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In the present study, new chalcone derivatives (5-7) obtained from the condensation reaction of cuminaldehyde and acetophenone compounds containing different substituents were reported. Chemical characterization (1H-NMR and 13C-NMR analysis) and molecular docking studies of the synthesized compounds were performed against the epidermal growth factor receptor (EGFR) and reference drug (metachalcone). Erlotinib was used as the reference ligand. Compound 5 (-7.6 kcal mol-1), compound 6 (-7.38 kcal mol-1), and compound 7 (-7.44 kcal mol-1) were found to be the strongest inhibitors of EGFR when compared to Erlotinib (-7.0 kcal mol-1). In addition, an ADME estimation was made. It was determined that the synthesized compounds could be potent EGFR inhibitors compared to Erlotinib. Compounds 5-7 and the target protein showed a better binding affinity for EGFR than the reference compound (Erlotinib). The synthesized compounds can be potent inhibitors for EGFR-mutated cancers. [ABSTRACT FROM AUTHOR]

Chalcone is flavonoids class that have activity as sunscreen. The objective of this research is to find out the optimum formula of chalcone lotion, physical properties and stability of optimum formula lotion o/w, and sunscreen activity by spectrofotometry.         The optimum formula was obtained by Simplex Lattice Design (SLD) method using Design Expert® version 10. To determine the optimum formula used three responses, namely viscosity, spreading, and adhessiveness. The physical properties of the lotion o/w were carried out including spreading test, adhessiveness test, and viscosity. The physical stability test of lotion o/w was done by cycling test. The sunscreen lotion activity o/w is determined by spectrophotometry by determining SPF, %Erythema Transmission, and %Pigmentation Transmission. Data were analyzed by t-test and One Way ANOVA with 95% confidence level. The results showed that the optimum lotion formula was found in combination of 2.40% cetyl alcohol, 0.36% carbopol, and 5.74% glycerin. The optimum formula of chalcone lotion has a viscosity of 73.48 ± 6.18 dPas, adhesiveness of 7.14 ± 1.26 seconds, and a spreading power of 24.99 ± 1.11 cm2. The results of statistical analysis showed that the lotion has a pretty good stability. Lotion has activity as sunscreen at concentration of chalcone in lotion 0,05% with SPF 36,927 and can provide protection against erythema and pigmentation.

Die Chalconisomerase (CHI) ist ein Schlüsselenzym in der Biosynthese von Flavonoiden in Pflanzen. Die erste bakterielle CHI (CHIera) wurde in Eubacterium ramulus identifiziert, aber Häufigkeit, evolutionärer Ursprung, Substratspektrum und Stereoselektivität sind bislang unklar. Hier beschreiben wir die Identifizierung von 66 neuen bakteriellen CHIs in Genbank durch eine neuartige Sequenz‐Struktur‐Funktions‐Evolutions (SSFE)‐Strategie. Diese neuen bakteriellen CHIs weisen ein breites Substratspektrum gegenüber einer Reihe hydroxylierter und methoxylierter Chalcone auf. Die Mutagenese der CHIera, basierend auf einem Substratbindemodell dieser neuen bakteriellen CHIs, resultierte in mehreren Varianten mit deutlich verbesserter Aktivität gegenüber diesen Chalconen. Zusätzlich wurden präparative Reaktionen mit diesen bakteriellen CHIs für fünf Chalcone durchgeführt, die (S)‐Selektivität mit bis zu 96 % ee ergaben. Dies ermöglicht eine alternative biokatalytische Route zur Synthese von (S)‐Flavanonen in hohen Ausbeuten. [ABSTRACT FROM AUTHOR]

ABSTRACT Samples collected from different plants (Potato, Carrot, Pear) from many sources shown signs of infection with bacteria. The isolated bacteria causing each disease were identified seven isolates of Erwinia carotovoa var. carotovora and five isolates belong to E.chrysanthemi that isolated of potato and fore isolates of E.c.c that isolated of carrot and fore isolates of E.amylovora isolated of Pear E.c.c. and E.ch caused black stem disease in potato and E.c.c. caused Rut Root for carrot and E.a. caused fire Blight.Chalcon used as a method for resisting these diseases and have shown that chalcon (acetophenon benzayl dehyde) better than chalcon (aceto phenon para methoxy benzayl dehyde) in resisting thes diseases except E.amylovora which have better result in chalcon (aceto phenon Paramethoxy benzayl dehyde) in 5% concentration.

Abstract: A series of 2-arylmethylideneferroceno[e]cyclohexanone was prepared by base-catalysed condensation of ferroceno[b]cyclohexanone with a variety of aryl aldehydes including formylferrocene. The decreased reactivity of these novel chalcones towards nucleophic reagents was interpreted by the comparison of DFT reactivity indices calculated for a selection of appropriate models. The conversion of five representative chalcones into ferroceno[g]indazoles of potential biological interest could be achieved by thiosemicarbazide-mediated cyclisation catalysed by hydrochloric acid in ethanol at reflux. The relative configurations of the novel chalcones and ferrocenoindazoles with the elements of planar-, helical- and central chirality were established by NMR methods and single-crystal X-ray diffraction. [Copyright &y& Elsevier]

The reaction of chalcones and guanidine was investigated in the presence of an oxidizing agent. Depending on the order of the addition either a 4,6-diaryl-pyrimidine-2-ylamine or 2-amino-5,5-disubstituted-3,5-dihydro-imidazol-4-one was obtained. The structures of the imidazolinones were elucidated by NMR spectroscopy and X-ray crystallography and for its formation a mechanism was proposed. [Copyright &y& Elsevier]