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Your search keyword '"Chan, Chang Yien"' showing total 18 results
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18 results on '"Chan, Chang Yien"'

1. An international, multi-center study evaluated rituximab therapy in childhood steroid-resistant nephrotic syndrome

Author

Chan, Eugene Yu-hin, Sinha, Aditi, Yu, Ellen L.M., Akhtar, Naureen, Angeletti, Andrea, Bagga, Arvind, Banerjee, Sushmita, Boyer, Olivia, Chan, Chang-Yien, Francis, Anna, Ghiggeri, Gian Marco, Hamada, Riku, Hari, Pankaj, Hooman, Nakysa, Hopf, Luke Sydney, I, Mohamad Ikram, Ijaz, Iftikhar, Ivanov, Dmytro D., Kalra, Suprita, Kang, Hee Gyung, Lucchetti, Laura, Lugani, Francesca, Ma, Alison Lap-tak, Morello, William, Camargo Muñiz, María Dolores, Pradhan, Subal Kumar, Prikhodina, Larisa, Raafat, Reem H., Sinha, Rajiv, Teo, Sharon, Tomari, Kouki, Vivarelli, Marina, Webb, Hazel, Yap, Hui Kim, Yap, Desmond Yat-hin, and Tullus, Kjell

Published
2024
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3. Long-Term Efficacy and Safety of Repeated Rituximab to Maintain Remission in Idiopathic Childhood Nephrotic Syndrome: An International Study

Author

Chan, Eugene Yu-hin, Yu, Ellen L.M., Angeletti, Andrea, Arslan, Zainab, Basu, Biswanath, Boyer, Olivia, Chan, Chang-Yien, Colucci, Manuela, Dorval, Guillaume, Dossier, Claire, Drovandi, Stefania, Ghiggeri, Gian Marco, Gipson, Debbie S., Hamada, Riku, Hogan, Julien, Ishikura, Kenji, Kamei, Koichi, Kemper, Markus J., Ma, Alison Lap-tak, Parekh, Rulan S., Radhakrishnan, Seetha, Saini, Priya, Shen, Qian, Sinha, Rajiv, Subun, Chantida, Teo, Sharon, Vivarelli, Marina, Webb, Hazel, Xu, Hong, Yap, Hui Kim, and Tullus, Kjell

Published
2022
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6. Heterogenous antibody and T‐cell responses to SARS‐CoV‐2 mRNA vaccines among immunocompromised young people

Author

Lu, Liangjian, primary, Chan, Chang Yien, additional, Chan‐Ng, Pauline P. L., additional, Than, Mya, additional, Tan, Pamela S. Y., additional, Lim, Lee Kean, additional, Teo, Sharon, additional, Lau, Perry YW, additional, Ng, Kar Hui, additional, Ang, Elizabeth Y., additional, Karthik, Sivaramakrishnan Venkatesh, additional, Aw, Marion M., additional, Tambyah, Paul A., additional, Yap, Hui Kim, additional, and Lee, Bee Wah, additional

Published
2023
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7. Angiomotin mutation causes glomerulopathy and renal cysts by upregulating hepatocyte nuclear factor transcriptional activity

Author

Zhang, Yaochun, primary, Lu, Liangjian, additional, Hu, Zhenhua, additional, Dai, Yu, additional, Ahmad, Nurul Jannah Binti, additional, Ng, Jun Li, additional, Chan, Chang Yien, additional, Hossain, Md. Zakir, additional, Loh, Alwin Hwai Liang, additional, Ward, Jerrold M., additional, Tan, Puay Hoon, additional, Davila, Sonia, additional, Kumar, Vikrant, additional, Hunziker, Walter, additional, Lin, Haishu, additional, Yap, Hui Kim, additional, and Ng, Kar Hui, additional

Published
2022
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8. Zinc and vitamin C intake increases spike and neutralising antibody production following SARS‐CoV‐2 infection

Author

Quek, Amy May Lin, primary, Ooi, Delicia Shu Qin, additional, Teng, Ooiean, additional, Chan, Chang Yien, additional, Ng, Geelyn Jeng Lin, additional, Ng, Mei Yen, additional, Yee, Sidney, additional, Cheong, Ee Wan, additional, Weng, Ruifen, additional, Cook, Alex R., additional, Hartman, Mikael, additional, Angeli, Veronique, additional, Tambyah, Paul Anantharajah, additional, and Seet, Raymond Chee Seong, additional

Published
2022
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10. Persistent Dengue Infection in an Immunosuppressed Patient Reveals the Roles of Humoral and Cellular Immune Responses in Virus Clearance

Author

Ng, Kar-Hui, primary, Zhang, Summer Lixin, additional, Tan, Hwee Cheng, additional, Kwek, Swee Sen, additional, Sessions, October Michael, additional, Chan, Chang-Yien, additional, Liu, Isaac Desheng, additional, Lee, Chun Kiat, additional, Tambyah, Paul Ananth, additional, Ooi, Eng Eong, additional, and Yap, Hui-Kim, additional

Published
2019
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18. Multicenter study on the genetics of glomerular diseases among southeast and south Asians: Deciphering Diversities - Renal Asian Genetics Network (DRAGoN).

Author

Lu L, Yap YC, Nguyen DQ, Chan YH, Ng JL, Zhang YC, Chan CY, Than M, Liu ID, Asim S, Moorani K, Naeem B, Ijaz I, Nguyen TMT, Lee ML, Eng C, Huque SS, Ng YH, Ganesan I, Chao SM, Chong SL, Tan PH, Loh A, Davila S, Kumar V, Ling JZ, Moorakonda RB, Tan KM, Ng AY, Poon KS, Schaefer F, Lipska-Zietkiewicz B, Yap HK, and Ng KH

Subjects
Asian People genetics, Child, Collagen Type IV genetics, Female, Humans, Male, Mutation, Proteinuria, Nephritis, Hereditary diagnosis, Nephrotic Syndrome genetics
Abstract

Multinational studies have reported monogenic etiologies in 25%-30% of children with steroid-resistant nephrotic syndrome. Such large studies are lacking in Asia. We established Deciphering Diversities: Renal Asian Genetics Network (DRAGoN) and aimed to describe the genetic and clinical spectrums in Asians. We prospectively studied a cohort of 183 probands with suspected genetic glomerulopathies from South and Southeast Asia, of whom 17% had positive family history. Using multi-gene panel sequencing, we detected pathogenic variants in 26 (14%) probands, of whom one-third had COL4A4 or COL4A5 variants (n = 9, 5%). Of those with COL4A5 defects, only 25% had features suggestive of Alport syndrome. Besides traditional predictors for genetic disease (positive family history and extrarenal malformations), we identified novel predictors, namely older age (6.2 vs. 2.4 years; p = 0.001), hematuria (OR 5.6; 95% CI 2.1-14.8; p < 0.001), and proteinuria in the absence of nephrotic syndrome (OR 4.6; 95% CI 1.8-11.8; p = 0.001) at first manifestation. Among patients who first presented with proteinuria without nephrotic syndrome, the genetic diagnostic rates were >60% when a second risk factor (positive family history or extrarenal manifestation) co-existed. The genetic spectrum of glomerulopathies appears different in Asia. Collagen IV genes may be included in sequencing panels even when suggestive clinical features are absent., (© 2022 John Wiley & Sons A/S . Published by John Wiley & Sons Ltd.)

Published
2022
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