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2. Randomized trial of conventional versus radiofrequency needle transseptal puncture for cryoballoon ablation: the CRYO-LATS trial

Author

Andrade, Jason G., Macle, Laurent, Bennett, Matthew T., Hawkins, Nathaniel M., Essebag, Vidal, Champagne, Jean, Roux, Jean-Francois, Makanjee, Bhavanesh, Tang, Anthony, Skanes, Allan, Khaykin, Yaariv, Morillo, Carlos, Jolly, Umjeet, Lockwood, Evan, Amit, Guy, Angaran, Paul, Sapp, John, Wardell, Stephan, Wells, George A., Verma, Atul, and Deyell, Marc W.

Published
2022
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5. Safety of the oral factor XIa inhibitor asundexian compared with apixaban in patients with atrial fibrillation (PACIFIC-AF): a multicentre, randomised, double-blind, double-dummy, dose-finding phase 2 study

Author

Auer, Johann, Hubauer, Martin, Pandzic, Sead, Preishuber, Eva, Primus-Grabscheit, Carina, Reitgruber, Dietmar, Schmalzer, Florian, Adlbrecht, Christopher, Schober, Andreas, Hajos, Johannes, Keil, Christoph, Schratter, Alexandra, Frick, Matthias, Benda, Magdalena Anna, Mächler, Maximilian, Mutschlechner, Beatrix, Saely, Christoph, Sprenger, Lukas, Lichtenauer, Michael, Eber, Miriam, Hoppe, Uta, Kolbitsch, Tobias, Jirak, Peter Michael, Mirna, Moritz, Schönbauer, Robert, Bergler-Klein, Jutta, Hengstenberg, Christian, Stojkovic, Stefan, Scherr, Daniel, Manninger-Wünscher, Martin, Rohrer, Ursula, Stühlinger, Markus, Schgoer, Wilfried, Schwarzl, Jana, Pürerfellner, Helmut, Derndorfer, Michael, Ebner, Christian, Eder, Veronika, Kollias, Georgios, Sturmberger, Thomas, Sieghartsleitner, Stefan, Vijgen, Johan, Koopman, Peter, Dujardin, Karl, Anné, Wim, De Ceuninck, Michel, Tavernier, Rene, Duytschaever, Mattias, Knecht, Sébastien, Missault, Luc, Vandekerckhove, Yves, Rossenbacker, Tom, Ector, Bavo, Charlier, Filip, Debruyne, Philippe, Dewilde, Willem, Janssens, Luc, Roosen, John, Vankelecom, Bart, Heidbuchel, Hein, Delesie, Michiel, Vervoort, Gert, Rombouts, Hans, Vanassche, Thomas, Engelen, Matthias, Verhamme, Peter, Willems, Rik, Constance, Christian, Pranno, Nicolas, Cox, Jafna, Bata, Iqbal, Macle, Laurent, Aguilar, Martin, Tourigny, Julia Cadrin, Dubuc, Marc, Dyrda, Katia, Guerra, Peter, Khairy, Paul, Mondésert, Blandine, Rivard, Léna, Roy, Denis, Tadros, Rafik, Talajic, Mario, Thibault, Bernard, Nault, Isabelle, Blier, Louis, Champagne, Jean, Molin, Franck, O'Hara, Gilles, Philippon, François, Plourde, Benoit, Sarrazin, Jean-François, Steinberg, Christian, Coufal, Zdenek, Balazsik, David, Mikulica, Michal, Zapeca, Jakub, Cermak, Ondrej, Drasnar, Tomas, Falc, Matej, Hornof, Josef, Racz, Blazej, Weissova, Danica, Linkova, Hana, Paskova, Eva, Petr, Robert, Sirakova, Andrea, Kettner, Jiri, Benak, Ales, Holek, Martin, Podpera, Ivo, Podperova, Monika, Vancura, Vlastimil, Jandik, Tomas, Smid, Jiri, Dedek, Vratislav, Banik, Jan, Durdil, Vaclav, Hnat, Tomas, Lellouche, Nicolas, Rouffiac, Ségolène, Taldir, Guillaume, Bridonneau, Valentin, Couffon, Philippe, Daudin, Magalie, Hamon, Cécile, Lacaze, Jonathan, Quentin, Anne, Thebault, Christophe, Boiffard, Emmanuel, Billon, Olivier, Miette, Fabien, Pouliquen, Hervé, Turlotte, Guillaume, Gorka, Hervé, Albert, Franck, Bayle, Sandrine, Bensaid, Reda, Dasoveanu, Madalina, Demichili, Thibaud, Dutoiu, Teodora, Khalil, Cliff, Loghin, Caterina, Range, Grégoire, Roussel, Laurent, Socié, Pierre, Thuaire, Christophe, Extramiana, Fabrice, Algalarrondo, Vincent, Boughanmi, Haten, El Mansour, Noreddine, Mohammad, Usman, Sellier, Romain, Elbaz, Meyer, Laperche, Clémence, Maury, Philippe, Kiss, Robert, Borsanyi, Tunde, Gingl, Zoltan, Polgar, Balaza, Benczur, Bela, Bodor, Alexandra, Hepp, Tamas, Malati, Eva, Nagy, Laszlo, Erdei, Norbert, Kapus, Jozsef, Kapus, Katalin, Toth, Brigitta, Matoltsy, Andras, Kiss, Tunde, Merkely, Bela, Herczeg, Szilvia, Kiss, Orsolya, Sallo, Zoltan, Toth, Kalman, Habon, Tamas, Rabai, Miklos, Totsimon, Kinga, Zilahi, Zsolt, Bencze, Gabriella, Santa, Janos, Aradi, Daniel, Kelemen, Barbara, Bolognese, Leonardo, Nesti, Martina, Notarstefano, Pasquale Giovanni, D'Orazio, Simona, Cosmi, Franco, Becattini, Cecilia, Agnelli, Giancarlo, Broccatelli, Belinda, Mosconi, Maria Giulia, Paciaroni, Maurizio, Urbini, Chiara, Parato, Vito Maurizio, Notaristefani, Camilla, Scarano, Michele, Ameri, Pietro, Ghigliotti, Giorgio, Guglielmi, Giulia, Lotti, Roberta, Merlo, Andrea Carlo, Muiesan, Maria Lorenza, Abondio, Andrea, Berasi, Caterina, Mattiuzzo, Elena, Mutti, Claudio, Salvetti, Massimo, Pignatelli, Pasquale, Menichelli, Danilo, Pastori, Daniele, Tamiya, Eiji, Matsumoto, Takahiro, Takabe, Tomosato, Yamamoto, Shoichi, Yamashita, Haruyo, Higashiue, Shinichi, Furuya, Onichi, Hiramatsu, Norihiko, Kasuga, Kensuke, Kojima, Saburo, Komooka, Masatoshi, Kuroyanagi, Satoshi, Matsuura, Makoto, Takemoto, Tetsushi, Yamamoto, Shuji, Saito, Katusmi, Abe, Takuro, Ishida, Issei, Iwanami, Yuji, Kataoka, Shohei, Moriyama, Tetsu, Murohashi, Akira, Sasaki, Akihito, Nakamura, Yuichiro, Ueno, Tetsuya, Shimane, Akira, Hamana, Tomoyo, Ichibori, Hirotoshi, Inoue, Tomohiro, Itoh, Mitsuaki, Iwane, Seigo, Kawai, Hiroya, Kokawa, Tatsuya, Masumoto, Akiko, Matsuo, Koki, Miyata, Taishi, Nakano, Shinsuke, Oishi, Shogo, Onishi, Tetsuari, Sawada, Takahiro, Saito, Takayuki, Shoda, Mitsuhiko, Takahashi, Nobuyuki, Takaya, Tomofumi, Taniguchi, Yasuyo, Tsukamoto, Shota, Tsukishiro, Yasue, Tsukiyama, Yoshiro, Tsunamoto, Hiroshi, Uzu, Kenzo, Yamamoto, Hiroyuki, Yamamoto, Tetsuya, Yokoi, Kiminobu, Yoshida, Chiaki, Watanabe, Nobuhiro, Betsuyaku, Tetsuo, Adachi, Kumiko, Awane, Kouichi, Goto, Daisuke, Sakakibara, Mamoru, Watanabe, Masashi, Ueno, Hideki, Hiroe, Yoshitaka, Matsuo, Koshi, Ayata, Kenji, Fukuda, Ko, Hata, Yoshiki, Hashimoto, Katsushi, Matsumi, Hiroaki, Nikaido, Akira, Okamoto, Shuichi, Sime, Iveta, Stirna, Valters, Reinholde, Ilze, Hansone, Silvija, Kozlovska, Anita, Romanova, Janina, Klincare, Dace, Pontaga, Natalja, Dirmans, Igors, Kalnins, Artis, Upite, Dana, Gersamija, Arcils, Teleznikovs, Arturs, Rozkova, Nadezda, Safro, Jelena, Anguera Camós, Ignasi, Domenico Dallaglio, Paolo, Salguero Bodes, Rafael, Arnbas, Fernando, Borrego, Luis, Marco, Alvaro, Jimenez, Javier Ramos, Gómez-Doblas, Juan José, Pérez Cabeza, Alejandro, Ferreira Gonzålez, Ignacio, Limeres Freire, Javier, Lopez Grau, Merce, Viñolas Prat, Xavier, Moreno Weidmann, Zoraida, Guerra Ramos, Jose Maria, Alonso Martin, Maria Concepcion, Campos Garcia, Bieito, Mogro Carranza, Javier Mauricio, Mendez Zurita, Francisco Javier, Rodriguez Font, Enrique, Gonzales Matos, Carlos Eduardo, García Hernando, Víctor, Lindholm, Carl-Johan, Thulin, Jörgen, Wallén, Håkan, Hagwall, Kristina, Eliasson, Ken, Lundvall, Martin, Olsson, Jens, Kjellman, Björn, Lind, Markus, Johansson, Lars, Svedberg, Niclas, Berglund, Stefan, Söderberg, Julia, Zedigh, Christer, Mooe, Thomas, Axelsson, Mattias, Binsell, Emil, Huber, Daniel, Müller, Christian, Danier, Isabelle, Kühne, Michael, Okamura, Bernhard, Schoepfer, Hadrien, Simmen, Cornelia, Reichlin, Tobias, Chollet, Laurève, Lam, Anna, Wittmer, Severin, Rickli, Hans, Gall, Christian, Hametner, Greta, Intorp, Stephanie, Luescher, Daniel, Haegeli, Laurent, Berg, Jan Christopher, Ebrahimi, Ramin, Auricchio, Angelo, Crljenica, Carmela, Moccetti, Tizziano, Monti, Cristina, Pasotti, Elena, Petrova, Iveta, Rossi, Mariagrazia, Mach, François, Namdar, Mehdi, de Groot, Joris, Proost, Virginnio, Neefs, Joline, Linz, Dominik, van Stipdonk, Twan, den Uijl, Dennis, Alings, Marco, Schaap, Jeroen, Segers, Dolf, Wouters, Noemi, Bartels, Louis, Tieleman, Robert, Pisters, Ron, de Vries, Tim, Selig, Jaap, Kuijper, Aaf, Bot, Pieter, Keijzers, Mitran, Verdel, Gerardus, Tukkie, Raymond, van den Bos, Ewout, Kauer, Floris, Oemrawsingh, Rohit, Stevenhagen, Jeroen, van Es, Jan, Lip, Gregory, Gupta, Dhiraj, Kotalczyk, Agnieszka, Gunstone, Anthony, Brixey, Richard David, Gorog, Diana, Dinarvand, Danial, Gue, Ying, Kanji, Rahim, Memtsas, Vassilios, Senior, Roxy, Bioh, Gabriel, Wong, Yuk-Ki, Child, Nick, Piccini, Jonathan P, Caso, Valeria, Connolly, Stuart J, Fox, Keith A A, Oldgren, Jonas, Jones, W Schuyler, Gorog, Diana A, Durdil, Václav, Viethen, Thomas, Neumann, Christoph, Mundl, Hardi, and Patel, Manesh R

Published
2022
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7. The impact of institutional measures on optimal use of intravenous immunoglobulin.

Author

Champagne, Jean‐Nicolas, Desilets, Antoine, Roy, Guillaume, Landon‐Cardinal, Océane, Chapdelaine, Hugo, Matte, Geneviève, Bouchard, Claudia, Rioux‐Massé, Benjamin, and Lemay, Anne‐Sophie

Subjects
*BLOOD transfusion, *INTRAVENOUS immunoglobulins, *BLOOD banks, *IMMUNOREGULATION, *GATEKEEPING
Abstract

Background Methods Results Conclusions Intravenous immunoglobulin (IVIG) shortage represents an emerging issue in transfusion medicine. Limited data are available to determine effective strategies for optimal use. The objective of this retrospective observational study was to determine the impact of institutional measures on IVIG use at a large academic center.IVIG infusions from November 26, 2018 to September 25, 2022 were categorized according to their appropriateness (Recommended, Option of treatment, or Unrecommended), based on provincial guidelines, and separated into three phases: Reference, Transition, and Post‐Implementation phases, the latter following the adoption of restrictive measures, including mandatory standardized order forms, a blood bank gatekeeping strategy, and the creation of a stewardship committee.A total of 5431 IVIG infusions were administered to 544 patients, accounting for 295,033 g. The most common indication categories were neurology (30.4%), immunology (29.0%), and hematology (17.4%). From Reference to Post‐Implementation phase, IVIG infusions decreased from 2275 to 2000 with unrecommended indications dropping from 9.5% to 7.4% (p = 0.01), and a global reduction of 23.0% (from 131,163 g to 100,936 g of IVIG). Decrease in chronic immunomodulation accounted for 48.3% of total reduction (14,610 g of 30,227 g), whereas single‐use immunomodulation, 40.5% (12,237 g of 30,227 g). Moreover, an absolute reduction of 16.9% was observed in orders exceeding the recommended doses (20.8% to 3.9%; p < 0.0001). Together, the unrecommended and excessive IVIG doses decreased from 19,975 g (15.2%) to 6670 g (6.6%).A global reduction in IVIG use and a preferential decrease in the unrecommended orders were observed, most likely attributable to the bundle of restrictive strategies implemented. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Driving Restrictions and Early Arrhythmias in Patients Receiving a Secondary Prevention Implantable Cardioverter-Defibrillator (DREAM-ICD- II study)

Author

Steinberg, Christian, Dognin, Nicolas, Sodhi, Amit, Champagne, Catherine, Staples, John A., Champagne, Jean, Laksman, Zachary, Sarrazin, Jean-François, Bennett, Matthew, Plourde, Benoit, Deyell, Marc W., Andrade, Jason G., Roy, Karine, Yeung-Lai-Wah, John A., Hawkins, Nathaniel M., Mondésert, Blandine, Blier, Louis, Nault, Isabelle, O’Hara, Gilles, Krahn, Andrew D., Philippon, François, and Chakrabarti, Santabhanu

Published
2022
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11. Driving Restrictions and Early Arrhythmias in Patients Receiving a Primary-Prevention Implantable Cardioverter-Defibrillator (DREAM-ICD) Study

Author

Steinberg, Christian, Cheung, Christopher C., Wan, Darryl, Sodhi, Amit, Claros, Sebastian, Staples, John A., Philippon, François, Laksman, Zachary, Sarrazin, Jean-François, Bennett, Matthew, Plourde, Benoit, Deyell, Marc W., Andrade, Jason G., Roy, Karine, Yeung-Lai-Wah, John A., Molin, Franck, Hawkins, Nathaniel M., Blier, Louis, Nault, Isabelle, O’Hara, Gilles, Krahn, Andrew D., Champagne, Jean, and Chakrabarti, Santabhanu

Published
2020
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15. Pandemic Societies

Author

Clara Champagne, Jean-Louis Denis, Catherine Régis, Daniel M. Weinstock

Published
2021

17. Ethnic differences in patients with Brugada syndrome and arrhythmic events: New insights from Survey on Arrhythmic Events in Brugada Syndrome

Author

Milman, Anat, Andorin, Antoine, Postema, Pieter G., Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Michowitz, Yoav, Fogelman, Rami, Hochstadt, Aviram, Mizusawa, Yuka, Giustetto, Carla, Arbelo, Elena, Huang, Zhengrong, Corrado, Domenico, Delise, Pietro, Allocca, Giuseppe, Takagi, Masahiko, Wijeyeratne, Yanushi D., Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Jespersen, Camilla H., Tfelt-Hansen, Jacob, Veltmann, Christian, Priori, Silvia G., Behr, Elijah R., Yan, Gan-Xin, Brugada, Josep, Gaita, Fiorenzo, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2019
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18. Characterization and Management of Arrhythmic Events in Young Patients With Brugada Syndrome

Author

Michowitz, Yoav, Milman, Anat, Andorin, Antoine, Sarquella-Brugada, Georgia, Gonzalez Corcia, M. Cecilia, Gourraud, Jean-Baptiste, Conte, Giulio, Sacher, Frederic, Juang, Jimmy J.M., Kim, Sung-Hwan, Leshem, Eran, Mabo, Philippe, Postema, Pieter G., Hochstadt, Aviram, Wijeyeratne, Yanushi D., Denjoy, Isabelle, Giustetto, Carla, Mizusawa, Yuka, Huang, Zhengrong, Jespersen, Camilla H., Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Arbelo, Elena, Mazzanti, Andrea, Allocca, Giuseppe, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Priori, Silvia G., Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Brugada, Josep, Kusano, Kengo F., Hirao, Kenzo, Calo, Leonardo, Takagi, Masahiko, Tfelt-Hansen, Jacob, Yan, Gan-Xin, Gaita, Fiorenzo, Leenhardt, Antoine, Behr, Elijah R., Wilde, Arthur A.M., Nam, Gi-Byoung, Brugada, Pedro, Probst, Vincent, and Belhassen, Bernard

Published
2019
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19. Comparison of Ajmaline and Procainamide Provocation Tests in the Diagnosis of Brugada Syndrome

Author

Cheung, Christopher C., Mellor, Greg, Deyell, Marc W., Ensam, Bode, Batchvarov, Velislav, Papadakis, Michael, Roberts, Jason D., Leather, Richard, Sanatani, Shubhayan, Healey, Jeffrey S., Chauhan, Vijay S., Birnie, David H., Champagne, Jean, Angaran, Paul, Klein, George J., Yee, Raymond, Simpson, Christopher S., Talajic, Mario, Gardner, Martin, Yeung-Lai-Wah, John A., Chakrabarti, Santabhanu, Laksman, Zachary W., Sharma, Sanjay, Behr, Elijah R., and Krahn, Andrew D.

Published
2019
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20. Long-Term Outcomes After Ablation for Paroxysmal Atrial Fibrillation Using the Second-Generation Cryoballoon: Final Results From STOP AF Post-Approval Study

Author

Knight, Bradley, Novak, Paul, Sangrigoli, Robert, Champagne, Jean, Dubuc, Marc, Essebag, Vidal, Adler, Stuart, Jain, Sandeep, Svinarich, Thomas, John, Roy, Lockwood, Evan, Gandhi, Gaurang, Wish, Marc, Levy, Matthew, Gassis, Safwat, Johnson, Eric, Seger, John, Remole, Stephen, Collins, H. Wade, III, Oren, Jess, Andrade, Jason, Bernabei, Matthew, Osman, Ahmed, Wu, Richard, Merliss, Andrew, Mansour, Moussa, Miles, William, Su, Wilber, Blatt, Jacob, Seide, Hanscy, Becker, Giuliano, Souza, Joseph, Lloyd, Michael, Cameron, Craig, Baker, James, II, Mitra, Raman, Packer, Douglas, McLeod, Christopher, DeVille, Brian, Compton, Steven, Knight, Bradley P., Novak, Paul G., Adler, Stuart W., Svinarich, J. Thomas, Hokanson, Robert, Kueffer, Fred, Jain, Sandeep K., and John, Roy M.

Published
2019
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21. One‐year outcomes of pulmonary vein isolation with a novel cryoballoon: Primary results of the FROZEN AF trial.

Author

Ellenbogen, Kenneth A., Mittal, Suneet, Varma, Niraj, Aryana, Arash, Marrouche, Nassir, Anić, Ante, Nair, Devi, Champagne, Jean, Iacopino, Saverio, de Asmundis, Carlo, Weiner, Stanislav, Makati, Kevin, Raybuck, Jonathan D., Richards, Elizabeth, and Su, Wilber

Subjects
PULMONARY veins, PATIENT safety, CLINICAL trials, CRYOSURGERY, TREATMENT effectiveness, DESCRIPTIVE statistics, LONGITUDINAL method, ATRIAL fibrillation, RESEARCH, CATHETER ablation, DATA analysis software
Abstract

Introduction: Cryoablation therapy for pulmonary vein isolation (PVI) to treat paroxysmal atrial fibrillation (PAF) is well established. A novel 28 mm cryoballoon system designed to operate under low pressure to safely reach a lower nadir temperature and maintain constant balloon size during cooling has not been prospectively studied in a large patient population for safety and efficacy. The FROZEN AF (NCT04133168) trial was an international multicenter, open‐label, prospective, single‐arm study on the safety and performance of a novel cryoballoon system for treatment of PAF. Methods and Results: The study enrolled patients at 44 sites in 10 countries across North America, Europe, and Asia. Subjects were indicated for PVI treatment of PAF and had failed or were intolerant of one or more antiarrhythmic drugs. Procedural outcomes were defined based on the 2017 HRS consensus statement. Follow‐up was performed at 7 days, 3, 6, and 12 months. Data are reported as mean ± SD or median (IQR). PVI was performed with a 28 mm cryoballoon in 325 drug refractory PAF patients. Complete PVI was achieved in 95.7% of patients. In cryoablation lesions longer than 60 s, 60.1% of PV isolations required only a single cryoballoon application. Procedure related complications included: phrenic nerve palsy [temporary 4 (1.2%), persistent 0 (0.0%)], cardiac tamponade/perforation 2 (0.6%), and air embolism 1 (0.3%). Freedom from documented atrial arrhythmia recurrence at 12 months was 79.9% (AF 82.7%, AFL 96.5%, AT 98.1%), antiarrhythmic drugs (AAD) were continued or re‐initiated in 26.8% of patients after the 3‐month blanking period. Additionally, an extension arm enrolled 50 pts for treatment with 28/31 mm variable size cryoballoon. A single temporary PNP occurred in this group, which resolved before discharge. Freedom from documented recurrence at 12 months in these pts was 82.0%. Conclusions: This novel cryoballoon may facilitate PVI to treat PAF, providing more options to address the variety of anatomies present in patients with PAF. This cryoballoon system proved to be safe and effective for treatment of patients with drug refractory or drug intolerant PAF. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Early Repolarization Pattern Inheritance in the Cardiac Arrest Survivors With Preserved Ejection Fraction Registry (CASPER)

Author

Malhi, Navraj, So, Petsy P., Cheung, Christopher C., Laksman, Zachary W.M., Healey, Jeffrey S., Chauhan, Vijay S., Green, Martin S., Champagne, Jean, Steinberg, Christian, Sanatani, Shubhayan, Angaran, Paul, Duff, Henry, Roberts, Jason D., Arbour, Laura, Leather, Richard, Simpson, Christopher S., Tadros, Rafik, Talajic, Mario, Gardner, Martin, Siefer, Colette, and Krahn, Andrew D.

Published
2018
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28. Atrial fibrillation progression after cryoablation vs. radiofrequency ablation: the CIRCA-DOSE trial.

Author

Andrade, Jason G, Deyell, Marc W, Khairy, Paul, Champagne, Jean, Leong-Sit, Peter, Novak, Paul, Sterns, Lawrence, Roux, Jean-Francois, Sapp, John, Bennett, Richard, Bennett, Matthew, Hawkins, Nathaniel, Sanders, Prashanthan, and Macle, Laurent

Subjects
ATRIAL fibrillation, CATHETER ablation, CRYOSURGERY, HEART failure, ARRHYTHMIA
Abstract

Background and Aims Atrial fibrillation (AF) is a chronic progressive disorder. Persistent forms of AF are associated with increased rates of thromboembolism, heart failure, and death. Catheter ablation modifies the pathogenic mechanism of AF progression. No randomized studies have evaluated the impact of the ablation energy on progression to persistent atrial tachyarrhythmia. Methods Three hundred forty-six patients with drug-refractory paroxysmal AF were enrolled and randomly assigned to contact-force–guided RF ablation (CF-RF ablation, 115), 4 min cryoballoon ablation (CRYO-4, 115), or 2 min cryoballoon ablation (CRYO-2, 116). Implantable cardiac monitors placed at study entry were used for follow-up. The main outcome was the first episode of persistent atrial tachyarrhythmia. Secondary outcomes included atrial tachyarrhythmia recurrence and arrhythmia burden on the implantable monitor. Results At a median of 944.0 (interquartile range [IQR], 612.5–1104) days, 0 of 115 patients (0.0%) randomly assigned to CF-RF, 8 of 115 patients (7.0%) assigned to CRYO-4, and 5 of 116 patients (4.3%) assigned to CRYO-2 experienced an episode of persistent atrial tachyarrhythmia (P =.03). A documented recurrence of any atrial tachyarrhythmia ≥30 s occurred in 56.5%, 53.9%, and 62.9% of those randomized to CF-RF, CRYO-4, and CRYO-2, respectively; P =.65. Compared with that of the pre-ablation monitoring period, AF burden was reduced by a median of 99.5% (IQR 94.0%, 100.0%) with CF-RF, 99.9% (IQR 93.3%–100.0%) with CRYO-4, and 99.1%% (IQR 87.0%–100.0%) with CRYO-2 (P =.38). Conclusions Catheter ablation of paroxysmal AF using radiofrequency energy was associated with fewer patients developing persistent AF on follow-up. [ABSTRACT FROM AUTHOR]

Published
2024
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29. High‐power short‐duration versus low‐power long‐duration ablation for pulmonary vein isolation: A substudy of the AWARE randomized controlled trial.

Author

Joza, Jacqueline, Nair, Girish M., Birnie, David H., Nery, Pablo B., Redpath, Calum J., Sarrazin, Jean‐Francois, Champagne, Jean, Bernick, Jordan, Wells, George A., Essebag, Vidal, Roux, Jean‐Francois, Dussault, Charles, Parkash, Ratika, Bernier, Martin, Sterns, Laurence D., Sapp, John, Novak, Paul, Veenhuyzen, George, Morillo, Carlos A., and Singh, Sheldon M.

Subjects
CONFIDENCE intervals, ATRIAL fibrillation, CATHETER ablation, TREATMENT duration, REGRESSION analysis, TREATMENT effectiveness, COMPARATIVE studies, DESCRIPTIVE statistics, ELECTROCARDIOGRAPHY, RESEARCH funding, PULMONARY veins, PATIENT safety, EVALUATION
Abstract

Introduction: Pulmonary vein isolations (PVI) are being performed using a high‐power, short‐duration (HPSD) strategy. The purpose of this study was to compare the clinical efficacy and safety outcomes of an HPSD versus low‐power, long‐duration (LPLD) approach to PVI in patients with paroxysmal atrial fibrillation (AF). Methods: Patients were grouped according to a HPSD (≥40 W) or LPLD (≤35 W) strategy. The primary endpoint was the 1‐year recurrence of any atrial arrhythmia lasting ≥30 s, detected using three 14‐day ambulatory continuous ECG monitoring. Procedural and safety endpoints were also evaluated. The primary analysis were regression models incorporating propensity scores yielding adjusted relative risk (RRa) and mean difference (MDa) estimates. Results: Of the 398 patients included in the AWARE Trial, 173 (43%) underwent HPSD and 225 (57%) LPLD ablation. The distribution of power was 50 W in 75%, 45 W in 20%, and 40 W in 5% in the HPSD group, and 35 W with 25 W on the posterior wall in the LPLD group. The primary outcome was not statistically significant at 30.1% versus 22.2% in HPSD and LPLD groups with RRa 0.77 (95% confidence interval [CI]) 0.55–1.10; p =.165). The secondary outcome of repeat catheter ablation was not statistically significant at 6.9% and 9.8% (RRa 1.59 [95% CI 0.77–3.30]; p =.208) respectively, nor was the incidence of any ECG documented AF during the blanking period: 1.7% versus 8.0% (RRa 3.95 [95% CI 1.00–15.61; p =.049) in the HPSD versus LPLD group respectively. The total procedure time was significantly shorter in the HPSD group (MDa 97.5 min [95% CI 84.8–110.4)]; p <.0001) with no difference in adjudicated serious adverse events. Conclusions: An HPSD strategy was associated with significantly shorter procedural times with similar efficacy in terms of clinical arrhythmia recurrence. Importantly, there was no signal for increased harm with a HPSD strategy. [ABSTRACT FROM AUTHOR]

Published
2024
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31. Organ And Tissue Donation In Quebec: Bill 194 Proposes To Adopt Presumed Consent

Author

Champagne, Jean-Raphaël

Subjects
Bills, Legislative -- Interpretation and construction, Donation of organs, tissues, etc. -- Laws, regulations and rules, Government regulation, Business, international
Abstract

Recently, André Fortin, Health Critic for the Official Opposition, tabled Bill 194, An Act to establish a presumption of consent to organ or tissue donation after death (the 'Bill'). The [...]

Published
2023

35. PO-02-168 ONE-YEAR OUTCOMES OF PULMONARY VEIN ISOLATION WITH A NOVEL CRYOBALLOON IN 325 PATIENTS: PRIMARY RESULTS OF THE FROZEN AF TRIAL

Author

Ellenbogen, Kenneth A., primary, Mittal, Suneet, additional, Varma, Niraj, additional, Aryana, Arash, additional, Marrouche, Nassir F., additional, Anic, Ante, additional, Nair, Devi G., additional, Champagne, Jean, additional, Iacopino, Saverio, additional, de Asmundis, Carlo, additional, Weiner, Stanislav, additional, Gilligan, David M., additional, Raybuck, Jon, additional, Richards, Elizabeth, additional, and Su, Wilber W., additional

Published
2023
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36. Novel filamin C ( FLNC ) variant causes a severe form of familial mixed hypertrophic‐restrictive cardiomyopathy

Author

Gaudreault, Nathalie, primary, Ruel, Louis‐Jacques, additional, Henry, Cyndi, additional, Schleit, Jennifer, additional, Lagüe, Patrick, additional, Champagne, Jean, additional, Sénéchal, Mario, additional, Sarrazin, Jean‐François, additional, Philippon, François, additional, Bossé, Yohan, additional, and Steinberg, Christian, additional

Published
2023
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37. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS.

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frédéric, Mabo, Philippe, Kim, SungHwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi YD, Mazzanti, Andrea, Brugada, Ramon, Casado Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah Raphael, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo KF, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Abstract

SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2023

38. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram:Sub-Analysis From the SABRUS

Author

Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, Belhassen, Bernard, Milman, Anat, Sabbag, Avi, Conte, Giulio, Postema, Pieter G, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Juang, Jimmy Jm, Michowitz, Yoav, Leshem, Eran, Mizusawa, Yuka, Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D, Mazzanti, Andrea, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G, Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R, Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A M, Brugada, Pedro, Kusano, Kengo F, Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2023

39. Quebec Publishes Long-Awaited Draft Regulation On Documents Used In Research

Author

Champagne, Jean-Raphael

Subjects
Bills, Legislative -- Interpretation and construction, French language -- Laws, regulations and rules, Research -- Laws, regulations and rules, Government regulation, Business, international
Abstract

The National Assembly adopted Bill 96, An Act respecting French, the official and common language of Québec on May 24, 2022, ushering in new provisions of the Charter of the [...]

Published
2023

40. Cryoballoon or Radiofrequency Ablation for Atrial Fibrillation Assessed by Continuous Monitoring: A Randomized Clinical Trial

Author

Andrade, Jason G., Champagne, Jean, Dubuc, Marc, Deyell, Marc W., Verma, Atul, Macle, Laurent, Leong-Sit, Peter, Novak, Paul, Badra-Verdu, Mariano, Sapp, John, Mangat, Iqwal, Khoo, Clarence, Steinberg, Christian, Bennett, Matthew T., Tang, Anthony S.L., Khairy, Paul, Parkash, Ratika, Guerra, Peter, Dyrda, Katia, Rivard, Lena, Racine, Normand, Sterns, Lawrence, Leather, Rick, Seifer, Colette, Jolly, Umjeet, Raymond, Jean-Marc, Roux, Jean-Francois, Nault, Isabelle, Sarrazin, Jean-Francois, Ramanathan, Krishnan, Cheung, Christopher, Fordyce, Christopher, McKinney, Jimmy, Luong, Christina, Rizkallah, Jacques, Angaran, Paul, Ha, Andrew, Glover, Benedict, Skanes, Allan, and Gula, Lorne

Published
2019
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43. Progression of Atrial Fibrillation after Cryoablation or Drug Therapy

Author

Andrade, Jason G., primary, Deyell, Marc W., additional, Macle, Laurent, additional, Wells, George A., additional, Bennett, Matthew, additional, Essebag, Vidal, additional, Champagne, Jean, additional, Roux, Jean-Francois, additional, Yung, Derek, additional, Skanes, Allan, additional, Khaykin, Yaariv, additional, Morillo, Carlos, additional, Jolly, Umjeet, additional, Novak, Paul, additional, Lockwood, Evan, additional, Amit, Guy, additional, Angaran, Paul, additional, Sapp, John, additional, Wardell, Stephan, additional, Lauck, Sandra, additional, Cadrin-Tourigny, Julia, additional, Kochhäuser, Simon, additional, and Verma, Atul, additional

Published
2023
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44. Characteristics of Patients with Spontaneous Versus Drug-Induced Brugada Electrocardiogram: Sub-Analysis From the SABRUS

Author

Milman, Anat, primary, Sabbag, Avi, additional, Conte, Giulio, additional, Postema, Pieter G., additional, Andorin, Antoine, additional, Gourraud, Jean-Baptiste, additional, Sacher, Frederic, additional, Mabo, Philippe, additional, Kim, Sung-Hwan, additional, Maeda, Shingo, additional, Takahashi, Yoshihide, additional, Kamakura, Tsukasa, additional, Aiba, Takeshi, additional, Juang, Jimmy JM, additional, Michowitz, Yoav, additional, Leshem, Eran, additional, Mizusawa, Yuka, additional, Arbelo, Elena, additional, Huang, Zhengrong, additional, Denjoy, Isabelle, additional, Giustetto, Carla, additional, Wijeyeratne, Yanushi D., additional, Mazzanti, Andrea, additional, Brugada, Ramon, additional, Casado-Arroyo, Ruben, additional, Champagne, Jean, additional, Calo, Leonardo, additional, Sarquella-Brugada, Georgia, additional, Tfelt-Hansen, Jacob, additional, Priori, Silvia G., additional, Takagi, Masahiko, additional, Veltmann, Christian, additional, Delise, Pietro, additional, Corrado, Domenico, additional, Behr, Elijah R., additional, Gaita, Fiorenzo, additional, Yan, Gan-Xin, additional, Brugada, Josep, additional, Leenhardt, Antoine, additional, Wilde, Arthur A.M., additional, Brugada, Pedro, additional, Kusano, Kengo F., additional, Hirao, Kenzo, additional, Nam, Gi-Byoung, additional, Probst, Vincent, additional, and Belhassen, Bernard, additional

Published
2023
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45. Psychedelic-Assisted Therapies: Health Canada Takes Another Step Forward

Author

Champagne, Jean-Raphael

Subjects
Canada. Health Canada -- Powers and duties, Psychotherapy -- Laws, regulations and rules, Hallucinogenic drugs -- Usage, Government regulation, Business, international
Abstract

On December 5, 2022, Health Canada published the following Notice to stakeholders: Health Canada's expectations regarding risk-management measures for clinical trials involving psychedelic-assisted psychotherapy (the 'Notice'). The Notice is primarily [...]

Published
2022

48. Age of First Arrhythmic Event in Brugada Syndrome: Data From the SABRUS (Survey on Arrhythmic Events in Brugada Syndrome) in 678 Patients

Author

Milman, Anat, Andorin, Antoine, Gourraud, Jean-Baptiste, Sacher, Frederic, Mabo, Philippe, Kim, Sung-Hwan, Maeda, Shingo, Takahashi, Yoshihide, Kamakura, Tsukasa, Aiba, Takeshi, Conte, Giulio, Juang, Jimmy J.M., Leshem, Eran, Rahkovich, Michael, Hochstadt, Aviram, Mizusawa, Yuka, Postema, Pieter G., Arbelo, Elena, Huang, Zhengrong, Denjoy, Isabelle, Giustetto, Carla, Wijeyeratne, Yanushi D., Napolitano, Carlo, Michowitz, Yoav, Brugada, Ramon, Casado-Arroyo, Ruben, Champagne, Jean, Calo, Leonardo, Sarquella-Brugada, Georgia, Tfelt-Hansen, Jacob, Priori, Silvia G., Takagi, Masahiko, Veltmann, Christian, Delise, Pietro, Corrado, Domenico, Behr, Elijah R., Gaita, Fiorenzo, Yan, Gan-Xin, Brugada, Josep, Leenhardt, Antoine, Wilde, Arthur A.M., Brugada, Pedro, Kusano, Kengo F., Hirao, Kenzo, Nam, Gi-Byoung, Probst, Vincent, and Belhassen, Bernard

Published
2017
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49. Leucocyte-derived micro-RNAs as candidate biomarkers in Brugada syndrome.

Author

Steinberg, Christian, Gaudreault, Nathalie, Papadakis, Andreas I, Henry, Cyndi, Champagne, Jean, Philippon, François, O'Hara, Gilles, Blier, Louis, Plourde, Benoit, Nault, Isabelle, Roy, Karine, Sarrazin, Jean-François, Spatz, Alan, and Bossé, Yohan

Abstract

Aims Risk stratification for sudden cardiac death in patients with Brugada syndrome remains a major challenge. Contemporary risk prediction models have only modest predictive value. The aim of this study was to assess the role of micro-RNAs from peripheral blood as candidate biomarkers in Brugada syndrome. Methods and results In this prospective study, Brugada patients and unaffected control individuals were enrolled for analysis of leucocyte-derived microRNAs (miRNAs) levels. Expression levels of 798 different circulating miRNAs were analysed on the NanoString® nCounter platform. All results were cross-validated by using a quantitative polymerase chain reaction. Micro-RNA expression levels of Brugada patients were compared with clinical data. A total of 21 definite Brugada patients (38% with a history of ventricular arrhythmia or cardiac arrest) and 30 unaffected control individuals were included in the study. Micro-RNA analysis showed a distinct expression profile in Brugada patients with 42 differentially expressed markers (38 up-regulated, 4 down-regulated miRNAs). The symptom status of Brugada patients was associated with a distinct miRNA signature. Micro-RNAs 145-5p and 585-3p were significantly up-regulated in symptomatic Brugada patients (P = 0.04). Incorporating miRNAs 145-5p and 585-3p into a multivariable model demonstrated significantly increased symptom prediction (area under the curve = 0.96; 95% confidence interval: 0.88–1.00). Conclusion Brugada patients display a distinct miRNA expression profile compared with unaffected control individuals. There is also evidence that certain miRNAs (miR-145-5p and miR-585-3p) are associated with the symptom status of Brugada patients. The results suggest the principal utility of leucocyte-derived miRNAs as prognostic biomarkers for Brugada syndrome. [ABSTRACT FROM AUTHOR]

Published
2023
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50. Safety of Cefazolin Test Dose in Patients With Penicillin Allergy Just Prior to Cardiac Device Implantation: A Single-Centre Experience

Author

Sarrazin, Jean-François, primary, Laaouaj, Jamal, additional, Philippon, François, additional, Sanchez, Marina, additional, Gervais, Philippe, additional, Champagne, Jean, additional, Steinberg, Christian, additional, Nault, Isabelle, additional, Roy, Karine, additional, Plourde, Benoît, additional, Blier, Louis, additional, and O’Hara, Gilles, additional

Published
2022
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