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Your search keyword '"Challis, Pontus"' showing total 5 results
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5 results on '"Challis, Pontus"'

1. Factors associated with the increased incidence of necrotising enterocolitis in extremely preterm infants in Sweden between two population-based national cohorts (2004–2007 vs 2014–2016)

Author

Challis, Pontus, primary, Källén, Karin, additional, Björklund, Lars, additional, Elfvin, Anders, additional, Farooqi, Aijaz, additional, Håkansson, Stellan, additional, Ley, David, additional, Norman, Mikael, additional, Normann, Erik, additional, Serenius, Fredrik, additional, Sävman, Karin, additional, Hellström-Westas, Lena, additional, Um-Bergström, Petra, additional, Ådén, Ulrika, additional, Abrahamsson, Thomas, additional, and Domellöf, Magnus, additional

Published
2023
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2. Factors associated with the increased incidence of necrotising enterocolitis in extremely preterm infants in Sweden between two population-based national cohorts (2004--2007 vs 2014--2016).

Author

Challis, Pontus, Källén, Karin, Björklund, Lars, Elfvin, Anders, Farooqi, Aijaz, Håkansson, Stellan, Ley, David, Norman, Mikael, Normann, Erik, Serenius, Fredrik, Sävman, Karin, Hellström-Westas, Lena, Um-Bergström, Petra, Ådén, Ulrika, Abrahamsson, Thomas, and Domellöf, Magnus

Subjects
ENTEROCOLITIS, PREMATURE infants, INTRAVENTRICULAR hemorrhage, LOW birth weight, VERY low birth weight, NEONATAL necrotizing enterocolitis, MEDICAL sciences
Published
2024
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3. Association of Adherence to Surfactant Best Practice Uses With Clinical Outcomes Among Neonates in Sweden

Author

Challis, Pontus, Nydert, Per, Håkansson, Stellan, and Norman, Mikael

Subjects
Male, Sweden, Respiratory Distress Syndrome, Newborn, Research, Transient Tachypnea of the Newborn, Infant, Newborn, Pediatrik, Gestational Age, Off-Label Use, Pediatrics, Meconium Aspiration Syndrome, Online Only, Surface-Active Agents, Treatment Outcome, Pregnancy, Infant, Extremely Premature, Practice Guidelines as Topic, Humans, Female, Guideline Adherence, Practice Patterns, Physicians', Original Investigation, Drug Labeling
Abstract

Key Points Question What strategies for surfactant treatment of newborn infants are used, and how are these strategies associated with outcomes? Findings In this cohort study of 5209 infants who received 7980 surfactant administrations, late surfactant treatment (>2 hours after birth) was provided for 39% of very preterm infants and associated with higher neonatal morbidity. Off-label use occurred in 19% of infants without any association to outcome, and treatment omissions were associated with lower survival. Meaning In this study, adherence to best practices for surfactant use in newborn infants varied, with important clinical implications for neonatal outcomes., This cohort study evaluates registered use, off-label use, and omissions of surfactant treatment by gestational age and associations with outcomes, mainly among very preterm infants (gestational age, Importance While surfactant therapy for respiratory distress syndrome (RDS) in preterm infants has been evaluated in clinical trials, less is known about how surfactant is used outside such a framework. Objective To evaluate registered use, off-label use, and omissions of surfactant treatment by gestational age (GA) and associations with outcomes, mainly among very preterm infants (GA

Published
2021

5. Validation of the diagnosis of necrotising enterocolitis in a Swedish population-based observational study.

Author

Challis, Pontus, Larsson, Linn, Stoltz Sjöström, Elisabeth, Serenius, Fredrik, Domellöf, Magnus, and Elfvin, Anders

Subjects
*PREMATURE infants, *HOSPITAL records, *SCIENTIFIC observation, *SYMPTOMS, *INFANTS, *COMPARATIVE studies, *NEONATAL necrotizing enterocolitis, *PREMATURE infant diseases, *LONGITUDINAL method, *RESEARCH methodology, *MEDICAL cooperation, *RESEARCH, *RESEARCH funding, *EVALUATION research, *DISEASE incidence, RESEARCH evaluation
Abstract

Aim: The definition of necrotising enterocolitis (NEC) is based on clinical and radiological signs that can be difficult to interpret. The aim of the present study was to validate the incidence of NEC in the Extremely Preterm Infants in Sweden Study (EXPRESS) METHODS: The EXPRESS study consisted of all 707 infants born before 27 + 0 gestational weeks during the years 2004-2007 in Sweden. Of these infants, 38 were recorded as having NEC of Bell stage II or higher. Hospital records were obtained for these infants. Furthermore, to identify missed cases, all infants with a sudden reduction of enteral nutrition, in the EXPRESS study were identified (n = 71). Hospital records for these infants were obtained. Thus, 108 hospital records were obtained and scored independently by two neonatologists for NEC.Results: Of 38 NEC cases in the EXPRESS study, 26 were classified as NEC after validation. Four cases not recorded in the EXPRESS study were found. The incidence of NEC decreased from 6.3% to 4.3%.Conclusion: Validation of the incidence of NEC revealed over- and underestimation of NEC in the EXPRESS study despite carefully collected data. Similar problems may occur in other national data sets or quality registers. [ABSTRACT FROM AUTHOR]

Published
2019
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