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18. Nutritional Assessments by Bioimpedance Technique in Dialysis Patients.

Author

Ng, Jack Kit-Chung, Lau, Sam Lik-Fung, Chan, Gordon Chun-Kau, Tian, Na, and Li, Philip Kam-Tao

Abstract

Bioelectrical impedance analysis (BIA) has been extensively applied in nutritional assessments on the general population, and it is recommended in establishing the diagnosis of malnutrition and sarcopenia. The bioimpedance technique has become a promising modality through which to measure the whole-body composition in dialysis patients, where the presence of subclinical volume overload and sarcopenic obesity may be overlooked by assessing body weight alone. In the past two decades, bioimpedance devices have evolved from applying a single frequency to a range of frequencies (bioimpedance spectroscopy, BIS), in which the latter is incorporated with a three-compartment model that allows for the simultaneous measurement of the volume of overhydration, adipose tissue mass (ATM), and lean tissue mass (LTM). However, clinicians should be aware of common potential limitations, such as the adoption of population-specific prediction equations in some BIA devices. Inherent prediction error does exist in the bioimpedance technique, but the extent to which this error becomes clinically significant remains to be determined. Importantly, reduction in LTM has been associated with increased risk of frailty, hospitalization, and mortality in dialysis patients, whereas the prognostic value of ATM remains debatable. Further studies are needed to determine whether modifications of bioimpedance-derived body composition parameters through nutrition intervention can result in clinical benefits. [ABSTRACT FROM AUTHOR]

Published
2024
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19. Safety Profile and Clinical and Virological Outcomes of Nirmatrelvir-Ritonavir Treatment in Patients With Advanced Chronic Kidney Disease and Coronavirus Disease 2019

Author

Chan, Gordon Chun Kau, primary, Lui, Grace Chung Yan, additional, Wong, Candy Ngai Sze, additional, Yip, Sindy Sin Ting, additional, Li, Timothy Chun Man, additional, Cheung, Catherine Siu King, additional, Sze, Ryan Kin Ho, additional, Szeto, Cheuk Chun, additional, and Chow, Kai Ming, additional

Published
2023
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20. Urinary Long Non-Coding RNA Levels as Biomarkers of Lupus Nephritis

Author

Szeto, Cheuk-Chun, primary, So, Ho, additional, Poon, Peter Yam-Kau, additional, Luk, Cathy Choi-Wan, additional, Ng, Jack Kit-Chung, additional, Fung, Winston Wing-Shing, additional, Chan, Gordon Chun-Kau, additional, Chow, Kai-Ming, additional, Lai, Fernand Mac-Moune, additional, and Tam, Lai-Shan, additional

Published
2023
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25. Epidemiology and Outcomes of Hypernatraemia in Patients with COVID-19—A Territory-Wide Study in Hong Kong

Author

So, Benjamin Y. F., primary, Wong, Chun Ka, additional, Chan, Gordon Chun Kau, additional, Ng, Jack Kit Chung, additional, Lui, Grace Chung Yan, additional, Szeto, Cheuk Chun, additional, Hung, Ivan Fan Ngai, additional, Tse, Hung Fat, additional, Tang, Sydney C. W., additional, Chan, Tak Mao, additional, Chow, Kai Ming, additional, and Yap, Desmond Y. H., additional

Published
2023
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27. Epidemiology and outcomes of hyponatremia in patients with COVID-19—A territory-wide study in Hong Kong

Author

Chan, Gordon Chun Kau, primary, Wong, Chun Ka, additional, So, Benjamin Y. F., additional, Ng, Jack Kit Chung, additional, Lui, Grace Chung Yan, additional, Szeto, Cheuk Chun, additional, Hung, Ivan Fan Ngai, additional, Tse, Hung Fat, additional, Tang, Sydney C. W., additional, Chan, Tak Mao, additional, Chow, Kai Ming, additional, and Yap, Desmond Y. H., additional

Published
2023
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28. Additional file 1 of Plasma vaspin levels and clinical outcome in incident peritoneal dialysis patients

Author

Than, Win Hlaing, Chan, Gordon Chun-Kau, Kwan, Bonnie Ching-Ha, Lai, Ka-Bik, Chan, Ronald Cheong-Kin, Teoh, Jeromy Yuen Chun, Ng, Jack Kit-Chung, Fung, Winston Wing-Shing, Chow, Kai-Ming, Cheng, Phyllis Mei-Shan, Li, Philip Kam-Tao, and Szeto, Cheuk-Chun

Abstract

Additional file 1: Supplementary Table 1. Correlation between plasma vaspin level and baseline clinical and biochemical parameters according to diabetic status. PDE, peritoneal dialysis effluent; LDL, low-density lipoprotein; HDL, high-density lipoprotein; PTH, parathyroid hormone; SGA, subjective global assessment overall score; MIS, malnutrition inflammation score; E: I ratio, extra-cellular to intracellular volume ratio; D/P4, dialysate-to-plasma creatinine concentration at 4 hours; MTAC, mass transfer areas coefficient of creatinine; GFR, glomerular filtration rate; FEBM, fat-free edema-free body mass, NAPA for normalized protein nitrogen appearance; PWV, pulse wave velocity. Data are compared by Spearman’s rank correlation coefficient. Supplementary Table 2. Correlation between plasma vaspin level and insulin resistance. HbA1C, Hemoglobin A1C; HOMA, Homeostatic Model Assessment; IR, Insulin resistance; 2B, beta 2 cell function. Data are compared by Spearman’s rank correlation coefficient. Supplementary Table 3. Cox regression analysis for patient survival (all patients). HR, hazards ratio; AHR, adjusted hazards ratio; CI, confidence interval; GFR, glomerular filtration rate; CCI, Charlson’s comorbidity index; SGA, subjective global assessment overall score; MIS, malnutrition inflammation score; CR_PWV, carotid to radial pulse wave velocity; CF_PWV, carotid to femoral pulse wave velocity, BMI, body mass index; hsCRP, high sensitivity C-reactive protein; MTAC, mass transfer areas coefficient of creatinine; NPNA, normalized protein nitrogen appearance; E: I ratio, extra-cellular to intracellular volume ratio; HDL, high-density lipoprotein; LDL, Low-density lipoprotein; PTH, parathyroid hormone. *interaction between plasma vaspin level quartile and diabetic status. **male as compared to female

Published
2023
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29. Adipose and Plasma microRNAs miR-221 and 222 Associate with Obesity, Insulin Resistance, and New Onset Diabetes after Peritoneal Dialysis

Author

Chan, Gordon Chun Kau, primary, Than, Win Hlaing, additional, Kwan, Bonnie Ching Ha, additional, Lai, Ka Bik, additional, Chan, Ronald Cheong Kin, additional, Teoh, Jeremy Yuen Chun, additional, Ng, Jack Kit Chung, additional, Chow, Kai Ming, additional, Cheng, Phyllis Mei Shan, additional, Law, Man Ching, additional, Leung, Chi Bon, additional, Li, Philip Kam Tao, additional, and Szeto, Cheuk Chun, additional

Published
2022
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36. Supplemental Material, sj-docx-1-ptd-10.1177_08968608221110491 - Predictors and prognostic significance of persistent fluid overload: A longitudinal study in Chinese peritoneal dialysis patients

Author

Ng, Jack Kit-Chung, Kwan, Bonnie Ching-Ha, Chan, Gordon Chun-Kau, Chow, Kai Ming, Pang, Wing Fai, Cheng, Phyllis Mei-Shan, Leung, Chi Bon, Li, Philip Kam-Tao, and Szeto, Cheuk Chun

Subjects
Medicine
Abstract

Supplemental Material, sj-docx-1-ptd-10.1177_08968608221110491 for Predictors and prognostic significance of persistent fluid overload: A longitudinal study in Chinese peritoneal dialysis patients by Jack Kit-Chung Ng, Bonnie Ching-Ha Kwan, Gordon Chun-Kau Chan, Kai Ming Chow, Wing Fai Pang, Phyllis Mei-Shan Cheng, Chi Bon Leung, Philip Kam-Tao Li and Cheuk Chun Szeto in Peritoneal Dialysis International

Published
2022
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37. Intrarenal and Urinary Glycogen Synthase Kinase-3 Beta Levels in Diabetic and Nondiabetic Chronic Kidney Disease.

Author

Zeng, Lingfeng, Ng, Jack Kit-Chung, Fung, Winston Wing-Shing, Chan, Gordon Chun-Kau, Chow, Kai-Ming, and Szeto, Cheuk-Chun

Subjects
GLYCOGEN synthase kinase-3, CHRONIC kidney failure, DIABETIC nephropathies, KIDNEY diseases, PROGNOSIS
Abstract

Background: Renal glycogen synthase kinase-3 beta (GSK3β) overactivity has been associated with a diverse range of kidney diseases. GSK3β activity in urinary exfoliated cells was reported to predict the progression of diabetic kidney disease (DKD). We compared the prognostic value of urinary and intrarenal GSK3β levels in DKD and nondiabetic chronic kidney disease (CKD). Methods: We recruited 118 consecutive biopsy-proved DKD patients and 115 nondiabetic CKD patients. Their urinary and intrarenal GSK3β levels were measured. They were then followed for dialysis-free survival and rate of renal function decline. Results: DKD group had higher intrarenal and urinary GSK3β levels than nondiabetic CKD (p < 0.0001 for both), but their urinary GSK3β mRNA levels were similar. Urinary p-GSK3β level is statistically significantly correlated with the baseline estimated glomerular filtration rate (eGFR), but urinary GSK3β level by ELISA, its mRNA level, the p-GSK3β level, or the p-GSK3β/GSK3β ratio had no association with dialysis-free survival or the slope of eGFR decline. In contrast, the intrarenal pY216-GSK3β/total GSK3β ratio significantly correlated with the slope of eGFR decline (r = −0.335, p = 0.006) and remained an independent predictor after adjusting for other clinical factors. Conclusion: Intrarenal and urinary GSK3β levels were increased in DKD. The intrarenal pY216-GSK3β/total GSK3β ratio was associated with the rate of progression of DKD. The pathophysiological roles of GSK3β in kidney diseases deserve further studies. [ABSTRACT FROM AUTHOR]

Published
2023
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38. Adipose expression of miR-130b and miR-17-5p with wasting, cardiovascular event and mortality in advanced chronic kidney disease patients

Author

Chan, Gordon Chun-Kau, primary, Than, Win Hlaing, additional, Kwan, Bonnie Ching-Ha, additional, Lai, Ka-Bik, additional, Chan, Ronald Cheong-Kin, additional, Ng, Jack Kit-Chung, additional, Chow, Kai-Ming, additional, Cheng, Phyllis Mei-Shan, additional, Law, Man-Ching, additional, Leung, Chi-Bon, additional, Li, Philip Kam-Tao, additional, and Szeto, Cheuk-Chun, additional

Published
2021
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39. Adipose expression of miR-130b and miR-17-5p with wasting, cardiovascular event and mortality in advanced chronic kidney disease patients.

Author

Chan, Gordon Chun-Kau, Than, Win Hlaing, Kwan, Bonnie Ching-Ha, Lai, Ka-Bik, Chan, Ronald Cheong-Kin, Ng, Jack Kit-Chung, Chow, Kai-Ming, Cheng, Phyllis Mei-Shan, Law, Man-Ching, Leung, Chi-Bon, Li, Philip Kam-Tao, and Szeto, Cheuk-Chun

Subjects
*CHRONIC kidney failure, *CHRONICALLY ill, *BODY composition, *MAJOR adverse cardiovascular events, *MUSCLE mass
Abstract

Background There are limited data on the association of adipose microRNA expression with body composition and adverse clinical outcomes in patients with advanced chronic kidney disease (CKD). We aimed to evaluate the association of adipose miR-130b and miR-17-5p expressions with body composition, functional state, cardiovascular outcome and mortality in incident dialysis patients. Methods We performed a single-center prospective cohort study. Patients who were planned for peritoneal dialysis were recruited. miR-130b and miR-17-5p expressions were measured from subcutaneous and pre-peritoneal fat tissue obtained during peritoneal dialysis catheter insertion. Body composition and physical function were assessed by bioimpedance spectroscopy and Clinical Frailty Scale. Primary outcome was 2-year survival. Secondary outcomes were 2-year technique survival and major adverse cardiovascular event (MACE) rate. Results Adipose expression of miR-130b and miR-17-5p correlated with parameters of muscle mass including intracellular water (miR-130b: r = 0.191, P = 0.02; miR-17-5p: r = 0.211, P = 0.013) and lean tissue mass (miR-17-5p: r = 0.176, P = 0.04; miR-17-5p: r = 0.176, P = 0.004). miR-130b expression predicted frailty significantly (P = 0.017). Adipose miR-17-5p expression predicted 2-year all-cause survival (P = 0.020) and technique survival (P = 0.036), while miR-130b expression predicted incidence of MACE (P = 0.015). Conclusions Adipose miR-130b and miR-17-5p expressions correlated with body composition parameters, frailty, and predicted cardiovascular events and mortality in advanced CKD patients. [ABSTRACT FROM AUTHOR]

Published
2022
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43. Extended antibiotic therapy for the prevention of relapsing and recurrent peritonitis in peritoneal dialysis patients: a randomized controlled trial

Author

Szeto, Cheuk-Chun, primary, Ng, Jack Kit-Chung, additional, Wing-Shing Fung, Winston, additional, Chan, Gordon Chun-Kau, additional, Cheng, Phyllis Mei-Shan, additional, Lai, Ka-Bik, additional, Pang, Wing-Fai, additional, Chow, Kai-Ming, additional, Leung, Chi-Bon, additional, and Li, Philip Kam-Tao, additional

Published
2021
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44. Progression in Physical Frailty in Peritoneal Dialysis Patients

Author

Chan, Gordon Chun-Kau, primary, Ng, Jack Kit-Chung, additional, Chow, Kai-Ming, additional, Kwong, Vickie Wai-Ki, additional, Pang, Wing-Fai, additional, Cheng, Phyllis Mei-Shan, additional, Law, Man-Ching, additional, Leung, Chi Bon, additional, Li, Philip Kam-Tao, additional, and Szeto, Cheuk-Chun, additional

Published
2021
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45. Tackling Dialysis Burden around the World: A Global Challenge

Author

Li, Philip Kam-Tao, primary, Chan, Gordon Chun-Kau, additional, Chen, Jianghua, additional, Chen, Hung-Chun, additional, Cheng, Yuk-Lun, additional, Fan, Stanley L.-S., additional, He, John Cijiang, additional, Hu, Weixin, additional, Lim, Wai-Hon, additional, Pei, York, additional, Teo, Boon Wee, additional, Zhang, Ping, additional, Yu, Xueqing, additional, and Liu, Zhi-Hong, additional

Published
2021
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48. change in the prevalence of obesity and new-onset diabetes in Chinese peritoneal dialysis patients over 25 years.

Author

Than, Win Hlaing, Ng, Jack Kit-Chung, Chan, Gordon Chun-Kau, Fung, Winston Wing-Shing, Chow, Kai-Ming, and Szeto, Cheuk-Chun

Subjects
PERITONEAL dialysis, HEMODIALYSIS patients, CHRONIC kidney failure, OBESITY, PROGNOSIS, TYPE 2 diabetes
Abstract

Background The global prevalence of both obesity and end-stage kidney diseases (ESKDs) has increased in recent decades. Given the complicated interaction between obesity and ESKD, we examined the change in the prevalence of obesity in incident Chinese peritoneal dialysis (PD) patients over the past 25 years. Methods We reviewed the anthropometric measures of incident PD patients in a single Hong Kong center from 1995 to 2019. The results are reported in five 5-year periods. Patients with and without diabetes were analyzed separately, and the incidence of new-onset diabetes after PD was explored. Results We reviewed 1681 patients. Their mean age was 58.4 ± 12.5 years; 931 patients (55.4%) had pre-existing diabetes. From 1995–99 to 2015–19, the prevalence of obesity or overweight at the initiation of PD increased progressively for every 5-year period (from 21.9% to 26.2, 37.9, 42.7 and 47.3%, P < 0.001 for linearity). The increase in the prevalence of obesity or overweight was more pronounced in diabetic patients (from 33.7% to 59.6%) than non-diabetic ones (from 13.2% to 32.3%). Among nondiabetics patients, the incidence of new-onset diabetes after started on PD showed an insignificant rising trend during that period (from 18.0, 19.7, 17.8 and 22.4% to 23.3%, P = 0.106). The incidence of new-onset impaired fasting glucose or diabetes was significantly higher in obese or overweight patients than the others (56.9% versus 51.4%, P < 0.001). Conclusions The prevalence of obesity has increased substantially in both diabetic and nondiabetic new PD patients in Hong Kong over the past 25 years. The incidence of new-onset diabetes was significantly higher in new PD patients with pre-existing obesity or overweight than those without obesity. The prognostic implication and impacts on the healthcare system deserve further studies. [ABSTRACT FROM AUTHOR]

Published
2022
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49. Depression Does Not Predict Clinical Outcome of Chinese Peritoneal Dialysis Patients After Adjusting for the Degree of Frailty

Author

CHAN, Gordon Chun-Kau, primary, NG, Jack Kit-Chung, additional, CHOW, Kai-Ming, additional, Kwan, Bonnie CH, additional, KWONG, Vickie Wai-Ki, additional, PANG, Wing-Fai, additional, CHENG, Phyllis Mei-Shan, additional, LAW, Man-Ching, additional, LEUNG, Chi-Bon, additional, LI, Philip Kam-Tao, additional, and Szeto, Cheuk Chun, additional

Published
2020
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