, additional, Tan, Darren Jun Hao, additional, Chan, Kai En, additional, Huang, Daniel Q., additional, Chew, Nicholas W.S., additional, Nah, Benjamin, additional, Siddqui, Mohammad S., additional, Sanyal, Arun J., additional, Noureddin, Mazen, additional, and Muthiah, Mark, additional

Published
2023
Full Text
View/download PDF

28. Hepatic steatosis and advanced hepatic fibrosis are independent predictors of long‐term mortality in acute myocardial infarction

Author

Chin, YipHan, primary, Lim, Jieyu, additional, Kong, Gwyneth, additional, Ng, Cheng Han, additional, Goh, Rachel, additional, Muthiah, Mark, additional, Mehta, Anurag, additional, Chong, Bryan, additional, Lin, Chaoxing, additional, Chan, Kai En, additional, Kong, William, additional, Poh, Kian Keong, additional, Foo, Roger, additional, Chai, Ping, additional, Yeo, Tiong‐Cheng, additional, Low, Adrian F., additional, Lee, Chi Hang, additional, Tan, Huay Cheem, additional, Chan, Mark Yan‐Yee, additional, Richards, A Mark, additional, Loh, Poay‐Huan, additional, and Chew, Nicholas W. S., additional

Published
2023
Full Text
View/download PDF

29. Examining the interim proposal for name change to steatotic liver disease in the US population

Author

Ng, Cheng Han, primary, Chan, Kai En, additional, Muthiah, Mark, additional, Tan, Caitlyn, additional, Tay, Phoebe, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Fu, Clarissa Elysia, additional, Yong, Jie Ning, additional, Wong, Zhen Yu, additional, Koh, Benjamin, additional, Chew, Nicholas WS, additional, Syn, Nicholas, additional, Huang, Daniel Q., additional, Young Dan, Yock, additional, Siddiqui, Mohammad S., additional, Sanyal, Arun J., additional, and Noureddin, Mazen, additional

Published
2023
Full Text
View/download PDF

30. De novo metabolic syndrome after liver transplantation: a meta-analysis on cumulative incidence, risk factors, and outcomes

Author

Lim, Wen Hui, primary, Tan, Caitlyn, additional, Xiao, Jieling, additional, Tan, Darren Jun Hao, additional, Ng, Cheng Han, additional, Yong, Jie Ning, additional, Fu, Clarissa, additional, Chan, Kai En, additional, Zeng, Rebecca Wenling, additional, Ren, Yi Ping, additional, Goh, Xin Lei, additional, Chew, Nicholas, additional, Tseng, Michael, additional, Syn, Nicholas, additional, Mak, Lung Yi, additional, Fung, James, additional, Muthiah, Mark, additional, Siddiqui, Mohammad Shadab, additional, and Tan, Eunice X.X., additional

Published
2023
Full Text
View/download PDF

31. A Meta-analysis on Associated Risk of Mortality in Nonalcoholic Fatty Liver Disease

Author

Fu, Clarissa Elysia, primary, Ng, Cheng Han, additional, Yong, Jie Ning, additional, Chan, Kai En, additional, Xiao, Jieling, additional, Nah, Benjamin, additional, Bong, Shirley Huey Shin, additional, Win, Khin Maung, additional, Bwa, Aung Hlaing, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Zeng, Rebecca Wenling, additional, Chew, Nicholas, additional, Teng, Margaret L.P., additional, Siddiqui, Mohammad Shadab, additional, Oben, Jude A., additional, Sanyal, Arun J., additional, Wong, Vincent Wai-Sun, additional, Noureddin, Mazen, additional, and Muthiah, Mark, additional

Published
2023
Full Text
View/download PDF

32. A qualitative systematic review of anonymous/unspecified living kidney and liver donors’ perspectives

Author

Lim, Wen Hui, primary, Chan, Kai En, additional, Ng, Cheng Han, additional, Tan, Darren Jun Hao, additional, Tay, Phoebe Wen Lin, additional, Chin, Yip Han, additional, Yong, Jie Ning, additional, Xiao, Jieling, additional, Fu, Clarissa Elysia, additional, Nah, Benjamin, additional, Tiong, Ho Yee, additional, Syn, Nicholas, additional, Devi, Kamala, additional, Griva, Konstadina, additional, Mak, Loey Lung Yi, additional, Huang, Daniel Q., additional, Fung, James, additional, Siddiqui, Mohammad Shadab, additional, Muthiah, Mark, additional, and Tan, Eunice X. X., additional

Published
2022
Full Text
View/download PDF

33. A network meta-analysis of 12,116 individuals from randomized controlled trials in the treatment of depression after acute coronary syndrome

Author

Lim, Grace En Hui, primary, Tang, Ansel, additional, Chin, Yip Han, additional, Yong, Jie Ning, additional, Tan, Darren, additional, Tay, Phoebe, additional, Chan, Yu Yi, additional, Lim, Denzel Ming Wei, additional, Yeo, Jun Wei, additional, Chan, Kai En, additional, Devi, Kamala, additional, Ong, Colin Eng Choon, additional, Foo, Roger S. Y., additional, Tan, Huay-Cheem, additional, Chan, Mark Y., additional, Ho, Roger, additional, Loh, Poay Huan, additional, and Chew, Nicholas W. S., additional

Published
2022
Full Text
View/download PDF

34. Placebo Adverse Events in Non-alcoholic Steatohepatitis Clinical Trials: A Pooled Analysis of 2,944 Participants

Author

Tay, Phoebe Wen Lin, primary, Ng, Cheng Han, additional, Lin, Snow Yunni, additional, Chin, Yip Han, additional, Xiao, Jieling, additional, Lim, Wen Hui, additional, Lim, Sze Yinn, additional, Fu, Clarissa Elysia, additional, Chan, Kai En, additional, Quek, Jingxuan, additional, Tan, Darren Jun Hao, additional, Chew, Nicholas, additional, Syn, Nicholas, additional, Keitoku, Taisei, additional, Tamaki, Nobuharu, additional, Siddiqui, Mohammad Shadab, additional, Noureddin, Mazen, additional, Muthiah, Mark, additional, Huang, Daniel Q., additional, and Loomba, Rohit, additional

Published
2022
Full Text
View/download PDF

36. Hepatic, Extra-hepatic Outcomes and Causes of Mortality in NAFLD – An Umbrella Overview of Systematic Review of Meta-Analysis

Author

Xiao, Jieling, primary, Ng, Cheng Han, additional, Chan, Kai En, additional, Fu, Clarissa, additional, Tay, Phoebe, additional, Yong, Jie Ning, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Syn, Nicholas, additional, Wong, Zhen Yu, additional, Tseng, Michael, additional, Chew, Nicholas, additional, Huang, Daniel Q., additional, Dan, Yock Yong, additional, Wong, Vincent Wai-Sun, additional, Loomba, Rohit, additional, Siddiqui, Mohammad S., additional, Sanyal, Arun J., additional, Noureddin, Mazen, additional, and Muthiah, Mark D., additional

Published
2022
Full Text
View/download PDF

37. DEXA Scan Body Fat Mass Distribution in Obese and Non-Obese Individuals and Risk of NAFLD—Analysis of 10,865 Individuals

Author

Tan, Caitlyn, primary, Chan, Kai En, additional, Ng, Cheng Han, additional, Tseng, Michael, additional, Syn, Nicholas, additional, Tang, Ansel Shao Pin, additional, Chin, Yip Han, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Chew, Nicholas, additional, Ong, Elden Yen Hng, additional, Koh, Teng Kiat, additional, Xiao, Jieling, additional, Chee, Douglas, additional, Valsan, Arun, additional, Siddiqui, Mohammad Shadab, additional, Huang, Daniel, additional, Noureddin, Mazen, additional, Wijarnpreecha, Karn, additional, and Muthiah, Mark D., additional

Published
2022
Full Text
View/download PDF

38. Depression in non-alcoholic fatty liver disease is associated with an increased risk of complications and mortality

Author

Ng, Cheng Han, primary, Xiao, Jieling, additional, Chew, Nicholas W. S., additional, Chin, Yip Han, additional, Chan, Kai En, additional, Quek, Jingxuan, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Loke, Ryan Wai Keong, additional, Tan, Caitlyn, additional, Tang, Ansel Shao Pin, additional, Goh, Xin Lei, additional, Nah, Benjamin, additional, Syn, Nicholas, additional, Young, Dan Yock, additional, Tamaki, Nobuharu, additional, Huang, Daniel Q., additional, Siddiqui, Mohammad Shadab, additional, Noureddin, Mazen, additional, Sanyal, Arun, additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

39. The Spectrum and Impact of Metabolic Dysfunction in MAFLD: A Longitudinal Cohort Analysis of 32,683 Overweight and Obese Individuals

Author

Chan, Kai En, primary, Ng, Cheng Han, additional, Fu, Clarissa Elysia, additional, Quek, Jingxuan, additional, Kong, Gwyneth, additional, Goh, Yi Jie, additional, Zeng, Rebecca Wenling, additional, Tseng, Michael, additional, Aggarwal, Manik, additional, Nah, Benjamin, additional, Chee, Douglas, additional, Wong, Zhen Yu, additional, Zhang, Sitong, additional, Wang, Jiong-Wei, additional, Chew, Nicholas W.S., additional, Dan, Yock Young, additional, Siddiqui, Mohammad Shadab, additional, Noureddin, Mazen, additional, Sanyal, Arun J., additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

41. A poor perspective of self weight significantly increases adverse outcomes in non-alcoholic fatty liver disease (NAFLD)

Author

Fu, Clarissa Elysia, primary, Ng, Cheng Han, additional, Chew, Nicholas W. S., additional, Heng, Zane En Qi, additional, Chin, Yip Han, additional, Quek, Jingxuan, additional, Lim, Wen Hui, additional, Xiao, Jieling, additional, Chan, Kai En, additional, Tan, Darren Jun Hao, additional, Tan, Caitlyn, additional, Zhang, Sitong, additional, Koh, Teng Kiat, additional, Nah, Benjamin, additional, Dan, Yock Young, additional, Syn, Nicholas, additional, Siddiqui, Mohammad Shadab, additional, Sanyal, Arun J., additional, Noureddin, Mazen, additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

42. Statins decrease overall mortality and cancer related mortality but are underutilized in NAFLD: a longitudinal analysis of 12,538 individuals

Author

Ng, Cheng Han, primary, Teng, Margaret LP, additional, Chew, Nicholas WS, additional, Chan, Kai En, additional, Yong, Jie Ning, additional, Quek, Jingxuan, additional, Tan, Darren Jun Hao, additional, Lim, Wen Hui, additional, Lee, Gabriel Sheng Jie, additional, Wong, Jessica, additional, Kaewdech, Apichat, additional, Huang, Daniel Q, additional, Wang, Jiongwei, additional, Chan, Mark Y, additional, Noureddin, Mazen, additional, Siddiqui, Mohammad Shadab, additional, Sanyal, Arun, additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

48. Historical Changes in Weight Classes and the Influence of NAFLD Prevalence: A Population Analysis of 34,486 Individuals

Author

Nah, Benjamin Kai Yi, primary, Ng, Cheng Han, additional, Chan, Kai En, additional, Tan, Caitlyn, additional, Aggarwal, Manik, additional, Zeng, Rebecca Wenling, additional, Xiao, Jieling, additional, Chin, Yip Han, additional, Tan, Eunice X. X., additional, Ren, Yi Ping, additional, Chee, Douglas, additional, Neo, Jonathan, additional, Chew, Nicholas W. S., additional, Tseng, Michael, additional, Siddiqui, Mohammad Shadab, additional, Sanyal, Arun J., additional, Dan, Yock Young, additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

49. Complete alcohol abstinence increases the risk of NAFLD but not severity. A population analysis with transient elastography

Author

Xiao, Jieling, primary, Ng, Cheng Han, additional, Chan, Kai En, additional, Tang, Ansel Shao Pin, additional, Teh, Readon, additional, Ling, Abel Ho Zhi, additional, Yong, Jie Ning, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Tan, Caitlyn, additional, Win, Khin Maung, additional, Bwa, Aung Hlaing, additional, Chew, Nicholas W. S., additional, Huang, Daniel, additional, Dan, Yock Young, additional, Noureddin, Mazen, additional, Siddiqui, Mohammad Shadab, additional, Sanyal, Arun, additional, Tamaki, Nobuharu, additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

50. Hypertension is prevalent in non-alcoholic fatty liver disease and increases all-cause and cardiovascular mortality

Author

Ng, Cheng Han, primary, Wong, Zhen Yu, additional, Chew, Nicholas W. S., additional, Chan, Kai En, additional, Xiao, Jieling, additional, Sayed, Nilofer, additional, Lim, Wen Hui, additional, Tan, Darren Jun Hao, additional, Loke, Ryan Wai Keong, additional, Tay, Phoebe Wen Lin, additional, Yong, Jie Ning, additional, Kong, Gywneth, additional, Huang, Daniel Q., additional, Wang, Jiong-Wei, additional, Chan, Mark, additional, Dalakoti, Mayank, additional, Tamaki, Nobuharu, additional, Noureddin, Mazen, additional, Siddiqui, Mohammad Shadab, additional, Sanyal, Arun J., additional, and Muthiah, Mark, additional

Published
2022
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results