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29 results on '"Chamberlain, Florence"'

11. A Timely Oral Option: Single-Agent Vinorelbine in Desmoid Tumors

Author

Gennatas, Spyridon, primary, Chamberlain, Florence, additional, Smrke, Alannah, additional, Stewart, James, additional, Hayes, Andrew, additional, Roden, Lorna, additional, Messiou, Christina, additional, Kowa, Jie-Ying, additional, Estival, Anna, additional, Chauhan, Dharmisha, additional, Thway, Khin, additional, Fisher, Cyril, additional, van der Graaf, Winette T. A., additional, Jones, Robin L., additional, and Benson, Charlotte, additional

Published
2020
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13. The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

Author

Constantinidou, Anastasia, Tong, Daniel, Engelmann, Bodil, Chamberlain, Florence, Thway, Khin, Fisher, Cyril, Hayes, Andrew, Fotiadis, Nicos, Messiou, Christina, Miah, Aisha B., Zaidi, Shane H., Benson, Charlotte, Graaf, Winette Van Der, Jones, Robin L., Constantinidou, Anastasia [0000-0001-5316-7574], and Messiou, Christina [0000-0002-0557-9379]

Subjects
Adult, Male, Cancer Research, medicine.medical_specialty, Adolescent, Pleural effusion, medicine.medical_treatment, Disease, Systemic therapy, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, medicine, Combined Modality Therapy, Humans, Young adult, Disease management (health), Watchful Waiting, Epithelioid hemangioendothelioma, Aged, Neoplasm Staging, business.industry, Disease Management, General Medicine, Middle Aged, medicine.disease, Prognosis, Pleural Effusion, Oncology, 030220 oncology & carcinogenesis, Hemangioendothelioma, Epithelioid, Female, Neoplasm Recurrence, Local, business, Watchful waiting, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9]
Abstract

Contains fulltext : 208930.pdf (Publisher’s version ) (Open Access) BACKGROUND/AIM: Epithelioid haemangioendothelioma (EHE) is a rare tumor with a wide spectrum of clinical behavior. There is no consensus on the role of local therapy in symptomatic, multi-focal disease. PATIENTS AND METHODS: A retrospective review of patients presenting to the Royal Marsden Hospital between January 2000 and December 2017 was conducted. RESULTS: Fifty-three patients with EHE were identified, of which 18 patients (34.0%) received local therapy, and 11 patients (20.8%) underwent active surveillance. A variety of local treatment modalities were used with few toxicities, and local recurrence was managed with other local treatments or systemic therapy. Distal disease progression was infrequent (n=4, 7.5%). Patients who developed pleural effusion (n=5, 9.4%) had poor outcome irrespective of treatment. CONCLUSION: Local therapy has a role in a selected patient group managed in a multidisciplinary setting, including patients with indolent disease, and patients with a solitary area of progression/symptomatic disease.

Published
2019

16. The Role of Local Therapy in Multi-focal Epithelioid Haemangioendothelioma

Author

TONG, DANIEL, primary, CONSTANTINIDOU, ANASTASIA, additional, ENGELMANN, BODIL, additional, CHAMBERLAIN, FLORENCE, additional, THWAY, KHIN, additional, FISHER, CYRIL, additional, HAYES, ANDREW, additional, FOTIADIS, NICOS, additional, MESSIOU, CHRISTINA, additional, MIAH, AISHA B., additional, ZAIDI, SHANE H., additional, BENSON, CHARLOTTE, additional, VAN DER GRAAF, WINETTE, additional, and JONES, ROBIN L., additional

Published
2019
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19. Complications From Paracentesis For Malignant Ascites At A Tertiary Cancer Centre

Author

Chamberlain, Florence

Abstract

Introduction:Malignant ascites is associated with poor survival and can cause a significant symptom burden. Paracentesis is the most common procedure to manage malignant ascites with a complication rate of around 20% reported in the literature. ObjectivesTo investigate the rate of complications with day-case paracentesis in a tertiary cancer centre.MethodsA retrospective study of all day case ascitic drainages performed in one ambulatory unit during November 2015-May 2017. Patients with hepatocellular carcinoma or known non-malignant cirrhotic liver disease were excluded.ResultsForty-eight patients underwent 128 paracentesis. The median age was 59 years, 89% of patients were female; ovarian (n=12) and breast (n=11) were the commonest tumour types. Median number of paracentesis per patient was 2 (interquartile range 1-3), median days between each drain was 20 (interquartile range 14-35 days) and median volume drained was 5L (interquartile range 4-7L). Symptom control was achieved in 94% of paracentesis performed.8.3% of patients experienced a serious complication following ascitic drainage (spontaneous bacterial peritonitis (n=2) and acute kidney injury (n=3)). Admission was required after 5.4% of paracentesis for abdominal pain and nausea (n=3), unsuccessful insertion (n=1), hyponatraemia (n=1) and hypovolaemia requiring intravenous fluids (n=2). Median survival from first ascitic drainage to death was 145 days (95% CI, 53-243). Despite small numbers, there was a significant difference in survival between patients who did and did not develop complications following drainage (p=

Published
2017

20. Adult soft tissue myoepithelial carcinoma: treatment outcomes and efficacy of chemotherapy.

Author

Chamberlain, Florence, Cojocaru, Elena, Scaranti, Mariana, Noujaim, Jonathan, Constantinou, Anastasia, Thway, Khin, Fisher, Cyril, Messiou, Christina, Strauss, Dirk C., Miah, Aisha, Zaidi, Shane, Benson, Charlotte, Gennatas, Spyridon, and Jones, Robin L.

Abstract

Soft tissue myoepithelial carcinomas are a rare, malignant subgroup of myoepithelial tumours mostly arising in the extremities with equal predilection for women and men. The mainstay of management of localised disease is complete surgical resection. Despite optimal treatment, 40-45% of tumours recur. Data regarding the efficacy of systemic therapy for advanced and metastatic disease are lacking. The primary aim of this study was to evaluate the outcome of all patients with soft tissue myoepithelial carcinoma treated at a single referral centre. The secondary aim was to establish the efficacy of systemic therapies in patients with advanced disease. A retrospective review of the prospectively maintained Royal Marsden Sarcoma Unit database was performed to identify soft tissue myoepithelial carcinoma patients treated between 1996 and 2019. Patient baseline characteristics and treatment history were recorded. Response to systemic therapy was evaluated using RECIST 1.1. We identified 24 patients treated at our institution between 1996 and 2019,12 males and 12 females. Median age at presentation was 49.6 years [interquartile range (IQR) 40.5-63.3 years]. Twenty-two out of 24 patients (91.7%) underwent primary surgical resection. Nine patients (37.5%) received systemic treatment. A partial response was documented in one patient treated with doxorubicin. The median progression-free survival for first-line chemotherapy was 9.3 months. Myoepithelial carcinoma frequently recurs after complete surgical resection. Conventional chemotherapy demonstrated some activity in myoepithelial carcinoma, however, more effective systemic therapies are required and enrolment in clinical trial should be encouraged. [ABSTRACT FROM AUTHOR]

Published
2020
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21. Low-grade Fibromyxoid Sarcoma: Treatment Outcomes and Efficacy of Chemotherapy.

Author

CHAMBERLAIN, FLORENCE, ENGELMANN, BODIL, AL-MUDERIS, OMAR, MESSIOU, CHRISTINA, THWAY, KHIN, MIAH, AISHA, ZAIDI, SHANE, CONSTANTINIDOU, ANASTASIA, BENSON, CHARLOTTE, GENNATAS, SPYRIDON, and JONES, ROBIN L.

Subjects
SARCOMA, CANCER chemotherapy, CHROMOSOMAL translocation, RADIOTHERAPY
Abstract

Background: Low-grade fibromyxoid sarcoma (LGFMS) is a rare sarcoma subtype with a generally indolent pattern of clinical behaviour, but treatments for advanced disease are limited. Patients and Methods: A retrospective search of a prospectively maintained institutional database identified 102 patients treated from December 1994 to August 2018. We evaluated the outcome of patients and the efficacy and safety of non-surgical therapies in LGFMS. Results: Ninety-four out of 102 (92.2%) underwent primary resection, seven (6.9%) were treated with systemic therapy and one (1.0%) is currently being treated with pre-operative radiotherapy. The RECIST 1.1 response rate to first-line chemotherapy was 0%, and median progression-free survival was 1.84 months (95% confidence intervaI=0.10-3.6 months). Conclusion: Conventional systemic therapy has limited efficacy in advanced LGFMS. [ABSTRACT FROM AUTHOR]

Published
2020
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24. Motion sickness in migraine and vestibular disorders

Author

Murdin, Louisa, Chamberlain, Florence, Cheema, Sanjay, Arshad, Qadeer, Gresty, Michael A, Golding, John F, and Bronstein, Adolfo

Subjects
Adult, Male, Motion Sickness, Migraine Disorders, PostScript, Middle Aged, Severity of Illness Index, NEUROOTOLOGY, Young Adult, Vestibular Diseases, Case-Control Studies, Humans, Female
Published
2014

28. Chemotherapy for Hodgkin's lymphoma in a patient receiving clozapine for treatment-resistant schizophrenia: use of the Mental Capacity Act 2005

Author

Chamberlain, Florence Elizabeth, Walsh, Nicholas, and Falkowski, Jan

Abstract

Treatment resistance occurs in approximately 30% of individuals with schizophrenia and is commonly treated with clozapine. Nodular sclerosing Hodgkin's lymphoma is a subtype of Hodgkin's lymphoma predominantly affecting those under 50 years of age. In this case report, an individual with treatment-resistant schizophrenia developed nodular sclerosing Hodgkin's lymphoma and is treated with concurrent clozapine and systemic chemotherapy. The aim of this case report is to act as guidance for clinicians and to outline the difficulties of treating individuals with psychiatric illness under the Mental Capacity Act 2005 when the proposed treatment could lead to high levels of morbidity and mortality.

Published
2015
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