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Your search keyword '"Chamorovskaia LT"' showing total 4 results
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4 results on '"Chamorovskaia LT"'

1. [Effects of combined action of heavy metal salts and phenol on energetics of isolated rat liver mitochondria].

Author

Mitrokhin NM, Zhigacheva IV, Chamorovskaia LT, and Burov IuV

Subjects
Animals, Drug Combinations, Drug Synergism, Male, Metals administration & dosage, Mitochondria, Liver metabolism, Oxidative Phosphorylation, Oxygen Consumption, Phenol, Phenols administration & dosage, Rats, Rats, Wistar, Salts, Metals toxicity, Mitochondria, Liver drug effects, Phenols toxicity
Abstract

Experiments were carried out to investigate effects of heavy metal salts and phenol both alone and in different combinations on respiration rate and coupling of respiration and oxidative phosphorylation by rat liver mitochondria. Oxygen consumption measurements were obtained using a Clark electrode and lactate plus glutamate as substrates. It is shown that a 50% decrease of the respiratory rate was achieved in less concentrations of substances in the mixture compared with the effects of the individual substances. For respiratory control recovery by EDTA titration more amounts of complexion for model mixtures was necessary. The results evidence synergism of the substances responsible for a considerable increase in toxicity. Mitochondrial test-systems are suggested for rapid prognosis of toxicity of multicomponent mixtures of substances.

Published
1992

2. [Activation of lipid peroxidation in the liver mitochondria and acute toxicity of chemical compounds].

Author

MItrokhin NM, Zhigacheva IV, and Chamorovskaia LT

Subjects
Acute Disease, Animals, Antioxidants pharmacology, Chemical and Drug Induced Liver Injury pathology, Chemical and Drug Induced Liver Injury prevention & control, In Vitro Techniques, Lipid Peroxidation drug effects, Male, Mitochondria, Liver drug effects, Oxidative Phosphorylation drug effects, Rats, Chemical and Drug Induced Liver Injury etiology, Disease Models, Animal, Edetic Acid pharmacology, Lipid Peroxidation physiology, Mitochondria, Liver metabolism, Solvents toxicity
Abstract

The effect of toxic substances on the functional state of liver mitochondria has been studied. It has been shown, that the contact of toxic substances with mitochondria lead to the reduction of the degree of association of oxidation with phosphorylation. EDTA in concentrations necessary to inhibit lipid peroxide oxidation prevents toxic effects. Preliminary antioxidant treatment of mitochondria prevents toxic damage of membranes. A close correlation has been established between chemical compounds toxicity and the concentration of antioxidants necessary for the prevention of toxic effects, as well as between chemical compounds toxicity and cumulation of malonic dialdehyde in mitochondria membranes.

Published
1991

3. [Spectrum of action of certain tripeptides on the central nervous system].

Author

Lavretskaia EF, Klusha VE, Svirskis ShV, Chamorovskaia LT, and Mutsenietse RK

Subjects
Animals, Biogenic Amines analysis, Brain Chemistry drug effects, Caudate Nucleus drug effects, Injections, Intraperitoneal, Injections, Intraventricular, Male, Mice, Motor Activity, Rats, Central Nervous System drug effects, Gastrins pharmacology, Oligopeptides pharmacology, Oxytocin pharmacology, Peptide Fragments pharmacology, Thyrotropin-Releasing Hormone pharmacology
Published
1981

4. [Psychotropic properties of the tetrapeptide taftsin and its effect on learning].

Author

Lavretskaia EF, Ashmarin IP, Kamenskiĭ AA, Chamorovskaia LT, and Antonova LV

Subjects
Amphetamine administration & dosage, Animals, Apomorphine administration & dosage, Arecoline administration & dosage, Brain drug effects, Drug Interactions, Hexobarbital administration & dosage, Levodopa administration & dosage, Male, Mice, Motor Activity drug effects, Orientation drug effects, Perphenazine administration & dosage, Reserpine administration & dosage, Tuftsin administration & dosage, Behavior, Animal drug effects, Immunoglobulin Fragments pharmacology, Learning drug effects, Psychotropic Drugs, Tuftsin pharmacology
Abstract

Experiments on mice and rats have disclosed that taftsin so far known for its stimulatory action on phagocytosis has psychotropic properties. Taftsin potentiates the motor and orienting activity of the animals, reduces the effects of hexenal, reserpine, potentiates the action of amphetamine and arecoline. It shortens the latent period and time of the reaction during training of the rats in a T-shaped maze, but does not increase the number of the training animals. The effect of taftsin has a biphasic nature and seems likely to be related to the effect on alpha-adrenergic systems of the brain.

Published
1981

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