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The integration of multimegawatt fast chargers into local distribution grids is becoming increasingly relevant due to recent initiatives to push for higher charging power, especially for applications like heavy-duty vehicles. However, the high-power capacity of these chargers, especially when multiple units operate simultaneously at specific locations, raises several important considerations for the optimal design and integration of multimegawatt fast chargers. These include, for example, power electronics architectures and dedicated designs, grid stability, and the incorporation of renewable energy systems. Thus, this paper provides a comprehensive analysis of the key factors influencing the optimal integration of these ultra-high-power chargers, looking into impacts on medium-voltage (MV) networks, the design considerations for medium-voltage power electronics in DC chargers, and the potential of renewable energy systems to offset grid demand. Additionally, this paper explores the potential high-level communication requirements necessary for efficient and reliable charger operation, including a proposal for a robust communication interface layer stack. This investigation aims to provide a holistic understanding of the challenges and opportunities associated with integrating multimegawatt fast chargers into existing power systems, offering insights into the enhancement of both performance and sustainability.

Author(s): Dipak K. Raj [sup.1] [sup.2] , Alok Das Mohapatra [sup.1] [sup.2] , Anup Jnawali [sup.1] [sup.2] , Jenna Zuromski [sup.1] [sup.2] , Ambrish Jha [sup.1] , Gerald Cham-Kpu [sup.1] [...], Malaria caused by Plasmodium falciparum remains the leading single-agent cause of mortality in children.sup.1, yet the promise of an effective vaccine has not been fulfilled. Here, using our previously described differential screening method to analyse the proteome of blood-stage P. falciparum parasites.sup.2, we identify P. falciparum glutamic-acid-rich protein (PfGARP) as a parasite antigen that is recognized by antibodies in the plasma of children who are relatively resistant--but not those who are susceptible--to malaria caused by P. falciparum. PfGARP is a parasite antigen of 80 kDa that is expressed on the exofacial surface of erythrocytes infected by early-to-late-trophozoite-stage parasites. We demonstrate that antibodies against PfGARP kill trophozoite-infected erythrocytes in culture by inducing programmed cell death in the parasites, and that vaccinating non-human primates with PfGARP partially protects against a challenge with P. falciparum. Furthermore, our longitudinal cohort studies showed that, compared to individuals who had naturally occurring anti-PfGARP antibodies, Tanzanian children without anti-PfGARP antibodies had a 2.5-fold-higher risk of severe malaria and Kenyan adolescents and adults without these antibodies had a twofold-higher parasite density. By killing trophozoite-infected erythrocytes, PfGARP could synergize with other vaccines that target parasite invasion of hepatocytes or the invasion of and egress from erythrocytes. Antibodies against Plasmodium falciparum glutamic-acid-rich protein (PfGARP), an antigen expressed on the surface of infected red blood cells, kill P. falciparum parasites by inducing programmed cell death and reduce the risk of severe malaria.